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1.发明申请
公开(公告)号：WO2023018758A1
公开(公告)日：2023-02-16
申请号：PCT/US2022/039899
申请日：2022-08-10
摘要： Sputtering machines and substrate holders for such systems are described which include one or more magnets apart from the magnets typical of sputtering guns. The added magnets produce a magnetic field bias which is a new means for controlling depositional flux, ionization degree of a sputtered species, and microstructure properties of deposited coatings. An exemplary substrate holder may have a magnet or magnet array near or next to the surface supporting the substrate, and the magnet may assume multiple different magnetic field configurations depending on the desired properties of the resulting magnetic field bias within the reaction chamber.
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公开(公告)号：WO2022173823A1
公开(公告)日：2022-08-18
申请号：PCT/US2022/015810
申请日：2022-02-09
发明人： CLARK, Gene, Chatman , MEZZAROMA, Eleonora , RABENDER, Christopher , MIKKELSEN, Ross, B. , YAKOVLEV, Vasily , SMITH, Neil
IPC分类号： A61K31/519 , A61P11/00 , A61P31/12
摘要： The invention features methods of treating a SARS-CoV-2 infection in a subject, the method comprising administering to the subject an effective amount of sepiapterin or a pharmaceutically acceptable salt thereof.
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公开(公告)号：WO2022170017A1
公开(公告)日：2022-08-11
申请号：PCT/US2022/015181
申请日：2022-02-04
发明人： GERK, Phillip
摘要： Ursolic acid (UA) preparations and a self-nanoemulsifying drug delivery system (SNEDDS) composition containing at least one UA preparation selected from monopotassium ursolate (UAK), dipotassium ursolate (UAK2), monocholine ursolate (UAmC), dicholine ursolate (UAdC), pharmacological salts thereof, and mixtures thereof are provided. Methods for synthesizing UA preparations and delivering UA preparations to subjects in need thereof are also provided.
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公开(公告)号：WO2022159170A1
公开(公告)日：2022-07-28
申请号：PCT/US2021/060524
申请日：2021-11-23
摘要： A combined flossing and interproximal brushing dental device, comprising: a handle having a proximal end and a distal end, wherein the proximal end is configured to be held by a user; a first arm; a second arm; dental floss engaging members positioned at or towards a free end of the first arm and at or towards a free end of the second arm, wherein said first arm and said second arm are spaced apart on the handle and the dental floss engaging members are configured to hold dental floss, extending between the first arm and the second arm; and an interproximal brush forming all or a part of the first arm.
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公开(公告)号：WO2022098528A1
公开(公告)日：2022-05-12
申请号：PCT/US2021/056434
申请日：2021-10-25
发明人： WANG, Weining , ZHU, Zan , XU, Ping
摘要： A filter having antibacterial activity is provided. The filter comprises at least one layer of polymer nanofibers and antibacterial particles positioned on or within the at least one layer of polymer nanofibers, wherein the antibacterial particles comprise a quaternary ammonium compound grafted onto a surface of a metal-organic framework. Methods of manufacturing the filter and decontaminating a fluid are also provided.
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公开(公告)号：WO2022056357A1
公开(公告)日：2022-03-17
申请号：PCT/US2021/050021
申请日：2021-09-13
IPC分类号： A41D13/11 , A41D13/005 , A41D31/06
摘要： A self-cleaning face covering is provided. The face covering includes a fabric layer having a resisitive heating element disposed on the fabric; and an infrared reflective layer arranged between the fabric layer and an inner surface of the face covering configured to reduce heat transfer to the inner surface. Methods of cleaning the face covering are also provided.
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7.发明申请
公开(公告)号：WO2021263180A1
公开(公告)日：2021-12-30
申请号：PCT/US2021/039207
申请日：2021-06-25
申请人： DURECT CORPORATION , VIRGINIA COMMONWEALTH UNIVERSITY , THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF VETERANS AFFAIRS
发明人： REN, Shunlin , WANG, Yaping , LIN, WeiQi
IPC分类号： A61K8/738 , A61K31/565 , A61K31/575 , A61K31/724
摘要： Aspects of the present disclosure include methods for treating at least one of cancer and non-cancerous transformation related to Epstein-Barr virus, such as at least one of Hodgkin's lymphoma, soft tissue sarcoma, leiomyosarcoma, nasopharyngeal carcinoma, Burkitt's lymphoma, T-cell lymphoma, gastric carcinoma, invasive breast cancer, and hierarchically organized carcinoma. Hierarchically organized carcinomas include, but are not limited to, pancreatic ductal adenocarcinoma, urothelial cancer, colorectal cancer, head and neck cancer, non-small cell lung cancer, esophagus cancer, breast cancer, thyroid cancer, oral cancer, cervical cancer, ovarian cancer, and liver cancer. In practicing the subject methods, an effective amount of at least one compound selected from 25-hydroxycholesterol-3-sulfate (25HC3S), 25-hydroxycholesterol-disulfate (25HCDS), 27-hydroxycholesterol-3-sulfate (27HC3S), 27-hydroxycholesterol-disulfate (27HCDS), 24-hydroxycholesterol-3-sulfate (24HC3S), 24-hydroxycholesterol-disulfate (24HCDS), and 24,25-epoxycholesterol-3-sulfate, or salt thereof is administered to the subject.
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公开(公告)号：WO2021206932A1
公开(公告)日：2021-10-14
申请号：PCT/US2021/024319
申请日：2021-03-26
发明人： PETERS, Michael, H.
IPC分类号： C07K14/705 , C07K14/00 , C07K14/165 , A61P31/14
摘要： Antiviral peptides having sequence identity to a portion of ACE2 are provided. The peptides are useful for inhibiting coronavirus particle attachment to cells and thus are used for the treatment of coronavirus infections.
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公开(公告)号：WO2021050629A1
公开(公告)日：2021-03-18
申请号：PCT/US2020/050050
申请日：2020-09-10
IPC分类号： A61K31/7068 , A61K47/30 , A61K9/14 , A61P35/00
摘要： Polymeric drugs for disease therapy are provided. The repeat units of the polymers comprise at least one chemotherapeutic agent, e.g. a cancer drug. The linkages between repeat units are hydrolysable under physiological conditions, e.g. at targeted sites in vivo. Nanoparticles formed from the polymers are also provided.
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10.发明申请
公开(公告)号：WO2020264070A1
公开(公告)日：2020-12-30
申请号：PCT/US2020/039485
申请日：2020-06-25
发明人： BERTINO, Massimo , SELDEN, Tyler
摘要： Drying polar solvents which do not form hydrogen bonds with a wet gel or aerogel, or eutectics or solvent mixtures with the drying solvents, are utilized in a solvent exchange with wet gels used in the formation of aerogels. Preferably the drying solvents are non-polar solvents. The drying solvent or solvent mixtures results in profoundly less shrinkage, thereby allowing for the production of aerogels of preferred materials properties.
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