公开(公告)号：WO2006129120A3

公开(公告)日：2006-12-07

申请号：PCT/GB2006/002042

申请日：2006-06-02

申请人： JAMES BLACK FOUNDATION ,  MCDONALD, Iain, Mair ,  BUCK, Ildiko, Maria ,  DUNSTONE, David, John ,  LINNEY, Ian, Duncan ,  PETHER, Michael, John ,  SPENCER, John ,  STEEL, Katherine, Isobel, Mary ,  TISSELLI, Patrizia ,  WRIGHT, Paul, Trevor ,  HULL, Robert, Anthony, David ,  AUSTIN, Carol ,  HARPER, Elaine, Anne ,  GRIFFIN, Eric ,  KALINDJIAN, Sarkis, Barret ,  LOW, Caroline, Minli, Rachel

发明人： MCDONALD, Iain, Mair ,  BUCK, Ildiko, Maria ,  DUNSTONE, David, John ,  LINNEY, Ian, Duncan ,  PETHER, Michael, John ,  SPENCER, John ,  STEEL, Katherine, Isobel, Mary ,  TISSELLI, Patrizia ,  WRIGHT, Paul, Trevor ,  HULL, Robert, Anthony, David ,  AUSTIN, Carol ,  HARPER, Elaine, Anne ,  GRIFFIN, Eric ,  KALINDJIAN, Sarkis, Barret ,  LOW, Caroline, Minli, Rachel

IPC分类号： C07D255/04 ,  A61K31/55

摘要： The present invention is concerned with benzotriazepinone derivatives, their intermediates, uses thereof and processes for their production. In particular, the present invention relates to parathyroid hormone (PTH) and parathyroid hormone related protein (PTHrp) receptor ligands, (PTH-l or PTH/PTHrp receptor ligands). The invention also relates to methods of preparing such ligands and to compounds which are useful as intermediates in such methods.

公开(公告)号：WO2011048409A1

公开(公告)日：2011-04-28

申请号：PCT/GB2010/051751

申请日：2010-10-18

申请人： ASTRAZENECA AB ,  PULMAGEN THERAPEUTICS (SYNERGY) LIMITED ,  DONALD, David, Keith ,  JENNINGS, Andrew, Stephen, Robert ,  RAY, Nicholas, Charles ,  ROUSSEL, Fabien ,  SUTTON, Jonathan, Mark ,  TISSELLI, Patrizia ,  WILSON, Michelle

发明人： DONALD, David, Keith ,  JENNINGS, Andrew, Stephen, Robert ,  RAY, Nicholas, Charles ,  ROUSSEL, Fabien ,  SUTTON, Jonathan, Mark ,  TISSELLI, Patrizia ,  WILSON, Michelle

IPC分类号： C07D211/22 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  A61K31/538 ,  A61K31/451 ,  A61P11/00 ,  A61P29/00 ,  A61P37/00 ,  A61P35/00 ,  A61P25/28 ,  A61P17/06 ,  A61P9/00

CPC分类号： C07D413/12 ,  C07D211/22 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

摘要： Compounds of formula (I) having activities at muscarinic and β 2 -receptors (MABAs) for use in therapy.

摘要翻译： 在毒蕈碱和β2受体（MABAs）中具有用于治疗的活性的式（I）化合物。

公开(公告)号：WO2006129120A2

公开(公告)日：2006-12-07

申请号：PCT/GB2006002042

申请日：2006-06-02

申请人： JAMES BLACK FOUNDATION ,  MCDONALD IAIN MAIR ,  BUCK ILDIKO MARIA ,  DUNSTONE DAVID JOHN ,  LINNEY IAN DUNCAN ,  PETHER MICHAEL JOHN ,  SPENCER JOHN ,  STEEL KATHERINE ISOBEL MARY ,  TISSELLI PATRIZIA ,  WRIGHT PAUL TREVOR ,  HULL ROBERT ANTHONY DAVID ,  AUSTIN CAROL ,  HARPER ELAINE ANNE ,  GRIFFIN ERIC ,  KALINDJIAN SARKIS BARRET ,  LOW CAROLINE MINLI RACHEL

发明人： MCDONALD IAIN MAIR ,  BUCK ILDIKO MARIA ,  DUNSTONE DAVID JOHN ,  LINNEY IAN DUNCAN ,  PETHER MICHAEL JOHN ,  SPENCER JOHN ,  STEEL KATHERINE ISOBEL MARY ,  TISSELLI PATRIZIA ,  WRIGHT PAUL TREVOR ,  HULL ROBERT ANTHONY DAVID ,  AUSTIN CAROL ,  HARPER ELAINE ANNE ,  GRIFFIN ERIC ,  KALINDJIAN SARKIS BARRET ,  LOW CAROLINE MINLI RACHEL

IPC分类号： C07D255/04 ,  A61K31/55 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D471/04

CPC分类号： C07D255/04 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D471/04

摘要： The present invention is concerned with benzotriazepinone derivatives, their intermediates, uses thereof and processes for their production. In particular, the present invention relates to parathyroid hormone (PTH) and parathyroid hormone related protein (PTHrp) receptor ligands, (PTH-l or PTH/PTHrp receptor ligands). The invention also relates to methods of preparing such ligands and to compounds which are useful as intermediates in such methods.

摘要翻译： 本发明涉及苯并三氮杂酮衍生物，其中间体，其用途及其制备方法。 特别地，本发明涉及甲状旁腺激素（PTH）和甲状旁腺激素相关蛋白（PTHrp）受体配体（PTH-1或PTH / PTHrp受体配体）。 本发明还涉及制备这种配体的方法和可用作这些方法中的中间体的化合物。

公开(公告)号：WO2008009963A3

公开(公告)日：2008-01-24

申请号：PCT/GB2007/002767

申请日：2007-07-20

申请人： JAMES BLACK FOUNDATION LIMITED ,  LOW, Caroline, Minli, Rachel ,  MCDONALD, Lain, Mair ,  PETHER, Michael, John ,  SPENCER, John ,  TISSELLI, Patrizia ,  WRIGHT, Paul, Trevor

发明人： LOW, Caroline, Minli, Rachel ,  MCDONALD, Lain, Mair ,  PETHER, Michael, John ,  SPENCER, John ,  TISSELLI, Patrizia ,  WRIGHT, Paul, Trevor

IPC分类号： C07D239/26 ,  C07D239/28 ,  C07D239/34 ,  C07D239/42 ,  C07D403/12 ,  A61K31/505 ,  A61K31/506 ,  A61P35/00

摘要： The present invention is concerned with pyrimidine derivatives, their intermediates, uses thereof and processes for their production. In particular, the present invention relates to parathyroid hormone (PTH) and parathyroid hormone related protein (PTHrp) receptor ligands, (PTH-I or PTH/PTHrp receptor ligands). The invention also relates to methods of preparing such ligands and to compounds which are useful as intermediates in such methods.

公开(公告)号：WO2008009963A2

公开(公告)日：2008-01-24

申请号：PCT/GB2007002767

申请日：2007-07-20

申请人： BLACK JAMES FOUNDATION ,  LOW CAROLINE MINLI RACHEL ,  MCDONALD LAIN MAIR ,  PETHER MICHAEL JOHN ,  SPENCER JOHN ,  TISSELLI PATRIZIA ,  WRIGHT PAUL TREVOR

发明人： LOW CAROLINE MINLI RACHEL ,  MCDONALD LAIN MAIR ,  PETHER MICHAEL JOHN ,  SPENCER JOHN ,  TISSELLI PATRIZIA ,  WRIGHT PAUL TREVOR

IPC分类号： C07D239/26 ,  A61K31/505 ,  A61K31/506 ,  A61P35/00 ,  C07D239/28 ,  C07D239/34 ,  C07D239/42 ,  C07D403/12

CPC分类号： C07D403/12 ,  C07D239/26 ,  C07D239/28 ,  C07D239/34 ,  C07D239/42

摘要： The present invention is concerned with pyrimidine derivatives, their intermediates, uses thereof and processes for their production. In particular, the present invention relates to parathyroid hormone (PTH) and parathyroid hormone related protein (PTHrp) receptor ligands, (PTH-I or PTH/PTHrp receptor ligands). The invention also relates to methods of preparing such ligands and to compounds which are useful as intermediates in such methods.

摘要翻译： 本发明涉及嘧啶衍生物，其中间体，其用途及其生产方法。 特别地，本发明涉及甲状旁腺激素（PTH）和甲状旁腺激素相关蛋白（PTHrp）受体配体（PTH-1或PTH / PTHrp受体配体）。 本发明还涉及制备这种配体的方法和可用作这些方法中的中间体的化合物。

公开(公告)号：WO2010018352A1

公开(公告)日：2010-02-18

申请号：PCT/GB2008/002728

申请日：2008-08-12

申请人： ARGENTA DISCOVERY LIMITED ,  ASTRAZENECA AB ,  NADIN, Alan, John ,  OSBOURN, Susan, Elizabeth ,  TISSELLI, Patrizia ,  RAY, Nicholas, Charles

发明人： NADIN, Alan, John ,  OSBOURN, Susan, Elizabeth ,  TISSELLI, Patrizia ,  RAY, Nicholas, Charles

IPC分类号： C07D471/08 ,  A61K31/439 ,  A61P11/00 ,  C07D271/06 ,  C07D271/10

CPC分类号： C07D471/08 ,  C07D271/06 ,  C07D271/10

摘要： The invention provides named compounds of formula (I), pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions and their use in in the treatment of diseases where enhanced M3 receptor activation is implicated.

摘要翻译： 本发明提供命名的式（I）化合物，含有它们的药物组合物，制备药物组合物的方法及其用于治疗涉及M3受体活化增强的疾病的用途。

公开(公告)号：WO2007135350A1

公开(公告)日：2007-11-29

申请号：PCT/GB2006/004512

申请日：2006-12-04

申请人： JAMES BLACK FOUNDATION ,  MCDONALD, Iain, Mair ,  SPENCER, John ,  BUCK, Ildiko, Maria ,  DUNSTONE, David, John ,  LINNEY, Ian, Duncan ,  TISSELLI, Patrizia ,  HULL, Robert, Anthony, David ,  AUSTIN, Carol ,  HARPER, Elaine, Anne ,  SYKES, David ,  GRIFFIN, Eric ,  SHAXTED, Mark

发明人： MCDONALD, Iain, Mair ,  SPENCER, John ,  BUCK, Ildiko, Maria ,  DUNSTONE, David, John ,  LINNEY, Ian, Duncan ,  TISSELLI, Patrizia ,  HULL, Robert, Anthony, David ,  AUSTIN, Carol ,  HARPER, Elaine, Anne ,  SYKES, David ,  GRIFFIN, Eric ,  SHAXTED, Mark

IPC分类号： C07D255/04 ,  A61K31/55 ,  A61P5/20

CPC分类号： C07D255/04

摘要： The present invention is concerned with benzotriazepinone derivatives, their intermediates, uses thereof and processes for their production. In particular, the present invention relates to parathyroid hormone (PTH) and parathyroid hormone related protein (PTHrp) receptor ligands, (PTH-1 or PTH/PTHrp receptor ligands). The invention also relates to methods of preparing such ligands and to compounds which are useful as intermediates in such methods.

摘要翻译： 本发明涉及苯并三氮杂酮衍生物，其中间体，其用途及其制备方法。 特别地，本发明涉及甲状旁腺激素（PTH）和甲状旁腺激素相关蛋白（PTHrp）受体配体（PTH-1或PTH / PTHrp受体配体）。 本发明还涉及制备这种配体的方法和可用作这些方法中的中间体的化合物。

公开(公告)号：WO2006129120A9

公开(公告)日：2007-03-22

申请号：PCT/GB2006002042

申请日：2006-06-02

申请人： JAMES BLACK FOUNDATION ,  MCDONALD IAIN MAIR ,  BUCK ILDIKO MARIA ,  DUNSTONE DAVID JOHN ,  LINNEY IAN DUNCAN ,  PETHER MICHAEL JOHN ,  SPENCER JOHN ,  STEEL KATHERINE ISOBEL MARY ,  TISSELLI PATRIZIA ,  WRIGHT PAUL TREVOR ,  HULL ROBERT ANTHONY DAVID ,  AUSTIN CAROL ,  HARPER ELAINE ANNE ,  GRIFFIN ERIC ,  KALINDJIAN SARKIS BARRET ,  LOW CAROLINE MINLI RACHEL

发明人： MCDONALD IAIN MAIR ,  BUCK ILDIKO MARIA ,  DUNSTONE DAVID JOHN ,  LINNEY IAN DUNCAN ,  PETHER MICHAEL JOHN ,  SPENCER JOHN ,  STEEL KATHERINE ISOBEL MARY ,  TISSELLI PATRIZIA ,  WRIGHT PAUL TREVOR ,  HULL ROBERT ANTHONY DAVID ,  AUSTIN CAROL ,  HARPER ELAINE ANNE ,  GRIFFIN ERIC ,  KALINDJIAN SARKIS BARRET ,  LOW CAROLINE MINLI RACHEL

IPC分类号： C07D255/04 ,  A61K31/55 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D471/04

CPC分类号： C07D255/04 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D471/04

摘要： The present invention is concerned with benzotriazepinone derivatives, their intermediates, uses thereof and processes for their production. In particular, the present invention relates to parathyroid hormone (PTH) and parathyroid hormone related protein (PTHrp) receptor ligands, (PTH-l or PTH/PTHrp receptor ligands). The invention also relates to methods of preparing such ligands and to compounds which are useful as intermediates in such methods.

摘要翻译： 本发明涉及苯并三氮杂酮衍生物，其中间体，其用途及其制备方法。 特别地，本发明涉及甲状旁腺激素（PTH）和甲状旁腺激素相关蛋白（PTHrp）受体配体（PTH-1或PTH / PTHrp受体配体）。 本发明还涉及制备这种配体的方法和可用作这些方法中的中间体的化合物。