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    AN APPARATUS FOR DRIVE CONTROL, POWER CONVERSION, AND START-UP CONTROL
    1.
    发明申请
    AN APPARATUS FOR DRIVE CONTROL, POWER CONVERSION, AND START-UP CONTROL 审中-公开
    用于驱动控制，功率转换和启动控制的装置

    公开(公告)号：WO2003100958A1

    公开(公告)日：2003-12-04

    申请号：PCT/US2003/016630

    申请日：2003-05-27

    Applicant: VIRGINIA TECH INTELLECTUAL PROPERTY, INC. ,  RAMU, Krishnan

    Inventor： RAMU, Krishnan

    IPC: H02P5/00

    CPC classification number: H02K19/103 ,  H02K1/24 ,  H02K7/09 ,  H02K16/00 ,  H02K16/04 ,  H02K17/00 ,  H02K21/12 ,  H02M2001/009 ,  H02M2003/1552 ,  H02M2003/1555 ,  H02P1/163 ,  H02P1/18 ,  H02P6/21 ,  H02P25/034 ,  H02P25/089 ,  H02P25/092 ,  H02P2201/09

    Abstract: A power converter for a switched reluctance motor (SRM) or a permanent magnet brushless direct current (dc) motor (PMBDCM) that includes a front-end boost partial circuit (551) for connecting with a first phase winding of the motor (552) to form a front-end boost circuit (553) and a back-end boost partial circuit (554) for connecting with a second phase winding of the motor (555) to form a back-end boost circuit (554). The front-end boost partial circuit (551) generates a first step-up voltage in cooperation with the inductance provided by the first phase winding (552). The back-end boost partial circuit (554) generates a second step-up voltage in cooperation with the inductance provided by the second phase winding (555).

    Abstract translation: 一种用于开关磁阻电动机（SRM）或永磁无刷直流（dc）电动机（PMBDCM）的电力转换器，其包括用于与电动机（552）的第一相绕组连接的前端升压部分回路（551） 以形成用于与电动机（555）的第二相绕组连接以形成后端升压电路（554）的前端升压电路（553）和后端升压部分电路（554）。 前端升压部分电路（551）与由第一相绕组（552）提供的电感协调生成第一升压电压。 后端升压部分电路（554）与由第二相绕组（555）提供的电感协调生成第二升压电压。

    PRODUCTION OF LYSOSOMAL ENZYMES IN PLANT-BASED EXPRESSION SYSTEMS
    2.
    发明申请
    PRODUCTION OF LYSOSOMAL ENZYMES IN PLANT-BASED EXPRESSION SYSTEMS 审中-公开
    在基于植物的表达系统中生产菌体酶

    公开(公告)号：WO1997010353A1

    公开(公告)日：1997-03-20

    申请号：PCT/US1996014730

    申请日：1996-09-13

    Applicant: VIRGINIA TECH INTELLECTUAL PROPERTY, INC. ,  CROPTECH DEVELOPMENT CORPORATION

    Inventor： VIRGINIA TECH INTELLECTUAL PROPERTY, INC. ,  CROPTECH DEVELOPMENT CORPORATION ,  RADIN, David, N. ,  CRAMER, Carole, L. ,  OISHI, Karen, K. ,  WEISSENBORN, Deborah, L.

    IPC: C12P21/06

    CPC classification number: C12Y302/01045 ,  A61K38/00 ,  C12N9/2402 ,  C12N15/8237 ,  C12N15/8257 ,  C12Y302/01018 ,  C12Y302/01022 ,  C12Y302/01024 ,  C12Y302/01049 ,  C12Y302/01076

    Abstract: The invention relates to the production of enzymatically active recombinant human and animal lysosomal enzymes involving construction and expression of recombinant expression constructs comprising coding sequences of human or animal lysosomal enzymes in a plant expression system. The plant expression system provides for post-translational modification and processing to produce a recombinant gene product exhibiting enzymatic activity. The invention is demonstrated by working examples in which transgenic tobacco plants having recombinant expression constructs comprising human hGC and IDUA nucleotide sequences produces enzymatically active modified human glucocerebrosidase and human alpha -L-iduronidase. The recombinant lysosomal enzymes produced in accordance with the invention may be used for a variety of purposes, including but not limited to enzyme replacement therapy for the therapeutic treatment of human and animal lysosomal storage diseases.

    Abstract translation: 本发明涉及酶活性重组人和动物溶酶体酶的生产，其涉及重组表达构建体的构建和表达，其包含在植物表达系统中编码人或动物溶酶体酶的序列。 植物表达系统提供翻译后修饰和加工以产生显示酶活性的重组基因产物。 本发明通过其中具有包含人hGC和IDUA核苷酸序列的重组表达构建体的转基因烟草植物产生酶促活性修饰的人类葡糖脑苷脂酶和人α-L-胆碱苷酶的实施例来证明。 根据本发明生产的重组溶酶体酶可用于多种目的，包括但不限于用于治疗性治疗人和动物溶酶体贮积病的酶替代疗法。

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