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公开(公告)号：WO2004035730A3
公开(公告)日：2006-07-06
申请号：PCT/US0239938
申请日：2002-12-12
Applicant: STRUCTURAL GENOMIX INC , LEWIS HAL , SAUDER J MICHAEL , BUCHANAN SEAN GRANT
Inventor： LEWIS HAL , SAUDER J MICHAEL , BUCHANAN SEAN GRANT
CPC classification number: C12N9/1077
Abstract: The present invention provides machine readable media embedded with the three-dimensional molecular structure coordinates of ATP phosphoribosyltransferase, and subsets thereof, including binding pockets, methods of using the structure to identify and design affecters, including inhibitors and activator, mutants of ATP-PRT, and compounds and compositions that affect ATP-PRT activity.
Abstract translation: 本发明提供了嵌入ATP磷酸核糖基转移酶及其子集的三维分子结构坐标的机器可读介质，包括结合口袋，使用该结构鉴定和设计影响因子的方法，包括ATP-PRT的抑制剂和激活剂，突变体， 以及影响ATP-PRT活性的化合物和组合物。
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公开(公告)号：WO2004059291A3
公开(公告)日：2004-12-23
申请号：PCT/US0341217
申请日：2003-12-18
Applicant: STRUCTURAL GENOMIX INC , NOLAND BRIAN
Inventor： NOLAND BRIAN
IPC: C12Q1/42 , C12Q1/48 , G01N20060101
CPC classification number: C12Q1/48 , G01N2333/912
Abstract: The invention relates to a novel method of assaying phosphate transfer, such as that mediated by kinases or phosphatases, using fluorescence resonance energy transfer. These assays may be used, for example, for high throughput screening of enzymes having phosphate transfer activity.
Abstract translation: 本发明涉及使用荧光共振能量转移测定磷酸转移的新方法，例如由激酶或磷酸酶介导的转移。 这些测定法可用于例如具有磷酸盐转移活性的酶的高通量筛选。
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公开(公告)号：WO2004035730A2
公开(公告)日：2004-04-29
申请号：PCT/US2002/039938
申请日：2002-12-12
Applicant: STRUCTURAL GENOMIX, INC. , LEWIS, Hal , SAUDER, J., Michael , BUCHANAN, Sean, Grant
Inventor： LEWIS, Hal , SAUDER, J., Michael , BUCHANAN, Sean, Grant
IPC: C12N
CPC classification number: C12N9/1077
Abstract: The present invention provides machine readable media embedded with the three-dimensional molecular structure coordinates of ATP phosphoribosyltransferase, and subsets thereof, including binding pockets, methods of using the structure to identify and design affecters, including inhibitors and activator, mutants of ATP-PRT, and compounds and compositions that affect ATP-PRT activity.
Abstract translation: 本发明提供了嵌入ATP磷酸核糖基转移酶的三维分子结构坐标的机读介质及其子集，包括结合口袋，使用该结构识别和设计影响因子的方法，包括ATP-PRT的抑制剂和活化剂，突变体， 以及影响ATP-PRT活性的化合物和组合物。
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公开(公告)号：WO2003065978A3
公开(公告)日：2003-08-14
申请号：PCT/US2002/038070
申请日：2002-11-27
Applicant: STRUCTURAL GENOMIX, INC. , PARK, Frances , GAJIWALA, Ketan, S. , BUCHANAN, Sean, Grant , SAUDER, J., Michael
Inventor： PARK, Frances , GAJIWALA, Ketan, S. , BUCHANAN, Sean, Grant , SAUDER, J., Michael
Abstract: The present invention provides machine readable media embedded with the three-dimensional molecular structure coordinates of putative flavin oxidoreductase, and subsets thereof, including binding pockets, methods of using the structure to identify and design affecters, including inhibitors and activator, mutants of FMNBP, and compounds and compositions that affect FMNBP activity.
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公开(公告)号：WO2004058177A3
公开(公告)日：2005-05-26
申请号：PCT/US0340935
申请日：2003-12-18
Applicant: STRUCTURAL GENOMIX INC , ATWELL SHANE , HENDLE JORG , BUCHANAN SEAN GRANT , FEIL INGEBORG , RUSSELL MARIJANE , BADGER JOHN , TOMIMOTO MASAKI , SAUDER MICHAEL J
Inventor： ATWELL SHANE , HENDLE JORG , BUCHANAN SEAN GRANT , FEIL INGEBORG , RUSSELL MARIJANE , BADGER JOHN , TOMIMOTO MASAKI , SAUDER MICHAEL J
IPC: C07K14/705 , C12N9/12 , G06T15/20 , G09G5/40 , G11B5/84
CPC classification number: C12N9/1205 , C07K14/705 , C07K2299/00
Abstract: The present invention provides machine readable media embedded with the three-dimensional molecular structure coordinates of SYKKD and subsets thereof, including binding pockets, methods of using the structure to identify and design affecters, including inhibitors and activator, mutants of SYKKD, and compounds and compositions that affect SYK activity.
Abstract translation: 本发明提供了嵌入有SYKKD及其子集的三维分子结构坐标的机器可读介质，包括结合口袋，使用该结构识别和设计影响剂的方法，包括抑制剂和活化剂，SYKKD突变体，以及化合物和组合物 影响SYK活动。
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Patent Agency Ranking
公开(公告)号：WO2005005611A2
公开(公告)日：2005-01-20
申请号：PCT/US2004/021154
申请日：2004-06-30
Applicant: STRUCTURAL GENOMIX, INC. , ANTONYSAMY, Stephen, Suresh , HENDLE, Jorg , LOUIE, Gordon, V.
Inventor： ANTONYSAMY, Stephen, Suresh , HENDLE, Jorg , LOUIE, Gordon, V.
IPC: C12N
CPC classification number: C12N9/1205 , C07K2299/00
Abstract: The present invention provides machine readable media embedded with the three-dimensional molecular structure coordinates of CHK2KD and subsets thereof, including biniding ockets, methods of using the sturcture to identify and desing affecters, including inhibitors and activator, mutants of CHK2KD, CHK2KD crystals and compounds and compositions that affect CHK2 activity.
Abstract translation: 本发明提供了嵌入有CHK2KD及其子集的三维分子结构坐标的机器可读介质，包括二元箱，使用结构识别和设计影响者的方法，包括抑制剂和激活剂， CHK2KD突变体，CHK2KD晶体以及影响CHK2活性的化合物和组合物。
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公开(公告)号：WO2004107114A2
公开(公告)日：2004-12-09
申请号：PCT/US2004016188
申请日：2004-05-21
Applicant: STRUCTURAL GENOMIX INC , LOUIE GORDON V , BUCHANAN SEAN GRANT , LEON BARBARA CHIE , ARNOLD WILLIAM D
Inventor： LOUIE GORDON V , BUCHANAN SEAN GRANT , LEON BARBARA CHIE , ARNOLD WILLIAM D
CPC classification number: C12N9/1205 , C07K2299/00
Abstract: The present invention provides machine readable media embedded with the threedimensional molecular structure coordinates of Ab1KD and variants and subsets thereof, including binding pockets, methods of using the structure to identify and design affecters, including inhibitors and activator Ab1KD crystals and compounds and compositions that affect Abl activity.
Abstract translation: 本发明提供了嵌入Ab1KD的三维分子结构坐标及其变体和子集的机读可读介质，包括结合口袋，使用结构鉴定和设计影响因子的方法，包括抑制剂和活化剂Ab1KD晶体以及影响Abl的化合物和组合物 活动。
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公开(公告)号：WO2004081180A2
公开(公告)日：2004-09-23
申请号：PCT/US2004/006739
申请日：2004-03-05
Applicant: STRUCTURAL GENOMIX, INC. , ATWELL, Shane , MILLER, Ian , FEIL, Ingeborg , BADGER, John
Inventor： ATWELL, Shane , MILLER, Ian , FEIL, Ingeborg , BADGER, John
IPC: C12N
CPC classification number: C07K14/715 , C07K2319/00 , C07K2319/21 , C07K2319/40 , G06F19/16 , Y02A90/26
Abstract: The present invention provides machine readable media embedded with the three-dimensional molecular structure coordinates of EPHA7KD and subsets thereof, including binding pockets, methods of using the structure to identify and design affecters, including inhibitors and activator, mutants of EPHA7KD, EPHA7KD crystals and compounds and compositions that affect EPHA7 activity.
Abstract translation: 本发明提供嵌入有EPHA7KD及其子集的三维分子结构坐标的机器可读介质，包括结合口袋，使用该结构识别和设计影响剂的方法，包括抑制剂和活化剂，EPHA7KD，EPHA7KD晶体和化合物的突变体 和影响EPHA7活性的组合物。
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公开(公告)号：WO2004035804A2
公开(公告)日：2004-04-29
申请号：PCT/US2002/035146
申请日：2002-11-01
Applicant: STRUCTURAL GENOMIX, INC. , PARK, Frances , GAJIWALA, Ketan, S. , BUCHANAN, Sean, Grant
Inventor： PARK, Frances , GAJIWALA, Ketan, S. , BUCHANAN, Sean, Grant
IPC: C12Q
CPC classification number: G06F19/16 , C07K2299/00 , G01N33/6803 , G01N2333/32 , G06F19/28
Abstract: The present invention provides machine readable media embedded with the three-dimensional molecular structure coordinates of BNAB protein, and subsets thereof, including binding pockets, methods of using the structure to identify and design affecters, including inhibitors and activator, mutants of BNAB, and compounds and compositions that affect BNAB activity.
Abstract translation: 本发明提供了嵌入了BNAB蛋白的三维分子结构坐标的机器可读介质及其子集，包括结合口袋，使用结构鉴定和设计影响因子的方法，包括抑制剂和活化剂，BNAB的突变体和化合物 和影响BNAB活性的组合物。
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公开(公告)号：WO2003083060A3
公开(公告)日：2003-10-09
申请号：PCT/US2003/009068
申请日：2003-03-21
Applicant: STRUCTURAL GENOMIX, INC. , ANTONYSAMY, Stephen, S. , FEIL, Ingeborg , BUCHANAN, Sean, G. , XU, Jian
Inventor： ANTONYSAMY, Stephen, S. , FEIL, Ingeborg , BUCHANAN, Sean, G. , XU, Jian
IPC: C12N9/12
Abstract: The present invention provides machine readable media embedded with the three-dimensional molecular structure coordinates of MST3KD and subsets thereof, including binding pockets, methods of using the structure to identify and design affecters, including inhibitors and activator, mutants of MST3KD, and compounds and compositions that affect MST3KD activity.
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