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公开(公告)号：WO2009155324A3
公开(公告)日：2010-02-18
申请号：PCT/US2009047623
申请日：2009-06-17
Applicant: ABBOTT LAB , BROPHY SUSAN E , CHI LIANLI , DATWYLER SAUL A , HAWKSWORTH DAVID J , LAIRD DON M , MANOJ SHARMILA , PINKUS MARY S , PUCCI DOMINICK L , RAMSAY CAROL S , SOGIN DAVID C , TU BAILIN , TYNER JOAN D , YU ZHIGUANG , ZIEMANN ROBERT N
Inventor： BROPHY SUSAN E , CHI LIANLI , DATWYLER SAUL A , HAWKSWORTH DAVID J , LAIRD DON M , MANOJ SHARMILA , PINKUS MARY S , PUCCI DOMINICK L , RAMSAY CAROL S , SOGIN DAVID C , TU BAILIN , TYNER JOAN D , YU ZHIGUANG , ZIEMANN ROBERT N
IPC: C07K16/22 , C07K14/515 , C12N5/20 , C12N15/13
CPC classification number: C07K16/22 , C07K14/475 , C07K2317/92 , G01N33/74 , G01N2333/475
Abstract: The present disclosure relates to glycosylated and deglycosylated human PlGF-1, methods of using the glycosylated and deglycosylated human PlGF-1, antibodies that bind to human PlGF-1, methods of using the antibodies and human PlGF-1 immunoassays and kits.
Abstract translation: 本公开涉及糖基化和去糖基化的人PlGF-1，使用糖基化和去糖基化的人PlGF-1的方法，与人PlGF-1结合的抗体，使用抗体和人PlGF-1免疫测定和试剂盒的方法。
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公开(公告)号：WO2009052390A1
公开(公告)日：2009-04-23
申请号：PCT/US2008/080325
申请日：2008-10-17
Applicant: Abbott Laboratories , TU, Bailin , TYNER, Joan D.
Inventor： TU, Bailin , TYNER, Joan D.
IPC: C07K14/47
CPC classification number: C07K14/47 , C07K2317/56 , C07K2317/92 , Y10T436/105831
Abstract: The present invention relates to glycosylated mammalian NGAL, and methods of using said glycosylated mammalian NGAL.
Abstract translation: 本发明涉及糖基化哺乳动物NGAL，以及使用所述糖基化哺乳动物NGAL的方法。
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3.发明申请
公开(公告)号：WO2008070727A3
公开(公告)日：2008-06-12
申请号：PCT/US2007/086516
申请日：2007-12-05
Applicant: ABBOTT LABORATORIES , TU, Bailin , TYNER, Joan D , SCHEFFEL, James W , WHITE, Michael K , WERNEKE, Jeffrey M , ZIEMANN, Robert N , HAWKSWORTH, David J , PINKUS, Mary S , GUTIERREZ, Robin A
Inventor： TU, Bailin , TYNER, Joan D , SCHEFFEL, James W , WHITE, Michael K , WERNEKE, Jeffrey M , ZIEMANN, Robert N , HAWKSWORTH, David J , PINKUS, Mary S , GUTIERREZ, Robin A
Abstract: Recombinant antibodies, including chimeric antibodies, specific for hepatitis C (HCV) antigenic proteins are provided. The recombinant antibodies specifically bind to diagnostically relevant regions of HCV proteins and are thus suitable for use, for example, as diagnostic reagents for the detection of HCV, and/or as standardization reagents or positive control reagents in assays for the detection of HCV. The recombinant antibodies can also be used in the treatment or prevention of a HCV infection.
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公开(公告)号：WO2009155324A2
公开(公告)日：2009-12-23
申请号：PCT/US2009/047623
申请日：2009-06-17
Applicant: ABBOTT LABORATORIES , BROPHY, Susan, E. , CHI, Lianli , DATWYLER, Saul, A. , HAWKSWORTH, David, J. , LAIRD, Don, M. , MANOJ, Sharmila , PINKUS, Mary, S. , PUCCI, Dominick, L. , RAMSAY, Carol, S. , SOGIN, David, C. , TU, Bailin , TYNER, Joan, D. , YU, Zhiguang , ZIEMANN, Robert, N.
Inventor： BROPHY, Susan, E. , CHI, Lianli , DATWYLER, Saul, A. , HAWKSWORTH, David, J. , LAIRD, Don, M. , MANOJ, Sharmila , PINKUS, Mary, S. , PUCCI, Dominick, L. , RAMSAY, Carol, S. , SOGIN, David, C. , TU, Bailin , TYNER, Joan, D. , YU, Zhiguang , ZIEMANN, Robert, N.
IPC: C07K16/22 , C07K14/515 , C12N15/13 , C12N5/20
CPC classification number: C07K16/22 , C07K14/475 , C07K2317/92 , G01N33/74 , G01N2333/475
Abstract: The present disclosure relates to glycosylated and deglycosylated human PlGF-1, methods of using the glycosylated and deglycosylated human PlGF-1, antibodies that bind to human PlGF-1, methods of using the antibodies and human PlGF-1 immunoassays and kits.
Abstract translation: 本公开涉及糖基化和去糖基化的人PlGF-1，使用糖基化和去糖基化的人PlGF-1的方法，与人PlGF-1结合的抗体，使用抗体和人PlGF-1免疫测定和试剂盒的方法。
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公开(公告)号：WO2009052392A1
公开(公告)日：2009-04-23
申请号：PCT/US2008/080331
申请日：2008-10-17
Applicant: ABBOTT LABORATORIES , BIRKENMEYER, Larry G. , DESAI, Suresh M. , GRENIER, Frank C. , HAWKSWORTH, David J. , OLEJNICZAK, Edward T. , RUAN, Qiaoqiao , SIEGEL, Robert W. , TETIN, Sergey Y. , TIEMAN, Bryan C. , TU, Bailin , TYNER, Joan D. , WORKMAN, Ryan F. , ZIEMANN, Robert N.
Inventor： BIRKENMEYER, Larry G. , DESAI, Suresh M. , GRENIER, Frank C. , HAWKSWORTH, David J. , OLEJNICZAK, Edward T. , RUAN, Qiaoqiao , SIEGEL, Robert W. , TETIN, Sergey Y. , TIEMAN, Bryan C. , TU, Bailin , TYNER, Joan D. , WORKMAN, Ryan F. , ZIEMANN, Robert N.
CPC classification number: C07K14/47 , C07K2317/56 , C07K2317/92 , Y10T436/105831
Abstract: The present invention relates to NGAL immunoassays and kits, and to methods of using glycosylated mammalian NGAL and antibodies that bind to mammalian NGAL in immunoassays and kits. Among other things, the methods and kits can be employed to determine the amount of human NGAL monomer in a test sample, as well as to determine the proportion of human NGAL monomer to human NGAL dimer contained in a test sample.
Abstract translation: 本发明涉及NGAL免疫测定和试剂盒，以及在免疫测定和试剂盒中使用结合哺乳动物NGAL的糖基化哺乳动物NGAL和抗体的方法。 除此之外，方法和试剂盒可用于确定测试样品中人NGAL单体的量，以及确定测试样品中包含的人NGAL单体对人NGAL二聚体的比例。
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Patent Agency Ranking
公开(公告)号：WO2006088700A3
公开(公告)日：2006-08-24
申请号：PCT/US2006/004318
申请日：2006-02-08
Applicant: ABBOTT LABORATORIES , SHIH, Jessie, W. , TYNER, Joan, D. , MATIAS, Matthew, S. , PINKUS, Mary, S. , BROPHY, Susan, E. , DAGHFAL, David, J. , HAWKSWORTH, David, J. , TIEMAN, Bryan, C.
Inventor： SHIH, Jessie, W. , TYNER, Joan, D. , MATIAS, Matthew, S. , PINKUS, Mary, S. , BROPHY, Susan, E. , DAGHFAL, David, J. , HAWKSWORTH, David, J. , TIEMAN, Bryan, C.
Abstract: The present invention relates to antibodies that specifically bind to human BNP and immunoassays using said antibodies in the quantification of human BNP or a fragment of human BNP in a test sample.
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7.发明申请NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (NGAL) PROTEIN ISOFORMS ENRICHED FROM URINE AND RECOMBINANT CHINESE HAMSTER OVARY (CHO) CELLS AND RELATED COMPOSITIONS, ANTIBODIES, AND METHODS OF ENRICHMENT, ANALYSIS AND USE 审中-公开来自尿素和重组中华肝细胞（CHO）细胞和相关组合物，抗体和增殖，分析和使用方法的中性粒细胞凝胶相关LIPOCALIN（NGAL）蛋白质体积
公开(公告)号：WO2010054025A1
公开(公告)日：2010-05-14
申请号：PCT/US2009/063319
申请日：2009-11-04
Applicant: ABBOTT LABORATORIES , ALI, Salman , BONN, Ryan M. , GRENIER, Frank C. , RAE, Tracey D. , RUPPRECHT, Kevin R. , SYED, Hina N. , TU, Bailin , TYNER, Joan D. , WORKMAN, Ryan F.
Inventor： ALI, Salman , BONN, Ryan M. , GRENIER, Frank C. , RAE, Tracey D. , RUPPRECHT, Kevin R. , SYED, Hina N. , TU, Bailin , TYNER, Joan D. , WORKMAN, Ryan F.
CPC classification number: G01N33/728 , C07K14/47 , G01N33/48
Abstract: A composition comprising neutrophil gelatinase-associated lipocalin (NGAL), which has been enriched from urine, has a molecular weight of about 24.9 kDa to about 25.9 kDa, and comprises a plurality of isoforms having isoelectric points (pIs) ranging from about 5.9 to about 9.1; a composition comprising NGAL, which has been enriched from recombinant Chinese hamster ovary (CHO) cells, has a molecular weight of about 25.9 kDa to about 27.9 kDa, and comprises a plurality of isoforms having pIs ranging from about 5.6 to about 9.1; a method of obtaining from urine a composition comprising a plurality of isoforms of NGAL, which method comprises enriching NGAL in urine without separating molecules based on charge; a method of obtaining from recombinant CHO cells a composition comprising a plurality of isoforms of NGAL, which method comprises enriching NGAL in a composition without separating molecules based on charge; and a method of analyzing NGAL isoforms enriched from urine or recombinant CHO cells comprising analyzing an enriched composition comprising NGAL isoforms by two-dimensional electrophoresis and Western blot.
Abstract translation: 包含从尿中富集的嗜中性粒细胞明胶酶相关脂质运载蛋白（NGAL）的组合物具有约24.9kDa至约25.9kDa的分子量，并且包含多个等电点（pIs）范围为约5.9至约 9.1; 已经从重组的中国仓鼠卵巢（CHO）细胞中富集的包含NGAL的组合物具有约25.9kDa至约27.9kDa的分子量，并且包含具有约5.6至约9.1的pI的多种同种型; 从尿中获得包含多个NGAL同种型的组合物的方法，该方法包括在尿液中富集NGAL而不分离基于电荷的分子; 从重组CHO细胞获得包含多个NGAL亚型的组合物的方法，该方法包括在组合物中富集NGAL而不分离基于电荷的分子; 以及分析从尿液或重组CHO细胞富集的NGAL同种型的方法，包括通过二维电泳和Western印迹分析包含NGAL同种型的富集组合物。
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公开(公告)号：WO2009155381A1
公开(公告)日：2009-12-23
申请号：PCT/US2009/047714
申请日：2009-06-17
Applicant: ABBOTT LABORATORIES , DATWYLER, Saul , HAWKSWORTH, David, J. , LAIRD, Don, M. , PUCCI, Dominick, L. , SOGIN, David, C. , TYNER, Joan, D. , ZIEMANN, Robert, N. , LESNIEWSKI, Richard, R. , MCKEEGAN, Evelyn, Mary
Inventor： DATWYLER, Saul , HAWKSWORTH, David, J. , LAIRD, Don, M. , PUCCI, Dominick, L. , SOGIN, David, C. , TYNER, Joan, D. , ZIEMANN, Robert, N. , LESNIEWSKI, Richard, R. , MCKEEGAN, Evelyn, Mary
IPC: G01N33/53
CPC classification number: G01N33/574 , G01N33/74 , G01N2800/50 , G01N2800/52
Abstract: The present disclosure relates to, among other things, methods for determining whether a subject receiving treatment with a drug has obtained an efficacious blood level of the drug. Moreover, the present disclosure also relates to methods of determining whether a subject predisposed to or suffering from a disease will benefit from treatment with a drug, and the response of a subject receiving treatment (e.g., such as for cancer) by monitoring biomarkers of angiogenesis. In particular, the disclosure relates to P/GF-1 companion diagnostic methods and products.
Abstract translation: 本公开涉及用于确定接受药物治疗的受试者是否已经获得了药物有效血液水平的方法。 此外，本公开还涉及确定倾向于或患有疾病的受试者是否将受益于药物治疗的受试者以及通过监测血管发生生物标志物（例如癌症）的受试者的反应的方法 。 特别地，本公开涉及P / GF-1伴随诊断方法和产品。
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公开(公告)号：WO2009052400A1
公开(公告)日：2009-04-23
申请号：PCT/US2008080340
申请日：2008-10-17
Applicant: ABBOTT LAB , BIRKENMEYER LARRY G , DESAI SURESH M , HAWKSWORTH DAVID J , OLEJNICZAK EDWARD T , RUAN QIAOQIAO , SIEGEL ROBERT W , TESTIN SERGE Y , TIEMAN BRYAN C , TU BAILIN , TYNER JOAN D , ZIEMANN ROBERT N
Inventor： BIRKENMEYER LARRY G , DESAI SURESH M , HAWKSWORTH DAVID J , OLEJNICZAK EDWARD T , RUAN QIAOQIAO , SIEGEL ROBERT W , TESTIN SERGE Y , TIEMAN BRYAN C , TU BAILIN , TYNER JOAN D , ZIEMANN ROBERT N
IPC: C07K16/18
CPC classification number: C07K14/47 , C07K2317/56 , C07K2317/92 , Y10T436/105831
Abstract: The present invention relates to antibodies specific for glycosylated mammalian NGAL, and to methods of making and using such antibodies.
Abstract translation: 本发明涉及糖基化哺乳动物NGAL的特异性抗体，以及制备和使用这种抗体的方法。
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10.发明申请ANTIBODIES AND IMPROVED TEST SAMPLE HANDLING METHODS FOR USE IN ASSAYS FOR MYELOPEROXIDASE 审中-公开抗体和改进的测试样品处理方法用于测定木鳖子酶
公开(公告)号：WO2009023331A2
公开(公告)日：2009-02-19
申请号：PCT/US2008063930
申请日：2008-05-16
Applicant: ABBOTT LAB , DATWYLER SAUL A , HAWKSWORTH DAVID J , HSU STEPHEN C , MATIAS MATTHEW S , PACENTI DAVID P , PINKUS MARY S , SHIH JESSIE W , TIEMAN BRYAN C , TYNER JOAN D , ZIEMANN ROBERT N
Inventor： DATWYLER SAUL A , HAWKSWORTH DAVID J , HSU STEPHEN C , MATIAS MATTHEW S , PACENTI DAVID P , PINKUS MARY S , SHIH JESSIE W , TIEMAN BRYAN C , TYNER JOAN D , ZIEMANN ROBERT N
IPC: C12Q1/28 , G01N33/573
CPC classification number: G01N33/573 , C12Q1/28 , G01N2333/908 , G01N2800/32 , G01N2800/50 , G01N2800/56
Abstract: The present disclosure relates to isolated antibodies that can be used in an assay to determine the concentration levels of myeloperoxidase (MPO) in a test sample. Additionally, the present disclosure also relates to the use of improved test sample handling methods in assays in order to preserve the original MPO levels in the test sample.
Abstract translation: 本公开涉及可用于测定中以测定测试样品中髓过氧化物酶（MPO）的浓度水平的分离的抗体。 另外，本公开还涉及在测定中使用改进的测试样品处理方法以保留测试样品中的原始MPO水平。
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