公开(公告)号：WO2012040410A2

公开(公告)日：2012-03-29

申请号：PCT/US2011052675

申请日：2011-09-22

Applicant: SIEMENS CORP ,  SIEMENS AG ,  LIU DAVID ,  WU DIJIA ,  ZHOU SHAOHUA KEVIN ,  COSTA MARIA JIMENA ,  SUEHLING MICHAEL ,  TIETJEN CHRISTIAN

Inventor： LIU DAVID ,  WU DIJIA ,  ZHOU SHAOHUA KEVIN ,  COSTA MARIA JIMENA ,  SUEHLING MICHAEL ,  TIETJEN CHRISTIAN

IPC: G06T7/00

CPC classification number: G06T7/0016 ,  G06T7/41 ,  G06T2207/10072 ,  G06T2207/20012 ,  G06T2207/20041 ,  G06T2207/20081 ,  G06T2207/20104 ,  G06T2207/30056

Abstract: A method and system for automatically detecting liver lesions in medical image data, such as 3D CT images, is disclosed. A liver region is segmented in a 3D image. Liver lesion center candidates are detected in the segmented liver region. Lesion candidates are segmented corresponding to the liver lesion center candidates, and lesions are detected from the segmented lesion candidates using learning based verification.

Abstract translation: 公开了一种用于自动检测医学图像数据（例如3D CT图像）中的肝脏病变的方法和系统。 肝脏区域在3D图像中被分割。 在分段的肝脏区域中检测到肝脏病变中心候选者。 根据肝脏病变中心候选者对病变候选者进行分段，并且使用基于学习的验证从分段病变候选者中检测病变。

公开(公告)号：WO2004104047A1

公开(公告)日：2004-12-02

申请号：PCT/IT2004/000284

申请日：2004-05-19

Applicant: COSTA, Maria, Assunta ,  GERACI, Domenico ,  COLOMBO, Paolo ,  PASSANTINO, Rosa ,  BONURA, Angela

Inventor： COSTA, Maria, Assunta ,  GERACI, Domenico ,  COLOMBO, Paolo ,  PASSANTINO, Rosa ,  BONURA, Angela

IPC: C07K19/00

CPC classification number: C07K14/415 ,  A61K39/36 ,  Y02A50/396

Abstract: A multimer protein molecule comprising at least a first amino acid sequence having substantially the sequence of one of the Parietaria judaica major allergens Par j 1 or Par j 2 and a second amino acid sequence having substantially the sequence of one of the Parietaria judaica major allergens Par j 1 or Par j 2, and a third sequence of one of the Parietaria judaica major allergens Par j 1 or Par j 2. The molecule is also mutated in the amino acid region corresponding to loop 1, so that is hypoallergenic. The molecule can be utilized for medical use as a hypoallergenic agent.

Abstract translation: 包含至少第一个氨基酸序列的多聚体蛋白质分子，其具有基本上具有Parietaria judaica主要变应原Parj 1或Par j 2之一的序列的第一氨基酸序列和基本上具有Parietaria judaica主要变应原Par之一的序列的第二个氨基酸序列 j 1或Par j 2，以及Parietaria judaica主要变应原Parj 1或Par j 2之一的第三序列。该分子也在对应于环1的氨基酸区域中突变，因此是低变应原性的。 该分子可用作医疗用作低变应原剂。

公开(公告)号：WO03040163B1

公开(公告)日：2004-03-25

申请号：PCT/PT0200016

申请日：2002-11-07

Applicant: INST NAC DE ENGENHARIA E TECNO ,  UNIV CAMBRIDGE TECH ,  COSTA MARIA ,  GREEN LUKE ,  SCHMIDT RICHARD ,  LEY STEVE ,  ELEUTERIO MARIA ,  ALVES SUSANA ,  RUBALCAVA CONCEPCION ,  CARDOSO FERNANDO ,  RITTER GERD

Inventor： COSTA MARIA ,  GREEN LUKE ,  SCHMIDT RICHARD ,  LEY STEVE ,  ELEUTERIO MARIA ,  ALVES SUSANA ,  RUBALCAVA CONCEPCION ,  SCHIMMEL JORG ,  RITTER GERD

IPC: A61P37/04 ,  C07J69/00 ,  C07H15/256

CPC classification number: C07J69/00

Abstract: The present invention relates to new saponins for increasing the immune response in mammals and finds application in the field of immunology, supplying in particular new adjuvants, obtained by hemi-synthesis, starting from terpene sources. It also embraces the methods for the use of the new saponins as adjuvants to increase the immune response to an antigen in a mammal. The saponins of the present invention are suitable for veterinary and human pharmaceutical compositions which include one or more antigens, in particular those of synthetic origin, and one or more diluents, in pharmaceutically acceptable vehicles. These compositions can be used as immunopotenciators and/or immunomodulators in animals and human beings. The present invention further constitutes a vaccination method that includes the administration of one or more antigens and one or optionally more than one hemi-synthetic saponin of the invention.

Abstract translation: 本发明涉及用于增加哺乳动物免疫应答的新皂苷，并且在免疫学领域中得到应用，特别是从萜烯源开始通过半合成获得的新佐剂。 它还包括使用新皂甙作为佐剂以增加对哺乳动物抗原的免疫应答的方法。 本发明的皂苷适用于兽药和人类药物组合物，其包括一种或多种抗原，特别是合成来源的抗原，以及一种或多种稀释剂在药学上可接受的载体中。 这些组合物可用作动物和人类的免疫调节剂和/或免疫调节剂。 本发明还构成疫苗接种方法，其包括施用本发明的一种或多种抗原和一种或任选的多于一种的半合成皂苷。

公开(公告)号：WO0220790A9

公开(公告)日：2003-05-30

申请号：PCT/IT0100471

申请日：2001-09-11

Applicant: CONSIGLIO NAZIONALE RICERCHE ,  GERACI DOMENICO ,  COLOMBO PAOLO ,  DURO GIOVANNI ,  IZZO VINCENZO ,  COSTA MARIA ASSUNTA

Inventor： GERACI DOMENICO ,  COLOMBO PAOLO ,  DURO GIOVANNI ,  IZZO VINCENZO ,  COSTA MARIA ASSUNTA

IPC: A61K38/11 ,  C07K14/415 ,  C12N15/28 ,  A61K39/36 ,  C12N15/70 ,  G01N33/68

CPC classification number: C07K14/415 ,  A61K38/00

Abstract: The present invention relates to hypoallergenic variants of ns-LTPs allergens, to pharmaceutical compositions comprising them and to the use of such variants for the preparation of medicaments suitable in the treatment and in the prevention of the allergic forms associated with an ns-LTP allergen, in particular to the allergen corresponding to the variant used.

Abstract translation: 本发明涉及ns-LTPs变应原的低变应原变体，包含它们的药物组合物以及这些变体用于制备适合于治疗和预防与ns-LTP变应原相关的过敏形式的药物的用途， 特别是对应于所用变体的变应原。

公开(公告)号：WO2012040410A3

公开(公告)日：2012-04-19

申请号：PCT/US2011052675

申请日：2011-09-22

Applicant: SIEMENS CORP ,  SIEMENS AG ,  LIU DAVID ,  WU DIJIA ,  ZHOU SHAOHUA KEVIN ,  COSTA MARIA JIMENA ,  SUEHLING MICHAEL ,  TIETJEN CHRISTIAN

Inventor： LIU DAVID ,  WU DIJIA ,  ZHOU SHAOHUA KEVIN ,  COSTA MARIA JIMENA ,  SUEHLING MICHAEL ,  TIETJEN CHRISTIAN

IPC: G06T7/00

CPC classification number: G06T7/0016 ,  G06T7/41 ,  G06T2207/10072 ,  G06T2207/20012 ,  G06T2207/20041 ,  G06T2207/20081 ,  G06T2207/20104 ,  G06T2207/30056

Abstract: A method and system for automatically detecting liver lesions in medical image data, such as 3D CT images, is disclosed. A liver region is segmented in a 3D image. Liver lesion center candidates are detected in the segmented liver region. Lesion candidates are segmented corresponding to the liver lesion center candidates, and lesions are detected from the segmented lesion candidates using learning based verification.

Abstract translation: 公开了一种用于自动检测医学图像数据中肝脏病变的方法和系统，如3D CT图像。 肝脏区域被分割成3D图像。 肝脏病变中心候选人在分段肝脏区域检测到。 病变候选者对应于肝脏病变中心候选物，并且使用基于学习的验证从分割的病变候选物检测病变。

公开(公告)号：WO2012040410A9

公开(公告)日：2012-03-29

申请号：PCT/US2011/052675

申请日：2011-09-22

Applicant: SIEMENS CORPORATION ,  SIEMENS AKTIENGESELLSCHAFT ,  LIU, David ,  WU, Dijia ,  ZHOU, Shaohua Kevin ,  COSTA, Maria Jimena ,  SUEHLING, Michael ,  TIETJEN, Christian

Inventor： LIU, David ,  WU, Dijia ,  ZHOU, Shaohua Kevin ,  COSTA, Maria Jimena ,  SUEHLING, Michael ,  TIETJEN, Christian

IPC: G06T7/00

Abstract: A method and system for automatically detecting liver lesions in medical image data, such as 3D CT images, is disclosed. A liver region is segmented in a 3D image. Liver lesion center candidates are detected in the segmented liver region. Lesion candidates are segmented corresponding to the liver lesion center candidates, and lesions are detected from the segmented lesion candidates using learning based verification.

公开(公告)号：WO2008081397A3

公开(公告)日：2008-07-10

申请号：PCT/IB2007/055320

申请日：2007-12-27

Applicant: UNIVERSIDADE DE AVEIRO ,  LABRINCHA BATISTA, João António ,  PEIXOTO MARQUES RIBEIRO, Manuel Joaquim ,  CORDEIRO DA COSTA, Maria Grácia

Inventor： LABRINCHA BATISTA, João António ,  PEIXOTO MARQUES RIBEIRO, Manuel Joaquim ,  CORDEIRO DA COSTA, Maria Grácia

IPC: C22B7/00 ,  C09C3/06 ,  C09C1/00

Abstract: The invention relates to the production of mixed-metal-oxide inorganic pigments, using industrial waste as raw materials, comprising the following steps: (i) characterization and selection of wastes; (ii) their treatment, if required; (iii) formulation + dosing + mixing of components; (iv) drying + calcination; and (v) washing + milling. Selected wastes might be used in the as- received condition or after drying or calcination. The present invention deals with materials that are produced by colorants or pigments producers mainly for use in the ceramic sector, since formulations are stable at high temperatures and act as colorants of glazes or ceramic bodies. The use of high temperatures might also assure the desirable inertization of possible hazardous species.

公开(公告)号：WO2004043233A2

公开(公告)日：2004-05-27

申请号：PCT/US2003/035690

申请日：2003-11-07

Applicant: ROTHENBERG, Sheldon, P. ,  da COSTA, Maria ,  SEQUEIRA, Jeffrey

Inventor： ROTHENBERG, Sheldon, P. ,  da COSTA, Maria ,  SEQUEIRA, Jeffrey

IPC: A61B

CPC classification number: G01N33/564 ,  G01N33/82 ,  G01N2500/00 ,  G01N2800/24

Abstract: The present invention identifies autoantibodies to folate receptors. Methods to identify these autoantibodies to the human folate receptors are also provided. The present invention also contemplates diagnostic methods and test kits to be used in a clinical setting for identifying a subject at risk of folate-sensitive abnormalities or disorders as observed in neural tube defect complicatedpregnancies. In addition, infertility, spontaneous abortion, male sterility, unsuccessful in vitro fertilization,neurologic disorders and impaired folate absorption may also be associated with these autoantibodiesto folate receptors.

Abstract translation: 本发明鉴定了叶酸受体的自身抗体。 还提供了鉴定人叶酸受体的这些自身抗体的方法。 本发明还考虑用于临床设置中用于鉴定在神经管缺陷复杂妊娠中观察到的具有叶酸敏感性异常或障碍风险的受试者的诊断方法和测试试剂盒。 此外，不孕不育，自然流产，雄性不育，体外受精失败，神经系统疾病和叶酸受体受损也可能与这些自身抗体对叶酸受体有关。

公开(公告)号：WO2003097606A1

公开(公告)日：2003-11-27

申请号：PCT/IB2000/001057

申请日：2000-07-28

Applicant: HERBEX, PRODUTOS QUÍMICOS, SA ,  SARAGGA, José, Manuel ,  CORREIA, Pedro, Brito ,  ROMÃO, Carlos, Crispim ,  CORREIA, Luís, Brito ,  PEREIRA, Maria, Florbela ,  FERNANDES, Ana, Cristina ,  BORGES, José, Enrique ,  TAVARES, Regina ,  COSTA, Maria do Céu ,  TEIXEIRA, Fátima

Inventor： CORREIA, Pedro, Brito ,  ROMÃO, Carlos, Crispim ,  CORREIA, Luís, Brito ,  PEREIRA, Maria, Florbela ,  FERNANDES, Ana, Cristina ,  BORGES, José, Enrique ,  TAVARES, Regina ,  COSTA, Maria do Céu ,  TEIXEIRA, Fátima

IPC: C07D213/89

CPC classification number: C07D213/89 ,  C07D213/61 ,  C07D213/65 ,  C07D401/12

Abstract: The present invention describes a new process for the preparation of omeprazole, lansoprazole and pantoprazole of formula (XXI), (XXXIII), and which involves the formation of pyridines N-oxide using a rhenium compound as a catralyst, followed by nitration of the 4-position with nitric acid fuming in presence of a claycop. The chlorination of the 2-methyl group of pyridine was achieved by using the POCI 3 /Et 3 N, which allowed the preparation of the derivates 2-chloromethylpyridines in only one step. These derivates reacted with the mercaptobenzimidazolic derivatives in presence of ultra-sonic radiation, giving the thioethers. The oxidation of these thioethers was done with several oxidizing agents and the required anti-ulcer compounds were obtained after the substitution of nitro group by the corresponding OR groups.

Abstract translation: 本发明描述了制备式（XXI），（XXXIII）的奥美拉唑，兰索拉唑和泮托拉唑的新方法，其涉及使用铼化合物作为催化剂形成吡啶N-氧化物，然后硝化4 - 在硝酸存在下，用硝酸发烟。 通过使用POCI> 3 <3> N来实现吡啶的2-甲基的氯化，其允许仅在一个步骤中制备衍生物2-氯甲基吡啶。 这些衍生物在超声辐射存在下与巯基苯并咪唑衍生物反应，得到硫醚。 这些硫醚的氧化用几种氧化剂进行，并且在用相应的OR基团取代硝基之后获得所需的抗溃疡化合物。

公开(公告)号：WO2003040163A3

公开(公告)日：2003-05-15

申请号：PCT/PT2002/000016

申请日：2002-11-07

Applicant: INSTITUTO NACIONAL DE ENGENHARIA E TECNOLOGIA INDUSTRIAL ,  CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LIMITED ,  CARDOSO, Fernando ,  RITTER, Gerd ,  COSTA, Maria ,  GREEN, Luke ,  SCHMIDT, Richard ,  LEY, Steve ,  ELEUTÉRIO, Maria ,  ALVES, Susana ,  RUBALCAVA, Concepcion

Inventor： RITTER, Gerd ,  COSTA, Maria ,  GREEN, Luke ,  SCHMIDT, Richard ,  LEY, Steve ,  ELEUTÉRIO, Maria ,  ALVES, Susana ,  RUBALCAVA, Concepcion ,  SCHIMMEL, Jorg

IPC: C07J69/00

Abstract: The present invention relates to new saponins for increasing the immune response in mammals and finds application in the field of immunology, supplying in particular new adjuvants, obtained by hemi-synthesis, starting from terpene sources. It also embraces the methods for the use of the new saponins as adjuvants to increase the immune response to an antigen in a mammal. The saponins of the present invention are suitable for veterinary and human pharmaceutical compositions which include one or more antigens, in particular those of synthetic origin, and one or more diluents, in pharmaceutically acceptable vehicles. These compositions can be used as immunopotenciators and/or immunomodulators in animals and human beings. The present invention further constitutes a vaccination method that includes the administration of one or more antigens and one or optionally more than one hemi-synthetic saponin of the invention.