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1.发明申请A SOLID STATE FORM OF PLADIENOLIDE PYRIDINE COMPOUNDS AND METHODS OF USE 审中-公开普拉地尼德吡啶类化合物的固态形式及使用方法
公开(公告)号：WO2017087667A1
公开(公告)日：2017-05-26
申请号：PCT/US2016/062525
申请日：2016-11-17
Applicant: EISAI R&D MANAGEMENT CO., LTD. , KEANEY, Gregg F. , WANG, John , GERARD, Baudouin , ARAI, Kenzo , LIU, Xiang , ZHENG, Guo, Zhu , KIRA, Kazunobu , TIVITMAHAISOON, Parcharee , PRAJAPATI, Sudeep , GEARHART, Nicholas C. , KOTAKE, Yoshihiko , NAGAO, Satoshi , KANADA SONABE, Regina, Mikie , MIYANO, Masayuki , MURAI, Norio , BUONAMICI, Silvia , YU, Lihua , PARK, Eunice, Sun , CHAN, Betty , SMITH, Peter, G. , THOMAS, Michael P. , PAZOLLI, Ermira , LIM, Kian, Huat
Inventor： KEANEY, Gregg F. , WANG, John , GERARD, Baudouin , ARAI, Kenzo , LIU, Xiang , ZHENG, Guo, Zhu , KIRA, Kazunobu , TIVITMAHAISOON, Parcharee , PRAJAPATI, Sudeep , KOTAKE, Yoshihiko , KANADA SONABE, Regina, Mikie , MIYANO, Masayuki , MURAI, Norio , BUONAMICI, Silvia , YU, Lihua , PARK, Eunice, Sun , SMITH, Peter, G. , PAZOLLI, Ermira , LIM, Kian, Huat
IPC: C07D405/06 , A61K31/4427 , A61P35/00
CPC classification number: C07D405/06
Abstract: The present disclosure provides a novel solid state form of pladienolide pyridine compounds, compositions comprising at least one such solid state form, and methods of preparation and use and the same. The novel solid state form of pladienolide pyridine compounds may be useful in the treatment of cancer, such as, for example, cancers in which agents that target the spliceosome and mutations therein are known to be useful.
Abstract translation: 本公开提供了一种新型固体形式的普拉二烯内酯吡啶化合物，包含至少一种此类固体形式的组合物，以及制备和使用方法及其相关方法。 该新型固体形式的普拉二烯内酯吡啶化合物可用于治疗癌症，例如癌症，其中靶向剪接体的试剂及其突变已知是有用的。
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公开(公告)号：WO2019199667A3
公开(公告)日：2019-10-17
申请号：PCT/US2019/026313
申请日：2019-04-08
Applicant: KEANEY, Gregg F. , WANG, John , GERARD, Baudouin , ARAI, Kenzo , LIU, Xiang , ZHENG, Guo Zhu , KIRA, Kazunobu , MARCAURELLE, Lisa A. , NEVALAINEN, Marta , HAO, Ming-Hong , O'SHEA, Morgan Welzel , TIVITMAHAISOON, Parcharee , PRAJAPATI, Sudeep , LUO, Touping , GEARHART, Nicholas C. , LOWE, Jason T. , KOTAKE, Yoshihiko , NAGAO, Satoshi , KANADA SONOBE, Regina Mikie , MIYANO, Masayuki , MURAI, Norio , COOK, Andrew , ELLERY, Shelby , ENDO, Atsushi , PALACINO, James , REYNOLDS, Dominic
Inventor： KEANEY, Gregg F. , WANG, John , GERARD, Baudouin , ARAI, Kenzo , LIU, Xiang , ZHENG, Guo Zhu , KIRA, Kazunobu , MARCAURELLE, Lisa A. , NEVALAINEN, Marta , HAO, Ming-Hong , O'SHEA, Morgan Welzel , TIVITMAHAISOON, Parcharee , PRAJAPATI, Sudeep , LUO, Touping , GEARHART, Nicholas C. , LOWE, Jason T. , KOTAKE, Yoshihiko , NAGAO, Satoshi , KANADA SONOBE, Regina Mikie , MIYANO, Masayuki , MURAI, Norio , COOK, Andrew , ELLERY, Shelby , ENDO, Atsushi , PALACINO, James , REYNOLDS, Dominic
IPC: C07D313/00 , C07D407/12 , C07D407/14 , A61K31/497 , A61K31/4427 , A61K31/365 , A61P35/00
Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.
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Patent Agency Ranking
公开(公告)号：WO2019199667A2
公开(公告)日：2019-10-17
申请号：PCT/US2019/026313
申请日：2019-04-08
Applicant: KEANEY, Gregg F. , WANG, John , GERARD, Baudouin , ARAI, Kenzo , LIU, Xiang , ZHENG, Guo Zhu , KIRA, Kazunobu , MARCAURELLE, Lisa A. , NEVALAINEN, Marta , HAO, Ming-Hong , O'SHEA, Morgan Welzel , TIVITMAHAISOON, Parcharee , PRAJAPATI, Sudeep , LUO, Touping , GEARHART, Nicholas C. , LOWE, Jason T. , KOTAKE, Yoshihiko , NAGAO, Satoshi , KANADA SONOBE, Regina Mikie , MIYANO, Masayuki , MURAI, Norio , COOK, Andrew , ELLERY, Shelby , ENDO, Atsushi , PALACINO, James , REYNOLDS, Dominic
Inventor： KEANEY, Gregg F. , WANG, John , GERARD, Baudouin , ARAI, Kenzo , LIU, Xiang , ZHENG, Guo Zhu , KIRA, Kazunobu , MARCAURELLE, Lisa A. , NEVALAINEN, Marta , HAO, Ming-Hong , O'SHEA, Morgan Welzel , TIVITMAHAISOON, Parcharee , PRAJAPATI, Sudeep , LUO, Touping , GEARHART, Nicholas C. , LOWE, Jason T. , KOTAKE, Yoshihiko , NAGAO, Satoshi , KANADA SONOBE, Regina Mikie , MIYANO, Masayuki , MURAI, Norio , COOK, Andrew , ELLERY, Shelby , ENDO, Atsushi , PALACINO, James , REYNOLDS, Dominic
IPC: C07D313/00 , C07D407/12 , C07D407/14 , A61K31/497 , A61K31/4427 , A61K31/365 , A61P35/00
Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.
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公开(公告)号：WO2015175594A1
公开(公告)日：2015-11-19
申请号：PCT/US2015/030464
申请日：2015-05-13
Applicant: EISAI R&D MANAGEMENT CO., LTD. , KEANEY, Gregg F. , WANG, John , GERARD, Baudouin , ARAI, Kenzo , LIU, Xiang , ZHENG, Guo Zhu , KIRA, Kazunobu , TIVITMAHAISOON, Parcharee , PRAJAPATI, Sudeep , GEARHART, Nicholas C. , KOTAKE, Yoshihiko , NAGAO, Satoshi , KANADA SONOBE, Regina , MIYANO, Masayuki , MURAI, Norio
Inventor： KEANEY, Gregg F. , WANG, John , GERARD, Baudouin , ARAI, Kenzo , LIU, Xiang , ZHENG, Guo Zhu , KIRA, Kazunobu , TIVITMAHAISOON, Parcharee , PRAJAPATI, Sudeep , GEARHART, Nicholas C. , KOTAKE, Yoshihiko , NAGAO, Satoshi , KANADA SONOBE, Regina , MIYANO, Masayuki , MURAI, Norio
IPC: C07D405/06 , A61P35/00
CPC classification number: C07D405/14 , C07D405/06
Abstract: The present invention provides novel pladienolide pyridine compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancer, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful.
Abstract translation: 本发明提供新颖的扁桃苷内酰吡啶化合物，含有这些化合物的药物组合物，以及使用该化合物作为治疗剂的方法。 这些化合物可用于治疗癌症，特别是癌症，其中靶向剪接体的试剂和其中的突变已知是有用的。
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公开(公告)号：WO2009138340A1
公开(公告)日：2009-11-19
申请号：PCT/EP2009/055443
申请日：2009-05-06
Applicant: F. HOFFMANN-LA ROCHE AG , ARZENO, Humberto Bartolome , DUNN, James Patrick , GOLDSTEIN, David Michael , GONG, Leyi , HAN, Xiaochun , HOGG, Joan Heather , JAHANGIR, Alam , PALMER, Wylie Solang , REUTER, Deborah Carol , SILVA, Tania , TIVITMAHAISOON, Parcharee , TREJO-MARTIN, Teresa Alejandra , WU, Shao-Yong
Inventor： ARZENO, Humberto Bartolome , DUNN, James Patrick , GOLDSTEIN, David Michael , GONG, Leyi , HAN, Xiaochun , HOGG, Joan Heather , JAHANGIR, Alam , PALMER, Wylie Solang , REUTER, Deborah Carol , SILVA, Tania , TIVITMAHAISOON, Parcharee , TREJO-MARTIN, Teresa Alejandra , WU, Shao-Yong
IPC: C07D401/14 , A61K31/506 , A61P29/00
CPC classification number: C07D401/14
Abstract: The invention relates to prodrugs of JNK inhibitors and corresponding methods, formulations, and compositions for inhibiting JNK and treating JNK-mediated disorders. The application discloses prodrugs of JNK inhibitors, as described below in formula (I), wherein m, n, p, q, Q, r, R 1 , R 2 , R 3 , X, X 1 , X 2 , X 3 , X 4 , X 5 , Y 1 , Y 2 , Z 1 , and Z 2 are as defined herein. The compounds and compositions disclosed herein are useful to modulate the activity of JNK and treat diseases associated with JNK activity. Disclosed are methods and formulations for inhibiting JNK and treating JNK-mediated disorders, and the like, with the compounds, and processes for making said compounds, and corresponding compositions, disclosed herein.
Abstract translation: 本发明涉及JNK抑制剂的前药以及用于抑制JNK和治疗JNK介导的病症的相应方法，制剂和组合物。 本申请公开了如下式（I）所述的JNK抑制剂的前药，其中m，n，p，q，Q，r，R1，R2，R3，X，X1，X2，X3，X4，X5， Y2，Z1和Z2如本文所定义。 本文公开的化合物和组合物可用于调节JNK的活性并治疗与JNK活性相关的疾病。 公开了用于抑制JNK和治疗JNK介导的病症等的方法和制剂，以及本文公开的化合物，以及制备所述化合物的方法和相应的组合物。
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公开(公告)号：WO2008068171A9
公开(公告)日：2008-06-12
申请号：PCT/EP2007/062920
申请日：2007-11-28
Applicant: F. HOFFMANN-LA ROCHE AG , DUNN, James Patrick , GOLDSTEIN, David Michael , GONG, Leyi , HOGG, Joan Heather , MICHOUD, Christophe , PALMER, Wylie Solang , SIDDURI, Achyutharao , SILVA, Tania , TIVITMAHAISOON, Parcharee , TREJO-MARTIN, Teresa Alejandra
Inventor： DUNN, James Patrick , GOLDSTEIN, David Michael , GONG, Leyi , HOGG, Joan Heather , MICHOUD, Christophe , PALMER, Wylie Solang , SIDDURI, Achyutharao , SILVA, Tania , TIVITMAHAISOON, Parcharee , TREJO-MARTIN, Teresa Alejandra
IPC: C07D403/04 , C07D487/04 , C07D471/04 , A61K31/4178 , A61K31/506 , A61P29/00 , A61P35/00 , A61P25/00
Abstract: The invention is concerned with novel JNK modulator of formula (I) wherein X 1 , X 2 , X 3 , X 4 , X 5 , X 6 , R, R 1 , Z and n are as defined in the description and the claims, as well as physiologically acceptable salts thereof.
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公开(公告)号：WO2008068171A1
公开(公告)日：2008-06-12
申请号：PCT/EP2007062920
申请日：2007-11-28
Applicant: HOFFMANN LA ROCHE , DUNN JAMES PATRICK , GOLDSTEIN DAVID MICHAEL , GONG LEYI , HOGG JOAN HEATHER , MICHOUD CHRISTOPHE , PALMER WYLIE SOLANG , SIDDURI ACHYUTHARAO , SILVA TANIA , TIVITMAHAISOON PARCHAREE , TREJO-MARTIN TERESA ALEJANDRA
Inventor： DUNN JAMES PATRICK , GOLDSTEIN DAVID MICHAEL , GONG LEYI , HOGG JOAN HEATHER , MICHOUD CHRISTOPHE , PALMER WYLIE SOLANG , SIDDURI ACHYUTHARAO , SILVA TANIA , TIVITMAHAISOON PARCHAREE , TREJO-MARTIN TERESA ALEJANDRA
IPC: C07D403/04 , A61K31/4178 , A61K31/506 , A61P25/00 , A61P29/00 , A61P35/00 , C07D471/04 , C07D487/04
CPC classification number: C07D403/04 , C07D471/04 , C07D487/04
Abstract: The invention is concerned with novel JNK modulator of formula (I) wherein X 1 , X 2 , X 3 , X 4 , X 5 , X 6 , R, R 1 , Z and n are as defined in the description and the claims, as well as physiologically acceptable salts thereof.
Abstract translation: 本发明涉及式（I）的新型JNK调节剂，其中X 1，X 2，X 3，X 4， / SUP>，X 5，X 6，R 1，R 1，Z和n如说明书和权利要求中所定义，如 以及其生理上可接受的盐。
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