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公开(公告)号：WO2011003935A1
公开(公告)日：2011-01-13
申请号：PCT/EP2010/059713
申请日：2010-07-07
Applicant: COMPLIX NV , LOVERIX, Stefan , DESMET, Johan , LASTERS, Ignace , VANWETSWINKEL, Sophie , VAN GELDER, Patrick
Inventor： LOVERIX, Stefan , DESMET, Johan , LASTERS, Ignace , VANWETSWINKEL, Sophie , VAN GELDER, Patrick
CPC classification number: C07K14/001 , C07K14/635 , C07K2318/20 , G01N33/574 , G01N2333/635
Abstract: The present invention relates to PTHrP-binding single-chain 3-stranded alpha-helical coiled coil molecules, denoted 'Alphabodies', nucleic acids encoding said Aiphabodies, host cells comprising said nucleic acids, as well as pharmaceutical compositions comprising said Alphabodies, and methods for the treatment, prevention and diagnosis of cancer using said Alphabodies.
Abstract translation: 本发明涉及表示为“Alphabodies”，编码所述Aiphabodies的核酸，包含所述核酸的宿主细胞以及包含所述Alphabody的药物组合物的PTHrP结合单链3-链α-螺旋卷曲螺旋分子，以及方法 用于使用所述的Alphabodies来治疗，预防和诊断癌症。
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公开(公告)号：WO2011003935A9
公开(公告)日：2011-06-03
申请号：PCT/EP2010059713
申请日：2010-07-07
Applicant: COMPLIX NV , LOVERIX STEFAN , DESMET JOHAN , LASTERS IGNACE , VANWETSWINKEL SOPHIE , VAN GELDER PATRICK
Inventor： LOVERIX STEFAN , DESMET JOHAN , LASTERS IGNACE , VANWETSWINKEL SOPHIE , VAN GELDER PATRICK
CPC classification number: C07K14/001 , C07K14/635 , C07K2318/20 , G01N33/574 , G01N2333/635
Abstract: The present invention relates to PTHrP-binding single-chain 3-stranded alpha-helical coiled coil molecules, denoted 'Alphabodies', nucleic acids encoding said Aiphabodies, host cells comprising said nucleic acids, as well as pharmaceutical compositions comprising said Alphabodies, and methods for the treatment, prevention and diagnosis of cancer using said Alphabodies.
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公开(公告)号：WO2011003935A4
公开(公告)日：2011-04-07
申请号：PCT/EP2010059713
申请日：2010-07-07
Applicant: COMPLIX NV , LOVERIX STEFAN , DESMET JOHAN , LASTERS IGNACE , VANWETSWINKEL SOPHIE , VAN GELDER PATRICK
Inventor： LOVERIX STEFAN , DESMET JOHAN , LASTERS IGNACE , VANWETSWINKEL SOPHIE , VAN GELDER PATRICK
CPC classification number: C07K14/001 , C07K14/635 , C07K2318/20 , G01N33/574 , G01N2333/635
Abstract: The present invention relates to PTHrP-binding single-chain 3-stranded alpha-helical coiled coil molecules, denoted 'Alphabodies', nucleic acids encoding said Aiphabodies, host cells comprising said nucleic acids, as well as pharmaceutical compositions comprising said Alphabodies, and methods for the treatment, prevention and diagnosis of cancer using said Alphabodies.
Abstract translation: 本发明涉及称为'Alphabodies'的PTHrP-结合单链3-链α-螺旋卷曲螺旋分子，编码所述Aiphabody的核酸，包含所述核酸的宿主细胞，以及包含所述Alphabody的药物组合物，以及方法 用于使用所述Alphabody进行癌症的治疗，预防和诊断。
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公开(公告)号：WO2011003936A1
公开(公告)日：2011-01-13
申请号：PCT/EP2010/059714
申请日：2010-07-07
Applicant: COMPLIX NV , DESMET, Johan , LASTERS, Ignace , VANWETSWINKEL, Sophie
Inventor： DESMET, Johan , LASTERS, Ignace , VANWETSWINKEL, Sophie
IPC: C07K14/16
CPC classification number: C07K14/005 , A61K38/00 , A61K39/00 , C07K16/1063 , C07K2318/20 , C12N2740/16122 , G01N33/56988 , G01N2333/162 , G01N2500/00
Abstract: The present invention relates to HIV- 1 gρ41-binding single-chain 3-stranded alpha-helical coiled coil molecules, denoted "Alphabodies", nucleic acids encoding said Alphabodies, host cells comprising said nucleic acids, as well as pharmaceutical compositions comprising said Alphabodies, and methods for the treatment, prevention and diagnosis of HIV infection using said Alphabodies.
Abstract translation: 本发明涉及表示为“Alphabodies”的编码所述Alphabody的核酸，包含所述核酸的宿主细胞以及药物组合物的HIV-1β1-结合单链3链α-螺旋卷曲螺旋分子，以及包含 阿拉伯人，以及使用所述阿拉伯人治疗，预防和诊断艾滋病毒感染的方法。
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