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    PROTOILLUDENE SYNTHASE
    4.
    发明申请
    PROTOILLUDENE SYNTHASE 审中-公开

    公开(公告)号：WO2012016912A1

    公开(公告)日：2012-02-09

    申请号：PCT/EP2011/063048

    申请日：2011-07-28

    Applicant: FRAUNHOFER INSTITUT FÜR MOLEKULARBIOLOGIE UND ANGEWANDTE ÖKOLOGIE ,  JENNEWEIN, Stefan ,  ENGELS, Benedikt ,  GROTHE, Torsten ,  STADLER, Marc

    Inventor： JENNEWEIN, Stefan ,  ENGELS, Benedikt ,  GROTHE, Torsten ,  STADLER, Marc

    IPC: C12N9/88

    CPC classification number: C12N9/88

    Abstract: The present invention relates to an isolated polynucelotide encoding a polypeptide with protoilludene synthase activity and comprising a sequence selected from the group consisting of a) SEQ ID Nos. 1 or 14 of the attached sequence listing; b) a nucleic acid sequence complementary to SEQ ID Nos. 1 or 14; c) nucleic acid sequences which hybridize under stringent conditions to the nucleic acid sequences defined in a) and b) or their complementary strands, as well as to the polypeptide encoded by the isolated polynucleotide, as well as their uses for the production of melleolides.

    Abstract translation: 本发明涉及一种编码具有原始烯醇合酶活性的多肽的分离的聚赖苷，并且包含选自所附序列表中的a）SEQ ID NO：1或14的序列; b）与SEQ ID NO：1或14互补的核酸序列; c）在严格条件下与a）和b）或其互补链中所定义的核酸序列以及由分离的多核苷酸编码的多肽以及它们用于生产melleolides的用途杂交的核酸序列。

    TERPENOID SPIRO KETAL COMPOUNDS WITH LXR AGONISTS ACTIVITY, THEIR USE AND FORMULATIONS WITH THEM
    5.
    发明申请
    TERPENOID SPIRO KETAL COMPOUNDS WITH LXR AGONISTS ACTIVITY, THEIR USE AND FORMULATIONS WITH THEM 审中-公开
    具有LXR激动剂的TERPENOID SPIRO KETAL化合物活性，与他们的使用和配方

    公开(公告)号：WO2012079721A1

    公开(公告)日：2012-06-21

    申请号：PCT/EP2011006157

    申请日：2011-12-08

    Applicant: INTERMED DISCOVERY GMBH ,  GROTHE TORSTEN ,  STADLER MARC ,  KOEPCKE BAERBEL ,  ROEMER ERNST ,  BITZER JENS ,  WABNITZ PHILIPP ,  KUEPER THOMAS

    Inventor： GROTHE TORSTEN ,  STADLER MARC ,  KOEPCKE BAERBEL ,  ROEMER ERNST ,  BITZER JENS ,  WABNITZ PHILIPP ,  KUEPER THOMAS

    IPC: A61K9/00 ,  A61K9/08 ,  A61K9/10 ,  A61K31/56 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/00 ,  A61P25/28

    CPC classification number: C07D471/10 ,  A61K31/56 ,  A61K31/58 ,  A61K36/07

    Abstract: The invention relates to the use, or methods (especially with regard to animals, especially human, that are in need of such treatment) comprising the use, respectively, of an extract and/or especially one or more natural spiro triterpenoids and derivatives thereof, especially from the blazeispirol family, obtainable from Agaricus species, alone or as supplement, as active ingredient in the prophylactic and/or therapeutic treatment of a disease, disorder or condition that responds to the modulation of Liver X receptor, either in humans or in other mammals, and/or to the use of said extract and/or natural compound(s) or mixtures for the treatment of said disease, disorder or condition, as well as corresponding methods of treatment, or their use in the manufacture of a pharmaceutical or nutraceutical formulation for said treatment. The invention relates also to said extract and/or compound(s) for use in the treatment or in the preparation of a medicament (including a nutraceutical) for the prophylactic and/or therapeutic treatment of said disorder, disorder or condition, as well as their preparation. It also relates to pharmaceutical or nutraceutical formulations comprising said extract and/or natural compound(s) which are useful in said prophylactic and/or therapeutic treatment. They can also be used for non-therapeutic, e.g. cosmetic, purposes only.

    Abstract translation: 本发明涉及分别使用提取物和/或特别是一种或多种天然螺三萜类化合物及其衍生物的用途或方法（特别是涉及动物，特别是人类，需要这种治疗） 特别是从作为活性成分的单独或作为补充剂的姬松茸物种获得的风疹家族，用于预防和/或治疗治疗响应肝脏X受体的调节的疾病，病症或病症，在人或其他 哺乳动物和/或使用所述提取物和/或天然化合物或混合物来治疗所述疾病，病症或病症，以及相应的治疗方法或其在制造药物或制剂中的用途 用于所述治疗的营养制剂。 本发明还涉及用于治疗或制备用于预防和/或治疗所述病症，障碍或病症的药物（包括营养药物）的所述提取物和/或化合物，以及 他们的准备。 它还涉及包含可用于所述预防和/或治疗性治疗的所述提取物和/或天然化合物的药物或营养制剂。 它们也可以用于非治疗性的，例如， 化妆品，用途。

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