公开(公告)号：WO2009142713A1

公开(公告)日：2009-11-26

申请号：PCT/US2009/003068

申请日：2009-05-15

Applicant: NESTEC S.A. ,  DESTAILLATS, Frederic ,  TISSOT-FAVRE, Delphine ,  PAN, Yuanlong ,  DIONISI, Fabiola ,  CRUZ-HERNANDEZ, Cristina ,  THABUIS, Clementine ,  MARTIN, Jean-charles

Inventor： DESTAILLATS, Frederic ,  TISSOT-FAVRE, Delphine ,  PAN, Yuanlong ,  DIONISI, Fabiola ,  CRUZ-HERNANDEZ, Cristina ,  THABUIS, Clementine ,  MARTIN, Jean-charles

IPC: A01N43/40 ,  A61K31/44 ,  C11D3/00

CPC classification number: A61K31/164 ,  A23K10/18 ,  A23K20/105 ,  A23K50/40 ,  A23L33/115 ,  A23V2002/00 ,  A61K31/44 ,  A61K45/06 ,  A61K2300/00 ,  A23V2200/332 ,  A23V2250/186

Abstract: The invention provides methods for using fatty acid alkanolamides for reducing lipid absorption from the intestine of an animal. Reducing lipid absorption results in fewer lipids available for an animal to convert to body fat. Converting fewer lipids to body fat means that the animal reduces body fat, body weight, and/or body weight gain when consuming an equivalent amount of lipids without the fatty acid alkanolamides.

Abstract translation: 本发明提供了使用脂肪酸链烷醇酰胺来减少动物肠内脂质吸收的方法。 减少脂质吸收导致较少的脂质可用于动物转化为身体脂肪。 将更少的脂质转化为身体脂肪意味着当消耗等量的没有脂肪酸链烷醇酰胺的脂质时，动物减少体脂肪，体重和/或体重增加。

公开(公告)号：WO2013025399A1

公开(公告)日：2013-02-21

申请号：PCT/US2012/049825

申请日：2012-08-07

Applicant: NESTEC S.A. ,  TISSOT-FAVRE, Delphine ,  PAN, Yuanlong

Inventor： TISSOT-FAVRE, Delphine ,  PAN, Yuanlong

IPC: A61K31/164

CPC classification number: A61K31/164 ,  A23K20/158 ,  A23K50/40 ,  A23L33/12 ,  A61K31/16

Abstract: The invention provides methods for using fatty acid alkanolamides for ameliorating one or more symptoms or conditions caused by stress, e.g., loss of appetite, or for maintaining and enhancing nutrient and caloric intake by an animal under stress or that has experienced stress. Generally, the fatty acid alkanolamides in amounts of from about 0.1 to about 1500 mg/kg/day before, during or after stress, preferably on a regular or daily basis as a component of a food composition or as a dietary supplement.

Abstract translation: 本发明提供了使用脂肪酸链烷醇酰胺改善由压力引起的一种或多种症状或病症的方法，例如食欲不振，或用于维持和增强动物在压力下或经历压力的营养物和热量摄入。 通常，脂肪酸链烷醇酰胺的量在压力之前，期间或之后为约0.1至约1500mg / kg /天，优选作为食物组合物的组分或作为膳食补充剂的常规或每日。

公开(公告)号：WO2012154711A1

公开(公告)日：2012-11-15

申请号：PCT/US2012/036874

申请日：2012-05-08

Applicant: NESTEC S.A. ,  TISSOT-FAVRE, Delphine ,  PAN, Yuanlong ,  WELLS, George

Inventor： TISSOT-FAVRE, Delphine ,  PAN, Yuanlong ,  WELLS, George

IPC: A01N37/18

CPC classification number: A61K31/16 ,  A61K31/164

Abstract: The invention provides methods for promoting lean body mass growth in an animal. The methods comprise administering OEA to the animals, preferably in amounts of from about 0.01 to about 1000 mg/kg/day.

Abstract translation: 本发明提供了促进动物体内瘦体重增长的方法。 所述方法包括向动物施用OEA，优选以约0.01至约1000mg / kg /天的量施用。

公开(公告)号：WO2009121519A8

公开(公告)日：2009-10-08

申请号：PCT/EP2009/002226

申请日：2009-03-26

Applicant: NESTEC S.A. ,  AMEYE, Laurent ,  AUSTIN, Sean ,  TISSOT-FAVRE, Delphine

Inventor： AMEYE, Laurent ,  AUSTIN, Sean ,  TISSOT-FAVRE, Delphine

IPC: A61K31/7016 ,  A61P19/04 ,  A61P19/02

Abstract: The present invention generally relates to the protection and repair of connective tissues. In particular, the present invention relates to the use of chondroitin sulfates and its derivatives in connective tissue protection and repair. The present inventors have found that unsaturated disaccharidic chondroitin sulfate can be used for the preparation of a composition to develop, protect and/or repair connective tissues. This allows it for example to treat or prevent osteoarthritis or rheumatoid arthritis, and/or the symptoms thereof as well as to treat or prevent signs of skin ageing such as the appearance of wrinkles effectively.

公开(公告)号：WO2009121519A1

公开(公告)日：2009-10-08

申请号：PCT/EP2009002226

申请日：2009-03-26

Applicant: NESTEC SA ,  AMEYE LAURENT ,  AUSTIN LAURENT ,  TISSOT-FAVRE DELPHINE

Inventor： AMEYE LAURENT ,  AUSTIN LAURENT ,  TISSOT-FAVRE DELPHINE

IPC: A61K31/7016 ,  A61P19/02 ,  A61P19/04

CPC classification number: A61K31/7016

Abstract: The present invention generally relates to the protection and repair of connective tissues. In particular, the present invention relates to the use of chondroitin sulfates and its derivatives in connective tissue protection and repair. The present inventors have found that unsaturated disaccharidic chondroitin sulfate can be used for the preparation of a composition to develop, protect and/or repair connective tissues. This allows it for example to treat or prevent osteoarthritis or rheumatoid arthritis, and/or the symptoms thereof as well as to treat or prevent signs of skin ageing such as the appearance of wrinkles effectively.

Abstract translation: 本发明一般涉及结缔组织的保护和修复。 特别地，本发明涉及硫酸软骨素及其衍生物在结缔组织保护和修复中的用途。 本发明人已经发现，不饱和二糖硫酸软骨素可用于制备用于开发，保护和/或修复结缔组织的组合物。 这可以例如治疗或预防骨关节炎或类风湿性关节炎，和/或其症状，以及有效治疗或预防皮肤老化的迹象，例如出现皱纹。

公开(公告)号：WO2012154715A1

公开(公告)日：2012-11-15

申请号：PCT/US2012/036886

申请日：2012-05-08

Applicant: NESTEC S.A. ,  TISSOT-FAVRE, Delphine ,  PAN, Yuanlong

Inventor： TISSOT-FAVRE, Delphine ,  PAN, Yuanlong

IPC: A01N37/18

CPC classification number: A61K31/16 ,  A23K10/16 ,  A23K20/105 ,  A23K20/158 ,  A23K50/42 ,  A23K50/48 ,  A23L33/10 ,  A61K31/164 ,  A61K35/741 ,  A61K45/06

Abstract: The invention provides compositions and methods for preserving lean body mass during weight loss in an animal. The methods comprise administering OEA to the animals, preferably in amounts of from about 0.01 to about 1000 mg/kg/day.

Abstract translation: 本发明提供了用于在动物体重减轻期间保持瘦体重的组合物和方法。 所述方法包括向动物施用OEA，优选以约0.01至约1000mg / kg /天的量施用。

公开(公告)号：WO2011119210A1

公开(公告)日：2011-09-29

申请号：PCT/US2011/000514

申请日：2011-03-18

Applicant: NESTEC S.A. ,  TISSOT-FAVRE, Delphine ,  PAN, Yuanlong ,  BHATNAGAR, Sandeep ,  LEYVA, Manuel, Felipe ,  LYN, Sandra

Inventor： TISSOT-FAVRE, Delphine ,  PAN, Yuanlong ,  BHATNAGAR, Sandeep ,  LEYVA, Manuel, Felipe ,  LYN, Sandra

IPC: A23K1/18

CPC classification number: A23K1/164 ,  A23K10/18 ,  A23K20/105 ,  A23K20/158 ,  A23K20/163 ,  A23K40/20 ,  A23K40/25 ,  A23K50/42

Abstract: The invention provides methods for enhancing the palatability of comestible compositions by combining the comestible compositions with a palatability enhancing amount of one or more fatty acid alkanolamides and the compositions produced by such methods.

Abstract translation: 本发明提供了通过将可食用组合物与适口性增加量的一种或多种脂肪酸链烷醇酰胺和通过这些方法制备的组合物组合来增强可食用组合物适口性的方法。

公开(公告)号：WO2010019211A1

公开(公告)日：2010-02-18

申请号：PCT/US2009/004583

申请日：2009-08-10

Applicant: NESTEC S.A. ,  TISSOT-FAVRE, Delphine ,  DESTAILLATS, Frederic ,  THABUIS, Clementine ,  MARTIN, Jean-charles

Inventor： TISSOT-FAVRE, Delphine ,  DESTAILLATS, Frederic ,  THABUIS, Clementine ,  MARTIN, Jean-charles

IPC: A61K31/20

CPC classification number: C12Q1/6883 ,  A61K31/20 ,  C12Q2600/136 ,  C12Q2600/158 ,  A61K2300/00

Abstract: The invention provides (1) genes differentially expressed in animals administered fatty acid amides that affect one or more of food intake, satiety, lipid metabolism, and fat utilization and (2) compositions and methods relating to the use of the genes to identify new compounds that affect one or more of food intake, satiety, lipid metabolism, and fat utilization.

Abstract translation: 本发明提供了（1）在施用脂肪酸酰胺的动物中差异表达的基因，所述脂肪酸酰胺影响食物摄取，饱腹感，脂质代谢和脂肪利用中的一种或多种，​​以及（2）与使用该基因鉴定新化合物有关的组合物和方法 影响食物摄入，饱腹感，脂质代谢和脂肪利用的一种或多种。