公开(公告)号：WO2012149097A3

公开(公告)日：2012-11-01

申请号：PCT/US2012/035105

申请日：2012-04-26

Applicant: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF ARMY, ,  LIN, Ai J. ,  KOZAR, Michael P. ,  O'NEIL, Micahel T. ,  ZHANG, Liang

Inventor： LIN, Ai J. ,  KOZAR, Michael P. ,  O'NEIL, Micahel T. ,  ZHANG, Liang

IPC: A01N43/50 ,  A01N43/52 ,  A61K31/415

Abstract: The present invention relates to new guanidylimidazole derivatives and guanidylimidazoline derivatives, methods of making these compounds, compositions containing the same, and methods of using the same to prevent, treat, or inhibit malaria in a subject.

公开(公告)号：WO2012149093A1

公开(公告)日：2012-11-01

申请号：PCT/US2012/035099

申请日：2012-04-26

Applicant: THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF ARMY ,  LIN, Ai J. ,  LIU, Xianjun ,  KOZAR, Michael, P. ,  O'NEIL, Michael, T.

Inventor： LIN, Ai J. ,  LIU, Xianjun ,  KOZAR, Michael, P. ,  O'NEIL, Michael, T.

IPC: A01N43/50 ,  A61K31/415 ,  C07D233/00

CPC classification number: C07D233/88 ,  A61K31/4706 ,  A61K45/06 ,  Y02A50/411 ,  A61K2300/00

Abstract: The present invention relates to new 2-guanidino-4-oxo-imidazoline derivatives (deoxo-IZ), methods of making these compounds, compositions containing the same, and methods of using the same to prevent, treat, or inhibit malaria in a subject.

Abstract translation: 本发明涉及新的2-胍基-4-氧代 - 咪唑啉衍生物（脱氧-IZ），制备这些化合物的方法，含有它们的组合物及其用于预防，治疗或抑制受试者的疟疾的方法 。