公开(公告)号：WO2017199228A1

公开(公告)日：2017-11-23

申请号：PCT/IB2017/052987

申请日：2017-05-20

申请人： S & I OPHTHALMIC, LLC.

发明人： PAL, Ranjan Kumar ,  PATHAK, Sandeep Pankajbhai ,  RANA, Dijixa Pinakin ,  PRAJAPATI, Kaushikkumar Dhanjibhai ,  SRINIVASU, K ,  THENNATI, Rajamannar

IPC分类号： C07C209/88 ,  C07C211/27

CPC分类号： C07C209/88 ,  C07B2200/07 ,  C07C211/27

摘要： The present invention relates to a simple economical process for the purification of an acid addition salt of a compound of Formula (III) contaminated with an acid addition salt of a compound of Formula (III'), which comprises washing at least once the addtion salt of the compound of Formula III with an organic solvent capable of removing the acid addition salt of the compound of Formula III' to obtain the acid addition salt of the compound of Formula III in chiral purity of greater than 99.5 % and chromatographic purity of greater than 99 %.

摘要翻译： 本发明涉及纯化式（III'）化合物的酸加成盐污染的式（III）化合物的酸加成盐的简单经济的方法，其中 包括用能够除去式III'化合物的酸加成盐的有机溶剂洗涤式III化合物的加成盐的至少一次，以获得手性纯度大于100％的式III化合物的酸加成盐 99.5％，色谱纯度大于99％。

公开(公告)号：WO2017199227A1

公开(公告)日：2017-11-23

申请号：PCT/IB2017/052986

申请日：2017-05-20

申请人： S & I OPHTHALMIC, LLC.

发明人： SAMANTA, Biswajit ,  KUMBHANI, Anil Savajibhai ,  ADHYAPAK, Jay Prakashchandra ,  SRINIVASU, K ,  THENNATI, Rajamannar

IPC分类号： C07C67/317 ,  C07C227/10 ,  C07C229/38 ,  C07C51/09 ,  C07C69/84 ,  C07C69/92 ,  C07C65/05

CPC分类号： C07C67/317 ,  C07C51/09 ,  C07C227/10 ,  C07C229/38 ,  C07C69/92 ,  C07C69/84 ,  C07C65/05

摘要： The present invention relates to a simple economical process for the preparation of 3,4- dihydroxy-2-methyl benzoic acid C1-4 alkyl ester and novel intermediates for use in the process.

摘要翻译： 本发明涉及制备3,4-二羟基-2-甲基苯甲酸C 1-4烷基酯和用于该方法的新型中间体的简单经济的方法。