摘要:
An impulse mitigation system configured to mitigate blast impulse directed to a surface (or structure or target). The system includes a substrate in communication with the surface (or structure or target), wherein the substrate is configured to receive an impulse directed to the surface (or structure or target) and then relocate from the surface (or structure or target) in response to received impulse.
摘要:
Cellular materials and methods of making and using the cellular materials. A method of making a cellular material comprising or consisting of conducting phase separation of block copolymers resulting in a particular morphology; selective removal of one polymer from the block copolymers to form a lattice; conducting metal deposition on the lattice; and dissolving a remaining polymer to obtain the cellular material.
摘要:
A method for producing three-dimensional space frames or truss structures from simpler components and space frames or truss structures produced by the associated method. The various components, which may be made from virtually any material, are shaped in such a way so that they may be fitted together to create a space frame or truss structure. The components may be held together by any available attachment means, or by the interaction of the components themselves. The method and associated components allows for the assembly of three-dimensional space frames or truss structures from planar materials, significantly reducing cost and manufacturing time. These space frames or trusses can then be used as structural members, as the interior load-bearing portions of sandwich panels, or in any situation where high-strength and light weight are desirable.
摘要:
A set of target peptides are presented by HLA A*0201, B*0301, B*0702 and B*2705 on the surface of disease cells. They are envisioned to, among other things, stimulate an immune response to the proliferative disease, e.g., colorectal cancer, to function as immunotherapeutics in adoptive T cell therapy or as a vaccine, facilitate antibody recognition of tumor boundaries in surgical pathology samples, act as biomarkers for early detection and/or diagnosis of the disease, and/or act as targets in the generation antibody-like molecules which recognize the target-peptide/MHC complex.
摘要:
A device and related method that provides, but is not limited thereto, a two-phase heat transfer device with unique combination of enhanced evaporation and increased cooling capacity. An advantage associated with the device and method includes, but is not limited thereto, increased cooling capacity per unit area, controlled and optimized evaporation, 10 prevention of boiling, and prevention of drying of the evaporator. An aspect associated with an approach may include, but is not limited thereto, using a non-wetting coating or structure to keep working fluid away from the spaces between elongated members of an evaporator and using a wetting coating or structure to form thin films of working fluid around the distal region of the elongated members.
摘要:
The present invention provides compositions and methods useful for diagnosing, treating, and preventing cancer, particularly ovarian cancer and uterine cancer, based on the discovery that the oocyte specific protein, SAS1R (Sperm Acrosomal SLLP1 Receptor), which is a sperm protein receptor, is also expressed in various cancers, including ovarian cancer and uterine cancer. Six SAS1R variants have been previously identified, and they are encompassed by the invention. The present invention further provides antibodies useful for targeting SAS1R expressing cells and for killing such cells.
摘要:
Methods and kits are provided for diagnosing, prognosing and treating Alzheimer's disease (AD) by identifying heteroplasmic mitochondrial mutations in cytochrome c oxidase subunit 3 (C03). The methods are efficient, economical, and rapid, for diagnosis, prognosis and subsequent early treatment of AD in subjects.
摘要:
An armor system incorporates electromagnetic concepts into a robust, structurally efficient armor panel and exploits synergies between the elements of the system to reduce its aerial density. The electromagnetic concept provides capitatively charged electrodes whose rapid shorting by high aspect projectiles provides a reactive means for the defeat of hypervelocity, high aspect ratio metallic projectiles, such as metallic "jets" formed by shaped charges. In combination with the electromagnetic concept, the system exploits topology optimization of cellular core sandwich panels to provide efficient load supporting structures, provide high structural efficiency, and provide good environmental protection. The multifunctional system results in a low aerial density armor solution that can be easily tailored to match a wide variety of threat scenarios. The system can be fabricated in a variety of complex shapes including cylinders, hemispheres, beams and plates.
摘要:
Provided are isolated TCRs, TCR-like molecules, and portions thereof that bind to phosphopeptide-HLA-A2 complexes. The isolated TCRs, TCR-like molecules, or portions are optionally soluble TCRs, TCR-like molecules, or portions. Also provided are isolated nucleic acids encoding the disclosed TCRs, TCR-like molecules, or portions; host cells that contain the disclosed TCRs, TCR-like molecules, or portions; pharmaceutical compositions that include the disclosed TCRs, TCR-like molecules, portions, nucleic acids, and/or T cells; kits; and methods of using the same.
摘要:
A method for treating substrates or components; and substrates or components that have been treated by the associated method. The treatment may be applied to any iron or steel based alloy to create a treated layer that increases the strength of the substrate or component. The treatment may be especially useful for strengthening small structures, as with sandwich panels, small trusses, or other complex structures. The treatment may be used to improve strength, stiffness, fatigue resistance, and wear properties, among other benefits.