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    DEGRADABLE POLYMERS
    1.
    发明申请
    DEGRADABLE POLYMERS 审中-公开

    公开(公告)号：WO2004087777A3

    公开(公告)日：2004-10-14

    申请号：PCT/US2004/009905

    申请日：2004-03-29

    Applicant: CARNEGIE MELLON UNIVERSITY ,  MATYJASZEWSKI, Kryzysztof ,  CHUNG, Im, Sik ,  HUANG, Jinyu ,  SARBU, Traian ,  SIEGWART, Daniel, J. ,  SPANSWICK, James ,  TSAREVSKY, Nicolay, V.

    Inventor： MATYJASZEWSKI, Kryzysztof ,  CHUNG, Im, Sik ,  HUANG, Jinyu ,  SARBU, Traian ,  SIEGWART, Daniel, J. ,  SPANSWICK, James ,  TSAREVSKY, Nicolay, V.

    IPC: C08F220/36

    Abstract: Polymers comprising a polymer backbone comprising one or more degradable units are described. The polymer may additionally comprise two or more polymer segments comprising radically (co)polymerizable vinyl monomer units. The degradable units may be independently selected from, but not limited to, at least one of hydrodegradable, photodegradable and biodegradable units between the polymer segments and dispersed along the polymer backbone. The degradable units may be derived from one or more monomers comprising a heterocyclic ring that is capable of undergoing radical ring opening polymerization, a coupling agent, or from a polymerization initiator, radically polymerizable monomers, as well as other reactive sources. Embodiments of the degradable polymer of claim are capable of degrading by at least one of a hydrodegradation, photodegradation or biodegradation mechanisms to form at least one of telechelic oligomer and telechelic polymeric fragments of the polymer. The degradable polymer may be able to degrade into polymer fragments having a molecular weight distribution of less than 5, or in certain applications it may be preferable for embodiments of the polymer to be capable of forming polymer fragments having a molecular weight distribution of the polymer fragments less than 3.0 or even less than 2.5. Embodiments of the present invention also include methods of producing degradable polymers.

    PREPARATION OF FUNCTIONAL GEL PARTICLES WITH A DUAL CROSSLINK NETWORK
    4.
    发明申请
    PREPARATION OF FUNCTIONAL GEL PARTICLES WITH A DUAL CROSSLINK NETWORK 审中-公开
    双交联网络制备功能凝胶颗粒

    公开(公告)号：WO2008057163A3

    公开(公告)日：2008-07-24

    申请号：PCT/US2007021684

    申请日：2007-10-09

    Applicant: UNIV CARNEGIE MELLON ,  MATYJASZEWSKI KRZYSZTOF ,  SPANSWICK JAMES ,  MIN KE ,  TSAREVSKY NICOLAY V ,  OH JUNG KWON

    Inventor： MATYJASZEWSKI KRZYSZTOF ,  SPANSWICK JAMES ,  MIN KE ,  TSAREVSKY NICOLAY V ,  OH JUNG KWON

    IPC: C08F293/00 ,  A61K47/32

    CPC classification number: C08F293/005 ,  C08F283/00 ,  C08F290/00 ,  C08F290/06 ,  C08F291/00

    Abstract: Functional gel particle formed from a crosslinked polymeric network including a fraction of stable crosslinks and a second fraction of cleavable crosslinks are disclosed. Functional compounds may be chemically or physically encapsulated within and/or released from the gel particle by selective cleavage of the cleavable crosslinks. The functional compounds may be delivered and released to a pre-selected target site. Peripheral or other accessible functionality on the surface of the gel particle allows attachment of a surface reactive agent, thereby modifying one or more surface properties of the gel particle. Processes of preparing the gel particles and processes of delivering the functional compounds to a target site are also disclosed.

    Abstract translation: 公开了由交联聚合物网络形成的功能性凝胶颗粒，所述交联聚合物网络包括一部分稳定的交联和第二部分的可切割交联。 功能性化合物可以通过选择性切割可切割的交联物而化学地或物理地包封在凝胶颗粒内和/或从凝胶颗粒释放。 功能性化合物可以被递送并释放到预先选择的靶位点。 凝胶颗粒表面上的外周或其它可接近的官能团允许附着表面反应剂，从而改变凝胶颗粒的一种或多种表面性质。 还公开了制备凝胶颗粒的方法和将功能性化合物递送至目标部位的方法。

    PREPARATION OF FUNCTIONAL GEL PARTICLES WITH A DUAL CROSSLINK NETWORK
    5.
    发明申请
    PREPARATION OF FUNCTIONAL GEL PARTICLES WITH A DUAL CROSSLINK NETWORK 审中-公开
    功能性凝胶颗粒与双交联网络的制备

    公开(公告)号：WO2008057163A2

    公开(公告)日：2008-05-15

    申请号：PCT/US2007/021684

    申请日：2007-10-09

    Applicant: CARNEGIE MELLON UNIVERSITY ,  MATYJASZEWSKI, Krzysztof ,  SPANSWICK, James ,  MIN, Ke ,  TSAREVSKY, Nicolay, V. ,  OH, Jung, Kwon

    Inventor： MATYJASZEWSKI, Krzysztof ,  SPANSWICK, James ,  MIN, Ke ,  TSAREVSKY, Nicolay, V. ,  OH, Jung, Kwon

    CPC classification number: C08F293/005 ,  C08F283/00 ,  C08F290/00 ,  C08F290/06 ,  C08F291/00

    Abstract: Functional gel particle formed from a crosslinked polymeric network including a fraction of stable crosslinks and a second fraction of cleavable crosslinks are disclosed. Functional compounds may be chemically or physically encapsulated within and/or released from the gel particle by selective cleavage of the cleavable crosslinks. The functional compounds may be delivered and released to a pre-selected target site. Peripheral or other accessible functionality on the surface of the gel particle allows attachment of a surface reactive agent, thereby modifying one or more surface properties of the gel particle. Processes of preparing the gel particles and processes of delivering the functional compounds to a target site are also disclosed.

    Abstract translation: 公开了由交联的聚合物网络形成的功能性凝胶颗粒，其包括稳定的交联部分和可切割交联的第二部分。 官能化合物可以通过选择性裂解可切割交联而化学或物理地包封在凝胶颗粒内和/或从凝胶颗粒释放。 功能性化合物可以被递送并释放到预先选择的靶位点。 在凝胶颗粒表面上的周边或其他可接近的功能允许附着表面活性剂，从而改变凝胶颗粒的一个或多个表面性质。 还公开了制备凝胶颗粒的方法和将功能性化合物递送至靶位点的方法。

    MODIFICATION OF SURFACES WITH POLYMERS
    6.
    发明申请
    MODIFICATION OF SURFACES WITH POLYMERS 审中-公开
    用聚合物修饰表面

    公开(公告)号：WO2008021500A2

    公开(公告)日：2008-02-21

    申请号：PCT/US2007018268

    申请日：2007-08-17

    Applicant: UNIV PITTSBURGH ,  UNIV CARNEGIE MELLON ,  HUANG JINYU ,  RUSSELL ALAN J ,  TSAREVSKY NICOLAY V ,  MATYJASZEWSKI KRZYSZTOF

    Inventor： HUANG JINYU ,  RUSSELL ALAN J ,  TSAREVSKY NICOLAY V ,  MATYJASZEWSKI KRZYSZTOF

    IPC: C08F8/00 ,  C08F255/00 ,  C08F255/02 ,  C08F293/00

    CPC classification number: C08L33/14 ,  C08F120/34 ,  C08F255/02 ,  C08F265/06 ,  C08F291/00 ,  C08F293/005 ,  C08L53/00

    Abstract: A polymer formed by controlled radical polymerization includes groups that can be modified after controlled radical polymerization to form a radical. The polymer can be the reaction product of a controlled radical polymerization of radically polymerizable monomers, wherein at least one of the radically polymerizable monomers includes at least one group that can be modified after the controlled radical polymerization to form a radical. A compound includes a first group that is stimulated upon application of energy to the molecule to tether the molecule to a surface or to another polymer chain and a second group comprising a controlled radical polymerization initiator functionality. A block copolymer includes at least a first segment to impart a predetermined functionality to a target surface and at least a second segment including functional groups to interact with the targeted surface to attach the block copolymer to the surface. The first segment can free of functional groups that interact with the surface to attach the block copolymer to the surface.

    Abstract translation: 通过受控自由基聚合形成的聚合物包括可在受控自由基聚合后形成自由基的基团。 聚合物可以是可自由基聚合单体的受控自由基聚合的反应产物，其中至少一种可自由基聚合单体包括至少一个可在受控自由基聚合后形成自由基的基团。 化合物包括第一组和第二组，所述第一组在施加能量至分子以将分子束缚至表面或另一聚合物链时受到刺激，而第二组包含受控自由基聚合引发剂官能团。 嵌段共聚物包括至少第一链段以赋予目标表面预定的功能，并且至少第二链段包含官能团以与目标表面相互作用以将嵌段共聚物附着到表面。 第一段可以不含与表面相互作用的官能团，以将嵌段共聚物附着到表面。

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