公开(公告)号：WO2016109875A1

公开(公告)日：2016-07-14

申请号：PCT/CA2015/000008

申请日：2015-01-07

Applicant: SPECTRAL MEDICAL INC.

Inventor： THOMPSON, Michael ,  BLASZYKOWSKI, Christophe ,  SHEIKH, Sonia ,  ROMASCHIN, Alexander

IPC: G01N29/036 ,  A61M1/36 ,  G01N33/49 ,  G01N33/53 ,  A61K35/14

CPC classification number: A61M1/3612 ,  A61K38/12 ,  A61M1/3679 ,  A61M1/3687 ,  A61M2205/3303 ,  G01N29/022 ,  G01N29/036 ,  G01N29/2431 ,  G01N2291/0255 ,  G01N2291/0257

Abstract: The present invention provides an acoustic wave biosensor adapted for the detection of endotoxins and processes for preparing same. The biosensor comprises a piezoelectric substrate modified with a self-assembling monolayer. Immobilized on the self-assembling monolayer is a biochemical probe (preferably, polymyxin B). Such biosensor is functionalized to detect endotoxins utilizing an electromagnetic piezoelectric acoustic sensor. According to another aspect of the present invention, there is provided polymyxin B immobilized beads, processes for preparing same, and neutralization cartridges comprising such beads for the treatment of endotoxemia. Finally, the present invention provide a theranostic circuit device for the treatment of endotoxmeia that utilizes one or more hemoperfusion cartridges and an acoustic wave biosensor.

Abstract translation: 本发明提供一种适于检测内毒素的声波生物传感器及其制备方法。 生物传感器包括用自组装单层改性的压电基片。 固定在自组装单层上的是生物化学探针（优选多粘菌素B）。 这种生物传感器被功能化以利用电磁压电声传感器检测内毒素。 根据本发明的另一方面，提供了多粘菌素B固定化珠粒，其制备方法，以及包含用于治疗内毒素血症的珠粒的中和柱。 最后，本发明提供了一种用于治疗使用一个或多个血液灌注盒和声波生物传感器的内毒素的治疗电路装置。