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    PROCESS FOR THE PRODUCTION OF SILVER-CONTAINER PROSTHETIC DEVICES
    7.
    发明申请
    PROCESS FOR THE PRODUCTION OF SILVER-CONTAINER PROSTHETIC DEVICES 审中-公开
    生产银容器前置装置的方法

    公开(公告)号：WO2006058906A1

    公开(公告)日：2006-06-08

    申请号：PCT/EP2005/056391

    申请日：2005-12-02

    Applicant: POLITECNICO DI TORINO ,  DI NUNZIO, Serena ,  VERNE', Enrica

    Inventor： DI NUNZIO, Serena ,  VERNE', Enrica

    IPC: A61L27/30 ,  A61L27/54 ,  A61F2/00 ,  B05D7/02

    CPC classification number: A61L27/306 ,  A61L27/54 ,  A61L2300/104 ,  A61L2300/404

    Abstract: The object of the invention are prosthetic devices or implants, that can release in the implant site silver ions, thus providing an antibacterial and non-cytotoxic action, and a process to prepare them. The preparation process consists in the operation of subjecting the device, which is constituted by at least a surface layer or a part of a glass, ceramic or glass-ceramic material, containing metals' ions exchangeable with silver ions, to a silver ions containing aqueous solution ion-exchange process.

    Abstract translation: 本发明的目的是假体装置或植入物，其可以在植入物位置释放银离子，从而提供抗细菌和非细胞毒作用，以及制备它们的方法。 制备方法在于将至少含有金属离子与银离子交换的玻璃，陶瓷或玻璃 - 陶瓷材料的至少一部分或陶瓷或玻璃 - 陶瓷材料构成的装置的操作， 溶液离子交换过程。

    MULTIFUNCTIONAL TITANIUM SURFACES FOR BONE INTEGRATION
    8.
    发明申请
    MULTIFUNCTIONAL TITANIUM SURFACES FOR BONE INTEGRATION 审中-公开
    用于骨融合的多功能钛铁矿表面

    公开(公告)号：WO2009047730A3

    公开(公告)日：2010-03-18

    申请号：PCT/IB2008054148

    申请日：2008-10-09

    Applicant: TORINO POLITECNICO ,  SPRIANO SILVIA ,  VERNE ENRICA ,  FERRARIS SARA

    Inventor： SPRIANO SILVIA ,  VERNE ENRICA ,  FERRARIS SARA

    IPC: A61L27/06 ,  A61L27/30 ,  A61L27/54

    CPC classification number: A61L27/06 ,  A61L27/306 ,  A61L27/54 ,  A61L2300/412 ,  A61L2400/18

    Abstract: The process for the preparation of a prosthetic device or a medical implant comprising titanium or titanium alloy, through a surface modification treatment in order to make bioactive the surface of titanium or titanium alloy, comprising the steps of: a) an acid attack for the removal of native oxide present on said the surface; and b) surface controlled oxidation in an hydrogen peroxide solution in order to expose hydroxyl groups bound on the surface; the so obtained surface, bioactive from the inorganic point of view, could be further modified in order to make it bioactive also from the biological point of view by functionalization of the surface with proteins from extracellular matrix or enzymes. This process includes surface activation with trifluoroethanesulfonyl chloride and subsequent incubation of the activated surface into a solution of the biomolecule in order to obtain a covalent grafting.

    Abstract translation: 通过表面改性处理制备包括钛或钛合金的假体装置或医疗植入物的方法，以使钛或钛合金的表面生物活性化，其包括以下步骤：a）去除酸侵蚀 存在于所述表面上的天然氧化物; 和b）在过氧化氢溶液中进行表面控制氧化，以暴露结合在表面上的羟基; 如此获得的表面，从无机的角度看，生物活性可以被进一步修饰，以便通过从细胞外基质或酶的蛋白质官能化表面而从生物角度使其具有生物活性。 该方法包括用三氟乙磺酰氯进行表面活化，随后将活化的表面孵育成生物分子的溶液以获得共价接枝。

    INJECTABLE OSTEOINDUCTIVE BONE CEMENTS
    10.
    发明申请
    INJECTABLE OSTEOINDUCTIVE BONE CEMENTS 审中-公开
    可注射的骨质疏松

    公开(公告)号：WO2011141889A1

    公开(公告)日：2011-11-17

    申请号：PCT/IB2011/052094

    申请日：2011-05-12

    Applicant: POLITECNICO DI TORINO ,  VITALE BROVARONE, Chiara ,  VERNE', Enrica ,  BERGUI, Mauro ,  ONIDA, Barbara ,  BAINO, Francesco ,  MIOLA, Marta ,  FERRARIS, Sara ,  TALLIA, Francesca

    Inventor： VITALE BROVARONE, Chiara ,  VERNE', Enrica ,  BERGUI, Mauro ,  ONIDA, Barbara ,  BAINO, Francesco ,  MIOLA, Marta ,  FERRARIS, Sara ,  TALLIA, Francesca

    IPC: A61L27/50 ,  A61L24/00 ,  A61L27/44

    CPC classification number: A61L24/0068 ,  A61L24/0063 ,  A61L27/425 ,  A61L27/427 ,  A61L27/50 ,  A61L27/54 ,  A61L2300/44 ,  A61L2400/06 ,  A61L2430/02

    Abstract: An injectable composition for bone filling or consolidation, for use in surgery or therapy, characterized in that it comprises a biocompatible powdery material, which is hardenable or cross-linkable and selected from calcium sulphate hemi-hydrate and polymethylmethacrylate, a hardening or cross-linking agent for said material and a porous silica-based powdery material, having a specific surface area higher than 100 m 2 /g, which comprises a mesoporous bioactive glass, obtainable/achievable by a sol-gel method with the addition of a surfactant as structure-directing agent for pores formation, comprising an oxide mixture containing: SiO 2 : from 60 to 85% by moles CaO: from 10 to 30% by moles P 2 O 5 : from 2 to 10% by moles said composition, when applied to an affected area of a patient, being adapted to form a composite material wherein said hardenable or cross-linkable material constitutes a matrix and said mesoporous bioactive glass constitutes a dispersed phase in said matrix.

    Abstract translation: 一种用于手术或治疗的用于骨填充或固结的可注射组合物，其特征在于其包含可硬化或可交联并且选自硫酸钙半水合物和聚甲基丙烯酸甲酯的生物相容性粉末材料，硬化或交联 所述材料的试剂和比表面积高于100m 2 / g的多孔二氧化硅基粉末材料，其包含可通过溶胶 - 凝胶法获得/可实现的介孔生物活性玻璃，通过添加表面活性剂作为结构 - 包含氧化物混合物，其包含：SiO 2：60至85摩尔％CaO：10至30摩尔％P 2 O 5：所述组合物的2至10摩尔％当施用于 患者，适于形成复合材料，其中所述可硬化或可交联材料构成基质，所述介孔生物活性玻璃在所述基质中构成分散相。

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