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公开(公告)号：WO2006120125A1
公开(公告)日：2006-11-16
申请号：PCT/EP2006/061900
申请日：2006-04-27
Applicant: F. HOFFMANN-LA ROCHE AG , MICHOUD, Christophe
Inventor： MICHOUD, Christophe
IPC: C07C243/38 , C07C255/56 , C07D333/38 , C07D307/68 , C07D213/56 , A61P3/00 , A61K31/166 , A61K31/277 , A61K31/4409 , A61K31/341 , A61K31/381
CPC classification number: C07C243/38 , C07C255/57 , C07C2601/04 , C07C2601/08 , C07C2603/18 , C07D213/86 , C07D307/68 , C07D307/84 , C07D307/85 , C07D333/38
Abstract: Provided herein are compounds of the formula (I), as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.
Abstract translation: 本文提供式（I）化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如肥胖症，II型糖尿病和代谢综合征。
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公开(公告)号：WO2006029863A1
公开(公告)日：2006-03-23
申请号：PCT/EP2005/009927
申请日：2005-09-15
Applicant: F. HOFFMANN-LA ROCHE AG , CHEN, Li , CHEN, Shaoqing , MICHOUD, Christophe
Inventor： CHEN, Li , CHEN, Shaoqing , MICHOUD, Christophe
IPC: C07D417/06 , C07D417/14 , A61K31/4709 , A61P35/00
CPC classification number: C07D521/00 , C07D417/06 , C07D417/14
Abstract: The present invention provides thiazoline substituted quinoline derivatives, where the quinoline ring is substituted at the 2 position, of formula (I) which derivatives demonstrate CDK1 antiproliferative activity and are therefore useful as anti-cancer agents, pharmaceutical compositions containing said compounds as well as processes for their manufacture.
Abstract translation: 本发明提供了噻唑啉取代的喹啉衍生物，其中喹啉环在式（I）的2位被取代，该衍生物表现出CDK1抗增殖活性，因此可用作抗癌剂，含有所述化合物的药物组合物以及含有所述化合物的方法 为他们的制造。
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公开(公告)号：WO2012123471A1
公开(公告)日：2012-09-20
申请号：PCT/EP2012/054418
申请日：2012-03-14
Applicant: F. HOFFMANN-LA ROCHE AG , GILLESPIE, Paul , MICHOUD, Christophe , RUPERT, Kenneth Carey , THAKKAR, Kshitij Chhabilbhai
Inventor： GILLESPIE, Paul , MICHOUD, Christophe , RUPERT, Kenneth Carey , THAKKAR, Kshitij Chhabilbhai
IPC: C07D277/20 , C07D333/04 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14 , A61K31/381 , A61K31/426
CPC classification number: C07D277/20 , C07D333/04 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14
Abstract: Provided herein are compounds of the formula (I), as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of inflammatory diseases and disorders such as, for example, asthma and COPD.
Abstract translation: 本文提供式（I）化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗炎性疾病和病症，例如哮喘和COPD。
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4.发明申请4-PHENYL-THIAZOLE-5-CARBOXYLIC ACIDS AND 4-PHENYL-THIAZOLE-5-CARBOXYLIC ACID AMIDES AS PLK1 INHIBITORS 审中-公开4-苯基 - 噻唑-5-羧酸和作为PLK1抑制剂的4-苯基 - 噻唑-5-羧酸酰胺
公开(公告)号：WO2007096315A1
公开(公告)日：2007-08-30
申请号：PCT/EP2007/051541
申请日：2007-02-19
Applicant: F. HOFFMANN-LA ROCHE AG , BOYLAN, John Frederick , CAI, Jianping , FOTOUHI, Nader , GILLESPIE, Paul , GOODNOW JR., Robert Alan , LE, Kang , MICHOUD, Christophe
Inventor： BOYLAN, John Frederick , CAI, Jianping , FOTOUHI, Nader , GILLESPIE, Paul , GOODNOW JR., Robert Alan , LE, Kang , MICHOUD, Christophe
IPC: C07D417/04 , A61K31/427 , A61P35/00
CPC classification number: C07D417/04
Abstract: The invention is directed to compounds of formula (1) and pharmaceutically acceptable salts thereof, methods for the preparation thereof, and methods of use thereof.
Abstract translation: 本发明涉及式（1）的化合物及其药学上可接受的盐，其制备方法及其使用方法。
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公开(公告)号：WO2004089955A1
公开(公告)日：2004-10-21
申请号：PCT/EP2004/003447
申请日：2004-04-01
Applicant: F.HOFFMANN-LA ROCHE AG , CHEN, Yi , DERMATAKIS, Apostolos , LIU, Jin-Jun , LUK, Kin-Chun , MICHOUD, Christophe , ROSSMAN, Pamela, Loreen
Inventor： CHEN, Yi , DERMATAKIS, Apostolos , LIU, Jin-Jun , LUK, Kin-Chun , MICHOUD, Christophe , ROSSMAN, Pamela, Loreen
IPC: C07D487/04
CPC classification number: C07D487/04
Abstract: Disclosed are novel pyrimido compounds of the formula (I) that are selective inhibitors of both KDR and FGFR kinases. These compounds and their pharmaceutically acceptable salts are anti-proliferative agents useful in the treatment or control of solid tumors, in particular breast, colon, lung and prostate tumors. Also disclosed are pharmaceutical compositions containing these compounds and the use for treating cancer.
Abstract translation: 公开了式（I）的新型嘧啶化合物，其是KDR和FGFR激酶的选择性抑制剂。 这些化合物及其药学上可接受的盐是可用于治疗或控制实体瘤，特别是乳腺癌，结肠癌，肺癌和前列腺肿瘤的抗增殖剂。 还公开了含有这些化合物的药物组合物和用于治疗癌症的用途。
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Patent Agency Ranking
公开(公告)号：WO2012123467A1
公开(公告)日：2012-09-20
申请号：PCT/EP2012/054409
申请日：2012-03-14
Applicant: F. HOFFMANN-LA ROCHE AG , GILLESPIE, Paul , MICHOUD, Christophe , RUPERT, Kenneth Carey , THAKKAR, Kshitij Chhabilbhai , YI, Lin
Inventor： GILLESPIE, Paul , MICHOUD, Christophe , RUPERT, Kenneth Carey , THAKKAR, Kshitij Chhabilbhai , YI, Lin
IPC: C07D239/42 , C07D401/12 , C07D403/12 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14
CPC classification number: C07D239/42 , C07D401/12 , C07D403/12 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14
Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of inflammatory diseases and disorders such as, for example, asthma and COPD.
Abstract translation: 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗炎性疾病和病症，例如哮喘和COPD。
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公开(公告)号：WO2008028860A1
公开(公告)日：2008-03-13
申请号：PCT/EP2007/059040
申请日：2007-08-30
Applicant: F. HOFFMANN-LA ROCHE AG , GOLDSTEIN, David Michael , GONG, Leyi , MICHOUD, Christophe , PALMER, Wylie Solang , SIDDURI, Achyutharao
Inventor： GOLDSTEIN, David Michael , GONG, Leyi , MICHOUD, Christophe , PALMER, Wylie Solang , SIDDURI, Achyutharao
IPC: A61K31/4192 , A61K31/506 , A61P35/00 , A61P37/00 , C07D403/04 , C07D403/14
CPC classification number: C07D403/04 , C07D403/14
Abstract: The invention is concerned with novel benzotriazole derivatives of Formula (I) Wherein R, R 1 , R 2 , R 3 , and m are as defined in the description and the claims, as well as physiologically acceptable salts thereof. These compounds are JNK and CDK modulators.
Abstract translation: 本发明涉及式（I）的新型苯并三唑衍生物，其中R 1，R 2，R 2，R 3，和M分别为 在说明书和权利要求书中限定，以及其生理上可接受的盐。 这些化合物是JNK和CDK调节剂。
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公开(公告)号：WO2006002828A1
公开(公告)日：2006-01-12
申请号：PCT/EP2005/006806
申请日：2005-06-23
Applicant: F. HOFFMANN-LA ROCHE AG , CHEN, Li , CHEN, Shaoqing , MICHOUD, Christophe
Inventor： CHEN, Li , CHEN, Shaoqing , MICHOUD, Christophe
IPC: C07D417/06
CPC classification number: C07D417/06
Abstract: The present invention provides new thiazolinone disubstituted quinoline derivatives, where the quinoline ring is disubstituted at the 3, 4 positions, of formula (I) which derivatives demonstrate CDK1 antiproliferative activity and are therefore useful as anti-cancer agents.
Abstract translation: 本发明提供新的噻唑啉酮二取代喹啉衍生物，其中喹啉环在式（I）的3,4位上被二取代，该衍生物表现出CDK1抗增殖活性，因此可用作抗癌剂。
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公开(公告)号：WO2008068171A9
公开(公告)日：2008-06-12
申请号：PCT/EP2007/062920
申请日：2007-11-28
Applicant: F. HOFFMANN-LA ROCHE AG , DUNN, James Patrick , GOLDSTEIN, David Michael , GONG, Leyi , HOGG, Joan Heather , MICHOUD, Christophe , PALMER, Wylie Solang , SIDDURI, Achyutharao , SILVA, Tania , TIVITMAHAISOON, Parcharee , TREJO-MARTIN, Teresa Alejandra
Inventor： DUNN, James Patrick , GOLDSTEIN, David Michael , GONG, Leyi , HOGG, Joan Heather , MICHOUD, Christophe , PALMER, Wylie Solang , SIDDURI, Achyutharao , SILVA, Tania , TIVITMAHAISOON, Parcharee , TREJO-MARTIN, Teresa Alejandra
IPC: C07D403/04 , C07D487/04 , C07D471/04 , A61K31/4178 , A61K31/506 , A61P29/00 , A61P35/00 , A61P25/00
Abstract: The invention is concerned with novel JNK modulator of formula (I) wherein X 1 , X 2 , X 3 , X 4 , X 5 , X 6 , R, R 1 , Z and n are as defined in the description and the claims, as well as physiologically acceptable salts thereof.
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公开(公告)号：WO2008068171A1
公开(公告)日：2008-06-12
申请号：PCT/EP2007062920
申请日：2007-11-28
Applicant: HOFFMANN LA ROCHE , DUNN JAMES PATRICK , GOLDSTEIN DAVID MICHAEL , GONG LEYI , HOGG JOAN HEATHER , MICHOUD CHRISTOPHE , PALMER WYLIE SOLANG , SIDDURI ACHYUTHARAO , SILVA TANIA , TIVITMAHAISOON PARCHAREE , TREJO-MARTIN TERESA ALEJANDRA
Inventor： DUNN JAMES PATRICK , GOLDSTEIN DAVID MICHAEL , GONG LEYI , HOGG JOAN HEATHER , MICHOUD CHRISTOPHE , PALMER WYLIE SOLANG , SIDDURI ACHYUTHARAO , SILVA TANIA , TIVITMAHAISOON PARCHAREE , TREJO-MARTIN TERESA ALEJANDRA
IPC: C07D403/04 , A61K31/4178 , A61K31/506 , A61P25/00 , A61P29/00 , A61P35/00 , C07D471/04 , C07D487/04
CPC classification number: C07D403/04 , C07D471/04 , C07D487/04
Abstract: The invention is concerned with novel JNK modulator of formula (I) wherein X 1 , X 2 , X 3 , X 4 , X 5 , X 6 , R, R 1 , Z and n are as defined in the description and the claims, as well as physiologically acceptable salts thereof.
Abstract translation: 本发明涉及式（I）的新型JNK调节剂，其中X 1，X 2，X 3，X 4， / SUP>，X 5，X 6，R 1，R 1，Z和n如说明书和权利要求中所定义，如 以及其生理上可接受的盐。
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