公开(公告)号：WO2018136600A1

公开(公告)日：2018-07-26

申请号：PCT/US2018/014169

申请日：2018-01-18

Applicant: TEVA PHARMACEUTICALS INTERNATIONAL GMBH ,  TEVA PHARMACEUTICALS USA, INC. ,  NATIONAL UNIVERSITY OF SINGAPORE ,  AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ,  HAYDEN, Michael ,  POULADI, Mahmoud, Abdulhossein

Inventor： HAYDEN, Michael ,  POULADI, Mahmoud, Abdulhossein

IPC: A61P25/28 ,  C07D211/24

Abstract: The invention provides a method of treating a subject afflicted with fragile X syndrome (FXS) or a FXS related disorder, comprising periodically administering to the subject a pharmaceutical composition comprising an amount of pridopidine effective to treat the subject.

公开(公告)号：WO2016004250A2

公开(公告)日：2016-01-07

申请号：PCT/US2015/038901

申请日：2015-07-01

Applicant: TEVA PHARMACEUTICAL INDUSTRIES LTD. ,  HAYDEN, Michael ,  TOWFIC, Fadi, George ,  KOLITZ, Sarah, Elisabeth ,  ZESKIND, Benjamin, James ,  LADKANI, David ,  HASSON, Tal ,  HAYARDENY, Liat ,  GROSSMAN, Iris

Inventor： HAYDEN, Michael ,  TOWFIC, Fadi, George ,  KOLITZ, Sarah, Elisabeth ,  ZESKIND, Benjamin, James ,  LADKANI, David ,  HASSON, Tal ,  HAYARDENY, Liat ,  GROSSMAN, Iris

IPC: A61K38/16 ,  C12Q1/37

CPC classification number: G01N33/5023 ,  G01N33/5008

Abstract: abstract too long

Abstract translation: 抽象太久了

公开(公告)号：WO2015061367A1

公开(公告)日：2015-04-30

申请号：PCT/US2014/061647

申请日：2014-10-21

Applicant: TEVA PHARMACEUTICAL INDUSTRIES LTD. ,  TEVA PHARMACEUTICALS USA, INC. ,  TCHELET, Amir ,  HAYDEN, Michael ,  HAYARDENY, Liat ,  ROSS, Colin, James Douglas ,  GROSSMAN, Iris ,  LADKANI, David

Inventor： TCHELET, Amir ,  HAYDEN, Michael ,  HAYARDENY, Liat ,  ROSS, Colin, James Douglas ,  GROSSMAN, Iris ,  LADKANI, David

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  A61K38/02 ,  A61K38/16 ,  C12Q2600/106 ,  C12Q2600/156

Abstract: The present invention provides a method for treating a human subject afflicted with multiple sclerosis or a single clinical attack consistent with multiple sclerosis with a pharmaceutical composition comprising glatiramer acetate and a pharmaceutically acceptable carrier, comprising the steps of: (i) determining a genotype corresponding to the nucleotide polymorphisms consisting of: Group 1, of the subject at a location location of one or more single (SNPs) selected from the group.

Abstract translation: 本发明提供了一种治疗患有多发性硬化的人类受试者或与多发性硬化一致的单一临床攻击的方法，所述药物组合物包含乙酸格拉默和药学上可接受的载体，包括以下步骤：（i）确定对应于 所述核苷酸多态性由选自组中的一个或多个单个（SNP）的位置位置处的受试者的组1组成。

公开(公告)号：WO2014052935A3

公开(公告)日：2014-05-15

申请号：PCT/US2013062484

申请日：2013-09-27

Applicant: TEVA PHARMA ,  TEVA PHARMA ,  HAYDEN MICHAEL ,  FITZER-ATTAS CHERYL

Inventor： HAYDEN MICHAEL ,  FITZER-ATTAS CHERYL

IPC: A61K31/135 ,  A61K31/445

CPC classification number: A61K31/451 ,  A61K31/135 ,  A61K31/137 ,  A61K2300/00

Abstract: This invention provides a method of treating a patient afflicted with a neurodegenerative disorder, e.g., Huntington's disease, comprising administering to the patient rasagiline as an add-on therapy to or in combination with pridopidine. This invention also provides a package and a pharmaceutical composition comprising rasagiline and pridopidine for treating a patient afflicted with a neurodegenerative disorder. This invention also provides rasagiline for use as an add-on therapy or in combination with pridopidine in treating a patient afflicted with a neurodegenerative disorder. This invention further provides use of rasagiline and pridopidine in the preparation of a combination for treating a patient afflicted with a neurodegenerative disorder.

Abstract translation: 本发明提供了治疗患有神经退行性疾病例如亨廷顿舞蹈病的患者的方法，其包括向患者施用雷沙吉兰作为与特鲁替丁或与其结合的附加疗法。 本发明还提供了一种包含药物组合物和药物组合物，其包含用于治疗患有神经变性疾病的患者的雷沙吉兰和格列方啶。 本发明还提供雷沙吉兰作为附加疗法或与格列吡啶联合用于治疗患有神经变性疾病的患者。 本发明进一步提供了雷沙吉兰和格列吡啶在制备用于治疗患有神经变性疾病的患者的组合中的用途。

公开(公告)号：WO2007034350A3

公开(公告)日：2007-03-29

申请号：PCT/IB2006/053162

申请日：2006-09-07

Applicant: THE PROCTER & GAMBLE COMPANY ,  LAVON, Gary, Dean ,  HAMALL, Kenneth, Michael ,  BECK, Theodora ,  HAYDEN, Michael, Patrick ,  LUDWIG, Susan, Joy

Inventor： LAVON, Gary, Dean ,  HAMALL, Kenneth, Michael ,  BECK, Theodora ,  HAYDEN, Michael, Patrick ,  LUDWIG, Susan, Joy

IPC: A61F13/64

Abstract: A disposable absorbent article having laterally opposing interiorly attached barrier cuff strips and at least one deploy able belt strip. Each barrier cuff strip is attached to an interior surface of an absorbent assembly and has a longitudinally extending elastic gathering member attached adjacent to its proximal edge. The belt strip has a fixed end portion and opposing first and second edges connecting the fixed end portion and an opposing free end portion. The belt strip is attached in the fixed end portion and is deployed by being folded laterally outward such that the first edge extends laterally outward from one end point of a diagonal fold line and the second edge extends laterally outward from the opposing end point of the diagonal fold line. The belt strip may be tied to another belt strip or may be fastened to the waist region of the article or to another belt strip.

公开(公告)号：WO2007034350A2

公开(公告)日：2007-03-29

申请号：PCT/IB2006053162

申请日：2006-09-07

Applicant: PROCTER & GAMBLE ,  LAVON GARY DEAN ,  HAMALL KENNETH MICHAEL ,  BECK THEODORA ,  HAYDEN MICHAEL PATRICK ,  LUDWIG SUSAN JOY

Inventor： LAVON GARY DEAN ,  HAMALL KENNETH MICHAEL ,  BECK THEODORA ,  HAYDEN MICHAEL PATRICK ,  LUDWIG SUSAN JOY

CPC classification number: A61F13/64 ,  A61F13/4942 ,  A61F13/5622

Abstract: A disposable absorbent article having laterally opposing interiorly attached barrier cuff strips and at least one deploy able belt strip. Each barrier cuff strip is attached to an interior surface of an absorbent assembly and has a longitudinally extending elastic gathering member attached adjacent to its proximal edge. The belt strip has a fixed end portion and opposing first and second edges connecting the fixed end portion and an opposing free end portion. The belt strip is attached in the fixed end portion and is deployed by being folded laterally outward such that the first edge extends laterally outward from one end point of a diagonal fold line and the second edge extends laterally outward from the opposing end point of the diagonal fold line. The belt strip may be tied to another belt strip or may be fastened to the waist region of the article or to another belt strip.

Abstract translation: 一种一次性吸收制品，其具有横向相对的内部附着的阻挡箍带和至少一个可部署的带状带。 每个阻挡箍带附接到吸收组件的内表面，并且具有邻近其近侧边缘附接的纵向延伸的弹性聚集构件。 带条具有固定的端部和连接固定端部和相对的自由端部的相对的第一和第二边缘。 带条附着在固定端部，并且通过横向向外折叠而展开，使得第一边缘从对角折线的一个端点横向向外延伸，并且第二边缘从对角线的相对端点横向向外延伸 折线。 带条可以绑在另一条带上，或者可以固定在制品的腰部区域或另一条带条上。

公开(公告)号：WO2007034349A1

公开(公告)日：2007-03-29

申请号：PCT/IB2006/053161

申请日：2006-09-07

Applicant: THE PROCTER & GAMBLE COMPANY ,  LAVON, Gary, Dean ,  HAMALL, Kenneth, Michael ,  BECK, Theodora ,  HAYDEN, Michael, Patrick ,  LUDWIG, Susan, Joy

Inventor： LAVON, Gary, Dean ,  HAMALL, Kenneth, Michael ,  BECK, Theodora ,  HAYDEN, Michael, Patrick ,  LUDWIG, Susan, Joy

IPC: A61F13/64

CPC classification number: A61F13/5622 ,  A61F13/64

Abstract: A disposable absorbent article having laterally opposing interiorly attached side flaps and at least one deployable belt strip. Each side flap is formed by folding a portion of the absorbent assembly laterally inward and has a longitudinally extending elastic gathering member attached adjacent to its proximal edge. The belt strip has a fixed end portion and opposing first and second edges connecting the fixed end portion and an opposing free end portion. The belt strip is attached in the fixed end portion and is deployed by being folded laterally outward such that the first edge extends laterally outward from one end point of a diagonal fold line and the second edge extends laterally outward from the opposing end point of the diagonal fold line. The belt strip may be tied to another belt strip or may be fastened to the waist region of the article or to another belt strip.

Abstract translation: 一种一次性吸收制品，其具有横向相对的内部附接的侧翼和至少一个可展开的带条。 每个侧翼片通过将吸收组件的一部分横向向内折叠而形成，并且具有邻近其近侧边缘附接的纵向延伸的弹性聚集构件。 带条具有固定的端部和连接固定端部和相对的自由端部的相对的第一和第二边缘。 带条附着在固定端部，并且通过横向向外折叠而展开，使得第一边缘从对角折线的一个端点横向向外延伸，并且第二边缘从对角线的相对端点横向向外延伸 折线。 带条可以绑在另一个带条上，或者可以固定到制品的腰部区域或另一条带条上。

公开(公告)号：WO2007034348A1

公开(公告)日：2007-03-29

申请号：PCT/IB2006/053160

申请日：2006-09-07

Applicant: THE PROCTER & GAMBLE COMPANY ,  LAVON, Gary, Dean ,  HAMALL, Kenneth, Michael ,  BECK, Theodora ,  HAYDEN, Michael, Patrick ,  LUDWIG, Susan, Joy

Inventor： LAVON, Gary, Dean ,  HAMALL, Kenneth, Michael ,  BECK, Theodora ,  HAYDEN, Michael, Patrick ,  LUDWIG, Susan, Joy

IPC: A61F13/64

CPC classification number: A61F13/5622 ,  A61F13/64

Abstract: A disposable absorbent article having laterally opposing interiorly attached side flaps and at least one deployable belt strip. Each of the side flaps has a longitudinally extending elastic gathering member attached adjacent to its proximal edge. The belt strip has a fixed end portion disposed in one of the waist regions and opposing first and second edges connecting the fixed end portion and an opposing free end portion. The belt strip is attached in the fixed end portion and is deployed by being folded laterally outward such that the first edge extends laterally outward from one end point of a diagonal fold line and the second edge extends laterally outward from the opposing end point of the diagonal fold line. The belt strip may be tied to another belt strip or may be fastened to the waist region of the article or to another belt strip.

Abstract translation: 一种一次性吸收制品，其具有横向相对的内部连接的侧翼和至少一个可展开的带条。 每个侧翼具有邻近其近侧边缘附接的纵向延伸的弹性聚集构件。 带条具有设置在一个腰部区域中的固定端部和连接固定端部和相对的自由端部的相对的第一和第二边缘。 带条附着在固定端部，并且通过横向向外折叠而展开，使得第一边缘从对角折线的一个端点横向向外延伸，并且第二边缘从对角线的相对端点横向向外延伸 折线。 带条可以绑在另一条带上，或者可以固定在制品的腰部区域或另一条带条上。

公开(公告)号：WO2006086498A2

公开(公告)日：2006-08-17

申请号：PCT/US2006/004482

申请日：2006-02-08

Applicant: ASPREVA PHARMACEUTICALS SA ,  GLICKMAN, Richard ,  HAYDEN, Michael, R. ,  HALL, Noel

Inventor： GLICKMAN, Richard ,  HAYDEN, Michael, R. ,  HALL, Noel

IPC: A61K31/343 ,  A61K31/5377 ,  A61P9/00 ,  A61P9/10 ,  A61P29/00 ,  A61P37/00

CPC classification number: A61K31/365 ,  A61K31/343 ,  A61K31/5377

Abstract: The disclosure provides methods and compositions for treating a vascular, autoimmune, and/or inflammatory disease, or a condition associated therewith, with a dose of an inosine monophosphate dehydrogenase (IMPDH) inhibitor effective to treat the vascular, autoimmune and/or inflammatory disease, or associated condition but that does not produce immunosuppression sufficient to reduce the risk of allograft rejection. These lower doses of the immunosuppressant avoid the adverse consequences of severe immunosuppression while providing effective treatment of the vascular, autoimmune and/or inflammatory disease.

Abstract translation: 本公开内容提供了用一定剂量的肌苷单磷酸脱氢酶（IMPDH）抑制剂治疗血管性，自身免疫性和/或炎症性疾病或与其相关的病症的方法和组合物，所述肌苷酸单磷酸脱氢酶（IMPDH）抑制剂有效治疗血管 ，自身免疫性和/或炎性疾病或相关病症，但不产生足以降低同种异体移植排斥风险的免疫抑制。 这些较低剂量的免疫抑制剂避免严重免疫抑制的不良后果，同时提供血管，自身免疫和/或炎症疾病的有效治疗。

公开(公告)号：WO2003004045A2

公开(公告)日：2003-01-16

申请号：PCT/CA2002/001016

申请日：2002-07-05

Applicant: XENON GENETICS, INC. ,  UNIVERSITY OF BRITISH COLUMBIA ,  MACDONALD, Marcia, L. ,  GOLDBERG, Yigal, P. ,  HAYDEN, Michael, R.

Inventor： MACDONALD, Marcia, L. ,  GOLDBERG, Yigal, P. ,  HAYDEN, Michael, R.

IPC: A61K38/00

CPC classification number: G01N33/566 ,  A61K38/179 ,  G01N2333/726 ,  G01N2500/04 ,  G01N2500/10

Abstract: Mutations in Wnt receptor genes, such as FZD4, associated with hereditary human visual disorders, such as familial exudative vitreoretinopathy ("FEVR"), are disclosed along with methods of use of Wnt and/or Wnt receptor genes and proteins, including in assays for therapeutic agents useful in treating such diseases and/or ameliorating their effects as well as methods of diagnosing diseases and disorders caused by mutations in these genes.

Abstract translation: 公开了与遗传性人类视觉障碍相关的Wnt受体基因（例如FZD4）的突变，例如家族性渗出性玻璃体视网膜病（“FEVR”），以及Wnt和/或Wnt的使用方法 受体基因和蛋白质，包括在用于治疗这些疾病和/或改善其效果的治疗剂的测定中以及诊断由这些基因中的突变引起的疾病和病症的方法。