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    APPARATUS AND METHODS FOR TITRATING CALORIC VESTIBULAR STIMULATION
    3.
    发明申请
    APPARATUS AND METHODS FOR TITRATING CALORIC VESTIBULAR STIMULATION 审中-公开
    用于治疗卡路里血管刺激的装置和方法

    公开(公告)号：WO2012083102A1

    公开(公告)日：2012-06-21

    申请号：PCT/US2011/065328

    申请日：2011-12-16

    Applicant: SCION NEUROSTIM, LLC ,  ROGERS, Lesco L. ,  SMITH, Lanty L. ,  BLACK, Robert D.

    Inventor： ROGERS, Lesco L. ,  SMITH, Lanty L. ,  BLACK, Robert D.

    IPC: A61F7/00

    CPC classification number: A61F7/12 ,  A61B2018/00875 ,  A61F7/007 ,  A61F2007/0005 ,  A61F2007/0075 ,  A61F2007/0093 ,  A61F2007/0095 ,  A61F2007/0096 ,  A61F2007/0296 ,  A61N1/36036 ,  A61N2/002 ,  A61N2/006

    Abstract: A device for delivering caloric vestibular stimulation to an individual, includes: (a) an earpiece configured to be at least partially insertable into the ear canal of the individual for delivering a first thermal stimulus; (b) an input unit for receiving a user input indicating efficacy of said first thermal stimulus, and (c) a controller operatively associated with said earpiece and said input unit for: (i) controlling said earpiece to provide said first thermal stimulus, and (ii) receiving a signal corresponding to the user input and generating a control signal to control the earpiece and delivering a subsequent thermal stimulus different from said first thermal stimulus. In some embodiments, each thermal stimulus is an actively controlled time varying waveform stimulus.

    Abstract translation: 用于向个人输送热量前庭刺激的装置包括：（a）耳机，其被配置为至少部分地插入到个体的耳道中，用于传送第一热刺激; （b）用于接收指示所述第一热刺激的功效的用户输入的输入单元，以及（c）与所述耳机和所述输入单元可操作地相关联的控制器，用于：（i）控制所述耳机以提供所述第一热刺激，以及 （ii）接收与所述用户输入相对应的信号并产生控制信号以控制所述耳机并传送不同于所述第一热刺激的后续热刺激。 在一些实施例中，每个热刺激是主动控制的时变波形刺激。

    VESTIBULAR STIMULATION APPARATUS AND ASSOCIATED METHODS OF USE
    4.
    发明申请
    VESTIBULAR STIMULATION APPARATUS AND ASSOCIATED METHODS OF USE 审中-公开
    VESTIBULAR刺激装置及相关使用方法

    公开(公告)号：WO2009020862A2

    公开(公告)日：2009-02-12

    申请号：PCT/US2008/071935

    申请日：2008-08-01

    Applicant: SCION NEUROSTIM LLC ,  ROGERS, Lesco, L. ,  SMITH, Lanty, L.

    Inventor： ROGERS, Lesco, L. ,  SMITH, Lanty, L.

    CPC classification number: A61H39/06 ,  A61B5/01 ,  A61F7/00 ,  A61F7/007 ,  A61F7/12 ,  A61F2007/0005 ,  A61F2007/0075 ,  A61H2201/165 ,  A61H2201/5082 ,  A61H2205/027 ,  A61N1/36036 ,  A61N1/403 ,  B33Y80/00

    Abstract: A device and associated method for providing vestibular stimulation to an individual includes active elements positioned on or proximate an ear insert. The active elements include but are not limited to at least one electrode, at least one thermometer, and at least one thermoelectric transducer. The device includes a computerized control module regulating the active elements. The device incorporates an ear insert that allows the active elements to engage the individual's ear canal and therefore access the individual's vestibular system. Vestibular stimulation applied to the individual is customized for directly stimulating desired regions of the brain for therapeutic or diagnostic purposes. In a preferred embodiment, the device provides vestibular stimulation sufficient to promote physiological changes in the individual, the changes selected from the group consisting of circadian temperature cycle time shifts, ascorbic acid production, serotonin production, acetylcholine production, histamine production, and heat shock protein production.

    Abstract translation: 用于向个体提供前庭刺激的装置和相关联的方法包括定位在耳塞上或附近的有源元件。 有源元件包括但不限于至少一个电极，至少一个温度计和至少一个热电换能器。 该装置包括调节有源元件的计算机控制模块。 该装置包括耳塞，其允许有源元件接合个人的耳道，并且因此访问个人的前庭系统。 应用于个体的前庭刺激被定制用于直接刺激脑的所需区域用于治疗或诊断目的。 在优选的实施方案中，该装置提供足以促进个体的生理变化的前庭刺激，所述变化选自昼夜温度循环时间变化，抗坏血酸产生，5-羟色胺产生，乙酰胆碱生成，组胺产生和热休克蛋白 生产。

    DEVICES AND METHODS FOR VESTIBULAR AND/OR CRANIAL NERVE STIMULATION
    5.
    发明申请
    DEVICES AND METHODS FOR VESTIBULAR AND/OR CRANIAL NERVE STIMULATION 审中-公开
    用于前庭和/或丘脑神经刺激的装置和方法

    公开(公告)号：WO2011075574A1

    公开(公告)日：2011-06-23

    申请号：PCT/US2010/060771

    申请日：2010-12-16

    Applicant: SCION NEUROSTIM, LLC ,  SMITH, Lanty L. ,  ROGERS, Lesco L.

    Inventor： SMITH, Lanty L. ,  ROGERS, Lesco L.

    IPC: A61F7/12

    CPC classification number: A61F7/12 ,  A61F7/007 ,  A61F2007/0005 ,  A61F2007/0075 ,  A61F2007/0093 ,  A61F2007/0096

    Abstract: An in-ear stimulator for administering thermal stimulation to the ear canal of a subject includes (a) an earpiece configured to be insertable into the ear canal of said subject, the earpiece having an outer surface and an internal cavity formed therein, the internal cavity having an inner surface; and (b) at least one thermoelectric device thermally coupled to the earpiece internal cavity inner surface.

    Abstract translation: 用于向受试者的耳道给予热刺激的耳内刺激器包括：（a）耳机，其被构造成可插入所述受试者的耳道中，所述耳机具有外表面和 其中形成有内腔，所述内腔具有内表面; 和（b）至少一个与耳机内腔内表面热耦合的热电装置。

    VESTIBULAR STIMULATION APPARATUS AND ASSOCIATED METHODS OF USE
    6.
    发明申请
    VESTIBULAR STIMULATION APPARATUS AND ASSOCIATED METHODS OF USE 审中-公开
    前庭刺激设备和相关的使用方法

    公开(公告)号：WO2009020862A3

    公开(公告)日：2009-09-03

    申请号：PCT/US2008071935

    申请日：2008-08-01

    Applicant: SCION NEUROSTIM LLC ,  ROGERS LESCO L ,  SMITH LANTY L

    Inventor： ROGERS LESCO L ,  SMITH LANTY L

    IPC: A61H39/06

    CPC classification number: A61H39/06 ,  A61B5/01 ,  A61F7/00 ,  A61F7/007 ,  A61F7/12 ,  A61F2007/0005 ,  A61F2007/0075 ,  A61H2201/165 ,  A61H2201/5082 ,  A61H2205/027 ,  A61N1/36036 ,  A61N1/403 ,  B33Y80/00

    Abstract: A device and associated method for providing vestibular stimulation to an individual includes active elements positioned on or proximate an ear insert. The active elements include but are not limited to at least one electrode, at least one thermometer, and at least one thermoelectric transducer. The device includes a computerized control module regulating the active elements. The device incorporates an ear insert that allows the active elements to engage the individual's ear canal and therefore access the individual's vestibular system. Vestibular stimulation applied to the individual is customized for directly stimulating desired regions of the brain for therapeutic or diagnostic purposes. In a preferred embodiment, the device provides vestibular stimulation sufficient to promote physiological changes in the individual, the changes selected from the group consisting of circadian temperature cycle time shifts, ascorbic acid production, serotonin production, acetylcholine production, histamine production, and heat shock protein production.

    Abstract translation: 用于向个体提供前庭刺激的装置和相关方法包括位于耳朵插入物上或附近的有源元件。 有源元件包括但不限于至少一个电极，至少一个温度计和至少一个热电变换器。 该设备包括一个调节有源元件的计算机控制模块。 该装置结合了耳塞，其允许活动元件接合个人的耳道并因此进入个人的前庭系统。 定制用于个体的前庭刺激以直接刺激脑的期望区域用于治疗或诊断目的。 在一个优选的实施方案中，所述装置提供足以促进个体生理变化的前庭刺激，所述变化选自昼夜温度循环时间变化，抗坏血酸生成，血清素生成，乙酰胆碱生成，组胺产生和热休克蛋白 生产。

    SYSTEMS, DEVICES AND METHODS FOR BILATERAL CALORIC VESTIBULAR STIMULATION
    7.
    发明申请
    SYSTEMS, DEVICES AND METHODS FOR BILATERAL CALORIC VESTIBULAR STIMULATION 审中-公开
    系统，装置和方法用于双侧卡路里血管刺激

    公开(公告)号：WO2012083126A1

    公开(公告)日：2012-06-21

    申请号：PCT/US2011/065396

    申请日：2011-12-16

    Applicant: SCION NEUROSTIM, LLC ,  ROGERS, Lesco L. ,  SMITH, Lanty L. ,  BLACK, Robert D.

    Inventor： ROGERS, Lesco L. ,  SMITH, Lanty L. ,  BLACK, Robert D.

    IPC: A61F7/00

    CPC classification number: A61F7/12 ,  A61B2018/00875 ,  A61F7/007 ,  A61F2007/0005 ,  A61F2007/0075 ,  A61F2007/0093 ,  A61F2007/0095 ,  A61F2007/0096 ,  A61F2007/0296 ,  A61N1/36036 ,  A61N2/002 ,  A61N2/006

    Abstract: An in-ear stimulation device for administering caloric stimulation to the ear canal of a subject includes (a) first and second earpieces configured to be insertable into the ear canals of the subject; (b) at least first and second thermoelectric devices thermally coupled to respective ones of the first and second earpieces; (c) a first heat sink thermally coupled to the first thermoelectric device opposite the first earpiece and a second heat sink thermally coupled to the second thermoelectric device opposite the second earpiece; and (d) a controller comprising a waveform generator in communication with the first and second thermoelectric devices, the waveform generator configured to generate a first control signal to control a first caloric output to the first thermoelectric device and a second control signal to control a second caloric output to the second caloric device.

    Abstract translation: 用于对受试者的耳道施加热量刺激的入耳式刺激装置包括：（a）被配置为可插入对象的耳道中的第一和第二耳机; （b）至少第一和第二热电装置热耦合到第一和第二耳机中的相应的一个; （c）热耦合到与第一耳机相对的第一热电装置的第一散热器和与第二耳机相对的与第二热电装置热耦合的第二散热器; 和（d）包括与第一和第二热电装置连通的波形发生器的控制器，所述波形发生器被配置为产生第一控制信号以控制到第一热电装置的第一热量输出和第二控制信号以控制第二热电装置 热量输出到第二热量装置。

    DEVICES AND METHODS FOR VESTIBULAR AND/OR CRANIAL NERVE STIMULATION
    8.
    发明申请
    DEVICES AND METHODS FOR VESTIBULAR AND/OR CRANIAL NERVE STIMULATION 审中-公开
    用于血管和/或急性神经刺激的装置和方法

    公开(公告)号：WO2011075573A1

    公开(公告)日：2011-06-23

    申请号：PCT/US2010/060764

    申请日：2010-12-16

    Applicant: SCION NEUROSTIM, LLC ,  ROGERS, Lesco, L. ,  SMITH, Lanty, L.

    Inventor： ROGERS, Lesco, L. ,  SMITH, Lanty, L.

    IPC: A61F7/12

    CPC classification number: A61F7/12 ,  A61F7/007 ,  A61F2007/0005 ,  A61F2007/0075 ,  A61F2007/0093 ,  A61F2007/0096

    Abstract: An in-ear stimulator for administering thermal stimulation to the ear canal of a subject includes (a) an earpiece configured to be insertable into the ear canal of said subject, the earpiece having an outer surface and an internal cavity formed therein, the internal cavity having an inner surface; and (b) at least one thermoelectric device thermally coupled to the earpiece internal cavity inner surface.

    Abstract translation: 用于对受试者的耳道施加热刺激的入耳式刺激器包括（a）构造成可插入所述对象的耳道中的耳机，所述耳机具有形成在其中的外表面和内腔，所述内腔 具有内表面; 和（b）热耦合到听筒内腔内表面的至少一个热电装置。

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