公开(公告)号：WO2016182446A1

公开(公告)日：2016-11-17

申请号：PCT/NL2016/050345

申请日：2016-05-13

Applicant: UMC UTRECHT HOLDING B.V.

Inventor： BOUWMAN, Johannes Gijsbertus ,  SEEVINCK, Peter Roland

IPC: G01R33/28 ,  G01R33/56

CPC classification number: G01R33/286 ,  G01R33/5608

Abstract: A method of object detection in MRI comprises determining a filter representing an effect of an object in a frequency domain with respect to phase of a plurality of sampled data points of an MRI dataset (401) based on at least one phase saddle in a combined phase gradient field that is a combination of a phase gradient field caused by the object based on a shape and material of the object and a phase gradient field caused by an image sequence used to generate the MRI dataset. The filter is applied to a phase component of the sampled data points in the frequency domain. The effect of the object can comprise a change of the phase caused by the object.

Abstract translation: MRI中的物体检测方法包括基于组合阶段中的至少一个相位坐标来确定表示相对于MRI数据集（401）的多个采样数据点的相位的频域中的对象的影响的滤波器 梯度场，其是由基于物体的形状和材料的对象引起的相位梯度场的组合以及由用于生成MRI数据集的图像序列引起的相位梯度场。 滤波器被应用于频域中的采样数据点的相位分量。 对象的效果可以包括由对象引起的相位的改变。

公开(公告)号：WO2014142772A9

公开(公告)日：2015-02-12

申请号：PCT/TR2014000083

申请日：2014-03-14

Applicant: DEMIR HILMI VOLKAN

Inventor： DEMIR HILMI VOLKAN ,  UNAL EMRE ,  GOKYAR SAYIM

IPC: G01R33/28 ,  G01R33/34 ,  G01R33/36

CPC classification number: G01R33/34053 ,  G01R33/286 ,  G01R33/287 ,  G01R33/34007 ,  G01R33/34084 ,  G01R33/3628

Abstract: Embodiments of the present invention address the problems with previously known MRI enhancement resonators. The embodiments provide capacitances that are sufficiently large to result in resonance frequencies that are sufficiently low for medical MRI applications in devices that are sufficiently small for implantation into the body. Further, the capacitance and resonance frequency of the MRI enhancement resonator may be easily adjusted to particular desired values by selecting corresponding thin-film dielectrics, or thicknesses of such thin-film dielectrics. Moreover, the design and geometry of the embodiments provide MRI enhancement resonators with high Q-factors. The construction and material of such MRI enhancement resonators also yield flexible and biocompatible devices that are appropriate for applications involving implantation into the body.

Abstract translation: 本发明的实施例解决了先前已知的MRI增强谐振器的问题。 这些实施例提供足够大的电容，以产生对于植入体内足够小的装置中的医疗MRI应用来说足够低的共振频率。 此外，通过选择相应的薄膜电介质或这种薄膜电介质的厚度，可以容易地将MRI增强谐振器的电容和谐振频率调整到特定的期望值。 此外，实施例的设计和几何形状提供具有高Q因子的MRI增强谐振器。 这种MRI增强谐振器的结构和材料也产生适于涉及植入人体内的应用的柔性和生物相容性装置。

公开(公告)号：WO2012143021A1

公开(公告)日：2012-10-26

申请号：PCT/EP2011/002054

申请日：2011-04-21

Applicant: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E. V. ,  MERBOLDT, Klaus-Dietmar ,  FRAHM, Jens ,  UECKER, Martin ,  VOIT, Dirk

Inventor： MERBOLDT, Klaus-Dietmar ,  FRAHM, Jens ,  UECKER, Martin ,  VOIT, Dirk

IPC: G01R33/48

CPC classification number: G01R33/48 ,  G01R33/286 ,  G01R33/4826 ,  G01R33/5613 ,  G01R33/56316 ,  G01R33/56325

Abstract: A method of collecting magnetic resonance data for imaging an object with a predetermined spin density being arranged in a static magnetic field, comprises the steps subjecting said object to at least one radiofrequency pulse and magnetic field gradients for creating spatially encoded magnetic resonance signals, including at least two settings of spatially encoding phase-contrast gradients differently encoding the phase of said magnetic resonance signals in at least one field of view in a predetermined spatial dimension, acquiring at least two magnetic resonance signals, each with one of said at least two settings of different spatially encoding phase-contrast gradients, and determining at least one mean spin density position of said object along said spatial dimension by calculating the phase difference between said signals. Furthermore, a control device and a magnetic resonance imaging (MRI) device implementing the method are described.

Abstract translation: 收集用于对静电磁场中预定的自旋密度进行成像的磁共振数据的方法包括以下步骤：对所述物体进行至少一个射频脉冲和磁场梯度，以产生空间编码的磁共振信号，包括在 空间编码相位对比度梯度的至少两个设置在预定的空间维度中以至少一个视野不同地编码所述磁共振信号的相位，获取至少两个磁共振信号，每个磁共振信号具有所述至少两个设置中的一个 不同的空间编码相位对比度梯度，以及通过计算所述信号之间的相位差来确定所述物体沿着所述空间维度的至少一个平均自旋密度位置。 此外，描述了实现该方法的控制装置和磁共振成像（MRI）装置。

公开(公告)号：WO2011089551A3

公开(公告)日：2011-11-10

申请号：PCT/IB2011050230

申请日：2011-01-19

Applicant: KONINKL PHILIPS ELECTRONICS NV ,  PHILIPS INTELLECTUAL PROPERTY ,  SENEGAS JULIEN ,  PERKINS THOMAS

Inventor： SENEGAS JULIEN ,  PERKINS THOMAS

IPC: G01R33/565

CPC classification number: G01R33/56536 ,  G01R33/286 ,  G01R33/5601 ,  G01R33/5615

Abstract: The invention relates to a method of determining a susceptibility gradient map, the method comprising acquiring (300) a magnetic resonance k- space dataset, said dataset comprising magnetic resonance echo data, wherein a recursive iteration is used to determine the susceptibility gradient map. Further, the invention relates to a method of determining a susceptibility gradient map, the method comprising acquiring a magnetic resonance k-space dataset, said dataset comprising magnetic resonance echo data, wherein the acquired dataset comprises magnetic resonance echo data of multiple echoes with different echo times, wherein a susceptibility gradient map is determined separately for each echo time resulting in a temporary susceptibility gradient map, wherein the method further comprises calculating a total susceptibility gradient map by combining all determined temporary susceptibility gradient maps.

Abstract translation: 本发明涉及一种确定磁敏度梯度图的方法，所述方法包括获取（300）磁共振k空间数据集，所述数据集包括磁共振回波数据，其中使用递归迭代来确定磁敏度梯度图。 此外，本发明涉及一种确定磁敏度梯度图的方法，所述方法包括获取磁共振k空间数据集，所述数据集包括磁共振回波数据，其中所获取的数据集包括具有不同回波的多个回波的磁共振回波数据 时间，其中针对导致临时磁敏度梯度图的每个回波时间分别确定敏感度梯度图，其中所述方法还包括通过组合所有确定的临时磁敏度梯度图来计算总磁敏度梯度图。

公开(公告)号：WO2010148088A3

公开(公告)日：2011-03-31

申请号：PCT/US2010038824

申请日：2010-06-16

Applicant: SURGIVISION INC ,  JENKINS KIMBLE L ,  PIFERI PETER ,  VIJ KAMAL ,  GHIDOLI DANIELE ,  FLORES JESSE

Inventor： JENKINS KIMBLE L ,  PIFERI PETER ,  VIJ KAMAL ,  GHIDOLI DANIELE ,  FLORES JESSE

IPC: A61B5/055 ,  G06T15/10

CPC classification number: A61B5/062 ,  A61B5/0044 ,  A61B5/042 ,  A61B5/0422 ,  A61B5/053 ,  A61B5/055 ,  A61B5/065 ,  A61B5/415 ,  A61B5/418 ,  A61B18/02 ,  A61B18/18 ,  A61B34/10 ,  A61B34/20 ,  A61B2090/365 ,  A61B2090/374 ,  A61B2090/3954 ,  A61M5/00 ,  A61M25/01 ,  A61M25/0127 ,  A61M29/00 ,  A61M2025/0089 ,  A61M2025/0166 ,  A61M2025/0681 ,  A61M2025/09175 ,  G01R33/286 ,  G01R33/287

Abstract: An MRI-compatible catheter includes an elongated flexible shaft having opposite distal and proximal end portions. A handle is attached to the proximal end portion and includes an actuator in communication with the shaft distal end portion that is configured to articulate the shaft distal end portion. The distal end portion of the shaft may include an ablation tip and includes at least one RF tracking coil positioned adjacent the ablation tip that is electrically connected to an MRI scanner. The at least one RF tracking coil is electrically connected to a circuit that reduces coupling when the at least one RF tracking coil is exposed to an MRI environment. Each RF tracking coil is a 1-10 turn solenoid coil, and has a length along the longitudinal direction of the catheter of between about 0.25 mm and about 4 mm.

Abstract translation: MRI兼容导管包括具有相对的远端和近端部分的细长柔性轴。 手柄附接到基端部，并且包括与轴远端部连通的致动器，该致动器构造成铰接轴远端部。 轴的远端部分可以包括消融尖端，并且包括邻近消融尖端定位的至少一个RF跟踪线圈，其被电连接到MRI扫描器。 当至少一个RF跟踪线圈暴露于MRI环境时，至少一个RF跟踪线圈电连接到减少耦合的电路。 每个RF跟踪线圈是1-10圈电磁线圈，并且沿着导管的纵向方向具有在约0.25mm和约4mm之间的长度。

公开(公告)号：WO2010053609A9

公开(公告)日：2010-08-26

申请号：PCT/US2009052261

申请日：2009-07-30

Applicant: DARTMOUTH COLLEGE ,  SWARTZ HAROLD M ,  LESNIEWSKI PIOTR ,  LI HONG BIN

Inventor： SWARTZ HAROLD M ,  LESNIEWSKI PIOTR ,  LI HONG BIN

IPC: A61B5/05 ,  A61B5/055 ,  G05F1/00

CPC classification number: G01R33/341 ,  G01R33/286 ,  G01R33/287 ,  G01R33/34084 ,  G01R33/3415 ,  G01R33/58 ,  G01R33/60

Abstract: A coupler-resonator for electron paramagnetic resonance (EPR) spectroscopy in subjects has a wire loop formed into a coupling loop, a central transmission portion, and sensor loops. The sensor loops hold EPR sensor materials and are coated with biocompatible plastic. The coupler-resonator is implanted in a subject, the subject in a nonuniform magnetic field with a pickup coil for RF response measurement apparatus near the subject's skin and inductively coupled to the coupling loop. Resonances are measured at multiple sensor loops distinguished by sweeping magnetic field or radio frequency. A biopsy sampler has an outer needle with sensor loop and a central sampling needle with cavity for biopsy samples and EPR sensor material. A device for EPR of fingernails has sensor loops in a partial glove for holding loops next to fingertips. A device for EPR of teeth has sensor loops in plastic chips that can be held between the teeth.

Abstract translation: 用于受试者中电子顺磁共振（EPR）光谱学的耦合器 - 谐振器具有形成耦合环路，中心传输部分和传感器环路的导线环路。 传感器环路保持EPR传感器材料并涂有生物相容性塑料。 耦合谐振器植入受试者体内，受试者处于非均匀磁场中，在受试者皮肤附近具有用于RF响应测量装置的拾取线圈并且与耦合回路感应耦合。 谐振是在多个传感器回路测量的，通过扫描磁场或射频来区分。 活检采样器具有带传感器环的外针和带有用于活检样本和EPR传感器材料的腔的中央采样针。 用于手指甲的EPR的装置在部分手套中具有传感器环，用于将指尖附近的环扣住。 用于牙齿EPR的装置具有塑料片中的传感器环，其可以保持在牙齿之间。

公开(公告)号：WO2008106201A1

公开(公告)日：2008-09-04

申请号：PCT/US2008/002655

申请日：2008-02-28

Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION ,  KURPAD, Krishna, N. ,  UNAL, Orhan

Inventor： KURPAD, Krishna, N. ,  UNAL, Orhan

IPC: A61B5/055 ,  A61B5/06 ,  A61B19/00 ,  G01R33/28 ,  G01R33/36

CPC classification number: G01R33/34053 ,  A61B5/06 ,  A61B34/20 ,  A61B90/36 ,  A61B2034/2051 ,  A61B2090/374 ,  A61B2090/3954 ,  G01R33/286 ,  G01R33/287 ,  G01R33/34084 ,  G01R33/3657 ,  G01R33/3685

Abstract: A system and method of tracking a medical device and generating an image of a target area. The medical device includes a tracking device to create an imaging field-of-view that extends beyond the tip of the medical device while allowing the tip of the medical device to be visualized. The medical device further includes an imaging/visualization device to create an imaging field from the point of view of the medical device. A voltage standing wave suppression device is formed on the exterior surface of the medical device to prevent the formation of voltage standing waves and localized tissue heating. The voltage standing wave suppression device includes two cable traps spaced apart from one another with each cable trap being formed of a closely packed coiled region of a conductor extending the length of the medical device.

Abstract translation: 一种跟踪医疗装置并产生目标区域的图像的系统和方法。 该医疗装置包括跟踪装置，用于产生延伸超过医疗装置的尖端的成像视场，同时允许医疗装置的尖端可视化。 医疗装置还包括成像/可视化装置，用于从医疗装置的角度创建成像场。 在医疗装置的外表面上形成电压驻波抑制装置，以防止电压驻波和局部组织加热的形成。 电压驻波抑制装置包括彼此间隔开的两个电缆陷阱，每个电缆陷阱由延伸医疗装置的长度的导体的密集卷绕区域形成。

公开(公告)号：WO2008094855A1

公开(公告)日：2008-08-07

申请号：PCT/US2008/052178

申请日：2008-01-28

Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION ,  UNAL, Orhan ,  KURPAD, Krishna, N. ,  BRACE, Christopher, L.

Inventor： UNAL, Orhan ,  KURPAD, Krishna, N. ,  BRACE, Christopher, L.

IPC: G01R33/28 ,  A61B5/055 ,  A61B18/14

CPC classification number: G01R33/286 ,  A61B5/055 ,  A61B5/064 ,  A61B18/1492 ,  A61B34/20 ,  A61B34/25 ,  A61B2034/2051 ,  A61B2090/374 ,  G01R33/287 ,  G01R33/34084

Abstract: A multi-mode medical device system (500) and method of using same to perform an interventional procedure. The multi-mode medical device system includes a medical device (502) and an electrical circuit (504) coupled to the medical device (502). The electrical circuit includes an integrated- tracking device (506) (e.g., a solenoid) and an imaging/visualizing device (508) (e.g., a resonant loop). The multi-mode medical device system also includes a thermal ablation device (510) coupled to the medical device (502) and to the tracking device (506).

Abstract translation: 一种多模式医疗装置系统（500）及其使用方法，进行介入手术。 多模式医疗设备系统包括耦合到医疗设备（502）的医疗设备（502）和电路（504）。 电路包括集成跟踪装置（506）（例如，螺线管）和成像/可视化装置（508）（例如，谐振回路）。 多模式医疗装置系统还包括耦合到医疗装置（502）和跟踪装置（506）的热消融装置（510）。

公开(公告)号：WO2008035759A1

公开(公告)日：2008-03-27

申请号：PCT/JP2007/068367

申请日：2007-09-21

Applicant: テルモ株式会社 ,  栗田 朋香

Inventor： 栗田 朋香

IPC: C08F8/00 ,  A61B5/055 ,  A61F2/06 ,  A61L29/00 ,  A61L31/00 ,  A61M1/14 ,  A61M25/00 ,  C08F265/04

CPC classification number: A61L31/18 ,  A61B5/055 ,  A61B5/06 ,  A61L29/18 ,  A61L2400/10 ,  A61M1/10 ,  A61M1/1008 ,  A61M1/14 ,  A61M25/0127 ,  C08F265/00 ,  C08F265/04 ,  C08F293/00 ,  C08F293/005 ,  C08L51/003 ,  C08L53/00 ,  C09D151/003 ,  C09D153/00 ,  G01R33/286 ,  C08L2666/02 ,  C08L2666/04

Abstract: 　磁気共鳴画像診断および治療に用いる医療用器具を湿潤時に磁気共鳴画像下で容易に視認でき、かつ表面潤滑性を同時に発現する重合体と、それを被覆してなる医療用器具を提供する。 　磁気共鳴にて検出可能な核種の緩和時間を短縮する物質、および反応性基を有する部位と潤滑性を発現する部位とからなる共重合体を含む重合体を医療用器具に被覆することにより、優れた耐剥離製、高い潤滑性と磁気共鳴下での視認性、容易な塗布操作および高い安全性が得られる。

Abstract translation: 旨在提供一种聚合物，其使得在磁共振成像下使用在湿润状态下高度可见的磁共振成像进行诊断和治疗的医疗装置，同时显示表面润滑性， 涂覆有医疗器械的医疗器械。 通过用包含能够缩短通过磁共振检测到的核物质的松弛时间的物质和包含具有反应性基团的部分和表现出表面润滑性的另一部分的共聚物的聚合物涂覆医疗装置，可以获得高的 耐剥离性，高润滑性，在磁共振下的高可见度，易于涂布处理性和高安全性。

公开(公告)号：WO2007064739A3

公开(公告)日：2007-12-21

申请号：PCT/US2006045752

申请日：2006-11-29

Applicant: SURGIVISION INC ,  KARMARKAR PARAG V ,  JENKINS KIMBLE

Inventor： KARMARKAR PARAG V ,  JENKINS KIMBLE

IPC: A61B5/0476 ,  A61B5/055 ,  A61B19/00 ,  A61N1/18 ,  G01R33/28 ,  G01R33/341

CPC classification number: A61B90/11 ,  A61B5/0476 ,  A61B5/055 ,  A61B5/6847 ,  A61B5/6864 ,  A61B5/6865 ,  A61B5/7435 ,  A61B19/5244 ,  A61B34/10 ,  A61B34/20 ,  A61B90/14 ,  A61B2017/00039 ,  A61B2034/107 ,  A61B2034/2051 ,  A61B2090/374 ,  A61B2090/3954 ,  A61M39/08 ,  A61N1/0529 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/08 ,  A61N1/086 ,  A61N1/3718 ,  A61N1/372 ,  A61N2001/086 ,  G01R33/285 ,  G01R33/286 ,  G01R33/287 ,  G01R33/288 ,  G01R33/34084 ,  G01R33/4808

Abstract: MRI compatible localization and/or guidance systems for facilitating placement of an interventional therapy and/or device in vivo include: (a) a mount adapted for fixation to a patient; (b) a targeting cannula with a lumen configured to attach to the mount so as to be able to controllably translate in at least three dimensions; and (c) an elongate probe configured to snugly slidably advance and retract in the targeting cannula lumen, the elongate probe comprising at least one of a stimulation or recording electrode. In operation, the targeting cannula can be aligned with a first trajectory and positionally adjusted to provide a desired internal access path to a target location with a corresponding trajectory for the elongate probe. Automated systems for determining an MR scan plane associated with a trajectory and for determining mount adjustments are also described.

Abstract translation: 用于促进介入治疗和/或装置体内放置的MRI兼容的定位和/或引导系统包括：（a）适于固定于患者的安装座; （b）具有被配置为附接到所述安装件以便能够可控地平移至少三个维度的内腔的靶向插管; 以及（c）细长探针，其被配置为在所述靶向插管腔中紧密地滑动地前进和缩回，所述细长探针包括刺激或记录电极中的至少一个。 在操作中，瞄准套管可以与第一轨迹对准，并且被位置调节以便为具有针对细长探针的对应轨迹的目标位置提供期望的内部通路。 还描述了用于确定与轨迹相关联并用于确定安装调整的MR扫描平面的自动化系统。