公开(公告)号：WO2006127636A2

公开(公告)日：2006-11-30

申请号：PCT/US2006/019798

申请日：2006-05-22

Applicant: SUTURA, INC. ,  NOBLES, Anthony, A. ,  LEE, Raymond, S. ,  DECKER, Steven, E. ,  BROSCH, Benjamin, G.

Inventor： NOBLES, Anthony, A. ,  LEE, Raymond, S. ,  DECKER, Steven, E. ,  BROSCH, Benjamin, G.

IPC: A61B17/04 ,  A61B17/06

CPC classification number: A61B17/0483 ,  A61B17/0469 ,  A61B17/0482 ,  A61B17/06061 ,  A61B17/3421

Abstract: A knot-tying assist device (100, 200, 300, 320, 330, 340, 350, 370, 400) allows a physician to remotely tie and cinch a knot in two ends (20, 22) of a suture (14) extending from an incision (10) in a vessel or organ of a patient in order to seal an opening in the vessel or organ. The knot-tying assist device (100, 200, 300, 320, 330, 340, 350, 370, 400) includes a first receiving portion (106, 218, 306, 418) and a second receiving portion (108, 220, 308, 420) spaced apart along the device for receiving and holding the two ends (20, 22) of the suture (14). The receiving portions may hold the suture ends (20, 22) loosely, or alternatively may hold the suture ends (20, 22) under tension to facilitate tying the knot. The knot-tying device (100, 200, 300, 320, 330, 340, 350, 370, 400) further includes an engagement portion (120, 122, 204, 302, 402) to stabilize the knot-tying assist device relative to the treatment location. The engagement portion (120, 122, 204, 302, 402) may assist in maintaining tension on the two suture ends (20, 22) so that the suture can hold the incision 10 closed prior to the knot being tied and cinched.

Abstract translation: 打结辅助装置（100,200,3300,320,330,340,350,370,400）允许医生远程地将结在一个缝合线（14）的两端（20,22）上结扎并延伸 从患者的血管或器官中的切口（10）开始，以密封血管或器官中的开口。 结束辅助装置（100,200,300,320,330,340,350,370,400）包括第一接收部分（106,218,306,418）和第二接收部分（108,220,308） ，420），其沿着所述装置间隔开以接收和保持所述缝合线（14）的两个端部（20,22）。 接收部分可以松动地保持缝合线端部（20,22），或者可选地将缝合线端部（20,22）保持在张力下以便于结扎结。 打结装置（100,200,320,320,330,340,350,370,400）还包括一个接合部分（120,122,204,302,402），用于使打结辅助装置相对于 治疗位置。 接合部分（120,122,204,302,402）可以有助于维持两个缝合线端部（20,22）上的张力，使得缝合线可以在打结和收紧之前保持切口10闭合。

公开(公告)号：WO2006037039A3

公开(公告)日：2006-04-06

申请号：PCT/US2005/034801

申请日：2005-09-27

Applicant: SUTURA, INC. ,  NOBLES, Anthony, A. ,  DECKER, Steven, E. ,  TRAN, Hung ,  BROSCH, Benjamin, G.

Inventor： NOBLES, Anthony, A. ,  DECKER, Steven, E. ,  TRAN, Hung ,  BROSCH, Benjamin, G.

IPC: A61B17/00 ,  A61B17/04

Abstract: Methods and apparatus are provided for closing incisions within biological tissue. In one embodiment, a device and method are provided for suturing biological tissue, such as, for example, an organ or blood vessel. The suturing apparatus is particularly well suited for suturing an incision made in an artery, such as the femoral artery, following a catheterization procedure. The device eliminates the need to apply pressure to a patient's thigh for an extended period of time, and eliminates many of the complications and costs associated with the creation of a thrombus patch. In addition, the device comprises an improved handle portion which enables the physician to quickly and easily apply suture. The handle portion is very reliable and easy to manipulate. The suturing may be used in combination with existing catheter sheath introducers.

公开(公告)号：WO2007092323A1

公开(公告)日：2007-08-16

申请号：PCT/US2007/002920

申请日：2007-02-06

Applicant: SUTURA, INC. ,  NOBLES, Anthony A. ,  BROSCH, Benjamin G. ,  DECKER, Steven E. ,  HELDMAN, Alan R.

Inventor： NOBLES, Anthony A. ,  BROSCH, Benjamin G. ,  DECKER, Steven E. ,  HELDMAN, Alan R.

IPC: A61B17/04 ,  A61M25/09

CPC classification number: A61B17/0057 ,  A61B17/0482 ,  A61B2017/00637 ,  A61B2017/00663 ,  A61B2017/047 ,  A61B2017/0472 ,  A61B2017/0496 ,  A61B2017/06042 ,  A61B2017/22042 ,  A61M25/09 ,  A61M2025/09083 ,  A61M2025/09116 ,  A61M2025/09125 ,  A61M2025/09175

Abstract: A reverse tapered guidewire (10) may comprise a proximal segment (12) and a distal segment (14). The proximal segment (12) may have a cross-sectional diameter smaller than a cross-sectional diameter of the distal segment (14). The guidewire (10) may be inserted through an access site on a patient. A medical device may be advanced over the proximal segment (12) of the guidewire (10). After the medical device is withdrawn from the patient, the guidewire (10) may be used to re-access the site.

Abstract translation: 反向锥形导丝（10）可以包括近端段（12）和远端段（14）。 近端段（12）可以具有小于远端段（14）的横截面直径的横截面直径。 导丝（10）可以穿过患者的进入部位插入。 医疗装置可以在导丝（10）的近端段（12）上前进。 在从患者撤出医疗装置之后，可以使用导丝（10）来重新访问该部位。

公开(公告)号：WO2007001936A3

公开(公告)日：2007-07-26

申请号：PCT/US2006023676

申请日：2006-06-19

Applicant: SUTURA INC ,  NOBLES ANTHONY A ,  DECKER STEVEN E ,  RATERING EGBERT

Inventor： NOBLES ANTHONY A ,  DECKER STEVEN E ,  RATERING EGBERT

IPC: A61B17/04

CPC classification number: A61B17/0491 ,  A61B17/0467 ,  A61B17/0469 ,  A61B17/0485 ,  A61B17/0487 ,  A61B2017/045 ,  A61B2017/0459 ,  A61B2017/0488

Abstract: A knot placement device (100) allows a physician to apply a knot for securing two or more suture ends extending from an incision in a vessel or organ of a patient relative to each other in order to seal an opening in the vessel or organ. The knot placement (100) device has a handle (102) and an elongate shaft (104) and a push rod (118) slidably inserted in said shaft (104). A knot is disposed in the distal end of the shaft (104). An actuator (106) on the handle may be depressed to distally advance said push rod (118) relative to said shaft (104) and thereby distally advance said knot. The knot may include a knot body (124) having an inner cavity and a plug (126) sized to fit securely within the inner cavity. In use, the plug (126) may be inserted into the inner cavity of the knot body (124) to fixedly hold two or more suture ends (34) between the knot body (124) and the plug (126).

Abstract translation: 结节安置装置（100）允许医生施加结以固定从患者的血管或器官中的切口延伸的两个或更多个缝合线端部，以便密封血管或器官中的开口。 结布置（100）装置具有手柄（102）和细长轴（104）以及可滑动地插入所述轴（104）中的推杆（118）。 结（shaft）设置在轴（104）的远端中。 手柄上的致动器（106）可以被压下以相对于所述轴（104）向远侧推进所述推杆（118），并且由此向远侧推进所述结。 该结可以包括具有内腔和塞子（126）的结主体（124），塞子的尺寸被确定为牢固地配合在内腔内。 在使用中，插塞（126）可以插入结主体（124）的内腔中以将两个或更多个缝合线端部（34）固定地保持在结主体（124）和插塞（126）之间。

公开(公告)号：WO2006037039A2

公开(公告)日：2006-04-06

申请号：PCT/US2005034801

申请日：2005-09-27

Applicant: SUTURA INC ,  NOBLES ANTHONY A ,  DECKER STEVEN E ,  TRAN HUNG ,  BROSCH BENJAMIN G

Inventor： NOBLES ANTHONY A ,  DECKER STEVEN E ,  TRAN HUNG ,  BROSCH BENJAMIN G

IPC: A61B17/00 ,  A61B17/04

CPC classification number: A61B17/0057 ,  A61B17/0469 ,  A61B17/0482 ,  A61B17/0625 ,  A61B2017/00367 ,  A61B2017/00637 ,  A61B2017/00663 ,  A61B2017/00672 ,  A61B2017/0472 ,  A61B2017/2911 ,  A61B2017/2912

Abstract: Methods and apparatus are provided for closing incisions within biological tissue. In one embodiment, a device and method are provided for suturing biological tissue, such as, for example, an organ or blood vessel. The suturing apparatus is particularly well suited for suturing an incision made in an artery, such as the femoral artery, following a catheterization procedure. The device eliminates the need to apply pressure to a patient's thigh for an extended period of time, and eliminates many of the complications and costs associated with the creation of a thrombus patch. In addition, the device comprises an improved handle portion which enables the physician to quickly and easily apply suture. The handle portion is very reliable and easy to manipulate. The suturing may be used in combination with existing catheter sheath introducers.

Abstract translation: 提供了用于闭合生物组织内的切口的方法和装置。 在一个实施例中，提供了用于缝合生物组织的装置和方法，例如器官或血管。 缝合装置特别适用于在导管插入术后缝合在动脉（例如股动脉）上制成的切口。 该装置不需要长时间地向患者的大腿施加压力，并且消除了与创建血栓贴片相关的许多并发症和成本。 此外，该装置包括改进的手柄部分，其使医师能够快速且容易地应用缝线。 手柄部分非常可靠，易于操作。 缝合可以与现有的导管鞘引入器结合使用。

公开(公告)号：WO2008121738A2

公开(公告)日：2008-10-09

申请号：PCT/US2008/058519

申请日：2008-03-27

Applicant: SUTURA, INC. ,  NOBLES, Anthony, A. ,  BROSCH, Benjamin, G. ,  DECKER, Steven, E. ,  MULLEN, Michael, J.

Inventor： NOBLES, Anthony, A. ,  BROSCH, Benjamin, G. ,  DECKER, Steven, E. ,  MULLEN, Michael, J.

IPC: A61B17/04

CPC classification number: A61B17/0057 ,  A61B17/0469 ,  A61B17/0482 ,  A61B2017/00243 ,  A61B2017/00575 ,  A61B2017/00623 ,  A61B2017/047 ,  A61B2017/0472

Abstract: Methods and apparatuses are disclosed for closing a patent foramen ovale 8. Some of the disclosed apparatuses include an elongate body (20, 1020, 1020') having a proximal end and a distal end, with first and second suture clasp arms (31, 1031, 1031') adapted to hold end portions (52) of a suture (50) when in an extended position. A first suture catch mechanism (161, 161') is slidably housed in the elongate body and moves in a proximal-to-distal direction to engage the suture end held by the first suture clasp arm. and a second suture catch mechanism (165, 165') is slidably housed in the elongate body and moves in a distal-to-proximal direction to suture end held by the second suture clasp arm. The first suture clasp arm can be positioned around the septum primum (7) to deliver a suture thereto, and the second suture clasp arm can be positioned around the septum secundum (6) to deliver a suture thereto.

Abstract translation: 公开了用于闭合卵孔的专利的方法和装置8.所公开的装置中的一些包括具有近端和远端的细长体（20,1020,1020'），其具有第一和第二缝合线夹臂（31,1031 ，1031'），其适于在伸展位置时保持缝合线（50）的端部（52）。 第一缝合线捕获机构161,161'可滑动地容纳在细长体中并且在近端至远端方向上移动以接合由第一缝合线夹臂支撑的缝线端。 并且第二缝合线捕获机构（165,165'）可滑动地容纳在细长主体中，并且在远离近侧的方向上移动到由第二缝合线夹臂支撑的缝线端。 第一缝合线夹臂可以位于隔膜周围（7）周围以将缝合线递送到其上，并且第二缝合线夹臂可以位于隔膜隔膜（6）周围以将缝合线递送到其上。

公开(公告)号：WO0215795A3

公开(公告)日：2002-06-06

申请号：PCT/US0126724

申请日：2001-08-27

Applicant: SUTURA INC ,  NOBLES ANTHONY A ,  DECKER STEVEN E ,  PETERSON ROD

Inventor： NOBLES ANTHONY A ,  DECKER STEVEN E ,  PETERSON ROD

IPC: A61B17/04 ,  A61B17/06

CPC classification number: A61B17/0469 ,  A61B17/0467 ,  A61B2017/0474 ,  A61B2017/0477 ,  A61B2017/0496 ,  A61B2017/0619

Abstract: Suture cutter embodiments (100) include elements for cutting back the leads of a suture (140) after the suture has been tied into a knot (144), e.g., as a result of drawing tissue portions together. The suture cutter (100) may include mechanisms which can be used to push and position a knot (144), so that a single device may be used to both push a knot and trim the excess material therefrom.

Abstract translation: 缝合线切割器实施例（100）包括用于在缝合线已经被结扎到结（144）中之后用于切割缝合线（140）的引线的元件，例如由于将组织部分拉在一起。 缝合线切割器（100）可以包括可以用于推动和定位结（144）的机构，使得可以使用单个装置来同时推动结和修剪多余的材料。

公开(公告)号：WO2009137766A1

公开(公告)日：2009-11-12

申请号：PCT/US2009/043293

申请日：2009-05-08

Applicant: SUTURA, INC. ,  CREW, John, R. ,  BROSCH, Benjamin, G. ,  NOBLES, Anthony, A.

Inventor： CREW, John, R. ,  BROSCH, Benjamin, G. ,  NOBLES, Anthony, A.

IPC: A61B17/04

CPC classification number: A61B17/0469 ,  A61B17/04 ,  A61B17/0482 ,  A61B2017/047 ,  A61B2017/0472 ,  A61B2017/0488 ,  A61B2017/06042 ,  A61B2017/06057

Abstract: A device (100) for suturing an anatomic valve can comprise an elongate body (142), a suture catch mechanism (106), and a suture clasp arm (104). The suture catch mechanism (106) can be operatively coupled to the elongate body (142) for movement between a retracted position and an advanced position. The suture clasp arm (104) can be attached to the elongate body (142) for movement between a retracted position and an extended position. The suture clasp arm (104) can comprise a suture clasp (126) configured to releasably retain a suture portion (130). In some embodiments, the suture clasp (126) is positioned on the suture clasp arm (104) such that the suture catch mechanism (106) retrieves the suture portion (130) from the suture clasp arm (104) while the arm (104) is at least partially retracted. In some embodiments, the suture clasp arm (104) can be closed about a tissue portion without damaging the tissue portion.

Abstract translation: 用于缝合解剖瓣膜的装置（100）可以包括细长主体（142），缝合线捕获机构（106）和缝合线钩臂（104）。 缝合线捕获机构（106）可以可操作地联接到细长主体（142），以在缩回位置和前进位置之间移动。 缝线夹臂（104）可以附接到细长主体（142），以在缩回位置和延伸位置之间移动。 缝线夹臂（104）可以包括构造成可释放地保持缝线部分（130）的缝合线扣（126）。 在一些实施例中，缝线夹（126）定位在缝合线钩臂（104）上，使得缝合线捕获机构（106）从缝合线钩臂（104）检索缝合线部分（130），同时臂（104） 至少部分缩回。 在一些实施例中，缝合线夹臂（104）可围绕组织部分封闭，而不损坏组织部分。

公开(公告)号：WO2006127636A3

公开(公告)日：2007-03-15

申请号：PCT/US2006019798

申请日：2006-05-22

Applicant: SUTURA INC ,  NOBLES ANTHONY A ,  LEE RAYMOND S ,  DECKER STEVEN E ,  BROSCH BENJAMIN G

Inventor： NOBLES ANTHONY A ,  LEE RAYMOND S ,  DECKER STEVEN E ,  BROSCH BENJAMIN G

IPC: A61B17/04 ,  A61B17/06

CPC classification number: A61B17/0483 ,  A61B17/0469 ,  A61B17/0482 ,  A61B17/06061 ,  A61B17/3421

Abstract: A knot-tying assist device (100, 200, 300, 320, 330, 340, 350, 370, 400) allows a physician to remotely tie and cinch a knot in two ends (20, 22) of a suture (14) extending from an incision (10) in a vessel or organ of a patient in order to seal an opening in the vessel or organ. The knot-tying assist device (100, 200, 300, 320, 330, 340, 350, 370, 400) includes a first receiving portion (106, 218, 306, 418) and a second receiving portion (108, 220, 308, 420) spaced apart along the device for receiving and holding the two ends (20, 22) of the suture (14). The receiving portions may hold the suture ends (20, 22) loosely, or alternatively may hold the suture ends (20, 22) under tension to facilitate tying the knot. The knot-tying device (100, 200, 300, 320, 330, 340, 350, 370, 400) further includes an engagement portion (120, 122, 204, 302, 402) to stabilize the knot-tying assist device relative to the treatment location. The engagement portion (120, 122, 204, 302, 402) may assist in maintaining tension on the two suture ends (20, 22) so that the suture can hold the incision 10 closed prior to the knot being tied and cinched.

Abstract translation: 打结辅助装置（100,200,3300,320,330,340,350,370,400）允许医师远程地将结在一个缝合线（20,22）上绑扎并结合在缝合线（14）的两端延伸 从患者的血管或器官中的切口（10）开始，以密封血管或器官中的开口。 打结辅助装置（100,200,320,320,330,340,350,370,400）包括第一接收部分（106,218,306,418）和第二接收部分（108,220,308） ，420），沿着所述装置间隔开以接收和保持所述缝线（14）的两个端部（20,22）。 接收部分可以松动地保持缝合线端部（20,22），或者可以将缝合线端部（20,22）保持在张力下以便于结扎结。 打结装置（100,200,320,320,330,340,350,370,400）还包括一个接合部分（120,122,204,302,402），用于相对于 治疗位置。 接合部分（120,122,204,302,402）可以有助于维持两个缝合线端部（20,22）上的张力，使得缝合线可以在结被束缚和收紧之前保持切口10闭合。

公开(公告)号：WO2007001936A2

公开(公告)日：2007-01-04

申请号：PCT/US2006/023676

申请日：2006-06-19

Applicant: SUTURA, INC. ,  NOBLES, Anthony, A. ,  DECKER, Steven, E. ,  RATERING, Egbert

Inventor： NOBLES, Anthony, A. ,  DECKER, Steven, E. ,  RATERING, Egbert

IPC: A61B17/04

CPC classification number: A61B17/0491 ,  A61B17/0467 ,  A61B17/0469 ,  A61B17/0485 ,  A61B17/0487 ,  A61B2017/045 ,  A61B2017/0459 ,  A61B2017/0488

Abstract: A knot placement device (100) allows a physician to apply a knot for securing two or more suture ends extending from an incision in a vessel or organ of a patient relative to each other in order to seal an opening in the vessel or organ. The knot placement (100) device has a handle (102) and an elongate shaft (104) and a push rod (118) slidably inserted in said shaft (104). A knot is disposed in the distal end of the shaft (104). An actuator (106) on the handle may be depressed to distally advance said push rod (118) relative to said shaft (104) and thereby distally advance said knot. The knot may include a knot body (124) having an inner cavity and a plug (126) sized to fit securely within the inner cavity. In use, the plug (126) may be inserted into the inner cavity of the knot body (124) to fixedly hold two or more suture ends (34) between the knot body (124) and the plug (126).

Abstract translation: 打结放置装置（100）允许医师施加结以固定两个或更多个缝合端，所述两个或多个缝合端从病人的容器或器官相对于彼此延伸以密封容器或器官中的开口。 结装置（100）装置具有手柄（102）和细长轴（104）和可滑动地插入所述轴（104）中的推杆（118）。 一个结设置在轴（104）的远端。 手柄上的致动器（106）可以被压下以相对于所述轴（104）向远侧推进所述推杆（118），从而远端推进所述结。 结可以包括具有内腔的结体（124）和尺寸适于紧密配合在内腔内的插头（126）。 在使用中，插头（126）可以插入结体（124）的内腔中，以固定地保持在结体（124）和插塞（126）之间的两个或更多个缝合线端部（34）。