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公开(公告)号：WO2011109877A1
公开(公告)日：2011-09-15
申请号：PCT/AU2011/000284
申请日：2011-03-11
Applicant: THE AUSTRALIAN NATIONAL UNIVERSITY , PARISH, Christopher, Richard , SIMEONOVIC, Charmaine , FREEMAN, Craig, Geoffrey
IPC: A61K31/727 , A61P3/10 , A61K31/737 , A61P37/00
CPC classification number: A61K31/737 , A61K31/727 , A61K45/06 , A61K47/60 , A61K2300/00
Abstract: The present invention relates to a method for inhibiting oxidative damage of islet beta cells in vivo in a subject by administering to the subject a therapeutically effective amount of heparan sulfate capable of protecting islet beta cells from reactive oxygen species or in vitro by exposing isolated islet beta cells, prior to transplantation, to a concentration of heparan sulfate that protects them from reactive oxygen species.
Abstract translation: 本发明涉及一种抑制受试者体内胰岛β细胞氧化损伤的方法，该方法通过向受试者施用能够从活性氧物种保护胰岛β细胞的治疗有效量的硫酸乙酰肝素，或通过暴露分离的胰岛β 细胞在移植前，以硫酸乙酰肝素的浓度保护它们免受活性氧的影响。
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公开(公告)号：WO2008046162A1
公开(公告)日：2008-04-24
申请号：PCT/AU2007/001603
申请日：2007-10-22
Applicant: THE AUSTRALIAN NATIONAL UNIVERSITY , SIMEONOVIC, Charmaine , PARISH, Christopher, Richard , ZIOLKOWSKI, Andrew
IPC: A61K31/737 , A61K31/785 , A61K31/706 , A61K31/734 , A61K31/7125 , A61K31/7024 , A61K31/445 , A61K31/403 , A61K31/712 , A61K31/185 , A61P37/00 , A61K31/775 , A61K31/255 , A61K31/404 , A61K31/795 , A61K31/223 , A61K31/09
CPC classification number: A61K31/09 , A61K31/185 , A61K31/223 , A61K31/255 , A61K31/403 , A61K31/404 , A61K31/445 , A61K31/7024 , A61K31/706 , A61K31/712 , A61K31/7125 , A61K31/734 , A61K31/737 , A61K31/775 , A61K31/785 , A61K31/795
Abstract: This application realtes to a method of inhibiting the degradation of an extracellular matrix associated with islet beta cells, said method comprising contacting said extracellular matrix with an effective amount of a heparanase inhibitor.
Abstract translation: 该应用涉及抑制与胰岛β细胞相关的细胞外基质降解的方法，所述方法包括使所述细胞外基质与有效量的乙酰肝素酶抑制剂接触。
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