公开(公告)号：WO03040163B1

公开(公告)日：2004-03-25

申请号：PCT/PT0200016

申请日：2002-11-07

Applicant: INST NAC DE ENGENHARIA E TECNO ,  UNIV CAMBRIDGE TECH ,  COSTA MARIA ,  GREEN LUKE ,  SCHMIDT RICHARD ,  LEY STEVE ,  ELEUTERIO MARIA ,  ALVES SUSANA ,  RUBALCAVA CONCEPCION ,  CARDOSO FERNANDO ,  RITTER GERD

Inventor： COSTA MARIA ,  GREEN LUKE ,  SCHMIDT RICHARD ,  LEY STEVE ,  ELEUTERIO MARIA ,  ALVES SUSANA ,  RUBALCAVA CONCEPCION ,  SCHIMMEL JORG ,  RITTER GERD

IPC: A61P37/04 ,  C07J69/00 ,  C07H15/256

CPC classification number: C07J69/00

Abstract: The present invention relates to new saponins for increasing the immune response in mammals and finds application in the field of immunology, supplying in particular new adjuvants, obtained by hemi-synthesis, starting from terpene sources. It also embraces the methods for the use of the new saponins as adjuvants to increase the immune response to an antigen in a mammal. The saponins of the present invention are suitable for veterinary and human pharmaceutical compositions which include one or more antigens, in particular those of synthetic origin, and one or more diluents, in pharmaceutically acceptable vehicles. These compositions can be used as immunopotenciators and/or immunomodulators in animals and human beings. The present invention further constitutes a vaccination method that includes the administration of one or more antigens and one or optionally more than one hemi-synthetic saponin of the invention.

Abstract translation: 本发明涉及用于增加哺乳动物免疫应答的新皂苷，并且在免疫学领域中得到应用，特别是从萜烯源开始通过半合成获得的新佐剂。 它还包括使用新皂甙作为佐剂以增加对哺乳动物抗原的免疫应答的方法。 本发明的皂苷适用于兽药和人类药物组合物，其包括一种或多种抗原，特别是合成来源的抗原，以及一种或多种稀释剂在药学上可接受的载体中。 这些组合物可用作动物和人类的免疫调节剂和/或免疫调节剂。 本发明还构成疫苗接种方法，其包括施用本发明的一种或多种抗原和一种或任选的多于一种的半合成皂苷。

公开(公告)号：WO2003040163A2

公开(公告)日：2003-05-15

申请号：PCT/PT2002/000016

申请日：2002-11-07

Applicant: INSTITUTO NACIONAL DE ENGENHARIA E TECNOLOGIA INDUSTRIAL ,  CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LIMITED ,  CARDOSO, Fernando ,  COSTA, Maria ,  GREEN, Luke ,  SCHMIDT, Richard ,  LEY, Steve ,  ELEUTÉRIO, Maria ,  ALVES, Susana ,  RUBALCAVA, Concepcion

Inventor： COSTA, Maria ,  GREEN, Luke ,  SCHMIDT, Richard ,  LEY, Steve ,  ELEUTÉRIO, Maria ,  ALVES, Susana ,  RUBALCAVA, Concepcion

IPC: C07J69/00

CPC classification number: C07J69/00

Abstract: The present invention relates to new saponins for increasing the immune response in mammals and finds application in the field of immunology, supplying in particular new adjuvants, obtained by hemi-synthesis, starting from terpene sources. It also embraces the methods for the use of the new saponins as adjuvants to increase the immune response to an antigen in a mammal. The saponins of the present invention are suitable for veterinary and human pharmaceutical compositions which include one or more antigens, in particular those of synthetic origin, and one or more diluents, in pharmaceutically acceptable vehicles. These compositions can be used as immunopotenciators and/or immunomodulators in animals and human beings. The present invention further constitutes a vaccination method that includes the administration of one or more antigens and one or optionally more than one hemi-synthetic saponin of the invention.

Abstract translation: 本发明涉及用于增加哺乳动物免疫应答的新皂苷，并且在免疫学领域中得到应用，特别是从萜烯源开始通过半合成获得的新佐剂。 它还包括使用新皂甙作为佐剂以增加对哺乳动物抗原的免疫应答的方法。 本发明的皂苷适用于兽药和人类药物组合物，其包括一种或多种抗原，特别是合成来源的抗原，以及一种或多种稀释剂在药学上可接受的载体中。 这些组合物可用作动物和人类的免疫调节剂和/或免疫调节剂。 本发明还构成疫苗接种方法，其包括施用本发明的一种或多种抗原和一种或任选的多于一种的半合成皂苷。

公开(公告)号：WO2003040163A3

公开(公告)日：2003-05-15

申请号：PCT/PT2002/000016

申请日：2002-11-07

Applicant: INSTITUTO NACIONAL DE ENGENHARIA E TECNOLOGIA INDUSTRIAL ,  CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LIMITED ,  CARDOSO, Fernando ,  RITTER, Gerd ,  COSTA, Maria ,  GREEN, Luke ,  SCHMIDT, Richard ,  LEY, Steve ,  ELEUTÉRIO, Maria ,  ALVES, Susana ,  RUBALCAVA, Concepcion

Inventor： RITTER, Gerd ,  COSTA, Maria ,  GREEN, Luke ,  SCHMIDT, Richard ,  LEY, Steve ,  ELEUTÉRIO, Maria ,  ALVES, Susana ,  RUBALCAVA, Concepcion ,  SCHIMMEL, Jorg

IPC: C07J69/00

Abstract: The present invention relates to new saponins for increasing the immune response in mammals and finds application in the field of immunology, supplying in particular new adjuvants, obtained by hemi-synthesis, starting from terpene sources. It also embraces the methods for the use of the new saponins as adjuvants to increase the immune response to an antigen in a mammal. The saponins of the present invention are suitable for veterinary and human pharmaceutical compositions which include one or more antigens, in particular those of synthetic origin, and one or more diluents, in pharmaceutically acceptable vehicles. These compositions can be used as immunopotenciators and/or immunomodulators in animals and human beings. The present invention further constitutes a vaccination method that includes the administration of one or more antigens and one or optionally more than one hemi-synthetic saponin of the invention.