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    PHENYL ETHYNE COMPOUNDS
    2.
    发明申请
    PHENYL ETHYNE COMPOUNDS 审中-公开
    苯乙烯化合物

    公开(公告)号：WO2006115895A2

    公开(公告)日：2006-11-02

    申请号：PCT/US2006014517

    申请日：2006-04-18

    申请人： MERCK & CO INC ,  COSFORD NICHOLAS D ,  SEIDERS THOMAS J

    发明人： COSFORD NICHOLAS D ,  SEIDERS THOMAS J

    IPC分类号： C07C255/49

    CPC分类号： C07C255/50 ,  A01N37/34 ,  A01N43/40 ,  A01N43/54 ,  C07C255/51 ,  C07C255/53 ,  C07C255/58 ,  C07D213/65 ,  C07D239/42

    摘要： In accordance with the present invention, there is provided a novel class of heterocyclic compounds. Compounds of the invention contain a substituted or unsubstituted six membered heterocyclic ring that includes at least two nitrogen atoms. The ring additionally includes four carbon atoms. The heterocyclic ring has at least one substituent located at a ring position adjacent to a ring nitrogen atom. This mandatory substituent of the ring includes a moiety (B), linked to the heterocyclic ring via a carbon-carbon triple bond. The mandatory substituent is positioned adjacent to the ring nitrogen atom. Invention compounds are capable of a wide variety of uses. For example heterocyclic compounds can act to modulate physiological processes by functioning as agonists and antagonists of receptors in the nervous system. Invention compounds may also act as insecticides, and as fungicides. Pharmaceutical compositions containing invention compounds also have wide utility.

    摘要翻译： 根据本发明，提供了一类新的杂环化合物。 本发明化合物含有至少两个氮原子的取代或未取代的六元杂环。 该环另外包括四个碳原子。 该杂环具有至少一个位于与环氮原子相邻的环位置的取代基。 该环的强制取代基包括通过碳 - 碳三键与杂环连接的部分（B）。 强制性取代基位于环氮原子附近。 本发明化合物能够具有多种用途。 例如，杂环化合物可以通过在神经系统中作为受体的激动剂和拮抗剂起作用来调节生理过程。 本发明的化合物也可以作为杀虫剂和杀真菌剂。 含有本发明化合物的药物组合物也具有广泛的用途。

    PHENYL ETHYNE COMPOUNDS
    5.
    发明申请
    PHENYL ETHYNE COMPOUNDS 审中-公开

    公开(公告)号：WO2006115895A3

    公开(公告)日：2006-11-02

    申请号：PCT/US2006/014517

    申请日：2006-04-18

    申请人： MERCK & CO., INC. ,  COSFORD, Nicholas, D. ,  SEIDERS, Thomas, J.

    发明人： COSFORD, Nicholas, D. ,  SEIDERS, Thomas, J.

    IPC分类号： C07C255/50 ,  C07D239/08 ,  C07D213/62 ,  A61K31/275 ,  A61K31/435 ,  A61K31/505

    摘要： In accordance with the present invention, there is provided a novel class of heterocyclic compounds. Compounds of the invention contain a substituted or unsubstituted six membered heterocyclic ring that includes at least two nitrogen atoms. The ring additionally includes four carbon atoms. The heterocyclic ring has at least one substituent located at a ring position adjacent to a ring nitrogen atom. This mandatory substituent of the ring includes a moiety (B), linked to the heterocyclic ring via a carbon-carbon triple bond. The mandatory substituent is positioned adjacent to the ring nitrogen atom. Invention compounds are capable of a wide variety of uses. For example heterocyclic compounds can act to modulate physiological processes by functioning as agonists and antagonists of receptors in the nervous system. Invention compounds may also act as insecticides, and as fungicides. Pharmaceutical compositions containing invention compounds also have wide utility.

    GROUP 8 TRANSITION METAL CARBENE COMPLEXES AS ENANTIOSELECTIVE OLEFIN METATHESIS CATALYSTS
    6.
    发明申请
    GROUP 8 TRANSITION METAL CARBENE COMPLEXES AS ENANTIOSELECTIVE OLEFIN METATHESIS CATALYSTS 审中-公开
    第8族过渡金属碳烯配合物作为对映体烯烃分解催化剂

    公开(公告)号：WO02083742A3

    公开(公告)日：2002-12-19

    申请号：PCT/US0212165

    申请日：2002-04-16

    申请人： CALIFORNIA INST OF TECHN ,  GRUBBS ROBERT H ,  WARD DONALD W ,  SEIDERS THOMAS J ,  GOLDBERG STEVEN D

    发明人： GRUBBS ROBERT H ,  WARD DONALD W ,  SEIDERS THOMAS J ,  GOLDBERG STEVEN D

    IPC分类号： C07F15/00 ,  C08F4/06 ,  C08F4/80 ,  C07F9/70 ,  C07F9/90 ,  C07F9/94 ,  C07F15/02 ,  C07F15/04 ,  C07F15/06 ,  C07F17/02

    CPC分类号： C07F15/0046

    摘要： The invention pertains to the preparation and use of Group 8 transition metal carbene compounds as catalysts for olefin cross- metathesis reactions, and for enantioselective reactions in particular. The synthesis of these compounds and details of their use as catalysts is also provided. The carbene compounds are further ligated by a five-membered heterocycle ligand sigma bonded to the metal atom. This ligand has two nitrogen, phosphorus, oxygen or sulfur heteroatoms in the ring adjacent to the carbon atom bonded to the metal atom. This ligand is saturated, the two heteroatoms are preferably nitrogen with phenyl groups bonded to them, and the other two distal carbon atoms of the ligand are preferably chiral.

    摘要翻译： 本发明涉及第8族过渡金属卡宾化合物作为烯烃交叉复分解反应催化剂以及特别是对映选择性反应的制备和用途。 还提供了这些化合物的合成及其作为催化剂使用的细节。 卡宾化合物通过与金属原子键合的五元杂环配体σ进一步连接。 该配体在与金属原子键合的碳原子相邻的环中具有两个氮，磷，氧或硫杂原子。 该配体是饱和的，两个杂原子优选是具有与它们键合的苯基的氮，并且配体的另外两个远端碳原子优选是手性的。