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公开(公告)号：WO2022120365A1
公开(公告)日：2022-06-09
申请号：PCT/US2021/072709
申请日：2021-12-02
发明人： CHEN, Yong
摘要： Improved methods for drying for bio-compatible solid phase microextraction (BioSPME) coatings yielding coatings with highly consistent extraction efficiency and biocompatibility. The methods, adapted to flow-through drying systems involve determining relative humidity in and around the drying system, determining a drying temperature range based on the relative humidity, and maintaining the drying temperature within the determined range while drying the coating.
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公开(公告)号：WO2021067291A1
公开(公告)日：2021-04-08
申请号：PCT/US2020/053304
申请日：2020-09-29
发明人： EASTLUND, Erik , ZHANG, Zhigang , DAVIS, Gregory, D. , BELLER, Zachary, Walter , GORDON, Jeffrey, Ivan
IPC分类号： C12N15/10 , C12N15/113 , C12N15/63
摘要： Compositions and methods for remodeling complex populations of microbes are provided herein. RNA-guided nuclease systems are engineered to target sites in chromosomal DNA of a targeted prokaryotic, wherein the level of targeted prokaryote can be modulated in a mixed population of prokaryotes.
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公开(公告)号：WO2020243345A1
公开(公告)日：2020-12-03
申请号：PCT/US2020/034976
申请日：2020-05-28
IPC分类号： C01B32/15
摘要： Spherical carbon nanoparticles having diameters in the range from about 200 to about 900 nm and methods of making the same. According the methods provided herein, spherical nanopolymers are formed through a miniemulsion process, the spherical nanopolymers are polysulfonated then pyrolyzed to form spherical carbon nanoparticles. The surfaces may be further modified with, e.g., various adsorbents to further modify the properties. The formation process allows production of various pore structures, from non-porous to fully porous, with the tunability of pore structure allowing micropores, mesopores, macropores, and combinations of any of the foregoing, allowing for a wide range of surface areas making these nanocarbons suitable for many applications, including sample and bulk preparation, purification, and analysis, and drug delivery applications.
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公开(公告)号：WO2020160410A1
公开(公告)日：2020-08-06
申请号：PCT/US2020/016107
申请日：2020-01-31
摘要： Water-based antifungal composition having improved bioavailability; such formulations include a polyene macrolide antifungal agent, such as nystatin, a surfactant, a buffer, an organic amine base; and water. Also provided are methods for preparing water-based antifungal compositions.
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公开(公告)号：WO2019226347A1
公开(公告)日：2019-11-28
申请号：PCT/US2019/031271
申请日：2019-05-08
IPC分类号： G01N33/68
摘要： Methods and kits for detecting and/or quantitating target proteins in biological samples. In particular, the method comprises capture and immobilization of the target protein, protein denaturation, proteolytic digestion, and analysis using a mass spectrometry-based technique.
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公开(公告)号：WO2019213528A1
公开(公告)日：2019-11-07
申请号：PCT/US2019/030609
申请日：2019-05-03
发明人： BORGSCHULTE, Trissa , MASCARENHAS, Joaquina , ZILLMANN, Martin , SWARTZWELDER, Frank , KAYSER, Kevin
摘要： Processes for producing recombinant proteins having low levels of residual host cell proteins. The processes comprise utilizing engineered host cell lines in which specific host cell proteins are tagged with purification tags, wherein the purification tags can be used to remove those specific host cell proteins from the recombinant proteins.
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7.发明申请
公开(公告)号：WO2019200306A1
公开(公告)日：2019-10-17
申请号：PCT/US2019/027305
申请日：2019-04-12
IPC分类号： C12N15/113 , C12N15/90
摘要： Paired CRISPR nickase ribonucleoproteins engineered to target immune-related genomic loci and methods of using said ribonucleoproteins to modify the immune- related genomic loci.
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公开(公告)号：WO2019125783A1
公开(公告)日：2019-06-27
申请号：PCT/US2018/064350
申请日：2018-12-06
发明人： WILSON, Scott , KENT, Kevin , SHARMA, Chandana
CPC分类号： C08L71/02 , C08G65/08 , C12N5/0018
摘要： Described herein are poloxamer compositions for use as a shear protectant in cell culture and methods for preparing and using such compositions.
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公开(公告)号：WO2019040868A1
公开(公告)日：2019-02-28
申请号：PCT/US2018/047950
申请日：2018-08-24
申请人： SIGMA-ALDRICH CO. LLC , BETZ, William , FRANTZ, Curtis , KEELER, Michael , YE, Michael , ESPECSCHIED, Ken , SMITH, Sara , SMITH, Brittany A.
发明人： BETZ, William , FRANTZ, Curtis , KEELER, Michael , YE, Michael , ESPECSCHIED, Ken , SMITH, Sara , SMITH, Brittany A.
IPC分类号： B01J20/26 , B01J20/28 , B01J20/287 , B01J20/30 , B01J20/32 , B01D15/32 , G01N1/40 , G01N33/68
摘要： Polymeric adsorbents useful for solid phase extraction (SPE) comprising a copolymer formed by copolymerizing at least one hydrophobic monomer including divinylbenzene and at least one hydrophilic monomer including acrylonitrile. Also provided are SPE cartridges including a divinylbenzene-acrylonitrile hydrophilic-lipophilic balance adsorbent. Further provides are methods of using a divinylbenzene-acrylonitrile hydrophilic-lipophilic balance adsorbent in conventional and simplified SPE techniques.
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公开(公告)号：WO2019036414A1
公开(公告)日：2019-02-21
申请号：PCT/US2018/046613
申请日：2018-08-14
申请人： SIGMA-ALDRICH CO. LLC , CHEN, Yong , SHIMELIS, Olga I. , BELL, Dave , STENERSON, Katherine K. , AURAND, Craig , BARREY, Emily , LU, Xiaoning , GREENIZEN, Kurt , EMD MILLIPORE CORPORATION
发明人： CHEN, Yong , SHIMELIS, Olga I. , BELL, Dave , STENERSON, Katherine K. , AURAND, Craig , BARREY, Emily , LU, Xiaoning , GREENIZEN, Kurt
摘要： An apparatus for simultaneously extracting one or more analytes from a plurality of samples, the apparatus comprising a housing having an upper platform having a plurality of pins, each pin suitable for BioSPME, and a lower platform having a plurality of wells for sample solutions, such when the upper platform is fitted over the lower platform, the pins of the upper platform fit into the wells of the lower platform such that the pins are immersed into the samples, allowing for simultaneous extraction of analytes in each sample. The apparatus can be coupled with other instruments to enable measurement of total and free analytes in each sample. Also provided are methods of simultaneous extraction of analytes in a plurality of samples using the apparatus described herein.
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