公开(公告)号：WO2012149093A1

公开(公告)日：2012-11-01

申请号：PCT/US2012/035099

申请日：2012-04-26

Applicant: THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF ARMY ,  LIN, Ai J. ,  LIU, Xianjun ,  KOZAR, Michael, P. ,  O'NEIL, Michael, T.

Inventor： LIN, Ai J. ,  LIU, Xianjun ,  KOZAR, Michael, P. ,  O'NEIL, Michael, T.

IPC: A01N43/50 ,  A61K31/415 ,  C07D233/00

CPC classification number: C07D233/88 ,  A61K31/4706 ,  A61K45/06 ,  Y02A50/411 ,  A61K2300/00

Abstract: The present invention relates to new 2-guanidino-4-oxo-imidazoline derivatives (deoxo-IZ), methods of making these compounds, compositions containing the same, and methods of using the same to prevent, treat, or inhibit malaria in a subject.

Abstract translation: 本发明涉及新的2-胍基-4-氧代 - 咪唑啉衍生物（脱氧-IZ），制备这些化合物的方法，含有它们的组合物及其用于预防，治疗或抑制受试者的疟疾的方法 。

公开(公告)号：WO2004113357A3

公开(公告)日：2004-12-29

申请号：PCT/US2004/015711

申请日：2004-05-19

Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS ,  HUANG, Raven, H. ,  LIU, Xianjun

Inventor： HUANG, Raven, H. ,  LIU, Xianjun

IPC: C07H19/04

Abstract: Compounds of formula (XXIII), or pharmaceutically acceptable salts or esters thereof, are inhibitors of reverse transcriptase: R 4 is a nucleoside with Q substituting a 3' hydroxyl group, and Q is a moiety of formulas (XXIV)-(XXXII).

公开(公告)号：WO2007014226A3

公开(公告)日：2009-02-26

申请号：PCT/US2006028894

申请日：2006-07-26

Applicant: UNIV ILLINOIS ,  HERGENROTHER PAUL J ,  PUTT KARSON S ,  LIU XIANJUN

Inventor： HERGENROTHER PAUL J ,  PUTT KARSON S ,  LIU XIANJUN

IPC: A61K31/5355 ,  A61K31/4412 ,  A61K31/50 ,  A61K31/501 ,  C07D211/76 ,  C07D211/88 ,  C07D213/64 ,  C07D237/14 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D409/04 ,  C12Q1/34

CPC classification number: C07D213/74 ,  A61K31/50 ,  C07D237/14 ,  C07D237/16 ,  C07D237/20

Abstract: Compounds and related methods for synthesis, and the use of compounds for the treatment of neurodegenerative diseases are disclosed. Compounds are disclosed in connection with PARG and/or PARP inhibition. Therapeutic applications are relevant for preventing or inhibiting neurological cell death for a variety of neurodegenerative conditions including Parkinson's disease, ischemia, and stroke. Also disclosed is a high-throughput screen for identifying compounds capable of inhibiting PARG and/or PARP.

Abstract translation: 公开了用于合成的化合物和相关方法以及用于治疗神经变性疾病的化合物的用途。 关于PARG和/或PARP抑制公开了化合物。 治疗应用涉及预防或抑制神经元细胞死亡的各种神经变性疾病，包括帕金森病，局部缺血和中风。 还公开了用于鉴定能够抑制PARG和/或PARP的化合物的高通量筛选。

公开(公告)号：WO2007014226A2

公开(公告)日：2007-02-01

申请号：PCT/US2006/028894

申请日：2006-07-26

Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS ,  HERGENROTHER, Paul, J. ,  PUTT, Karson, S. ,  LIU, Xianjun

Inventor： HERGENROTHER, Paul, J. ,  PUTT, Karson, S. ,  LIU, Xianjun

IPC: A61K31/50 ,  C07D237/02

CPC classification number: C07D213/74 ,  A61K31/50 ,  C07D237/14 ,  C07D237/16 ,  C07D237/20

Abstract: Compounds and related methods for synthesis, and the use of compounds for the treatment of neurodegenerative diseases are disclosed. Compounds are disclosed in connection with PARG and/or PARP inhibition. Therapeutic applications are relevant for preventing or inhibiting neurological cell death for a variety of neurodegenerative conditions including Parkinson's disease, ischemia, and stroke. Also disclosed is a high-throughput screen for identifying compounds capable of inhibiting PARG and/or PARP.

Abstract translation: 公开了用于合成的化合物和相关方法以及用于治疗神经变性疾病的化合物的用途。 关于PARG和/或PARP抑制公开了化合物。 治疗应用涉及预防或抑制神经细胞死亡的各种神经变性疾病，包括帕金森病，局部缺血和中风。 还公开了用于鉴定能够抑制PARG和/或PARP的化合物的高通量筛选。

公开(公告)号：WO2004113357A2

公开(公告)日：2004-12-29

申请号：PCT/US2004/015711

申请日：2004-05-19

Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS ,  HUANG, Raven, H. ,  LIU, Xianjun

Inventor： HUANG, Raven, H. ,  LIU, Xianjun

IPC: C07H

CPC classification number: C07D473/00 ,  C07D405/04 ,  C07D471/04 ,  C07D473/18 ,  C07D473/34

Abstract: Compounds of formula (XXIII), or pharmaceutically acceptable salts or esters thereof, are inhibitors of reverse transcriptase: R 4 is a nucleoside with Q substituting a 3' hydroxyl group, and Q is a moiety of formulas (XXIV)-(XXXII).