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    METHOD FOR PREDICTING THE BINDING AFFINITY OF MHC/PEPTIDE COMPLEXES
    3.
    发明申请
    METHOD FOR PREDICTING THE BINDING AFFINITY OF MHC/PEPTIDE COMPLEXES 审中-公开

    公开(公告)号：WO2003105058A3

    公开(公告)日：2003-12-18

    申请号：PCT/EP2003/006049

    申请日：2003-06-10

    Applicant: ALGONOMICS N.V. ,  LASTERS, Ignace ,  DESMET, Johan

    Inventor： LASTERS, Ignace ,  DESMET, Johan

    IPC: G06F19/00

    Abstract: The present invention relates to a method for structure-based prediction of properties of peptides and peptide analogs in complex with major histocompatibility (MHC) class I and class II molecules. The said properties mainly relate to the three-dimensional structure of an MHC/peptide complex and the binding affinity of a peptide for an MHC receptor. The invention further relates to a computer program and a device therefor. The invention further relates to data produced by a method of the invention. The invention further relates to peptides and peptide analogs predicted to bind to target-MHC molecules. The present invention thus relates to the field of immunology, with possible applications in manufacture of vaccinates, de-immunization of proteins, and manufacture of therapeutic agents, especially immunotherapeutic agents.

    ALPHABODIES SPECIFICALLY BINDING TO CYTOKINES OR GROWTH FACTORS AND/OR CYTOKINE OR GROWTH FACTOR RECEPTORS
    4.
    发明申请
    ALPHABODIES SPECIFICALLY BINDING TO CYTOKINES OR GROWTH FACTORS AND/OR CYTOKINE OR GROWTH FACTOR RECEPTORS 审中-公开
    ALPHABODIES特异性结合细胞因子或生长因子和/或细胞因子或生长因子受体

    公开(公告)号：WO2012093172A1

    公开(公告)日：2012-07-12

    申请号：PCT/EP2012/050193

    申请日：2012-01-06

    Applicant: COMPLIX NV ,  LASTERS, Ignace ,  DESMET, Johan ,  HENDERIKX, Maria ,  WEHNERT, Anita ,  MEERSSEMAN, Geert

    Inventor： LASTERS, Ignace ,  DESMET, Johan ,  HENDERIKX, Maria ,  WEHNERT, Anita ,  MEERSSEMAN, Geert

    IPC: C07K16/24 ,  C07K14/00

    CPC classification number: C07K14/001 ,  C07K16/244 ,  C07K16/2866 ,  C07K2317/33 ,  C07K2318/20

    Abstract: Alphabodies that specifically bind to cytokines or growth factor and/or their receptors, as well as polypeptides that comprise or essentially consist of such Alphabodies. Further nucleic acids encoding such Alphabodies; methods for preparing such Alphabodies and polypeptides; host cells expressing or capable of expressing such Alphabodies and polypeptides; compositions, and in particular pharmaceutical compositions, that comprise such Alphabodies, polypeptides, nucleic acids and/or host cells; and uses of such Alphabodies or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes.

    Abstract translation: 与细胞因子或生长因子和/或其受体特异性结合的抗体，以及包含或基本上由此类Alphabody组成的多肽。 编码这样的阿片受体的另外的核酸; 制备此类抗体和多肽的方法; 表达或能够表达此类α受体和多肽的宿主细胞; 组合物，特别是药物组合物，其包含这样的阿片受体，多肽，核酸和/或宿主细胞; 以及这些阿拉伯抗体或多肽，核酸，宿主细胞和/或组合物的用途，特别是用于预防，治疗或诊断目的。

    METHOD FOR GENERATING INFORMATION RELATED TO THE MOLECULAR STRUCTURE OF A BIOMOLECULE
    8.
    发明申请
    METHOD FOR GENERATING INFORMATION RELATED TO THE MOLECULAR STRUCTURE OF A BIOMOLECULE 审中-公开
    用于产生与生物分子的分子结构相关的信息的方法

    公开(公告)号：WO0133438A3

    公开(公告)日：2002-03-28

    申请号：PCT/EP0010921

    申请日：2000-11-03

    Applicant: ALGONOMICS NV ,  DESMET JOHAN ,  LASTERS IGNACE ,  VLIEGHE DOMINIQUE ,  BOUTTON CARLO ,  STAS PHILIPPE ,  SPRIET JAN

    Inventor： DESMET JOHAN ,  LASTERS IGNACE ,  VLIEGHE DOMINIQUE ,  BOUTTON CARLO ,  STAS PHILIPPE ,  SPRIET JAN

    IPC: C07K1/00 ,  C40B40/06 ,  C40B40/10 ,  C40B40/12 ,  G06F17/50 ,  G06F19/16 ,  G06F19/00

    CPC classification number: G06F19/16 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/007 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00731 ,  C07K1/00 ,  C07K2299/00 ,  C40B40/06 ,  C40B40/10 ,  C40B40/12

    Abstract: A method for generating information related to the molecular structure of a biomolecule, comprising the steps of: (a) receiving a three-dimensional representation of said molecular structure, comprising a first set of residue portions and a template; and (b) modifying the representation of step (a) by at least one optimization cycle. Each optimization cycle comprises the steps of: (b1) perturbing a first representation of the molecular structure by modifying the structure of one or more of the first set of residue portions; (b2) relaxing the perturbed representation by optimizing the structure of one or more of the non-perturbed residue portions of the first set with respect to the one or more perturbed residue portions; (b3) evaluating the perturbed and relaxed representation of the molecular structure by using an energetic cost function and replacing the first representation by the perturbed and relaxed representation if the latter's global energy is more optimal than that of the first representation; and the method further comprises the steps of (c) terminating the optimization process according to step (b) when a predetermined termination criterion is reached; and (d) outputting to a storage medium or to a consecutive method a data structure comprising information extracted from step (b).

    Abstract translation: 一种用于产生与生物分子的分子结构相关的信息的方法，包括以下步骤：（a）接收所述分子结构的三维表示，包括第一组残基部分和模板; 和（b）通过至少一个优化周期来修改步骤（a）的表示。 每个优化周期包括以下步骤：（b1）通过修改第一组残留部分中的一个或多个的结构扰乱分子结构的第一表示; （b2）通过相对于一个或多个扰动残余部分优化第一组的非扰动残余部分的一个或多个的结构来放松扰动表示; （b3）通过使用能量成本函数来评估分子结构的扰动和松弛表示，并且如果后者的全局能量比第一表示更为优化，则通过扰动和轻松表示来代替第一表示; 并且所述方法还包括以下步骤：（c）当达到预定的终止标准时，终止根据步骤（b）的优化过程; 以及（d）向存储介质或连续方法输出包括从步骤（b）提取的信息的数据结构。

    ALPHABODIES SPECIFICALLY BINDING TO VIRAL PROTEINS AND METHODS FOR PRODUCING THE SAME
    9.
    发明申请
    ALPHABODIES SPECIFICALLY BINDING TO VIRAL PROTEINS AND METHODS FOR PRODUCING THE SAME 审中-公开
    特异性绑定到病毒蛋白质的方法及其生产方法

    公开(公告)号：WO2012092971A1

    公开(公告)日：2012-07-12

    申请号：PCT/EP2011/050137

    申请日：2011-01-06

    Applicant: COMPLIX NV ,  DESMET, Johan ,  LASTERS, Ignace ,  MEERSSEMAN, Geert ,  DEROO, Sabrina

    Inventor： DESMET, Johan ,  LASTERS, Ignace ,  MEERSSEMAN, Geert ,  DEROO, Sabrina

    IPC: C07K16/10 ,  C07K14/00

    CPC classification number: C07K16/08 ,  A61K39/00 ,  C07K16/1063 ,  C07K2317/92 ,  C07K2318/20 ,  G01N33/56988

    Abstract: The invention provides methods for the production of single-chain Alphabody polypeptides having detectable binding affinity for, or detectable in vitro activity on, a viral protein of interest, which comprising the step of producing a single-chain Alphabody library comprising at least 100 different-sequence single-chain Alphabody polypeptides, wherein said Alphabody polypeptides differ from each other in at least one of a defined set of 5 to 20 variegated amino acid residue positions, and wherein said variegated amino acid residue positions are located at specific positions in one or more of the alpha-helices of the Alphabody or the linker fragment connecting two consecutive alpha-helices of the Alphabody polypeptides. The invention further provides Alphabodies obtainable by the methods of the invention and uses thereof.

    Abstract translation: 本发明提供了生产具有对感兴趣的病毒蛋白质具有可检测的结合亲和力或可检测的体外活性的单链阿拉伯糖苷多肽的方法，其包括产生包含至少100个不同序列的单链Alphabody文库的步骤， 序列单链Alphabody多肽，其中所述Alphabody多肽在限定的5至20个杂化氨基酸残基位置中的至少一个中彼此不同，并且其中所述杂色氨基酸残基位置位于一个或多个 的Alphabody的α-螺旋或连接Alphabody多肽的两个连续的α-螺旋的连接子片段。 本发明还提供了可通过本发明的方法获得的阿尔培布本及其用途。

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