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公开(公告)号：WO2012158169A1
公开(公告)日：2012-11-22
申请号：PCT/US2011/037064
申请日：2011-05-18
申请人： AFFINERGY, INC. , DARBY, Martyn, Kerry , JUZUMIENE, Dalia, Isolda , SANFORD, Isaac, Gilliam , CULP, William, David, Jr. , CHEN, Yuchen , HODGES, Jonathan, Allen , KRAJEWSKA, Magdalena , NAIR, Shrikumar, Ambujakshan
发明人： DARBY, Martyn, Kerry , JUZUMIENE, Dalia, Isolda , SANFORD, Isaac, Gilliam , CULP, William, David, Jr. , CHEN, Yuchen , HODGES, Jonathan, Allen , KRAJEWSKA, Magdalena , NAIR, Shrikumar, Ambujakshan
CPC分类号： A61K38/08 , A61K35/14 , A61K35/28 , A61K38/014 , A61K38/10 , A61L27/54 , A61L2300/25 , A61L2400/18 , A61L2420/02
摘要： Compositions and methods for tissue repair are provided including cell binding peptides and BMP binding peptides. The cell binding peptides bind to one or more of stem cells and fibroblasts. The tissue for repair includes bone, tendon, muscle, connective tissue, ligament, cardiac tissue, bladder tissue, or dermis. Implantable devices for tissue repair are provided to which the cell and/or BMP binding peptides are attached, such as acellular extracellular matrix having attached binding peptide and bone graft material comprising a ceramic.
摘要翻译： 提供组织修复的组合物和方法，包括细胞结合肽和BMP结合肽。 细胞结合肽结合一种或多种干细胞和成纤维细胞。 用于修复的组织包括骨，肌腱，肌肉，结缔组织，韧带，心脏组织，膀胱组织或真皮。 提供用于组织修复的可植入装置，细胞和/或BMP结合肽所连接的装置，例如具有附着结合肽的细胞外细胞基质和包含陶瓷的骨移植材料。
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公开(公告)号：WO2011063165A9
公开(公告)日：2011-12-08
申请号：PCT/US2010057304
申请日：2010-11-18
申请人： AFFINERGY INC , SANFORD ISAAC GILLIAM , JUZUMIENE DALIA ISOLDA , DARBY MARTYN KERRY , NAIR SHRIKUMAR AMBUJAKSHAN , HODGES JONATHAN ALLEN
发明人： SANFORD ISAAC GILLIAM , JUZUMIENE DALIA ISOLDA , DARBY MARTYN KERRY , NAIR SHRIKUMAR AMBUJAKSHAN , HODGES JONATHAN ALLEN
IPC分类号： C07K14/00
CPC分类号： A61K47/48992 , A61K9/0024 , A61K38/10 , A61K47/02 , A61K47/42 , A61K47/64 , A61K47/6957 , A61L27/425 , A61L27/427 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2430/02
摘要： Compositions and methods are provided for capturing cells. Cell binding peptides are provided that bind to one or more of stem cells, fibroblasts, or endothelial cells. In the methods, a sample containing cells is contacted with a cell binding peptide attached to a substrate, and the cells present in the sample are captured onto the substrate through binding to the cell binding peptide.
摘要翻译： 提供组合物和方法用于捕获细胞。 提供结合一种或多种干细胞，成纤维细胞或内皮细胞的细胞结合肽。 在该方法中，将含有细胞的样品与附着于底物的细胞结合肽接触，通过结合细胞结合肽将存在于样品中的细胞捕获到底物上。
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公开(公告)号：WO2011063152A1
公开(公告)日：2011-05-26
申请号：PCT/US2010/057283
申请日：2010-11-18
申请人： AFFINERGY, INC. , SANFORD, Isaac, Gilliam , DARBY, Martyn, Kerry , HODGES, Jonathan, Allen , NAIR, Shrikumar, Ambujakshan , CHEN, Yuchen , HAMILTON, Paul, Theodore , SATHYA, Ganesan , GRON, Hanne , JANSEN, Michelle, Steffen
发明人： SANFORD, Isaac, Gilliam , DARBY, Martyn, Kerry , HODGES, Jonathan, Allen , NAIR, Shrikumar, Ambujakshan , CHEN, Yuchen , HAMILTON, Paul, Theodore , SATHYA, Ganesan , GRON, Hanne , JANSEN, Michelle, Steffen
IPC分类号： A61K38/16
CPC分类号： A61K47/48992 , A61K9/0024 , A61K38/10 , A61K47/02 , A61K47/42 , A61K47/64 , A61K47/6957 , A61L27/425 , A61L27/427 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2430/02
摘要： Compositions and methods for tissue repair are provided including cell binding peptides and growth factor binding peptides. The cell binding peptides bind to one or more of stem cells, fibroblasts, or endothelial cells. The growth factor binding peptides include platelet derived growth factor (PDGF) binding peptides and growth differentiation factor (GDF) binding peptides. The tissue for repair includes tendon, muscle, connective tissue, ligament, cardiac tissue, vascular tissue, or dermis. Implantable devices for tissue repair are provided to which the cell and growth factor binding peptides are attached, such as acellular extracellular matrix having attached binding peptide.
摘要翻译： 提供组织修复的组合物和方法，包括细胞结合肽和生长因子结合肽。 细胞结合肽与干细胞，成纤维细胞或内皮细胞中的一种或多种结合。 生长因子结合肽包括血小板衍生生长因子（PDGF）结合肽和生长分化因子（GDF）结合肽。 用于修复的组织包括肌腱，肌肉，结缔组织，韧带，心脏组织，血管组织或真皮。 提供用于组织修复的可植入装置，细胞和生长因子结合肽所连接的装置，例如具有连接结合肽的细胞外细胞基质。
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公开(公告)号：WO2011063140A3
公开(公告)日：2011-05-26
申请号：PCT/US2010/057266
申请日：2010-11-18
申请人： AFFINERGY, INC. , MELICAN, Mora, Carolynne , SANFORD, Isaac, Gilliam , HODGES, Jonathan, Allen , NAIR, Shrikumar, Ambujakshan , DARBY, Martyn, Kerry
发明人： MELICAN, Mora, Carolynne , SANFORD, Isaac, Gilliam , HODGES, Jonathan, Allen , NAIR, Shrikumar, Ambujakshan , DARBY, Martyn, Kerry
摘要： Compositions and methods are provided for promoting bone growth. An implantable bone graft material is provided comprising a resorbable ceramic and a resorbable polymer, wherein the polymer comprises a covalently attached stem cell binding peptide. The implantable bone graft materials are useful for promoting bone growth in a subject.
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公开(公告)号：WO2011063140A2
公开(公告)日：2011-05-26
申请号：PCT/US2010057266
申请日：2010-11-18
申请人： AFFINERGY INC , MELICAN MORA CAROLYNNE , SANFORD ISAAC GILLIAM , HODGES JONATHAN ALLEN , NAIR SHRIKUMAR AMBUJAKSHAN , DARBY MARTYN KERRY
发明人： MELICAN MORA CAROLYNNE , SANFORD ISAAC GILLIAM , HODGES JONATHAN ALLEN , NAIR SHRIKUMAR AMBUJAKSHAN , DARBY MARTYN KERRY
CPC分类号： A61K47/48992 , A61K9/0024 , A61K38/10 , A61K47/02 , A61K47/42 , A61K47/64 , A61K47/6957 , A61L27/425 , A61L27/427 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2430/02
摘要： Compositions and methods are provided for promoting bone growth. An implantable bone graft material is provided comprising a resorbable ceramic and a resorbable polymer, wherein the polymer comprises a covalently attached stem cell binding peptide. The implantable bone graft materials are useful for promoting bone growth in a subject.
摘要翻译： 提供了用于促进骨生长的组合物和方法。 提供了包含可再吸收陶瓷和可再吸收聚合物的可植入骨移植材料，其中所述聚合物包含共价连接的干细胞结合肽。 可植入的骨移植材料可用于促进受试者的骨生长。
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公开(公告)号：WO2011063165A1
公开(公告)日：2011-05-26
申请号：PCT/US2010/057304
申请日：2010-11-18
申请人： AFFINERGY, INC. , SANFORD, Isaac, Gilliam , JUZUMIENE, Dalia, Isolda , DARBY, Martyn, Kerry , NAIR, Shrikumar, Ambujakshan , HODGES, Jonathan, Allen
发明人： SANFORD, Isaac, Gilliam , JUZUMIENE, Dalia, Isolda , DARBY, Martyn, Kerry , NAIR, Shrikumar, Ambujakshan , HODGES, Jonathan, Allen
IPC分类号： C07K14/00
CPC分类号： A61K47/48992 , A61K9/0024 , A61K38/10 , A61K47/02 , A61K47/42 , A61K47/64 , A61K47/6957 , A61L27/425 , A61L27/427 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2430/02
摘要： Compositions and methods are provided for capturing cells. Cell binding peptides are provided that bind to one or more of stem cells, fibroblasts, or endothelial cells. In the methods, a sample containing cells is contacted with a cell binding peptide attached to a substrate, and the cells present in the sample are captured onto the substrate through binding to the cell binding peptide.
摘要翻译： 提供了用于捕获细胞的组合物和方法。 提供了与一种或多种干细胞，成纤维细胞或内皮细胞结合的细胞结合肽。 在该方法中，使含有细胞的样品与附着于底物的细胞结合肽接触，并通过与细胞结合肽结合将样品中存在的细胞捕获到底物上。
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