公开(公告)号：WO2007083182A3

公开(公告)日：2007-11-15

申请号：PCT/IB2006003468

申请日：2006-12-01

Applicant: ORCHID RES LAB LTD ,  SRINIVAS VISWESWARA AKELLA STA ,  TADIPARTHI RAVIKUMAR ,  SHARMA GANAPAVARAPU VEERA RAGH ,  THIRUNAVUKKARASU SAPPANIMUTHU ,  BHAKIARAJ DURAIRAJ PETER ,  KACHHADIA VIRENDRA ,  NARSIMHAN KILAMBI ,  THARA SATHYA NARAYANA ,  RAJAGOPAL SRIRAM ,  REEDY GADDAM OM ,  NARAYANAN SUKUNATH ,  PARAMESWARAN VENKATESAN ,  JANARTHANAM VENKATESAN

Inventor： SRINIVAS VISWESWARA AKELLA STA ,  TADIPARTHI RAVIKUMAR ,  SHARMA GANAPAVARAPU VEERA RAGH ,  THIRUNAVUKKARASU SAPPANIMUTHU ,  BHAKIARAJ DURAIRAJ PETER ,  KACHHADIA VIRENDRA ,  NARSIMHAN KILAMBI ,  THARA SATHYA NARAYANA ,  RAJAGOPAL SRIRAM ,  REEDY GADDAM OM ,  NARAYANAN SUKUNATH ,  PARAMESWARAN VENKATESAN ,  JANARTHANAM VENKATESAN

IPC: C07D233/96 ,  A61K31/505

CPC classification number: C07D239/42 ,  C07D213/30 ,  C07D239/32 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D407/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D417/12 ,  C07D417/14

Abstract: The present invention relates to novel heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof. The present invention more particularly provides novel hetereocycles of the general formula (I). Also included is a method of treatment of immunological diseases, inflammation, pain disorder, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; ischemic heart disease; atherosclerosis; cancer; ischemic-induced cell damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; adult respiratory distress syndrome (ARDS); psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; cachexia; asthma; bone resorption diseases; ischemia reperfusion injury; brain trauma; multiple sclerosis; sepsis; septic shock; toxic shock syndrome; fever, and myalgias due to infection in a mammal comprising administering an effective amount of a compound of formula (I) as described above.

Abstract translation: 本发明涉及通式（I）的新型杂环化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂化物，药学上可接受的盐和组合物，其代谢物和前药。 本发明更具体地提供了通式（I）的新颖的杂环。 还包括治疗免疫疾病，炎症，疼痛障碍，类风湿性关节炎的方法; 骨质疏松症; 多发性骨髓瘤 uveititis; 急性和慢性粒细胞白血病; 缺血性心脏病; 动脉粥样硬化; 癌症; 缺血诱导的细胞损伤; 胰腺β细胞破坏; 骨关节炎; 类风湿性脊柱炎; 痛风性关节炎 炎症性肠病; 成人呼吸窘迫综合征（ARDS）; 银屑病; 克罗恩病; 过敏性鼻炎; 溃疡性结肠炎 过敏性反应; 接触性皮炎; 肌肉退化; 恶病质; 哮喘; 骨吸收疾病; 缺血再灌注损伤; 脑外伤; 多发性硬化症 败血症; 败血性休克 中毒性休克综合征; 发热和由于哺乳动物感染引起的肌痛，包括给予有效量的如上所述的式（I）化合物。