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    LATERAL-FLOW IMMUNO-CHROMATOGRAPHIC ASSAY DEVICES
    1.
    发明申请
    LATERAL-FLOW IMMUNO-CHROMATOGRAPHIC ASSAY DEVICES 审中-公开
    侧向流动免疫色谱测定装置

    公开(公告)号：WO2010129302A1

    公开(公告)日：2010-11-11

    申请号：PCT/US2010/032616

    申请日：2010-04-27

    申请人： INNOVATIVE LABORATORY TECHNOLOGIES, INC. ,  RUVINSKY, Igor ,  SKLAN, Ella

    发明人： RUVINSKY, Igor ,  SKLAN, Ella

    IPC分类号： G01N33/53

    CPC分类号： G01N33/558 ,  G01N33/54386 ,  G01N33/6887 ,  G01N2333/4712

    摘要： Device including migration membrane, conjugate pad on migration membrane, plasma separation membrane on conjugate pad, pre-filter on plasma separation membrane. Migration membrane has test line configured for loading one or plurality of capture antibodies having specific binding affinity for assay target. Migration membrane configured for allowing lateral flow of blood plasma or serum across migration membrane to test line. Conjugate pad configured for loading one or plurality of detection antibodies having specific binding affinity for assay target. Plasma separation membrane configured for allowing passage of blood plasma or serum and trapping erythrocytes. Pre-filter configured for loading assay sample including erythrocytes and either or both blood plasma and blood serum. Pre-filter configured for allowing passage of blood plasma or serum through pre-filter and causing lateral flow of blood plasma or serum within pre-filter. Method includes providing device and carrying out diagnostic assay cycle.

    摘要翻译： 装置包括迁移膜，迁移膜上的结合垫，缀合垫上的血浆分离膜，血浆分离膜上的预过滤。 迁移膜具有配置用于装载一种或多种对测定靶具有特异性结合亲和力的捕获抗体的测试线。 迁移膜被配置为允许血浆或血清横向流动通过迁移膜到测试线。 缀合垫，其配置用于装载一种或多种对测定靶具有特异性结合亲和力的检测抗体。 血浆分离膜被配置为允许血浆或血清通过并捕获红细胞。 配置用于装载测定样品的预过滤器，包括红细胞和血浆和血清中的任一种或两种。 预过滤器被配置为允许血浆或血清通过预过滤器并导致血浆或血清在预过滤器内侧向流动。 方法包括提供装置和进行诊断测定循环。

    SYSTEM AND METHOD FOR ASSAYING DRUGS
    4.
    发明申请
    SYSTEM AND METHOD FOR ASSAYING DRUGS 审中-公开
    用于测定药物的系统和方法

    公开(公告)号：WO0240994A3

    公开(公告)日：2002-12-19

    申请号：PCT/IL0101051

    申请日：2001-11-14

    申请人： YISSUM RES DEV CO ,  SOREQ HERMONA ,  MESHORER ERAN ,  SKLAN ELLA ,  SHOHAM SHAI

    发明人： SOREQ HERMONA ,  MESHORER ERAN ,  SKLAN ELLA ,  SHOHAM SHAI

    IPC分类号： C12Q1/46 ,  G01N33/50 ,  G01N33/94

    CPC分类号： G01N33/944 ,  C12Q1/46 ,  G01N33/5088

    摘要： The invention relates to a method and system for evaluating an effect on the nervous system of a test drug by comparing the effect of such drug on AChE catalytic activity or isoform variance in the brain of a test animal following challenge by an AChE blocker (e.g. DFP) or a blocker of AChE and muscarinic receptors M1 and M2 (e.g. pyridostigmine) and comparing this effect with that of a known agent, preferably a non-selective muscarinic receptor blocker (e.g. scopolamine) or a specific M1 receptor blocker (e.g. pirenzepine).Also provided is a method of screening for a candidate drug that is a modulator of the expression of any one of AChE variants and isoforms by determining the effect of such drug on the translocation of an AChE isoform within a neuron.Further provided is a method of screening for a candidate drug aimed at affecting central nervous system properties which is a modulator of the interaction between AChE-R/RACK1/PKC.

    摘要翻译： 本发明涉及一种通过比较该药物对AChE阻断剂攻击后测试动物大脑中AChE催化活性或异构体方差的影响（例如DFP）来评估测试药物神经系统的影响的方法和系统 ）或AChE和毒蕈碱受体M1和M2（例如吡斯的明）的阻断剂，并将其与已知药物，优选非选择性毒蕈碱受体阻断剂（例如东莨菪碱）或特异性M1受体阻断剂（例如哌仑西平）的作用进行比较。 还提供了通过测定这种药物对神经元内的AChE同种型的易位的影响来筛选作为AChE变体和同种型中的任一种的表达调节剂的候选药物的方法。进一步提供的方法是 筛选旨在影响中枢神经系统性质的候选药物，这是AChE-R / RACK1 / PKC之间相互作用的调节剂。