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    BETA-CASEINS AND GUT MICROBIOTA
    2.
    发明申请
    BETA-CASEINS AND GUT MICROBIOTA 审中-公开
    BETA-CASEINS和肠道微生物

    公开(公告)号：WO2018063008A1

    公开(公告)日：2018-04-05

    申请号：PCT/NZ2016/050161

    申请日：2016-09-30

    Applicant: THE A2 MILK COMPANY LIMITED

    Inventor： CLARKE, Andrew John ,  BABIDGE, Catherine Mary ,  NI, Jiayi

    IPC: A61K35/20 ,  A61K38/17 ,  A61P1/00 ,  A23J1/20

    Abstract: Improving the balance of beneficial gut microbiota of an animal by providing a composition containing beta-casein, wherein at least 75% by weight of the beta-casein is a beta-casein variant that has a proline at position 67 of the beta-casein amino acid sequence.

    Abstract translation: 通过提供含有β-酪蛋白的组合物来改善动物的有益肠道微生物群的平衡，其中至少75重量％的β-酪蛋白是β-酪蛋白变体，其具有 β-酪蛋白氨基酸序列的第67位。

    BETA-CASEINS AND COGNITIVE FUNCTION
    3.
    发明申请
    BETA-CASEINS AND COGNITIVE FUNCTION 审中-公开
    BETA-CASEINS和认知功能

    公开(公告)号：WO2017171563A1

    公开(公告)日：2017-10-05

    申请号：PCT/NZ2017/050035

    申请日：2017-03-29

    Applicant: THE A2 MILK COMPANY LIMITED

    Inventor： CLARKE, Andrew John ,  YELLAND, Gregory Wayne

    IPC: A61K35/20 ,  A23C9/20 ,  A23L33/19 ,  A61P25/28

    Abstract: Improving the cognitive function of an animal by providing a composition containing beta-casein, wherein at least 75% by weight of the beta-casein is a beta-casein variant that does not produce BCM-7 on digestion in the gut of the animal.

    Abstract translation: 通过提供含有β-酪蛋白的组合物来改善动物的认知功能，其中至少75重量％的β-酪蛋白是不产生BCM-7的β-酪蛋白变体 在动物的肠道消化。

    BETA-CASEIN A2 AND ANTIOXIDANT CAPACITY
    4.
    发明申请
    BETA-CASEIN A2 AND ANTIOXIDANT CAPACITY 审中-公开
    BETA-CASEIN A2和抗氧化剂能力

    公开(公告)号：WO2016190750A1

    公开(公告)日：2016-12-01

    申请号：PCT/NZ2016/050081

    申请日：2016-05-20

    Applicant: THE A2 MILK COMPANY LIMITED

    Inventor： CLARKE, Andrew John

    IPC: A61K35/20 ,  A61P31/10 ,  A61P35/00 ,  A61P25/28 ,  A61P25/16 ,  A61P31/18 ,  A61P29/00 ,  A61P7/06 ,  A61P1/16 ,  A61P39/06

    CPC classification number: A61K38/1709 ,  A23C9/1526 ,  A23L33/19 ,  A23V2002/00 ,  A61K35/20

    Abstract: Improving the antioxidant capacity in an animal by increasing the level of glutathione in the blood or tissue of the animal comprising providing a composition containing beta- casein to the animal for consumption, where the beta-casein comprises at least 75% by weight of one or more beta-caseins not capable of producing beta-casomorphin-7 on enzymatic digestion. Uses include as an oxidant, for treating or preventing the symptoms of cancer, inflammation, kwashiorkor (protein deficiency), seizure, autism, Down's syndrome, chronic fatigue syndrome, Alzheimer's disease, Parkinson's disease, sickle cell anaemia, liver disease, cystic fibrosis, HIV, AIDS, infection, heart attack, stroke, and diabetes, avoiding or reducing the effects of aging, promoting the recovery of tissue following physical exercise, and promoting fertility.

    Abstract translation: 通过增加动物的血液或组织中的谷胱甘肽水平来改善动物的抗氧化能力，包括提供含有β-酪蛋白的组合物供动物消费，其中β-酪蛋白包含至少75重量％的一个或多个 更多的β-酪蛋白不能在酶消化中产生β-casomorphin-7。 用途包括用于治疗或预防癌症，炎症，呕吐（蛋白质缺乏），癫痫发作，自闭症，唐氏综合征，慢性疲劳综合征，阿尔茨海默病，帕金森病，镰状细胞性贫血，肝病，囊性纤维化等症状的氧化剂， 艾滋病毒，艾滋病，感染，心脏病，中风和糖尿病，避免或减少老化的影响，促进体育运动后组织的恢复，促进生育能力。

    BETA-CASEIN A2 AND BLOOD GLUCOSE LEVELS
    6.
    发明申请
    BETA-CASEIN A2 AND BLOOD GLUCOSE LEVELS 审中-公开
    BETA-CASEIN A2和血糖葡萄糖水平

    公开(公告)号：WO2015026245A1

    公开(公告)日：2015-02-26

    申请号：PCT/NZ2014/000172

    申请日：2014-08-22

    Applicant: THE A2 MILK COMPANY LIMITED

    Inventor： CLARKE, Andrew John

    IPC: A61K38/17 ,  A61P3/10 ,  A23J1/20

    CPC classification number: A61K38/1709 ,  A23K20/147 ,  A23L33/19 ,  A23L33/30 ,  A23L33/40 ,  A23V2002/00

    Abstract: Regulating the level of glucose in the blood of an animal comprising the consumption by the animal of a composition containing beta-casein, or providing the composition to the animal for consumption, where the beta-casein comprises at least 75% by weight beta-casein A2. Uses include managing the symptoms of hyperglycaemia and associated conditions including diabetes. The effect is both acute (post-exposure to the composition) and ongoing.

    Abstract translation: 调节动物血液中的葡萄糖水平，包括动物消耗含有β-酪蛋白的组合物，或将该组合物提供给动物消费，其中β-酪蛋白包含至少75重量％的β-酪蛋白 A2。 用途包括治疗高血糖症状及相关病症，包括糖尿病。 效果是急剧的（曝光后的组合）和持续的。

    BETA-CASEIN A2 AND REDUCING OR PREVENTING SYMPTOMS OF LACTOSE INTOLERANCE
    7.
    发明申请
    BETA-CASEIN A2 AND REDUCING OR PREVENTING SYMPTOMS OF LACTOSE INTOLERANCE 审中-公开
    β-CASEIN A2和减少或预防乳酸脱落症状

    公开(公告)号：WO2015005804A1

    公开(公告)日：2015-01-15

    申请号：PCT/NZ2014/000141

    申请日：2014-07-10

    Applicant: THE A2 MILK COMPANY LIMITED

    Inventor： CLARKE, Andrew John

    IPC: A61K35/20 ,  A61P1/00

    CPC classification number: A61K38/1709 ,  A23K20/147 ,  A23K50/40 ,  A23L33/19 ,  A23V2002/00 ,  A61K9/0095 ,  A61K35/20

    Abstract: Preventing or reducing the symptoms of lactose intolerance in an animal comprising the consumption by the animal of a composition containing beta-casein, or providing the composition to the animal for consumption, where the beta-casein comprises at least 75% by weight beta-casein A2. The effect is both acute (post-exposure to the composition) and ongoing (future exposure to lactose).

    Abstract translation: 预防或减少动物中乳糖不耐症的症状，其包括动物消耗含有β-酪蛋白的组合物，或将该组合物提供给动物进行消费，其中β-酪蛋白包含至少75重量％的β-酪蛋白 A2。 效果是急性（暴露于组合物）和持续（未来接触乳糖）。

    A2 BETA-CASEIN AND VISCOSITY OF MILK PRODUCTS
    9.
    发明申请
    A2 BETA-CASEIN AND VISCOSITY OF MILK PRODUCTS 审中-公开
    A2牛奶制品的BETA-CASEIN和粘度

    公开(公告)号：WO2017003300A1

    公开(公告)日：2017-01-05

    申请号：PCT/NZ2016/050104

    申请日：2016-06-29

    Applicant: THE A2 MILK COMPANY LIMITED

    Inventor： CLARKE, Andrew, John

    IPC: A23C9/20 ,  A23C9/00 ,  A23L33/19

    CPC classification number: A23C9/1524 ,  A23C9/1512 ,  A23C2210/30 ,  A23V2002/00 ,  A23V2200/244 ,  A23V2200/246 ,  A23V2250/54246

    Abstract: The use of milk for the preparation of a dairy product, wherein the milk contains at least 90% A2 beta-casein by weight of total beta-casein, and the dairy product has a viscosity at least 5% greater than the same dairy product prepared from milk containing less than 90% A2 beta-casein by weight of total beta-casein. Improved viscosity leads to improved foaming ability, frothing ability and/or mouthfeel of milk and dairy products.

    Abstract translation: 使用牛奶制备乳制品，其中所述乳含有按β-酪蛋白总重量计的至少90％的A2β-酪蛋白，并且所述乳制品具有比制备的相同乳制品大至少5％的粘度 从含有按β-酪蛋白总重量计小于90％的A2β-酪蛋白的牛奶。 改进的粘度导致乳和乳制品的发泡能力，发泡能力和/或口感改善。

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