公开(公告)号：WO2008075172A3

公开(公告)日：2008-10-02

申请号：PCT/IB2007003928

申请日：2007-12-03

Applicant: PFIZER PROD INC ,  BLAKE TANISHA DANIELLE ROWE ,  HAMPER BRUCE CAMERON ,  HUANG WEI ,  KIEFER JAMES RICHARD JR ,  MOON JOSEPH BLAIR ,  NEAL BRADLEY E ,  OLSON KIRK LANG ,  PELC MATTHEW JAMES ,  SCHWEITZER BARBARA ANN ,  THORARENSEN ALTI ,  TRUJILLO JOHN I ,  TURNER STEVE R

Inventor： BLAKE TANISHA DANIELLE ROWE ,  HAMPER BRUCE CAMERON ,  HUANG WEI ,  KIEFER JAMES RICHARD JR ,  MOON JOSEPH BLAIR ,  NEAL BRADLEY E ,  OLSON KIRK LANG ,  PELC MATTHEW JAMES ,  SCHWEITZER BARBARA ANN ,  THORARENSEN ALTI ,  TRUJILLO JOHN I ,  TURNER STEVE R

IPC: C07D213/82 ,  A61P11/00 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

CPC classification number: C07D401/12 ,  C07D213/82 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04

Abstract: The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein the substituents are as defined herein, compositions containing such compounds and the uses of such compounds for the treatment of various diseases and conditions such as asthma.

Abstract translation: 本发明涉及式（I）化合物及其药学上可接受的盐和溶剂合物，其中取代基如本文所定义，含有这些化合物的组合物以及这些化合物用于治疗各种疾病和病症例如哮喘的用途。

公开(公告)号：WO2009127949A1

公开(公告)日：2009-10-22

申请号：PCT/IB2009005255

申请日：2009-04-09

Applicant: PFIZER ,  MEYERS MARVIN JAY ,  PELC MATTHEW JAMES ,  THORARENSEN ALTI

Inventor： MEYERS MARVIN JAY ,  PELC MATTHEW JAMES ,  THORARENSEN ALTI

IPC: C07D211/70 ,  A61K31/4427 ,  A61K31/445 ,  A61P9/00 ,  A61P25/00 ,  A61P29/00 ,  C07D401/12 ,  C07D401/14 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04

CPC classification number: C07D401/14 ,  C07D413/14 ,  C07D471/04

Abstract: The present invention relates to compounds of Formula (I), wherein Ar is optionally substituted phenyl or heteroaryl and X, Y and Z are independently N or CH; or a pharmaceutically acceptable salt thereof; processes for the preparation of the compounds; intermediates used in the preparation of the compounds; compositions containing the compounds; and uses of the compounds in treating diseases or conditions associated with fatty acid amide hydrolase (FAAH) activity.

Abstract translation: 本发明涉及式（I）化合物，其中Ar为任选取代的苯基或杂芳基，X，Y和Z独立地为N或CH; 或其药学上可接受的盐; 化合物的制备方法; 用于制备化合物的中间体; 含有这些化合物的组合物; 以及该化合物在治疗与脂肪酰胺水解酶（FAAH）活性相关的疾病或病症中的用途。

公开(公告)号：WO2009127948A1

公开(公告)日：2009-10-22

申请号：PCT/IB2009005254

申请日：2009-04-09

Applicant: PFIZER ,  MEYERS MARVIN JAY ,  PELC MATTHEW JAMES ,  THORARENSEN ALTI ,  SCHWEITZER BARBARA ANN

Inventor： MEYERS MARVIN JAY ,  PELC MATTHEW JAMES ,  THORARENSEN ALTI ,  SCHWEITZER BARBARA ANN

IPC: C07D211/70 ,  A61K31/4427 ,  A61K31/445 ,  A61P9/00 ,  A61P25/00 ,  A61P29/00 ,  C07D401/12 ,  C07D413/12 ,  C07D413/14

CPC classification number: C07D413/12 ,  C07D413/14

Abstract: The present invention relates to compounds of Formula (I), wherein Ar is a 5-membered heteroaryl moiety and X, Y and Z are independently N or CH; or a pharmaceutically acceptable salt thereof; processes for the preparation of the compounds; intermediates used in the preparation of the compounds; compositions containing the compounds; and uses of the compounds in treating diseases or conditions associated with fatty acid amide hydrolase (FAAH) activity.

Abstract translation: 本发明涉及式（I）化合物，其中Ar是5元杂芳基部分，X，Y和Z独立地是N或CH; 或其药学上可接受的盐; 化合物的制备方法; 用于制备化合物的中间体; 含有这些化合物的组合物; 以及该化合物在治疗与脂肪酰胺水解酶（FAAH）活性相关的疾病或病症中的用途。

公开(公告)号：WO2008075172A2

公开(公告)日：2008-06-26

申请号：PCT/IB2007/003928

申请日：2007-12-03

Applicant: PFIZER PRODUCTS INC. ,  BLAKE, Tanisha, Danielle, Rowe ,  HAMPER, Bruce, Cameron ,  HUANG, Wei ,  KIEFER, James, Richard, Jr. ,  MOON, Joseph, Blair ,  NEAL, Bradley, E. ,  OLSON, Kirk, Lang ,  PELC, Matthew, James ,  SCHWEITZER, Barbara, Ann ,  THORARENSEN, Alti ,  TRUJILLO, John, I. ,  TURNER, Steve, R.

Inventor： BLAKE, Tanisha, Danielle, Rowe ,  HAMPER, Bruce, Cameron ,  HUANG, Wei ,  KIEFER, James, Richard, Jr. ,  MOON, Joseph, Blair ,  NEAL, Bradley, E. ,  OLSON, Kirk, Lang ,  PELC, Matthew, James ,  SCHWEITZER, Barbara, Ann ,  THORARENSEN, Alti ,  TRUJILLO, John, I. ,  TURNER, Steve, R.

CPC classification number: C07D401/12 ,  C07D213/82 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04

Abstract: The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein the substituents are as defined herein, compositions containing such compounds and the uses of such compounds for the treatment of various diseases and conditions such as asthma.

Abstract translation: 本发明涉及式（I）化合物及其药学上可接受的盐和溶剂合物，其中取代基如本文所定义，含有这些化合物的组合物以及这些化合物用于治疗各种疾病和病症例如哮喘的用途。