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公开(公告)号：WO2010099079A1
公开(公告)日：2010-09-02
申请号：PCT/US2010/024979
申请日：2010-02-23
Applicant: ABBOTT LABORATORIES , BROPHY, Susan E. , TU, Bailin , TYNER, Lowell J. , HUANG, Dagang , ZIEMANN, Robert N.
Inventor： BROPHY, Susan E. , TU, Bailin , HUANG, Dagang , ZIEMANN, Robert N.
CPC classification number: C07K16/18 , C07K14/4716 , C07K2317/24 , C07K2317/565 , C07K2317/622 , C07K2317/92
Abstract: The subject invention relates to antibodies to troponin I as well as methods of use thereof. In particular, such antibodies may be used to detect Troponin I in a patient and may also be used in the diagnosis of, for example, a myocardial infarction or acute coronary syndrome.
Abstract translation: 本发明涉及肌钙蛋白I的抗体及其使用方法。 特别地，这样的抗体可用于检测患者中的肌钙蛋白I，并且也可用于诊断例如心肌梗死或急性冠状动脉综合征。
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公开(公告)号：WO2009155324A3
公开(公告)日：2010-02-18
申请号：PCT/US2009047623
申请日：2009-06-17
Applicant: ABBOTT LAB , BROPHY SUSAN E , CHI LIANLI , DATWYLER SAUL A , HAWKSWORTH DAVID J , LAIRD DON M , MANOJ SHARMILA , PINKUS MARY S , PUCCI DOMINICK L , RAMSAY CAROL S , SOGIN DAVID C , TU BAILIN , TYNER JOAN D , YU ZHIGUANG , ZIEMANN ROBERT N
Inventor： BROPHY SUSAN E , CHI LIANLI , DATWYLER SAUL A , HAWKSWORTH DAVID J , LAIRD DON M , MANOJ SHARMILA , PINKUS MARY S , PUCCI DOMINICK L , RAMSAY CAROL S , SOGIN DAVID C , TU BAILIN , TYNER JOAN D , YU ZHIGUANG , ZIEMANN ROBERT N
IPC: C07K16/22 , C07K14/515 , C12N5/20 , C12N15/13
CPC classification number: C07K16/22 , C07K14/475 , C07K2317/92 , G01N33/74 , G01N2333/475
Abstract: The present disclosure relates to glycosylated and deglycosylated human PlGF-1, methods of using the glycosylated and deglycosylated human PlGF-1, antibodies that bind to human PlGF-1, methods of using the antibodies and human PlGF-1 immunoassays and kits.
Abstract translation: 本公开涉及糖基化和去糖基化的人PlGF-1，使用糖基化和去糖基化的人PlGF-1的方法，与人PlGF-1结合的抗体，使用抗体和人PlGF-1免疫测定和试剂盒的方法。
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公开(公告)号：WO2009155381A1
公开(公告)日：2009-12-23
申请号：PCT/US2009/047714
申请日：2009-06-17
Applicant: ABBOTT LABORATORIES , DATWYLER, Saul , HAWKSWORTH, David, J. , LAIRD, Don, M. , PUCCI, Dominick, L. , SOGIN, David, C. , TYNER, Joan, D. , ZIEMANN, Robert, N. , LESNIEWSKI, Richard, R. , MCKEEGAN, Evelyn, Mary
Inventor： DATWYLER, Saul , HAWKSWORTH, David, J. , LAIRD, Don, M. , PUCCI, Dominick, L. , SOGIN, David, C. , TYNER, Joan, D. , ZIEMANN, Robert, N. , LESNIEWSKI, Richard, R. , MCKEEGAN, Evelyn, Mary
IPC: G01N33/53
CPC classification number: G01N33/574 , G01N33/74 , G01N2800/50 , G01N2800/52
Abstract: The present disclosure relates to, among other things, methods for determining whether a subject receiving treatment with a drug has obtained an efficacious blood level of the drug. Moreover, the present disclosure also relates to methods of determining whether a subject predisposed to or suffering from a disease will benefit from treatment with a drug, and the response of a subject receiving treatment (e.g., such as for cancer) by monitoring biomarkers of angiogenesis. In particular, the disclosure relates to P/GF-1 companion diagnostic methods and products.
Abstract translation: 本公开涉及用于确定接受药物治疗的受试者是否已经获得了药物有效血液水平的方法。 此外，本公开还涉及确定倾向于或患有疾病的受试者是否将受益于药物治疗的受试者以及通过监测血管发生生物标志物（例如癌症）的受试者的反应的方法 。 特别地，本公开涉及P / GF-1伴随诊断方法和产品。
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公开(公告)号：WO2009086398A2
公开(公告)日：2009-07-09
申请号：PCT/US2008/088199
申请日：2008-12-23
Applicant: ABBOTT LABORATORIES , TYNER, Lowell , BROPHY, Susan E. , HAWKSWORTH, David J. , SHAH, Dinesh O. , SIEGEL, Robert W. , TIEMAN, Bryan C. , TU, Bailin , ZIEMANN, Robert N.
Inventor： BROPHY, Susan E. , HAWKSWORTH, David J. , SHAH, Dinesh O. , SIEGEL, Robert W. , TIEMAN, Bryan C. , TU, Bailin , ZIEMANN, Robert N.
IPC: C07K16/20 , G01N33/569
CPC classification number: G01N33/56905 , C07K16/20 , C07K2317/24 , C07K2317/56 , C07K2317/92 , G01N2333/44 , G01N2469/10 , G01N2469/20 , G01N2496/00
Abstract: The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi.
Abstract translation: 本公开涉及使用试剂检测克氏锥虫的表位的试剂和方法。
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公开(公告)号：WO2009052400A1
公开(公告)日：2009-04-23
申请号：PCT/US2008080340
申请日：2008-10-17
Applicant: ABBOTT LAB , BIRKENMEYER LARRY G , DESAI SURESH M , HAWKSWORTH DAVID J , OLEJNICZAK EDWARD T , RUAN QIAOQIAO , SIEGEL ROBERT W , TESTIN SERGE Y , TIEMAN BRYAN C , TU BAILIN , TYNER JOAN D , ZIEMANN ROBERT N
Inventor： BIRKENMEYER LARRY G , DESAI SURESH M , HAWKSWORTH DAVID J , OLEJNICZAK EDWARD T , RUAN QIAOQIAO , SIEGEL ROBERT W , TESTIN SERGE Y , TIEMAN BRYAN C , TU BAILIN , TYNER JOAN D , ZIEMANN ROBERT N
IPC: C07K16/18
CPC classification number: C07K14/47 , C07K2317/56 , C07K2317/92 , Y10T436/105831
Abstract: The present invention relates to antibodies specific for glycosylated mammalian NGAL, and to methods of making and using such antibodies.
Abstract translation: 本发明涉及糖基化哺乳动物NGAL的特异性抗体，以及制备和使用这种抗体的方法。
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Patent Agency Ranking6.发明申请ANTIBODIES AND IMPROVED TEST SAMPLE HANDLING METHODS FOR USE IN ASSAYS FOR MYELOPEROXIDASE 审中-公开抗体和改进的测试样品处理方法用于测定木鳖子酶
公开(公告)号：WO2009023331A2
公开(公告)日：2009-02-19
申请号：PCT/US2008063930
申请日：2008-05-16
Applicant: ABBOTT LAB , DATWYLER SAUL A , HAWKSWORTH DAVID J , HSU STEPHEN C , MATIAS MATTHEW S , PACENTI DAVID P , PINKUS MARY S , SHIH JESSIE W , TIEMAN BRYAN C , TYNER JOAN D , ZIEMANN ROBERT N
Inventor： DATWYLER SAUL A , HAWKSWORTH DAVID J , HSU STEPHEN C , MATIAS MATTHEW S , PACENTI DAVID P , PINKUS MARY S , SHIH JESSIE W , TIEMAN BRYAN C , TYNER JOAN D , ZIEMANN ROBERT N
IPC: C12Q1/28 , G01N33/573
CPC classification number: G01N33/573 , C12Q1/28 , G01N2333/908 , G01N2800/32 , G01N2800/50 , G01N2800/56
Abstract: The present disclosure relates to isolated antibodies that can be used in an assay to determine the concentration levels of myeloperoxidase (MPO) in a test sample. Additionally, the present disclosure also relates to the use of improved test sample handling methods in assays in order to preserve the original MPO levels in the test sample.
Abstract translation: 本公开涉及可用于测定中以测定测试样品中髓过氧化物酶（MPO）的浓度水平的分离的抗体。 另外，本公开还涉及在测定中使用改进的测试样品处理方法以保留测试样品中的原始MPO水平。
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7.发明申请RECOMBINANT ANTIBODIES AGAINST HEPATITIS C VIRUS AND METHODS OF OBTAINING AND USING SAME 审中-公开抗重度丙型肝炎病毒的重组抗体及其获取和使用方法
公开(公告)号：WO2008070727A2
公开(公告)日：2008-06-12
申请号：PCT/US2007086516
申请日：2007-12-05
Applicant: ABBOTT LAB , TU BAILIN , TYNER JOAN D , SCHEFFEL JAMES W , WHITE MICHAEL K , WERNEKE JEFFREY M , ZIEMANN ROBERT N , HAWKSWORTH DAVID J , PINKUS MARY S , GUTIERREZ ROBIN A
Inventor： TU BAILIN , TYNER JOAN D , SCHEFFEL JAMES W , WHITE MICHAEL K , WERNEKE JEFFREY M , ZIEMANN ROBERT N , HAWKSWORTH DAVID J , PINKUS MARY S , GUTIERREZ ROBIN A
CPC classification number: G01N33/5767 , C07K16/109 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/92
Abstract: Recombinant antibodies, including chimeric antibodies, specific for hepatitis C (HCV) antigenic proteins are provided. The recombinant antibodies specifically bind to diagnostically relevant regions of HCV proteins and are thus suitable for use, for example, as diagnostic reagents for the detection of HCV, and/or as standardization reagents or positive control reagents in assays for the detection of HCV. The recombinant antibodies can also be used in the treatment or prevention of a HCV infection.
Abstract translation: 提供了对丙型肝炎（HCV）抗原蛋白特异性的重组抗体，包括嵌合抗体。 重组抗体特异性结合HCV蛋白的诊断相关区域，因此适合用作检测HCV的诊断试剂，和/或用于检测HCV的测定中的标准化试剂或阳性对照试剂。 重组抗体也可用于治疗或预防HCV感染。
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公开(公告)号：WO2009052400A8
公开(公告)日：2009-04-23
申请号：PCT/US2008/080340
申请日：2008-10-17
Applicant: ABBOTT LABORATORIES , BIRKENMEYER, Larry, G. , DESAI, Suresh, M. , HAWKSWORTH, David, J. , OLEJNICZAK, Edward, T. , RUAN, Qiaoqiao , SIEGEL, Robert, W. , TETIN, Sergey, Y. , TIEMAN, Bryan, C. , TU, Bailin , TYNER, Joan, D. , ZIEMANN, Robert, N.
Inventor： BIRKENMEYER, Larry, G. , DESAI, Suresh, M. , HAWKSWORTH, David, J. , OLEJNICZAK, Edward, T. , RUAN, Qiaoqiao , SIEGEL, Robert, W. , TETIN, Sergey, Y. , TIEMAN, Bryan, C. , TU, Bailin , TYNER, Joan, D. , ZIEMANN, Robert, N.
IPC: C07K16/18
Abstract: The present invention relates to antibodies specific for glycosylated mammalian NGAL, and to methods of making and using such antibodies.
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9.发明申请
公开(公告)号：WO2009023331A3
公开(公告)日：2009-02-19
申请号：PCT/US2008/063930
申请日：2008-05-16
Applicant: ABBOTT LABORATORIES , DATWYLER, Saul A. , HAWKSWORTH, David J. , HSU, Stephen C. , MATIAS, Matthew S. , PACENTI, David P. , PINKUS, Mary S. , SHIH, Jessie W. , TIEMAN, Bryan C. , TYNER, Joan D. , ZIEMANN, Robert N.
Inventor： DATWYLER, Saul A. , HAWKSWORTH, David J. , HSU, Stephen C. , MATIAS, Matthew S. , PACENTI, David P. , PINKUS, Mary S. , SHIH, Jessie W. , TIEMAN, Bryan C. , TYNER, Joan D. , ZIEMANN, Robert N.
IPC: G01N33/53 , G01N33/573
Abstract: The present disclosure relates to isolated antibodies that can be used in an assay to determine the concentration levels of myeloperoxidase (MPO) in a test sample. Additionally, the present disclosure also relates to the use of improved test sample handling methods in assays in order to preserve the original MPO levels in the test sample.
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10.发明申请COMPOSITION AND METHOD FOR THE DIAGNOSIS AND TREATMENT OF IRON-RELATED DISORDERS 审中-公开用于诊断和治疗相关疾病的组合物和方法
公开(公告)号：WO2013090633A3
公开(公告)日：2013-08-22
申请号：PCT/US2012069584
申请日：2012-12-13
Applicant: ABBVIE DEUTSCHLAND , ABBVIE INC , MANOJ SHAMILA , BRATE ELAINE M , GRENIER FRANK C , HAWKSWORTH DAVID J , ZIEMANN ROBERT N , BIRKENMEYER LARRY G , MUELLER BERNHARD , POPP ANDREAS , BROPHY SUSAN , BELIGERE GANGAMANI S
Inventor： MANOJ SHAMILA , BRATE ELAINE M , GRENIER FRANK C , HAWKSWORTH DAVID J , ZIEMANN ROBERT N , BIRKENMEYER LARRY G , MUELLER BERNHARD , POPP ANDREAS , BROPHY SUSAN , BELIGERE GANGAMANI S
IPC: C07K16/28 , A61K39/395
CPC classification number: A61K39/3955 , A61K2039/505 , C07K16/22 , G01N33/564 , G01N33/566 , G01N33/574 , G01N33/6893 , G01N2800/085 , G01N2800/26 , G01N2800/347
Abstract: Provided herein are antibodies and methods of using the antibodies to treat, prevent, modulate, attenuate and diagnose iron-related disorders.
Abstract translation: 本文提供了使用抗体治疗，预防，调节，减弱和诊断铁相关疾病的抗体和方法。
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