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公开(公告)号：WO2023049762A1
公开(公告)日：2023-03-30
申请号：PCT/US2022/076800
申请日：2022-09-21
申请人： WASHINGTON UNIVERSITY , UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
IPC分类号： A61K38/17 , A61P31/14 , C07K14/705
摘要： The present disclosure relates to compositions and methods for treating or preventing a viral infection. The present disclosure also provide compositions and method for improving transfer of a therapeutic or imaging agent transfer across the blood-brain-barrier. In addition the present disclosure provides compositions and methods for treating various central nervous system disease and disorders including, for example, tauopathies.
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2.发明申请
公开(公告)号：WO2023039207A1
公开(公告)日：2023-03-16
申请号：PCT/US2022/043128
申请日：2022-09-09
申请人： UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , CAPOGROSSO, Marco , WEBER, Douglas John , VERMA, Nikhil , GERSZTEN, Peter C. , PIRONDINI, Elvira , SORENSEN, Erynn , CARRANZA URQUIZO, Erick Fabrizio , FISHER, Lee
发明人： POWELL, Marc
摘要： Disclosed herein are methods for treating impairment of a limb in a subject. Particular methods comprise applying a therapeutically effective amount of an electrical stimulus to dorsal roots, dorsal rootlets, or dorsal root ganglia, of sensory neurons innervating the limb of the subject, wherein the impairment is a motor impairment and/or a proprioception impairment due to neurological disorder or injury, the electrical stimulus is applied with one or more electrodes controlled by a neurostimulator, and the one or more electrodes are implanted in the epidural space at the dorsolateral aspect of the spinal cord and proximate to the dorsal roots or dorsal rootlets of the sensory neurons innervating the limb of the subject, or the one or more electrodes are implanted proximate to dorsal root ganglia of sensory neurons innervating the limb of the subject.
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3.发明申请
公开(公告)号：WO2023034955A1
公开(公告)日：2023-03-09
申请号：PCT/US2022/075886
申请日：2022-09-02
申请人： UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , LUO, Jianhua , SINGHI, Aatur Dilip , REN, Baoguo , TSENG, Chien-Cheng , MICHALOPOULOS, George , NALESNIK, Michael A. , WOOD-TRAGESER, Michelle A. , LIU, Shuchang , YU, Yanping
发明人： LUO, Jianhua , SINGHI, Aatur Dilip , REN, Baoguo , TSENG, Chien-Cheng , MICHALOPOULOS, George , NALESNIK, Michael A. , WOOD-TRAGESER, Michelle A. , LIU, Shuchang , YU, Yanping
IPC分类号： G06N20/10 , G06N20/20 , G16B25/10 , C12Q1/6886 , G16H50/20
摘要： Described herein are prediction models based on the transcriptomic, exomic, and/or radiological analyses on tissue samples to predict the likelihood of the original cancer (such as Hepatocellular carcinoma (HCC)) recurrence into the liver transplant. An example computerimplemented method for predicting the likelihood of liver cancer recurrence 5 into a liver transplant includes receiving gene expression data related to a liver tissue sample for a subject having a liver cancer, inputting the gene expression data into a trained machine learning model, and predicting, using the trained machine learning model, a risk of recurrence of the liver cancer in the subject after liver transplantation.
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公开(公告)号：WO2023034433A1
公开(公告)日：2023-03-09
申请号：PCT/US2022/042233
申请日：2022-08-31
申请人： UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , OREBAUGH, Steven L. , SNYDER, James V.
摘要： Described are examples of a training simulator for direct laryngoscopy, which reproduce the dynamics of the human airway and hyoid bone movement observed in the human anatomy during movement of the somatic skeleton and direct laryngoscopy procedures. Training simulators can include a skeleton structure having a styloid process analogue, a mandible analogue, and a longitudinally extending column configured to move between an extended state and a flexed state. A suspension chain can extend parallel to the column and be configured to move with the column. The suspension chain can include a hyoid analogue coupled to the styloid process analogue, the mandible analogue, and an anchor point situated along the column of the skeleton structure. Training simulators can also include a glottis analogue, the visibility of which can be greater when the column is in a flexed state, than when the column is in an extended state.
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公开(公告)号：WO2023023388A1
公开(公告)日：2023-02-23
申请号：PCT/US2022/040978
申请日：2022-08-20
申请人： UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , DUQUESNE UNIVERSITY OF THE HOLY SPIRIT
发明人： KELLUM, Jr., John Alston , EDGAR, Robert Hugh , WHITE, Cierra Lynn , VIATOR, John, Andrew , HEMPEL, John D.
摘要： A method of determining antibiotic resistance of bacteria includes dividing a sample including the bacteria into a plurality of sub-samples, mixing labeling: agents with each of the plurality of sub-samples. Each of the labeling agents is detectible via a detection system including a sensor to detect photoacoustic waves. The labeling: agents are further active to selectively bind with the bacteria. The method further includes applying an antibiotic to one or more of the plurality of sub-samples and not to one or more others of the plurality of sub- samples, characterizing at least one of the sub- samples to which the antibiotic has been applied and at least one of the sub-samples to which no antibiotic has been applied after a determined period of time via the detection system, and determining antibiotic resistance of the bacteria on the basis of the characterization via the detection system.
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公开(公告)号：WO2023018480A1
公开(公告)日：2023-02-16
申请号：PCT/US2022/034290
申请日：2022-06-21
发明人： WIPF, Peter , TASKER, Nikhil R. , PAZUR, Ethan J.
IPC分类号： C07D401/06 , C07D209/08 , C07D209/30 , C07D457/02 , A61K31/4439 , A61K31/4045 , A61K31/48 , A61P25/00 , A61P25/24 , A61P25/18 , A61P25/30 , C07D487/04 , A61K31/435
摘要： A compound, or a pharmaceutically acceptable salt thereof, of formula I wherein R1, R8, R9, R31, R32, R33, and R34 are each independently H, C1-C6 alkyl, or substituted C1-C6 alkyl; and R2, R4, R5, R6, and R7 are each independently H, F, Cl, Br, -OR1, -NR8R9, C1-C6 alkyl, or substituted C1-C6 alkyl.
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7.发明申请
公开(公告)号：WO2023003808A1
公开(公告)日：2023-01-26
申请号：PCT/US2022/037461
申请日：2022-07-18
摘要： The invention relates to dental bone grafting devices and magnesium meshes having features that are designed to corrode and/or absorb progressively, e.g., in stages, in order to improve dental bone regeneration, as well as methods for preparing the meshes. The meshes include a framework, and a geometric design is formed within the framework that includes design features. The geometric design and design features are selected and manipulated to provide the progressive corrosion and/or absorption profile of the mesh.
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公开(公告)号：WO2022261382A1
公开(公告)日：2022-12-15
申请号：PCT/US2022/032917
申请日：2022-06-09
申请人： UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人： TRINCHIERI, Giorgio , DZUTSEV, Amiran Kasanovich , MCCULLOCH, John Anthony , RODRIGUES, Richard R. , DAVAR, Diwakar , ZAROUR, Hassane Mohamed
IPC分类号： A61P35/00 , A61K35/741 , A61K35/17 , A61K39/395
摘要： Disclosed herein are methods for treating cancer by administering an immune checkpoint inhibitor and modifying an amount of one or more bacteria in an intestine of the subject.
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公开(公告)号：WO2022241117A2
公开(公告)日：2022-11-17
申请号：PCT/US2022/028993
申请日：2022-05-12
发明人： URISH, Kenneth , STECKBECK, Jonathan , DOBBINS, Despina, X. , PACHUDA, Nicholas , HUANG, David , PICONE, Bradd, N.
IPC分类号： A61P31/04 , A61F2/38 , A61K39/395 , C12N15/85
摘要： Provided in this disclosure are formulations and methods comprising antimicrobial peptides and at least one antibiotic that can treat or prevent microbial films when applied on an object. Also provided in this disclosure are formulations and methods comprising antimicrobial peptides and at least one antibiotic that can treat or prevent microbial films when administered to a subject. Also provided in this disclosure are formulations and methods comprising administering antimicrobial peptides and at least one antibiotic that can improve the survivability of subjects with bacterial infections. Also provided in this disclosure are formulations and methods comprising administering antimicrobial peptides and at least one antibiotic that can improve the survivability of subjects with periprosthetic joint infection.
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公开(公告)号：WO2022217051A1
公开(公告)日：2022-10-13
申请号：PCT/US2022/024021
申请日：2022-04-08
发明人： WASAN, Ajay D. , GILLMAN, Andrea G
摘要： Systems and methods are described for training a treatment prediction model using patient profiles. The training can include applying a machine-learning technique that causes the treatment prediction model to learn to predict a likelihood that a given patient will respond to a particular medical treatment according to a one or more criteria. A first subset of predictive features are identified from an expanded set of predictive features that are most predictive of whether a given patient will respond to the particular medical treatment according to the one or more criteria. The treatment prediction model is configured to generate predictions from values for the first subset of predictive features that are most predictive, without requiring values for a second subset of predictive features that are less predictive than features from the first subset. The treatment prediction model can be applied to generate a treatment response prediction for a new patient.
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