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    ANTITUMOR INDOLOPYRROLOCARBAZOLE DERIVATIVES
    1.
    发明申请
    ANTITUMOR INDOLOPYRROLOCARBAZOLE DERIVATIVES 审中-公开
    抗肿瘤剂吲哚吡咯烷酮衍生物

    公开(公告)号：WO1997009339A1

    公开(公告)日：1997-03-13

    申请号：PCT/JP1996002404

    申请日：1996-08-28

    Applicant: BANYU PHARMACEUTICAL CO., LTD. ,  KOJIRI, Katsuhisa ,  KONDO, Hisao ,  ARAKAWA, Hiroharu ,  OHKUBO, Mitsuru ,  SUDA, Hiroyuki

    Inventor： BANYU PHARMACEUTICAL CO., LTD.

    IPC: C07H17/02

    CPC classification number: C07H15/252

    Abstract: Compounds represented by general formula (I) or pharmaceutically acceptable salts thereof, wherein R represents C2-4 alkyl having 1 to 3 hydroxyl groups; R and R represent each hydrogen or OH; and G represents pentose or hexose, provided that R and R do not represent hydrogen at the same time, and excluding the case where R is OH at the 1-position and R is OH at the 11-position when R is CH(CH2OH)2, and another case where R is OH at the 2-position and R is OH at the 10-position when R is CH(CH2OH)2. Because of having an excellent antitumor effect, the compounds are useful as an antitumor agent in the field of medicines.

    Abstract translation: 由通式（I）表示的化合物或其药学上可接受的盐，其中R表示具有1至3个羟基的C 2-4烷基; R 1和R 2各自表示氢或OH; 并且G表示戊糖或己糖，条件是R 1和R 2不同时表示氢，并且不包括R 1在1-位是OH并且R 2是OH的情况 当R为CH（CH 2 OH）2时为11位，R为2位的R 1为OH并且当R为CH（CH 2 OH）2时，R 2为10位为OH）的另一种情况。 由于具有优异的抗肿瘤效果，所以这些化合物可用作药物领域的抗肿瘤剂。

    ANTITUMOR INDOLOPYRROLOCARBAZOLES
    2.
    发明申请
    ANTITUMOR INDOLOPYRROLOCARBAZOLES 审中-公开
    抗肿瘤剂吲哚酚

    公开(公告)号：WO1996004293A1

    公开(公告)日：1996-02-15

    申请号：PCT/JP1995001490

    申请日：1995-07-26

    Applicant: BANYU PHARMACEUTICAL CO., LTD. ,  KOJIRI, Katsuhisa ,  SHIMOKAWA, Haruki ,  OHKUBO, Mitsuru ,  KAWAMURA, Kenji ,  KONDO, Hisao ,  ARAKAWA, Hiroharu ,  SUDA, Hiroyuki

    Inventor： BANYU PHARMACEUTICAL CO., LTD.

    IPC: C07H19/23

    CPC classification number: C07H19/04 ,  C07H19/052 ,  C12P19/26

    Abstract: A compound represented by general formula [1] or a pharmaceutically acceptable salt thereof, having an excellent antitumor effect, and hence being useful as an antitumor agent, wherein X and X represent each independently hydrogen, halogen, amino, mono(lower alkyl)amino, di(lower alkyl)amino, hydroxy, lower alkoxy, aralkoxy, carboxy, lower alkoxycarbonyl, lower alkanoyloxy, or lower alkyl which may be substituted by one or two hydroxy groups; R represents hydrogen, amino, formylamino, lower alkanoylamino, mono(lower alkyl)amino, di(lower alkyl)amino, hydroxy, lower alkoxy, aralkoxy, aralkyl, lower alkylcarbonyl, arylcarbonyl or lower alkyl (wherein the lower alkanoylamino, mono(lower alkyl)amino, di(lower alkyl)amino, lower alkoxy, aralkoxy, aralkyl, lower alkylcarbonyl, arylcarbonyl and lower alkyl may be substituted by one to five groups selected from among carboxy, carbamoyl, sulfo, amino, cyano, mono(lower alkyl)amino, di(lower alkyl)amino, hydroxy, heterocycle which may be substituted by one to three hydroxy groups or by lower alkyl which may be substituted by one to three hydroxy groups, and halogen atoms); and R represents a disaccharide group.

    Abstract translation: 由通式[1]表示的化合物或其药学上可接受的盐，具有优异的抗肿瘤效果，因此可用作抗肿瘤剂，其中X 1和X 2各自独立地表示氢，卤素，氨基， 单（低级烷基）氨基，二（低级烷基）氨基，羟基，低级烷氧基，芳烷氧基，羧基，低级烷氧基羰基，低级烷酰氧基或可被一个或两个羟基取代的低级烷基; R 1表示氢，氨基，甲酰氨基，低级烷酰氨基，单（低级烷基）氨基，二（低级烷基）氨基，羟基，低级烷氧基，芳烷氧基，芳烷基，低级烷基羰基，芳基羰基或低级烷基（其中低级烷酰基氨基， 单（低级烷基）氨基，二（低级烷基）氨基，低级烷氧基，芳烷氧基，芳烷基，低级烷基羰基，芳基羰基和低级烷基可以被一至五个选自羧基，氨基甲酰基，磺基，氨基，氰基， （低级烷基）氨基，二（低级烷基）氨基，羟基，可被一至三个羟基取代的杂环或被一至三个羟基取代的低级烷基和卤素原子）。 R 2表示二糖基。

    ANTITUMOR INDOLOPYPROLOCARBAZOLE DERIVATIVE
    3.
    发明申请
    ANTITUMOR INDOLOPYPROLOCARBAZOLE DERIVATIVE 审中-公开
    抗肿瘤剂吲哚丙酸唑衍生物

    公开(公告)号：WO1995030682A1

    公开(公告)日：1995-11-16

    申请号：PCT/JP1995000868

    申请日：1995-05-02

    Applicant: BANYU PHARMACEUTICAL CO., LTD. ,  KOJIRI, Katsuhisa ,  KONDO, Hisao ,  ARAKAWA, Hiroharu ,  OHKUBO, Mitsuru ,  SUDA, Hiroyuki

    Inventor： BANYU PHARMACEUTICAL CO., LTD.

    IPC: C07H17/02

    CPC classification number: C07D403/04 ,  C07C243/16 ,  C07D403/14 ,  C07D487/14 ,  C07H19/04 ,  C07H19/044

    Abstract: A compound represented by general formula (I) or a pharmaceutically acceptable salt thereof, wherein R and R represent each OH, R being present at the 1- or 2-position while R being present at the 10- or 11-position, provided when R is present at the 1-position, R is present at the 11-position, while when R is present at the 2-position, R is present at the 10-position. As the compound has an excellent antitumor effect, it is useful as an antitumor drug in the medicinal field.

    Abstract translation: 由通式（I）表示的化合物或其药学上可接受的盐，其中R 1和R 2表示每个OH，R 1存在于1-或2-位，而R 2为 存在于10位或11位，当R 1存在于1-位时，R 2存在于11位，而当R 1存在于2-位时， R 2存在于10位。 由于该化合物具有优异的抗肿瘤效果，因此作为药用领域的抗肿瘤药物是有用的。

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