公开(公告)号：WO2019217387A1

公开(公告)日：2019-11-14

申请号：PCT/US2019/031072

申请日：2019-05-07

申请人： EINZIGER, Michael ,  SIMPSON, Ann, Marie

发明人： EINZIGER, Michael ,  SIMPSON, Ann, Marie

IPC分类号： C07D487/04 ,  A61K8/49 ,  A61Q19/02 ,  C07D209/12 ,  A61P17/00 ,  A61K31/404

摘要： The present invention relates to compounds, compositions, and methods for modulating skin pigmentation and treating or preventing UV-induced skin damage, erythema, aging of the skin, sunburn, and hyperpigmentation in a subject. The compounds, compositions, and methods of the present invention generally involve Malassezia- derived compounds, including malassezin and indirubin, and/or chemical analogs thereof. Other applications of the compounds and compositions disclosed herein include, but are not limited to, improving hyperpigmentation caused by a hyperpigmentation disorder, inducing melanocyte apoptosis, and modulating arylhydrocarbon receptor (AhR) activity, melanogenesis, melanin production, melanosome biogenesis, melanosome transfer, melanocyte activity, and melanin concentration.

公开(公告)号：WO2020076857A1

公开(公告)日：2020-04-16

申请号：PCT/US2019/055239

申请日：2019-10-08

申请人： EINZIGER, Michael ,  SIMPSON, Ann, Marie

发明人： EINZIGER, Michael ,  SIMPSON, Ann, Marie

IPC分类号： C07D487/04 ,  A61K8/49 ,  A61Q19/02 ,  C07D209/12 ,  A61P17/00 ,  A61K31/404

摘要： Compounds, compositions, and methods for modulating skin pigmentation and treating or preventing UV-induced skin damage, erythema, aging of the skin, sunburn, and hyperpigmentation in a subject. Malassezia -derived compounds and/or chemical analogs thereof, compositions that comprise such compounds, and methods of treating by administering the compounds and compositions, including methods of inducing melanocyte apoptosis, and modulating arylhydrocarbon receptor (AhR) activity, melanogenesis, and melanin concentration.

公开(公告)号：WO2020041663A8

公开(公告)日：2020-02-27

申请号：PCT/US2019/047831

申请日：2019-08-23

申请人： EINZIGER, Michael ,  SIMPSON, Ann Marie

发明人： EINZIGER, Michael ,  SIMPSON, Ann Marie

IPC分类号： C07D487/04 ,  A61K8/49 ,  A61Q19/02 ,  C07D209/12 ,  A61P17/00 ,  A61K31/404 ,  A61K31/407 ,  A61K31/519 ,  A61K8/492 ,  A61K8/4926 ,  A61K8/4953 ,  A61K8/4973 ,  A61P17/16 ,  A61Q17/04

摘要： The present invention relates to compounds, compositions, and methods for modulating skin pigmentation and treating or preventing UV-induced skin damage, erythema, aging of the skin, sunburn, and hyperpigmentation in a subject. The compounds, compositions, and methods of the present invention generally involve Malassezia- derived compounds, including malassezin and indirubin, and/or chemical analogs thereof. Other applications of the compounds and compositions disclosed herein include, but are not limited to, improving hyperpigmentation caused by a hyperpigmentation disorder, inducing melanocyte apoptosis, and modulating atylhydrocarbon receptor (AhR) activity, melanogenesis, melanin production, melanosome biogenesis, melanosome transfer, melanocyte activity, and melanin concentration.

公开(公告)号：WO2019241706A1

公开(公告)日：2019-12-19

申请号：PCT/US2019/037311

申请日：2019-06-14

申请人： EINZIGER, Michael ,  SIMPSON, Ann, Marie

发明人： EINZIGER, Michael ,  SIMPSON, Ann, Marie

IPC分类号： C07D487/04 ,  A61K8/49 ,  A61Q19/02 ,  C07D209/12 ,  A61P17/00 ,  A61K31/404

摘要： The present invention relates to compounds, compositions, and methods for modulating skin pigmentation and treating or preventing UV-induced skin damage, erythema, aging of the skin, sunburn, and hyperpigmentation in a subject. The compounds, compositions, and methods of the present invention generally involve Malassezia - derived compounds, including malassezin and indirubin, and/or chemical analogs thereof. Other applications of the compounds and compositions disclosed herein include, but are not limited to, improving hyperpigmentation caused by a hyperpigmentation disorder, inducing melanocyte apoptosis, and modulating arylhydrocarbon receptor (AhR) activity, melanogenesis, melanin production, melanosome biogenesis, melanosome transfer, melanocyte activity, and melanin concentration.

公开(公告)号：WO2019200232A1

公开(公告)日：2019-10-17

申请号：PCT/US2019/027181

申请日：2019-04-12

申请人： EINZIGER, Michael ,  SIMPSON, Ann, Marie

发明人： EINZIGER, Michael ,  SIMPSON, Ann, Marie

IPC分类号： C07D487/04 ,  A61K8/49 ,  A61Q19/02 ,  C07D209/12 ,  A61P17/00 ,  A61K31/404

摘要： The present invention relates to compounds, compositions, and methods for modulating skin pigmentation and treating or preventing UV-induced skin damage, erythema, aging of the skin, sunburn, and hyperpigmentation in a subject. The compounds, compositions, and methods of the present invention generally involve Malassezia -derived compounds, including malassezin and indirubin, and/or chemical analogs thereof. Other applications of the compounds and compositions disclosed herein include, but are not limited to, improving hyperpigmentation caused by a hyperpigmentation disorder, inducing melanocyte apoptosis, and modulating arylhydrocarbon receptor (AhR) activity, melanogenesis, melanin production, melanosome biogenesis, melanosome transfer, melanocyte activity, and melanin concentration.

公开(公告)号：WO2017156424A1

公开(公告)日：2017-09-14

申请号：PCT/US2017/021843

申请日：2017-03-10

申请人： EINZIGER, Michael ,  SIMPSON, Ann Marie

发明人： EINZIGER, Michael ,  SIMPSON, Ann Marie

IPC分类号： C07D487/04 ,  C07D209/12 ,  A61K8/49

摘要： The present invention relates to compounds, compositions, and methods for brightening skin. The compounds, compositions, and methods of the present invention generally involve compounds produced by a Malassezia yeast, and chemical analogs thereof. In addition to skin brightening applications, the compounds, compositions, and methods of the present invention may be used to modulate melanocyte activity, induce melanocyte apoptosis, agonize an arylhydrocarbon receptor (AhR), improve hyperpigmentation caused by a hyperpigmentation disorder, and modulate melanin production, melanosome biogenesis, and melanosome transfer.

摘要翻译： 本发明涉及用于增亮皮肤的化合物，组合物和方法。 本发明的化合物，组合物和方法通常涉及由马拉色酵母产生的化合物及其化学类似物。 除了皮肤增白应用之外，本发明的化合物，组合物和方法可用于调节黑素细胞活性，诱导黑素细胞凋亡，激动芳烃受体（AhR），改善由色素沉着过度病症引起的色素沉着过度，并调节黑素产生 ，黑素体生物合成和黑素体转移。