公开(公告)号：WO1996004293A1

公开(公告)日：1996-02-15

申请号：PCT/JP1995001490

申请日：1995-07-26

Applicant: BANYU PHARMACEUTICAL CO., LTD. ,  KOJIRI, Katsuhisa ,  SHIMOKAWA, Haruki ,  OHKUBO, Mitsuru ,  KAWAMURA, Kenji ,  KONDO, Hisao ,  ARAKAWA, Hiroharu ,  SUDA, Hiroyuki

Inventor： BANYU PHARMACEUTICAL CO., LTD.

IPC: C07H19/23

CPC classification number: C07H19/04 ,  C07H19/052 ,  C12P19/26

Abstract: A compound represented by general formula [1] or a pharmaceutically acceptable salt thereof, having an excellent antitumor effect, and hence being useful as an antitumor agent, wherein X and X represent each independently hydrogen, halogen, amino, mono(lower alkyl)amino, di(lower alkyl)amino, hydroxy, lower alkoxy, aralkoxy, carboxy, lower alkoxycarbonyl, lower alkanoyloxy, or lower alkyl which may be substituted by one or two hydroxy groups; R represents hydrogen, amino, formylamino, lower alkanoylamino, mono(lower alkyl)amino, di(lower alkyl)amino, hydroxy, lower alkoxy, aralkoxy, aralkyl, lower alkylcarbonyl, arylcarbonyl or lower alkyl (wherein the lower alkanoylamino, mono(lower alkyl)amino, di(lower alkyl)amino, lower alkoxy, aralkoxy, aralkyl, lower alkylcarbonyl, arylcarbonyl and lower alkyl may be substituted by one to five groups selected from among carboxy, carbamoyl, sulfo, amino, cyano, mono(lower alkyl)amino, di(lower alkyl)amino, hydroxy, heterocycle which may be substituted by one to three hydroxy groups or by lower alkyl which may be substituted by one to three hydroxy groups, and halogen atoms); and R represents a disaccharide group.

Abstract translation: 由通式[1]表示的化合物或其药学上可接受的盐，具有优异的抗肿瘤效果，因此可用作抗肿瘤剂，其中X 1和X 2各自独立地表示氢，卤素，氨基， 单（低级烷基）氨基，二（低级烷基）氨基，羟基，低级烷氧基，芳烷氧基，羧基，低级烷氧基羰基，低级烷酰氧基或可被一个或两个羟基取代的低级烷基; R 1表示氢，氨基，甲酰氨基，低级烷酰氨基，单（低级烷基）氨基，二（低级烷基）氨基，羟基，低级烷氧基，芳烷氧基，芳烷基，低级烷基羰基，芳基羰基或低级烷基（其中低级烷酰基氨基， 单（低级烷基）氨基，二（低级烷基）氨基，低级烷氧基，芳烷氧基，芳烷基，低级烷基羰基，芳基羰基和低级烷基可以被一至五个选自羧基，氨基甲酰基，磺基，氨基，氰基， （低级烷基）氨基，二（低级烷基）氨基，羟基，可被一至三个羟基取代的杂环或被一至三个羟基取代的低级烷基和卤素原子）。 R 2表示二糖基。