利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

10 条记录 (耗时 0.024 秒)

    STEM-LOOP COMPOSITIONS AND METHODS FOR INHIBITING INTERLEUKIN-8
    2.
    发明申请
    STEM-LOOP COMPOSITIONS AND METHODS FOR INHIBITING INTERLEUKIN-8 审中-公开

    公开(公告)号：WO2019222344A1

    公开(公告)日：2019-11-21

    申请号：PCT/US2019/032411

    申请日：2019-05-15

    申请人： VITRISA THERAPEUTICS, INC.

    发明人： ERICKSON, Carl ,  RUSCONI, Christopher P. ,  BHOWMICK, Arijit ,  LEVY, Matthew ,  WALKER, Matthew ,  MCLURE, Kevin G.

    IPC分类号： C12N15/115 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/712

    摘要： The application discloses methods and compositions for inhibiting functions associated with Interleukin-8 (IL8). The methods and compositions may involve the use of aptamers for binding to IL8 and preventing or reducing association of IL8 with CXCR1, CXCR2, or both. The methods and compositions may include one or more aptamers that bind to an N-terminal domain of IL8. The methods and compositions may include one or more aptamers that bind to a hydrophobic pocket of IL8. The methods and compositions may include one or more aptamers that bind to an N-loop of IL8. The methods and compositions may include one or more aptamers that bind to a GAG binding site of IL8. The application further provides anti-IL8 aptamers for the treatment of ocular diseases or disorders. In some cases, the anti-IL8 aptamers may have a stem-loop secondary structure.

    METHODS FOR IMPROVED APTAMER SELECTION
    3.
    发明申请
    METHODS FOR IMPROVED APTAMER SELECTION 审中-公开
    改进APTAMER选择的方法

    公开(公告)号：WO2017127762A1

    公开(公告)日：2017-07-27

    申请号：PCT/US2017/014459

    申请日：2017-01-20

    申请人： VITRISA THERAPEUTICS, INC.

    发明人： ERICKSON, Carl ,  RUSCONI, Christopher, P.

    IPC分类号： C12N15/10 ,  C12N15/115

    CPC分类号： C12N15/1048 ,  C12N15/111 ,  C12N2320/13

    摘要： Methods are provided herein for generating and selecting aptamers. The aptamers can be suitable as therapeutic aptamers for the treatment of a disease or disorder. The methods provided may improve the efficiency and/or effectiveness of generating a therapeutic aptamer over traditional methods. The methods may generally involve selective pressure including competitive elution to generate aptamers that specifically bind to therapeutically-relevant epitopes and have a desired mechanism of action.

    摘要翻译： 本文提供了用于产生和选择适体的方法。 适体可适合作为用于治疗疾病或病症的治疗适体。 所提供的方法可以提高产生治疗适体超过传统方法的效率和/或有效性。 所述方法通常可以包括选择性压力，包括竞争性洗脱以产生特异性结合治疗相关表位并具有期望的作用机制的适体。

    COMPOSITIONS AND METHODS FOR INHIBITING FACTOR D
    4.
    发明申请
    COMPOSITIONS AND METHODS FOR INHIBITING FACTOR D 审中-公开
    用于抑制因子的组合物和方法D

    公开(公告)号：WO2017127761A1

    公开(公告)日：2017-07-27

    申请号：PCT/US2017/014458

    申请日：2017-01-20

    申请人： VITRISA THERAPEUTICS, INC.

    发明人： ERICKSON, Carl ,  RUSCONI, Christopher P. ,  MCLURE, Kevin G.

    IPC分类号： C12N15/115 ,  A61K31/7088

    CPC分类号： C12N15/115 ,  A61K31/7105 ,  C12N2310/16

    摘要： The application discloses methods and compositions for the inhibition of the alternative complement pathway. The methods and compositions involve the use of aptamers for inhibiting complement Factor D. The application further provides anti-Factor D aptamers for the treatment of dry age-related macular degeneration, geographic atrophy, wet age-related macular degeneration or Stargardt disease.

    摘要翻译： 本申请公开了用于抑制替代补体途径的方法和组合物。 该方法和组合物涉及使用适体来抑制补体因子D.本申请还提供了用于治疗干性年龄相关性黄斑变性，地理萎缩，湿性年龄相关性黄斑变性或斯塔加特病的抗因子D适体。 p>