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    SYSTEM AND METHOD FOR DELIVERY OF DNA-BINDING CHEMOTHERAPY DRUGS USING NANOPARTICLES
    6.
    发明申请
    SYSTEM AND METHOD FOR DELIVERY OF DNA-BINDING CHEMOTHERAPY DRUGS USING NANOPARTICLES 审中-公开
    使用纳米颗粒递送DNA结合化学药物的系统和方法

    公开(公告)号：WO2012061402A2

    公开(公告)日：2012-05-10

    申请号：PCT/US2011/058805

    申请日：2011-11-01

    申请人： SYRACUSE UNIVERSITY ,  MAYE, Mathew ,  DABROWIAK, James ,  ALEXANDER, Colleen

    发明人： MAYE, Mathew ,  DABROWIAK, James ,  ALEXANDER, Colleen

    IPC分类号： A61K9/16 ,  A61K31/7042 ,  A61K47/48 ,  A61K47/02 ,  A61P35/00

    CPC分类号： A61K31/7042 ,  A61K47/6923 ,  Y10T428/2982

    摘要： System and method for loading the front line anticancer drug, doxorubicin (DOX) onto DNA-capped gold nanoparticles whose duplex DNA has been designed for specific DOX intercalation. Since each AuNP contains about 108 high affinity drug sites, this design allows for a high local DOX concentration on the particle. Drug binding was confirmed by monitoring the increase in DNA melting temperature, the shift in the plasmon resonance maximum, and the increase in the NP hydrodynamic radius as a function of [DOX]/[DNA] ratio. The feasibility of the nanoparticles as a drug delivery system was demonstrated by showing that particle-bound DOX could be transferred to a target DNA.

    摘要翻译： 将前线抗癌药物多柔比星（DOX）加载到DNA封端金纳米颗粒的系统和方法，其双链DNA已被设计用于特定的DOX嵌入。 由于每个AuNP含有约108个高亲和力的药物部位，因此该设计允许颗粒上的高的局部DOX浓度。 通过监测DNA熔解温度的升高，等离子体共振最大值的移动和作为[DOX] / [DNA]比率的函数的NP流体动力学半径的增加来证实药物结合。 通过显示颗粒结合的DOX可以转移到靶DNA来证明纳米颗粒作为药物递送系统的可行性。

    COENZYME Q10 PRODUCTION USING SPORIDIOBOLUS JOHNSONII
    7.
    发明申请
    COENZYME Q10 PRODUCTION USING SPORIDIOBOLUS JOHNSONII 审中-公开
    COENZYME Q10生产使用SPORIDIOBOLUS JOHNSONII

    公开(公告)号：WO2011130380A2

    公开(公告)日：2011-10-20

    申请号：PCT/US2011/032275

    申请日：2011-04-13

    申请人： SYRACUSE UNIVERSITY ,  DOYLE, Robert ,  DIXSON, David

    发明人： DOYLE, Robert ,  DIXSON, David

    IPC分类号： C12N1/16 ,  C12P1/02 ,  C12N1/06 ,  C12N9/00

    CPC分类号： C12R1/645 ,  C12P7/66

    摘要： A new isolate of Sporidiobolus johnsonii that is capable of producing over a significant percentage of CoQ 10 upon the addition of para -hydroxy benzoic acid in stationary phase, and a method of obtaining CoQ 10 from the S. johnsonii isolate which can be scaled up to industrial levels.

    摘要翻译： 一种新的Sporidiobolus johnsonii的分离物，其能够在固定相中加入对羟基苯甲酸后能够产生超过显着百分比的CoQ10，以及从约氏梭菌分离物中获得CoQ10的方法，其可以扩大到工业水平 。

    BRANCHED AND MULTI-CHAIN NUCLEIC ACID SWITCHES FOR SENSING AND SCREENING
    9.
    发明申请
    BRANCHED AND MULTI-CHAIN NUCLEIC ACID SWITCHES FOR SENSING AND SCREENING 审中-公开
    用于感测和筛选的分支和多链式核酸开关

    公开(公告)号：WO2006076046A2

    公开(公告)日：2006-07-20

    申请号：PCT/US2005/027527

    申请日：2005-08-02

    申请人： SYRACUSE UNIVERSITY ,  BORER, Philip, N. ,  HUDSON, Bruce, S.

    发明人： BORER, Philip, N. ,  HUDSON, Bruce, S.

    CPC分类号： C12N15/115 ,  C12N2310/16 ,  C12N2310/3517 ,  C12Q1/6818 ,  C12Q1/70 ,  C12Q1/701 ,  Y02A50/52 ,  Y02A50/58 ,  C12Q2541/101 ,  C12Q2525/313 ,  C12Q2525/205 ,  C12Q2525/301 ,  C12Q2565/301

    摘要： Embodiments of the invention relate to a branched or multichain nucleic acid switch adapted to switch from a first conformation to a second conformation upon ligand binding. The switch includes a probe strand, P, which includes the ligand binding domain; a switching framework which includes a cover strand (C), and a tether that holds P and C together and a signaling apparatus. Some embodiments include a toggle strand (T) where now the tether holds P, C, T, and the signaling apparatus together. As the switch changes between the first and second conformations; the signaling apparatus reports the state of the switch. The signaling entity is typically a lumiphore and a quencher located along the switching framework. Nucleic acid switches have applications in real time assays for diverse agents including infectious agents, environmental toxins, and terrorist agents, as well as screening' methods for such agents. Further applications are found for nanoelectronics, nanofabrication and nanomachines.

    摘要翻译： 本发明的实施方案涉及一种支链或多链核酸开关，其适于在配体结合时从第一构象切换到第二构象。 该开关包括探针链，其包括配体结合结构域; 包括盖链（C）和将P和C保持在一起的系链和信号装置的切换框架。 一些实施例包括切换链（T），其中系绳将P，C，T和信令装置保持在一起。 当开关在第一和第二构象之间变化时; 信令装置报告交换机的状态。 信令实体通常是沿着交换框架定位的集线器和猝熄器。 核酸开关可用于多种试剂的实时测定，包括感染因子，环境毒素和恐怖分子，以及筛选这些药剂的方法。 发现纳米电子学，纳米制造和纳米机械的其他应用。

    EAR MUFFLER
    10.
    发明申请
    EAR MUFFLER 审中-公开

    公开(公告)号：WO1998019498A1

    公开(公告)日：1998-05-07

    申请号：PCT/US1997019526

    申请日：1997-10-28

    申请人： SYRACUSE UNIVERSITY

    发明人： SYRACUSE UNIVERSITY ,  ZWISLOCKI, Jozef, J.

    IPC分类号： H04R25/02

    CPC分类号： A61F11/12 ,  A61F11/08 ,  H04R1/1083

    摘要： An ear muffler device (10) suitable for coupling to the entrance of the ear canal of a person to reduce the level of ambient noise in the ear canal. The device includes a muffler tube (12) of appropriate dimensions sufficient to isolate the ear canal from ambient air and having an inner cross-sectional area of at least approximately 1.15cm so as to substantially reduce the acoustic impedance at the entrance of the ear canal over a wide area of audible sound frequencies. A connecting tube (18) for attachment to the ear canal is coupled to the ear muffler tube (12). Resilient sealing means (20) adapted to seal the connecting tube (18) to the ear canal are attached to the open end of the connecting tube (18). The device further includes means (24) for securing it in the ear. A sound source isolated from ambient air may be attached near the end of the muffler tube (12).

    摘要翻译： 一种适于耦合到人的耳道入口的耳塞消声器装置（10），以减少耳道中的环境噪声水平。 该装置包括消声器管（12），其具有足以将耳道与环境空气隔离并具有至少大约1.15cm 2的内横截面面积的适当尺寸，以便基本上降低入口处的声阻抗 耳道在广泛的声音频率范围内。 用于附接到耳道的连接管（18）联接到耳塞消音器管（12）。 适于将连接管（18）密封到耳道的弹性密封装置（20）附接到连接管（18）的开口端。 该装置还包括用于将其固定在耳朵中的装置（24）。 与环境空气隔离的声源可以附接在消音器管（12）的端部附近。