公开(公告)号：WO2008039087A3

公开(公告)日：2008-08-14

申请号：PCT/NZ2007000285

申请日：2007-09-28

Applicant: AUCKLAND UNISERVICES LTD ,  STRIBBLING STEPHEN MARK ,  MOUNTJOY KATHLEEN GRACE ,  TERCEL MOANA ,  WILSON WILLIAM ROBERT ,  DENNY WILLIAM ALEXANDER ,  STEVENSON RALPH JAMES ,  LU GUO-LIANG

Inventor： STRIBBLING STEPHEN MARK ,  MOUNTJOY KATHLEEN GRACE ,  TERCEL MOANA ,  WILSON WILLIAM ROBERT ,  DENNY WILLIAM ALEXANDER ,  STEVENSON RALPH JAMES ,  LU GUO-LIANG

IPC: C07D403/12 ,  A61K31/395 ,  A61K31/403 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/00 ,  C07D209/56

CPC classification number: C07D209/60 ,  C07D403/12

Abstract: The present invention relates to compounds which are indoline derivatives of formula (I), wherein Rl, R2, R3, R4 and n are as defined in the specification, intermediates used in their synthesis and pharmaceutical compositions containing these compounds. The invention is also concerned with methods utilising these compounds in prophylactic or therapeutic treatment of obesity, weight gain, metabolic disorders resulting in obesity or weight gain and associated conditions such as high blood glucose and triglycerides, and Type II diabetes.

Abstract translation: 本发明涉及作为式（I）的二氢吲哚衍生物的化合物，其中R1，R2，R3，R4和n如本说明书中所定义，在其合成中使用的中间体和含有这些化合物的药物组合物。 本发明还涉及利用这些化合物在预防或治疗肥胖症，体重增加，导致肥胖或体重增加的代谢紊乱以及相关病症如高血糖和甘油三酸酯以及II型糖尿病中的方法。

公开(公告)号：WO2008039087A8

公开(公告)日：2009-07-09

申请号：PCT/NZ2007000285

申请日：2007-09-28

Applicant: AUCKLAND UNISERVICES LTD ,  STRIBBLING STEPHEN MARK ,  MOUNTJOY KATHLEEN GRACE ,  TERCEL MOANA ,  WILSON WILLIAM ROBERT ,  DENNY WILLIAM ALEXANDER ,  STEVENSON RALPH JAMES ,  LU GUO-LIANG

Inventor： STRIBBLING STEPHEN MARK ,  MOUNTJOY KATHLEEN GRACE ,  TERCEL MOANA ,  WILSON WILLIAM ROBERT ,  DENNY WILLIAM ALEXANDER ,  STEVENSON RALPH JAMES ,  LU GUO-LIANG

IPC: C07D403/12 ,  A61K31/395 ,  A61K31/403 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/00 ,  C07D209/56

CPC classification number: C07D209/60 ,  C07D403/12

Abstract: The present invention relates to compounds which are indoline derivatives of formula (I), wherein Rl, R2, R3, R4 and n are as defined in the specification, intermediates used in their synthesis and pharmaceutical compositions containing these compounds. The invention is also concerned with methods utilising these compounds in prophylactic or therapeutic treatment of obesity, weight gain, metabolic disorders resulting in obesity or weight gain and associated conditions such as high blood glucose and triglycerides, and Type II diabetes.

Abstract translation: 本发明涉及作为式（I）的二氢吲哚衍生物的化合物，其中R1，R2，R3，R4和n如说明书中所定义，用于其合成的中间体和含有这些化合物的药物组合物。 本发明还涉及利用这些化合物在预防或治疗肥胖症，体重增加，导致肥胖或体重增加的代谢紊乱以及相关病症如高血糖和甘油三酸酯以及II型糖尿病中的方法。

公开(公告)号：WO2008039087A2

公开(公告)日：2008-04-03

申请号：PCT/NZ2007/000285

申请日：2007-09-28

Applicant: AUCKLAND UNISERVICES LIMITED ,  STRIBBLING, Stephen Mark ,  MOUNTJOY, Kathleen Grace ,  TERCEL, Moana ,  WILSON, William, Robert ,  DENNY, William, Alexander ,  STEVENSON, Ralph, James ,  LU, Guo-Liang

Inventor： STRIBBLING, Stephen Mark ,  MOUNTJOY, Kathleen Grace ,  TERCEL, Moana ,  WILSON, William, Robert ,  DENNY, William, Alexander ,  STEVENSON, Ralph, James ,  LU, Guo-Liang

CPC classification number: C07D209/60 ,  C07D403/12

Abstract: The present invention relates to compounds which are indoline derivatives, with intermediates used in their synthesis and with pharmaceutical compositions containing these compounds. The invention is also concerned with methods utilising these compounds in prophylactic or therapeutic treatment of obesity, weight gain, metabolic disorders resulting in obesity or weight gain and associated conditions such as high blood glucose and triglycerides, and Type II diabetes.

Abstract translation: 本发明涉及二氢吲哚衍生物，其合成中使用的中间体和含有这些化合物的药物组合物。 本发明还涉及利用这些化合物在预防或治疗肥胖症，体重增加，导致肥胖或体重增加的代谢紊乱以及相关病症如高血糖和甘油三酸酯以及II型糖尿病中的方法。