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公开(公告)号：WO2010062955A1
公开(公告)日：2010-06-03
申请号：PCT/US2009/065919
申请日：2009-11-25
申请人： TOXCURE, INC. , SHAARI, Christopher
发明人： SHAARI, Christopher
CPC分类号： A61K38/164
摘要： The present invention provides a method of treating a neoplasm using a neurotoxin, preferably botulinum toxin. Neurotoxin administered around a neoplasm acts to decrease the contractile forces of the muscles surrounding a neoplasm which normally squeeze neoplastic cells through efferent channels leaving the neoplasm to distant sites. The present invention also provides a method of administering botulinum toxin at sites distant from the neoplasm, thereby enhancing cellular and humoral immunologic functions, which further contribute to neoplastic cell death. Following administration of botulinum toxin around or distant to a neoplasm as described herein, local, regional, and distant spread of neoplastic cells is reduced or eliminated. Immunomodulation with botulinum toxin is also valuable in treating other diseases that may or may not be associated with cancers, such as viral-induced growths, viral conditions, fungal disease, chronic wounds, graft versus host disease, autoimmune disease, and HIV.
摘要翻译： 本发明提供使用神经毒素（优选肉毒杆菌毒素）治疗肿瘤的方法。 在肿瘤周围施用的神经毒素用于降低肿瘤周围的肌肉的收缩力，其通常通过将肿瘤离开肿瘤到远端位置的传出通道挤压肿瘤细胞。 本发明还提供了在远离肿瘤的部位施用肉毒杆菌毒素的方法，从而增强细胞和体液免疫功能，这进一步有助于肿瘤细胞死亡。 在如本文所述施用肿瘤周围或远处的肉毒杆菌毒素之后，肿瘤细胞的局部，区域和远处的扩散被减少或消除。 肉毒杆菌毒素的免疫调节对于治疗可能与癌症相关的其它疾病（例如病毒诱导的生长，病毒病症，真菌性疾病，慢性伤口，移植物抗宿主病，自身免疫疾病和HIV）也是有价值的。
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公开(公告)号：WO2011112713A2
公开(公告)日：2011-09-15
申请号：PCT/US2011/027745
申请日：2011-03-09
申请人： TOXCURE, INC. , SHAARI, Christopher
发明人： SHAARI, Christopher
CPC分类号： A61M37/0015 , A61M5/00 , A61M5/3286 , A61M25/10 , A61M2025/105 , A61M2037/0023 , A61M2037/003 , A61M2210/0618 , A61M2210/0681
摘要： The invention is directed to a nasal delivery device comprising one or more microneedles, and to methods of nasally administering a composition with a nasal delivery device comprising one or more microneedles. In certain embodiments, the nasal delivery device comprises a substrate for administration of a composition to the nasal and/or sinus mucosa, wherein the substrate is non-absorbent and comprises one or more microneedles. In some embodiments, the nasal delivery device comprises a reservoir comprising one or more therapeutic agents, wherein the reservoir is in fluid communication with one or more microneedles.
摘要翻译： 本发明涉及包括一个或多个微针的鼻输送装置，以及用包含一个或多个微针的鼻输送装置鼻内施用组合物的方法。 在某些实施方案中，鼻输送装置包括用于将组合物施用于鼻和/或窦粘膜的底物，其中所述底物是非吸收性的并且包含一个或多个微针。 在一些实施方案中，鼻输送装置包括包含一种或多种治疗剂的储存器，其中储存器与一个或多个微针流体连通。
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公开(公告)号：WO2011041483A9
公开(公告)日：2011-04-07
申请号：PCT/US2010/050822
申请日：2010-09-30
申请人： TOXCURE, INC. , SHAARI, Christopher
发明人： SHAARI, Christopher
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公开(公告)号：WO2011112713A3
公开(公告)日：2012-01-05
申请号：PCT/US2011027745
申请日：2011-03-09
申请人： TOXCURE INC , SHAARI CHRISTOPHER
发明人： SHAARI CHRISTOPHER
CPC分类号： A61M37/0015 , A61M5/00 , A61M5/3286 , A61M25/10 , A61M2025/105 , A61M2037/0023 , A61M2037/003 , A61M2210/0618 , A61M2210/0681
摘要： The invention is directed to a nasal delivery device comprising one or more microneedles, and to methods of nasally administering a composition with a nasal delivery device comprising one or more microneedles. In certain embodiments, the nasal delivery device comprises a substrate for administration of a composition to the nasal and/or sinus mucosa, wherein the substrate is non-absorbent and comprises one or more microneedles. In some embodiments, the nasal delivery device comprises a reservoir comprising one or more therapeutic agents, wherein the reservoir is in fluid communication with one or more microneedles.
摘要翻译： 本发明涉及一种包括一个或多个微针的鼻输送装置，以及用包含一个或多个微针的鼻输送装置鼻内施用组合物的方法。 在某些实施方案中，鼻输送装置包括用于将组合物施用于鼻和/或窦粘膜的底物，其中所述底物是非吸收性的并且包含一个或多个微针。 在一些实施方案中，鼻输送装置包括包含一种或多种治疗剂的贮存器，其中储存器与一个或多个微针流体连通。
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公开(公告)号：WO2006034404A3
公开(公告)日：2006-03-30
申请号：PCT/US2005/033982
申请日：2005-09-23
IPC分类号： A61K39/08
摘要： The present invention provides a method of treating a cancer using a neurotoxin, preferably Botulinum toxin (“BTX”). The application of a neurotoxin around a cancer acts to decrease the contractile forces of the muscles surrounding a neoplasm which normally squeeze cancer cells through efferent channels leaving the cancer vicinity to distant sites. Also, the application of the toxin at sites distant from the cancer enhances cellular and humoral immunologic functions which further contributes to cancer cell death and spread. Following administration of botulinum toxin around and distant to a cancer, it is noticed that local, regional, and distant spread is reduced or eliminated. Immunomodulation with botulinum toxin is also valuable in treating other disease that may or may not be associated with cancers, such as viral-induced growths, viral conditions, fungal disease, chronic wounds, graft versus host disease, autoimmune disease, and HIV.
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公开(公告)号：WO2006034404A2
公开(公告)日：2006-03-30
申请号：PCT/US2005033982
申请日：2005-09-23
CPC分类号： A61K38/164 , A61K38/4893 , A61K39/08
摘要： The present invention provides a method of treating a cancer using a neurotoxin, preferably Botulinum toxin ("BTX"). The application of a neurotoxin around a cancer acts to decrease the contractile forces of the muscles surrounding a neoplasm which normally squeeze cancer cells through efferent channels leaving the cancer vicinity to distant sites. Also, the application of the toxin at sites distant from the cancer enhances cellular and humoral immunologic functions which further contributes to cancer cell death and spread. Following administration of botulinum toxin around and distant to a cancer, it is noticed that local, regional, and distant spread is reduced or eliminated. Immunomodulation with botulinum toxin is also valuable in treating other disease that may or may not be associated with cancers, such as viral-induced growths, viral conditions, fungal disease, chronic wounds, graft versus host disease, autoimmune disease, and HIV.
摘要翻译： 本发明提供使用神经毒素（优选肉毒杆菌毒素（“BTX”））治疗癌症的方法。 神经毒素在癌症周围的应用起到减少肿瘤周围肌肉的收缩力的作用，通常通过将癌细胞附近离开远处的传出通道挤压癌细胞。 此外，毒素在远离癌症的位置的应用增强细胞和体液免疫功能，这进一步有助于癌细胞死亡和扩散。 在癌症周围和远处施用肉毒杆菌毒素之后，注意到局部，区域和远处传播被减少或消除。 与肉毒杆菌毒素的免疫调节在治疗其他可能与癌症相关的疾病（例如病毒诱导的生长，病毒病症，真菌病，慢性伤口，移植物抗宿主病，自身免疫疾病和HIV）中也是有价值的。
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公开(公告)号：WO2011066316A9
公开(公告)日：2011-06-03
申请号：PCT/US2010/057868
申请日：2010-11-23
申请人： TOXCURE, INC. , SHAARI, Christopher
发明人： SHAARI, Christopher
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公开(公告)号：WO2011066316A2
公开(公告)日：2011-06-03
申请号：PCT/US2010057868
申请日：2010-11-23
申请人： TOXCURE INC , SHAARI CHRISTOPHER
发明人： SHAARI CHRISTOPHER
CPC分类号： A61K38/4893 , A61K31/337 , A61K38/28 , A61K45/00 , A61K45/06 , A61K2300/00
摘要： The present invention provides a method of treating a neoplasm using a neurotoxin, preferably botulinum toxin. Neurotoxin administered around a neoplasm acts to decrease the contractile forces of the muscles surrounding a neoplasm which normally squeeze neoplastic cells through efferent channels leaving the neoplasm to distant sites. The present invention also provides a method of administering botulinum toxin at sites distant from the neoplasm, thereby enhancing cellular and humoral immunologic functions, which further contribute to neoplastic cell death. Following administration of botulinum toxin around or distant to a neoplasm as described herein, local, regional, and distant spread of neoplastic cells is reduced or eliminated. Immunomodulation with botulinum toxin is also valuable in treating other diseases that may or may not be associated with cancers, such as viral-induced growths, viral conditions, fungal disease, chronic wounds, graft versus host disease, autoimmune disease, and HIV.
摘要翻译： 本发明提供使用神经毒素（优选肉毒杆菌毒素）治疗肿瘤的方法。 在肿瘤周围施用的神经毒素用于降低肿瘤周围的肌肉的收缩力，其通常通过将肿瘤离开肿瘤到远端位置的传出通道挤压肿瘤细胞。 本发明还提供了在远离肿瘤的部位施用肉毒杆菌毒素的方法，从而增强细胞和体液免疫功能，这进一步有助于肿瘤细胞死亡。 在如本文所述施用肿瘤周围或远处的肉毒杆菌毒素之后，肿瘤细胞的局部，区域和远处的扩散被减少或消除。 肉毒杆菌毒素的免疫调节对于治疗可能与癌症相关的其它疾病（例如病毒诱导的生长，病毒病症，真菌性疾病，慢性伤口，移植物抗宿主病，自身免疫疾病和HIV）也是有价值的。
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公开(公告)号：WO2011041483A2
公开(公告)日：2011-04-07
申请号：PCT/US2010050822
申请日：2010-09-30
申请人： TOXCURE INC , SHAARI CHRISTOPHER
发明人： SHAARI CHRISTOPHER
CPC分类号： A61K38/4893
摘要： The present invention provides methods for treating a substance addiction- related behavior in a patient with a substance addiction, comprising the step of locally administering a therapeutically effective amount of a botulinum neurotoxin to a location on the patient's body or in the vicinity of the area which comes into contact with a smoking tool or addictive substance, thereby altering, reducing or eliminating sensations associated with behaviors associated with substance addiction. Botulinum neurotoxin may be administered to a dermal, subdermal, mucosal or submucosal location or to a muscle area or in the vicinity of the location to which a smoking tool or addictive substance contacts.
摘要翻译： 本发明提供了用于治疗患有物质成瘾症的患者物质成瘾相关行为的方法，其包括将治疗有效量的肉毒杆菌神经毒素局部施用于患者身体或所述区域附近的位置 与吸烟工具或成瘾物质接触，从而改变，减少或消除与物质成瘾相关的行为相关的感觉。 肉毒杆菌神经毒素可以施用于皮肤，皮下，粘膜或粘膜下的位置，或施用于肌肉区域或吸烟工具或成瘾物质接触的位置附近。
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