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1.发明申请GENERATION OF CLONAL MESENCHYMAL PROGENITORS AND MESENCHYMAL STEM CELL LINES UNDER SERUM-FREE CONDITIONS 审中-公开无血清条件下克隆子宫肌细胞先天细胞和间充质干细胞系的生成
公开(公告)号：WO2011116117A2
公开(公告)日：2011-09-22
申请号：PCT/US2011/028700
申请日：2011-03-16
Inventor： VODYANYK, Maksym, A. , SLUKVIN, Igor, I.
IPC: C12N5/0775 , C12N5/0789 , C12N5/071 , C12N5/074
CPC classification number: C12N5/0662 , C12N5/0647 , C12N5/069 , C12N5/0692 , C12N2500/38 , C12N2500/44 , C12N2500/90 , C12N2501/115 , C12N2501/125 , C12N2501/135 , C12N2501/145 , C12N2501/155 , C12N2501/165 , C12N2501/23 , C12N2502/1394 , C12N2506/02 , C12N2506/45 , C12N2533/54 , C12N2533/70 , C12N2533/78
Abstract: Methods for obtaining multipotent Apelin receptor-positive lateral plate mesoderm cells, mesenchymal stem cells, and mesangioblasts under serum-free conditions are disclosed.
Abstract translation: 公开了在无血清条件下获得多能Apelin受体阳性侧板中胚层细胞，间充质干细胞和中成血管细胞的方法。
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公开(公告)号：WO2012006440A2
公开(公告)日：2012-01-12
申请号：PCT/US2011/043218
申请日：2011-07-07
Applicant: CELLULAR DYNAMICS INTERNATIONAL, INC. , YU, Junying , VODYANYK, Maksym, A.
Inventor： YU, Junying , VODYANYK, Maksym, A.
CPC classification number: C12N15/85 , C12N5/069 , C12N5/0692 , C12N2501/40 , C12N2506/02 , C12N2506/45 , G01N33/5064 , G01N2500/10
Abstract: The invention generally regards methods for providing endothelial cells and precursors of endothelial cells from a variety of cell sources, such as pluripotent stem cells. Also provided are therapeutic compositions including the provided endothelial cells, and methods of using them for the treatment of subjects.
Abstract translation: 本发明通常涉及从多种细胞来源（例如多能干细胞）提供内皮细胞和内皮细胞前体的方法。 还提供包括所提供的内皮细胞的治疗组合物，以及使用它们来治疗受试者的方法。
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3.发明申请ERYTHROID CELLS PRODUCING ADULT-TYPE ß-HEMOGLOBIN GENERATED FROM HUMAN EMBRYONIC STEM CELLS 审中-公开从人胚胎干细胞中产生成人型β-血红蛋白的红细胞
公开(公告)号：WO2007095064A3
公开(公告)日：2007-12-27
申请号：PCT/US2007003417
申请日：2007-02-08
Applicant: WISCONSIN ALUMNI RES FOUND , THOMSON JAMES A , GUMENYUK MARYNA E , SLUKVIN IGOR I , VODYANYK MAKSYM A
Inventor： THOMSON JAMES A , GUMENYUK MARYNA E , SLUKVIN IGOR I , VODYANYK MAKSYM A
IPC: C12N5/078
CPC classification number: C12N5/0641 , C12N2500/25 , C12N2501/125 , C12N2501/14 , C12N2501/145 , C12N2501/23 , C12N2501/39 , C12N2502/1394 , C12N2506/02
Abstract: Methods and compositions of erythroid cells that produce adult ß-hemoglobin, generated by culturing CD31+, CD31+/CD34+ or CD34+ cells from embryonic stem cells under serum-free culture conditions.
Abstract translation: 通过在无血清培养条件下培养来自胚胎干细胞的CD31 +，CD31 + / CD34 +或CD34 +细胞产生成熟的β-血红蛋白的红细胞系的方法和组合物。
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公开(公告)号：WO2012006440A3
公开(公告)日：2012-04-05
申请号：PCT/US2011043218
申请日：2011-07-07
Applicant: CELLULAR DYNAMICS INT INC , YU JUNYING , VODYANYK MAKSYM A
Inventor： YU JUNYING , VODYANYK MAKSYM A
CPC classification number: C12N15/85 , C12N5/069 , C12N5/0692 , C12N2501/40 , C12N2506/02 , C12N2506/45 , G01N33/5064 , G01N2500/10
Abstract: The invention generally regards methods for providing endothelial cells and precursors of endothelial cells from a variety of cell sources, such as pluripotent stem cells. Also provided are therapeutic compositions including the provided endothelial cells, and methods of using them for the treatment of subjects.
Abstract translation: 本发明一般涉及提供来自多种细胞来源如多能干细胞的内皮细胞和内皮细胞前体的方法。 还提供了包括所提供的内皮细胞的治疗组合物，以及使用它们治疗受试者的方法。
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公开(公告)号：WO2011130402A3
公开(公告)日：2012-02-02
申请号：PCT/US2011032309
申请日：2011-04-13
Applicant: CELLULAR DYNAMICS INT INC , YU JUNYING , CHAU FONGCHING KEVIN , JIANG JINLAN , JIANG YONG , VODYANYK MAKSYM A
Inventor： YU JUNYING , CHAU FONGCHING KEVIN , JIANG JINLAN , JIANG YONG , VODYANYK MAKSYM A
IPC: C12N5/0735
CPC classification number: C12N15/85 , A61K35/407 , C12N5/067 , C12N2501/12 , C12N2501/237 , C12N2501/60 , C12N2506/02 , C12N2506/45 , G01N33/5067
Abstract: The invention generally features methods for providing hepatocytes from a variety of cell sources, particularly pluripotent stem cells, therapeutic compositions featuring such cells, and methods of using them for the treatment of subjects.
Abstract translation: 本发明通常具有用于从各种细胞来源，特别是多能干细胞，特征在于这种细胞的治疗组合物提供肝细胞的方法，以及使用它们来治疗受试者的方法。
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Patent Agency Ranking6.发明申请GENERATION OF CLONAL MESENCHYMAL PROGENITORS AND MESENCHYMAL STEM CELL LINES UNDER SERUM-FREE CONDITIONS 审中-公开在无血清条件下产生骨髓间充质干细胞和细胞干细胞细胞系
公开(公告)号：WO2011116117A3
公开(公告)日：2011-11-10
申请号：PCT/US2011028700
申请日：2011-03-16
Applicant: WISCONSIN ALUMNI RES FOUND , VODYANYK MAKSYM A , SLUKVIN IGOR I
Inventor： VODYANYK MAKSYM A , SLUKVIN IGOR I
IPC: C12N5/0775 , C12N5/071 , C12N5/074 , C12N5/0789
CPC classification number: C12N5/0662 , C12N5/0647 , C12N5/069 , C12N5/0692 , C12N2500/38 , C12N2500/44 , C12N2500/90 , C12N2501/115 , C12N2501/125 , C12N2501/135 , C12N2501/145 , C12N2501/155 , C12N2501/165 , C12N2501/23 , C12N2502/1394 , C12N2506/02 , C12N2506/45 , C12N2533/54 , C12N2533/70 , C12N2533/78
Abstract: Methods for obtaining multipotent Apelin receptor-positive lateral plate mesoderm cells, mesenchymal stem cells, and mesangioblasts under serum-free conditions are disclosed.
Abstract translation: 公开了在无血清条件下获得多能Apelin受体阳性外侧板中胚层细胞，间充质干细胞和成血管细胞的方法。
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公开(公告)号：WO2006130651A3
公开(公告)日：2007-03-29
申请号：PCT/US2006021054
申请日：2006-05-31
Applicant: WISCONSIN ALUMNI RES FOUND , SLUKVIN IGOR I , THOMSON JAMES A , VODYANYK MAKSYM A , GUMENYUK MARYNA E
Inventor： SLUKVIN IGOR I , THOMSON JAMES A , VODYANYK MAKSYM A , GUMENYUK MARYNA E
IPC: C12N5/0784
CPC classification number: C12N5/0639 , C12N5/064 , C12N2506/02
Abstract: This invention relates to the culture of dendritic cells from human embryonic stem (ES) cells. Human ES cells are first cultured into hematopoietic cells by co-culture with stromal cells. The cells now differentiated into the hematopoietic lineage are then cultured with GM-CSF to create a culture of myeloid precursor cells. Culture of the myeloid precursor cells with the cytokines GM-CSF and IL-4 causes functional dendritic cells to be generated. The dendritic cells have a unique phenotype, as indicated by their combination of cell surface markers.
Abstract translation: 本发明涉及来自人胚胎干（ES）细胞的树突状细胞的培养。 首先通过与基质细胞共培养将人类ES细胞培养成造血细胞。 然后将分化成造血谱系的细胞与GM-CSF一起培养以产生骨髓前体细胞的培养物。 用细胞因子GM-CSF和IL-4培养骨髓前体细胞会导致产生功能性树突状细胞。 树突细胞具有独特的表型，如细胞表面标志物的组合所示。
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公开(公告)号：WO2012109208A3
公开(公告)日：2012-10-11
申请号：PCT/US2012024098
申请日：2012-02-07
Applicant: CELLULAR DYNAMICS INT INC , YU JUNYING , VODYANYK MAKSYM A
Inventor： YU JUNYING , VODYANYK MAKSYM A
CPC classification number: C12N5/0647 , A61K35/28 , C12N2501/60 , C12N2501/999 , C12N2506/02 , C12N2506/45 , C12N2510/00
Abstract: The invention generally regards methods for providing ematopoietic cells and precursors of hematopoietic cells from a variety of cell sources, such as pluripotent stem cells or somatic cells. Also provided are therapeutic compositions including the provided hematopoietic cells and precursors of hematopoietic cells, and methods of using such for the treatment of subjects.
Abstract translation: 本发明总体上涉及从多种细胞来源例如多能干细胞或体细胞提供造血细胞和造血细胞的前体的方法。 还提供了包括所提供的造血细胞和造血细胞的前体的治疗组合物，以及用于治疗受试者的方法。
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公开(公告)号：WO2012109208A2
公开(公告)日：2012-08-16
申请号：PCT/US2012/024098
申请日：2012-02-07
Applicant: CELLULAR DYNAMICS INTERNATIONAL, INC. , YU, Junying , VODYANYK, Maksym, A.
Inventor： YU, Junying , VODYANYK, Maksym, A.
CPC classification number: C12N5/0647 , A61K35/28 , C12N2501/60 , C12N2501/999 , C12N2506/02 , C12N2506/45 , C12N2510/00
Abstract: The invention generally regards methods for providing ematopoietic cells and precursors of hematopoietic cells from a variety of cell sources, such as pluripotent stem cells or somatic cells. Also provided are therapeutic compositions including the provided hematopoietic cells and precursors of hematopoietic cells, and methods of using such for the treatment of subjects.
Abstract translation: 本发明通常涉及用于从多种细胞来源例如多能干细胞或体细胞提供造血细胞和造血细胞前体的方法。 还提供了治疗组合物，包括所提供的造血细胞和造血细胞的前体，以及用于治疗受试者的方法。
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公开(公告)号：WO2011130402A2
公开(公告)日：2011-10-20
申请号：PCT/US2011/032309
申请日：2011-04-13
Applicant: CELLULAR DYNAMICS INTERNATIONAL, INC. , YU, Junying , CHAU, Fongching, Kevin , JIANG, Jinlan , JIANG, Yong , VODYANYK, Maksym, A.
Inventor： YU, Junying , CHAU, Fongching, Kevin , JIANG, Jinlan , JIANG, Yong , VODYANYK, Maksym, A.
IPC: C12N5/0735
CPC classification number: C12N15/85 , A61K35/407 , C12N5/067 , C12N2501/12 , C12N2501/237 , C12N2501/60 , C12N2506/02 , C12N2506/45 , G01N33/5067
Abstract: The invention generally features methods for providing hepatocytes from a variety of cell sources, particularly pluripotent stem cells, therapeutic compositions featuring such cells, and methods of using them for the treatment of subjects.
Abstract translation: 本发明通常具有从各种细胞来源，特别是多能干细胞，特征为这种细胞的治疗组合物提供肝细胞的方法，以及使用它们用于治疗受试者的方法。
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