Abstract:
A coupler-resonator for electron paramagnetic resonance (EPR) spectroscopy in subjects has a wire loop formed into a coupling loop, a central transmission portion, and sensor loops. The sensor loops hold EPR sensor materials and are coated with biocompatible plastic. The coupler-resonator is implanted in a subject, the subject in a nonuniform magnetic field with a pickup coil for RF response measurement apparatus near the subject's skin and inductively coupled to the coupling loop. Resonances are measured at multiple sensor loops distinguished by sweeping magnetic field or radio frequency. A biopsy sampler has an outer needle with sensor loop and a central sampling needle with cavity for biopsy samples and EPR sensor material. A device for EPR of fingernails has sensor loops in a partial glove for holding loops next to fingertips. A device for EPR of teeth has sensor loops in plastic chips that can be held between the teeth.
Abstract:
A coupler-resonator for electron paramagnetic resonance (EPR) spectroscopy in subjects has a wire loop formed into a coupling loop, a central transmission portion, and sensor loops. The sensor loops hold EPR sensor materials and are coated with biocompatible plastic. The coupler-resonator is implanted in a subject, the subject in a nonuniform magnetic field with a pickup coil for RF response measurement apparatus near the subject's skin and inductively coupled to the coupling loop. Resonances are measured at multiple sensor loops distinguished by sweeping magnetic field or radio frequency. A biopsy sampler has an outer needle with sensor loop and a central sampling needle with cavity for biopsy samples and EPR sensor material. A device for EPR of fingernails has sensor loops in a partial glove for holding loops next to fingertips. A device for EPR of teeth has sensor loops in plastic chips that can be held between the teeth.
Abstract:
An apparatus and method for triaging patients according to radiation exposure operates by measuring electron paramagnetic resonance spectra of fingernails, toenails, and/or teeth. When operating in vivo, radiation induced spectra are obtained from intact fingernails, toenails, or teeth placed within a magnet and with pickup coils located over nails between the cut edge at the end of the fingernail and skin proximal to the nail or placed adjacent to at least one tooth. When operating in vitro with fingernail clippings, one or more spectra are obtained. In an embodiment, at least three spectra are obtained with at least one after a delay at above twenty degrees Celsius, and at least one at power levels different from the others. The three spectra are used to determine and remove a mechanically induced signal from EPR spectra to determine radiation-induced spectra. The radiation induced spectra are used to determine a radiation dose, the dose is compared to triage limits, and a radiological triage tag is printed for the patients.
Abstract:
The present invention relates to the enhancement of radiation sensitivity by photodynamic therapy. More specifically, the invention relates to a method for treating a tumor by administering a photosensitizer to a subject, optically irradiating the tumor between about two and six hours after administration of the photosensitizer, and administering radiation therapy to the subject concurrently with or immediately after optical irradiation. Using this method, the tumor cells are killed, thereby treating the tumor.
Abstract:
A coupler-resonator for electron paramagnetic resonance (EPR) spectroscopy in subjects has a wire loop formed into a coupling loop, a central transmission portion, and sensor loops. The sensor loops hold EPR sensor materials and are coated with biocompatible plastic. The coupler-resonator is implanted in a subject, the subject in a nonuniform magnetic field with a pickup coil for RF response measurement apparatus near the subject's skin and inductively coupled to the coupling loop. Resonances are measured at multiple sensor loops distinguished by sweeping magnetic field or radio frequency. A biopsy sampler has an outer needle with sensor loop and a central sampling needle with cavity for biopsy samples and EPR sensor material. A device for EPR of fingernails has sensor loops in a partial glove for holding loops next to fingertips. A device for EPR of teeth has sensor loops in plastic chips that can be held between the teeth.
Abstract:
An apparatus and method for triaging patients according to radiation exposure operates by measuring electron paramagnetic resonance spectra of fingernails, toenails, and/or teeth. When operating in vivo, radiation induced spectra are obtained from intact fingernails, toenails, or teeth placed within a magnet and with pickup coils located over nails between the cut edge at the end of the fingernail and skin proximal to the nail or placed adjacent to at least one tooth. When operating in vitro with fingernail clippings, one or more spectra are obtained. In an embodiment, at least three spectra are obtained with at least one after a delay at above twenty degrees Celsius, and at least one at power levels different from the others. The three spectra are used to determine and remove a mechanically induced signal from EPR spectra to determine radiation-induced spectra. The radiation induced spectra are used to determine a radiation dose, the dose is compared to triage limits, and a radiological triage tag is printed for the patients.