公开(公告)号：WO2012006440A3

公开(公告)日：2012-04-05

申请号：PCT/US2011043218

申请日：2011-07-07

Applicant: CELLULAR DYNAMICS INT INC ,  YU JUNYING ,  VODYANYK MAKSYM A

Inventor： YU JUNYING ,  VODYANYK MAKSYM A

IPC: C12N5/071 ,  A61K35/12 ,  A61P7/06 ,  A61P9/00 ,  C12N5/10 ,  C12N15/12

CPC classification number: C12N15/85 ,  C12N5/069 ,  C12N5/0692 ,  C12N2501/40 ,  C12N2506/02 ,  C12N2506/45 ,  G01N33/5064 ,  G01N2500/10

Abstract: The invention generally regards methods for providing endothelial cells and precursors of endothelial cells from a variety of cell sources, such as pluripotent stem cells. Also provided are therapeutic compositions including the provided endothelial cells, and methods of using them for the treatment of subjects.

Abstract translation: 本发明一般涉及提供来自多种细胞来源如多能干细胞的内皮细胞和内皮细胞前体的方法。 还提供了包括所提供的内皮细胞的治疗组合物，以及使用它们治疗受试者的方法。

公开(公告)号：WO2011130402A3

公开(公告)日：2012-02-02

申请号：PCT/US2011032309

申请日：2011-04-13

Applicant: CELLULAR DYNAMICS INT INC ,  YU JUNYING ,  CHAU FONGCHING KEVIN ,  JIANG JINLAN ,  JIANG YONG ,  VODYANYK MAKSYM A

Inventor： YU JUNYING ,  CHAU FONGCHING KEVIN ,  JIANG JINLAN ,  JIANG YONG ,  VODYANYK MAKSYM A

IPC: C12N5/0735

CPC classification number: C12N15/85 ,  A61K35/407 ,  C12N5/067 ,  C12N2501/12 ,  C12N2501/237 ,  C12N2501/60 ,  C12N2506/02 ,  C12N2506/45 ,  G01N33/5067

Abstract: The invention generally features methods for providing hepatocytes from a variety of cell sources, particularly pluripotent stem cells, therapeutic compositions featuring such cells, and methods of using them for the treatment of subjects.

Abstract translation: 本发明通常具有用于从各种细胞来源，特别是多能干细胞，特征在于这种细胞的治疗组合物提供肝细胞的方法，以及使用它们来治疗受试者的方法。

公开(公告)号：WO2012109208A3

公开(公告)日：2012-10-11

申请号：PCT/US2012024098

申请日：2012-02-07

Applicant: CELLULAR DYNAMICS INT INC ,  YU JUNYING ,  VODYANYK MAKSYM A

Inventor： YU JUNYING ,  VODYANYK MAKSYM A

IPC: C12N5/074 ,  A61K35/12 ,  C12N5/02 ,  C12N5/10 ,  C12N15/63

CPC classification number: C12N5/0647 ,  A61K35/28 ,  C12N2501/60 ,  C12N2501/999 ,  C12N2506/02 ,  C12N2506/45 ,  C12N2510/00

Abstract: The invention generally regards methods for providing ematopoietic cells and precursors of hematopoietic cells from a variety of cell sources, such as pluripotent stem cells or somatic cells. Also provided are therapeutic compositions including the provided hematopoietic cells and precursors of hematopoietic cells, and methods of using such for the treatment of subjects.

Abstract translation: 本发明总体上涉及从多种细胞来源例如多能干细胞或体细胞提供造血细胞和造血细胞的前体的方法。 还提供了包括所提供的造血细胞和造血细胞的前体的治疗组合物，以及用于治疗受试者的方法。

公开(公告)号：WO2011056971A3

公开(公告)日：2011-09-22

申请号：PCT/US2010055444

申请日：2010-11-04

Applicant: CELLULAR DYNAMICS INT INC ,  YU JUNYING

Inventor： YU JUNYING

IPC: C12N5/074 ,  C12N5/02 ,  C12N15/85

CPC classification number: C12N5/0696 ,  A61K35/545 ,  C12N2501/10 ,  C12N2501/115 ,  C12N2501/15 ,  C12N2501/235 ,  C12N2501/60 ,  C12N2501/70 ,  C12N2510/00 ,  C12N2533/52

Abstract: Methods and composition of induction of pluripotent stem cells are disclosed. For example, in certain aspects methods for generating essentially vector-free induced pluripotent stem cells with cell signaling regulators are described. Furthermore, certain aspects of the invention provide novel compositions comprising induced pluripotent stem cells essentially free of exogenous retroviral vector elements in the presence of a medium comprising signaling inhibitors. In certain aspects, feeder-free episomal reprogramming methods may be provided.

Abstract translation: 公开了多能干细胞的诱导方法和组成。 例如，在某些方面，描述了用细胞信号调节剂产生基本上无载体的诱导多能干细胞的方法。 此外，本发明的某些方面提供了包含在包含信号传导抑制剂的培养基存在下基本上不含外源性逆转录病毒载体元件的诱导多能干细胞的新型组合物。 在某些方面，可以提供无饲料的游离重编程方法。

公开(公告)号：WO2016061071A8

公开(公告)日：2016-05-26

申请号：PCT/US2015055284

申请日：2015-10-13

Applicant: CELLULAR DYNAMICS INT INC

Inventor： YU JUNYING ,  ZHANG YING ,  HARMS LISA

IPC: C12N5/071

CPC classification number: C12N5/063 ,  A61K35/36 ,  C12N2500/38 ,  C12N2500/90 ,  C12N2501/01 ,  C12N2501/11 ,  C12N2501/113 ,  C12N2501/15 ,  C12N2501/155 ,  C12N2501/165 ,  C12N2501/33 ,  C12N2501/385 ,  C12N2501/998 ,  C12N2501/999 ,  C12N2506/02 ,  C12N2506/45 ,  C12N2533/52 ,  G01N33/5073

Abstract: Provided herein are methods for the generation of functional keratinocyte stem cells that are differentiated directly from human ESCs/iPSCs in a chemically defined serum-free cell culture system, as well as cells derived therefrom and methods of use thereof. Also provided are methods for culturing primary keratinocytes.

Abstract translation: 本文提供了用于产生在化学上限定的无血清细胞培养系统中直接与人ESCs / iPSC分化的功能性角化细胞干细胞的方法，以及由其衍生的细胞及其使用方法。 还提供了培养原代角质形成细胞的方法。

公开(公告)号：WO2008118820A2

公开(公告)日：2008-10-02

申请号：PCT/US2008057924

申请日：2008-03-21

Applicant: WISCONSIN ALUMNI RES FOUND ,  THOMSON JAMES ,  YU JUNYING

Inventor： THOMSON JAMES ,  YU JUNYING

IPC: C12N5/074

CPC classification number: C12N5/0607 ,  C12N5/0606 ,  C12N5/0696 ,  C12N2501/60 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/605 ,  C12N2501/606 ,  C12N2501/608 ,  C12N2502/99 ,  C12N2510/00 ,  C12N2799/027

Abstract: The present invention relates to methods for reprogramming a somatic cell to pluripotency by administering into the somatic cell at least one or a plurality of potency- determining factors. The invention also relates to pluripotent cell populations obtained using a reprogramming method.

Abstract translation: 本发明涉及通过向体细胞施用至少一种或多种效力决定因素来将体细胞重编程为多能性的方法。 本发明还涉及使用重编程方法获得的多能细胞群。