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    PROCESS FOR PURIFICATION OF (R,R)-(1-ALKYL-2,2-DIMETHYLPROPYL)-(1-PHENYLALKYL)-AMINES
    1.
    发明申请
    PROCESS FOR PURIFICATION OF (R,R)-(1-ALKYL-2,2-DIMETHYLPROPYL)-(1-PHENYLALKYL)-AMINES 审中-公开
    纯化（R，R） - （1-烷基-2,2-二甲基丙基） - （1-苯基烷基）胺的方法

    公开(公告)号：WO2017199228A1

    公开(公告)日：2017-11-23

    申请号：PCT/IB2017/052987

    申请日：2017-05-20

    申请人： S & I OPHTHALMIC, LLC.

    发明人： PAL, Ranjan Kumar ,  PATHAK, Sandeep Pankajbhai ,  RANA, Dijixa Pinakin ,  PRAJAPATI, Kaushikkumar Dhanjibhai ,  SRINIVASU, K ,  THENNATI, Rajamannar

    IPC分类号： C07C209/88 ,  C07C211/27

    CPC分类号： C07C209/88 ,  C07B2200/07 ,  C07C211/27

    摘要： The present invention relates to a simple economical process for the purification of an acid addition salt of a compound of Formula (III) contaminated with an acid addition salt of a compound of Formula (III'), which comprises washing at least once the addtion salt of the compound of Formula III with an organic solvent capable of removing the acid addition salt of the compound of Formula III' to obtain the acid addition salt of the compound of Formula III in chiral purity of greater than 99.5 % and chromatographic purity of greater than 99 %.

    摘要翻译： 本发明涉及纯化式（III'）化合物的酸加成盐污染的式（III）化合物的酸加成盐的简单经济的方法，其中 包括用能够除去式III'化合物的酸加成盐的有机溶剂洗涤式III化合物的加成盐的至少一次，以获得手性纯度大于100％的式III化合物的酸加成盐 99.5％，色谱纯度大于99％。