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公开(公告)号：WO2022025858A1
公开(公告)日：2022-02-03
申请号：PCT/US2020/000027
申请日：2020-07-27
Applicant: RYAN, Joseph, A.
Inventor： RYAN, Joseph, A.
Abstract: A multi-use support stand including a horizontal foot brace and a horizontal cross brace attached to a bottom of a vertical support post. An oblique support post is attached to a top portion of the vertical support post and a portion of the foot brace. One end of a horizontal extension arm is attached to a sliding "U" shaped channel. The channel is received around a portion of the oblique support post. A pin is received in a selected pin hole in the side of the support post for securing the sliding channel to the oblique support post. When a first and second support stands are placed next to each other, the horizontal extension arms are used for holding loads of sheet rock, plywood, bench table top, working platform, shelving, footbridge sections, dimensional lumber, and other application specific items needing to be supported horizontally or an elevated obtuse angle.
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公开(公告)号：WO2003051278A3
公开(公告)日：2003-06-26
申请号：PCT/US2002/021733
申请日：2002-07-10
Applicant: NORTH CAROLINA STATE UNIVERSITY , FRANZEN, Stefan , FELDHEIM, Daniel, L. , TKACHENKO, Alexander, G. , GODEK, Marisha, L. , RYAN, Joseph, A. , ANDERSON, Miles, F.
Inventor： FRANZEN, Stefan , FELDHEIM, Daniel, L. , TKACHENKO, Alexander, G. , GODEK, Marisha, L. , RYAN, Joseph, A. , ANDERSON, Miles, F.
IPC: A61K9/14
Abstract: A nanopartricle delivery vehicle, comprising a nanoparticle, an active agent and a nuclear localization signal and methods of modulating gene expression and protein expression employing the nanoparticle delivery vehicle. A representative method includes providing a nanoparticle delivery vehicle comprising a nanoparticle having a diameter of about 30 nm or less, an active agent and a nuclear localization signal; and contacting a target cell with the nanoparticle delivery vehicle, whereby an active agent is delivered to the nucleus of a target cell. Another representative method includes providing a nanoparticle delivery vehicle comprising a nanoparticle having a diameter greater than or equal to about 30 nm, an active agent and a nuclear localization signal; and contacting a target cell with the nanoparticle delivery vehicle, whereby an active agent is delivered to the cytoplasm of a cell.
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公开(公告)号：WO2003051278A2
公开(公告)日：2003-06-26
申请号：PCT/US2002/021733
申请日：2002-07-10
Applicant: NORTH CAROLINA STATE UNIVERSITY , FRANZEN, Stefan , FELDHEIM, Daniel, L. , TKACHENKO, Alexander, G. , GODEK, Marisha, L. , RYAN, Joseph, A. , ANDERSON, Miles, F.
Inventor： FRANZEN, Stefan , FELDHEIM, Daniel, L. , TKACHENKO, Alexander, G. , GODEK, Marisha, L. , RYAN, Joseph, A. , ANDERSON, Miles, F.
IPC: A61K
CPC classification number: A61K49/0047 , A61K9/5115 , A61K48/0025 , C12N15/88 , Y02A50/471 , Y10S977/773
Abstract: A nanopartricle delivery vehicle, comprising a nanoparticle, an active agent and a nuclear localization signal and methods of modulating gene expression and protein expression employing the nanoparticle delivery vehicle. A representative method includes providing a nanoparticle delivery vehicle comprising a nanoparticle having a diameter of about 30 nm or less, an active agent and a nuclear localization signal; and contacting a target cell with the nanoparticle delivery vehicle, whereby an active agent is delivered to the nucleus of a target cell. Another representative method includes providing a nanoparticle delivery vehicle comprising a nanoparticle having a diameter greater than or equal to about 30 nm, an active agent and a nuclear localization signal; and contacting a target cell with the nanoparticle delivery vehicle, whereby an active agent is delivered to the cytoplasm of a cell.
Abstract translation: 包含纳米颗粒，活性剂和核定位信号的纳米颗粒递送载体和使用纳米颗粒递送载体调节基因表达和蛋白质表达的方法。 代表性的方法包括提供包含直径约30nm或更小的纳米颗粒的纳米颗粒递送载体，活性剂和核定位信号; 并使靶细胞与纳米颗粒递送载体接触，由此将活性剂递送至靶细胞的细胞核。 另一种代表性的方法包括提供包含直径大于或等于约30nm的纳米颗粒的纳米颗粒递送载体，活性剂和核定位信号; 并使靶细胞与纳米颗粒递送载体接触，由此将活性剂递送至细胞的细胞质。
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