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公开(公告)号：WO2012099805A2
公开(公告)日：2012-07-26
申请号：PCT/US2012021402
申请日：2012-01-16
Applicant: OCEAN NANOTECH LLC , AGUILAR ZORAIDA , WANG YONGQIANG , XU HENGYI , HUI GEORGE , PUSIC KAE , UNIV HAWAII
Inventor： AGUILAR ZORAIDA , WANG YONGQIANG , XU HENGYI , HUI GEORGE , PUSIC KAE
CPC classification number: A61K39/39 , A61K9/0019 , A61K9/5176 , A61K39/015 , A61K47/6923 , A61K47/6929 , A61K2039/505 , A61K2039/55555 , A61K2039/55566 , C07K16/205 , C07K2317/73 , C12N2799/026
Abstract: A nanoparticle-based delivery system and methods for its use are disclosed. In one aspect, a nanoparticle-based delivery system comprising at least one molecule such as proteins, DNA/RNA or fragments thereof, carbohydrates, enzymes, chemicals, virus cells, bacteria, parts of a virus, parts of a bacteria, parts of a cell, part of a tissue, or a combination of one or more of these, which shall be referred to as immunogens, are chemically or physically combined with water soluble nanoparticles which, when administered to a living system, is capable of eliciting a desired immunological response More particularly, the invention relates to nanoparticle-based delivery systems that are specifically engineered to enhance humoral or cellular immune response without the use of adjuvants.
Abstract translation: 公开了一种基于纳米颗粒的递送系统及其使用方法。 一方面，包含至少一种分子如蛋白质，DNA / RNA或其片段，碳水化合物，酶，化学物质，病毒细胞，细菌，部分病毒，部分细菌的纳米粒子递送系统 细胞，组织的一部分或这些中的一种或多种的组合，其称为免疫原，与水溶性纳米颗粒化学或物理组合，当其施用于活体系时，能够引发所需的免疫学 反应更具体地，本发明涉及专门设计用于在不使用佐剂的情况下增强体液或细胞免疫应答的基于纳米颗粒的递送系统。
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2.发明申请MONODISPERSE CORE/SHELL AND OTHER COMPLEX STRUCTURED NANOCRYSTALS AND METHODS OF PREPARING THE SAME 审中-公开单体核/壳和其他复合结构纳米晶体及其制备方法
公开(公告)号：WO2004066361A2
公开(公告)日：2004-08-05
申请号：PCT/US2004001895
申请日：2004-01-22
Applicant: UNIV ARKANSAS , PENG XIAOGANG , LI JIANQUING , BATTAGLIA DAVID , WANG YONGQIANG ANDREW , WANG YUNJUN
Inventor： PENG XIAOGANG , LI JIANQUING , BATTAGLIA DAVID , WANG YONGQIANG ANDREW , WANG YUNJUN
IPC: B32B1/00 , C09K11/02 , C09K11/08 , C09K11/56 , C09K11/70 , C09K11/74 , C09K11/88 , C30B7/00 , C30B29/60 , G01N33/58 , H01L33/18 , H01L33/28 , H01S5/30 , H05B33/14 , H01L
CPC classification number: C09K11/025 , B82Y15/00 , B82Y30/00 , C09K11/02 , C09K11/565 , C09K11/703 , C09K11/7414 , C09K11/7492 , C09K11/883 , C30B7/00 , C30B29/605 , G01N33/588 , H01L31/0352 , H01L31/036 , H01L33/18 , H01L33/28 , H01S3/169 , H01S5/30 , Y10T428/2991
Abstract: The present invention provides new compositions containing naear ly monodisperse colloidal core/shell semiconductor nanocrystals with high photoluminescence quantum yields (PL QY), as well as other complex structured semiconductor nanocrystals. This invention also provides new synthetic methods for preparing these nanocrystals, and new devices comprising these compositions. In addition to core/shell semiconductor nanocrystals, this patent application also provides complex semiconductor nanostructures, quantum shells, quantum wells, doped nanocrystals, and other multiple-shelled semiconductor nanocrystals.
Abstract translation: 本发明提供了具有高光致发光量子产率（PL QY）以及其它复合结构化半导体纳米晶体的纳豆单分散胶体核/壳半导体纳米晶体的新组合物。 本发明还提供了用于制备这些纳米晶体的新的合成方法，以及包含这些组合物的新装置。 除了核/壳半导体纳米晶体之外，该专利申请还提供复杂的半导体纳米结构，量子壳，量子阱，掺杂的纳米晶体和其他多壳半导体纳米晶体。
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公开(公告)号：WO2017046676A1
公开(公告)日：2017-03-23
申请号：PCT/IB2016/055339
申请日：2016-09-08
Applicant: NOVARTIS AG , ABEND, Johanna , DRAGIC, Zorica , FEIRE, Adam Lloyd , KNAPP, Mark , KOVACS, Steven , TRAGGIAI, Elisabetta , WANG, Lichun , WANG, Yongqiang , WU, Danqing , WU, Qilong , XU, Fangmin
Inventor： ABEND, Johanna , DRAGIC, Zorica , FEIRE, Adam Lloyd , KNAPP, Mark , KOVACS, Steven , TRAGGIAI, Elisabetta , WANG, Lichun , WANG, Yongqiang , WU, Danqing , WU, Qilong , XU, Fangmin
IPC: C07K16/08
CPC classification number: C07K16/084 , A61K39/42 , A61K45/06 , C07K2317/20 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92
Abstract: The present invention relates to anti-VP1 antibodies, antibody fragments, and their uses for the prevention and treatment of polyoma virus infection and associated diseases.
Abstract translation: 本发明涉及抗VP1抗体，抗体片段及其用于预防和治疗多瘤病毒感染及相关疾病的用途。
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4.发明申请
公开(公告)号：WO2016028896A1
公开(公告)日：2016-02-25
申请号：PCT/US2015/045898
申请日：2015-08-19
Applicant: NOVARTIS AG , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , BROGDON, Jennifer , GILL, Saar , GLASS, David , KENDERIAN, Saad , LOEW, Andreas , MANNICK, Joan , MILONE, Michael , MURPHY, Leon , PORTER, David, L. , RUELLA, Marco , WANG, Yongqiang , WU, Qilong , ZHANG, Jiquan
Inventor： BROGDON, Jennifer , GILL, Saar , GLASS, David , KENDERIAN, Saad , LOEW, Andreas , MANNICK, Joan , MILONE, Michael , MURPHY, Leon , PORTER, David, L. , RUELLA, Marco , WANG, Yongqiang , WU, Qilong , ZHANG, Jiquan
IPC: C07K16/2866 , C07K16/28 , A61K39/395
CPC classification number: C07K16/2866 , A61K39/0011 , A61K2039/505 , A61K2039/507 , A61K2039/5156 , C07K16/244 , C07K2317/24 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/03 , C07K2319/33 , C12N5/0636
Abstract: The invention provides compositions and methods for treating diseases associated with expression of CD 123. The invention also relates to chimeric antigen receptor (CAR) specific to CD123, vectors encoding the same, and recombinant cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified cell expressing a CAR that comprises a CD123 binding domain.
Abstract translation: 本发明提供用于治疗与CD123表达相关的疾病的组合物和方法。本发明还涉及CD123特异性的嵌合抗原受体（CAR），编码它的载体，以及包含CD123 CAR的重组细胞。 本发明还包括施用表达包含CD123结合结构域的CAR的遗传修饰的细胞的方法。
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公开(公告)号：WO2012099805A3
公开(公告)日：2012-07-26
申请号：PCT/US2012/021402
申请日：2012-01-16
Applicant: OCEAN NANOTECH, LLC , AGUILAR, Zoraida , WANG, Yongqiang , XU, Hengyi , HUI, George , PUSIC, Kae , UNIVERSITY OF HAWAII
Inventor： AGUILAR, Zoraida , WANG, Yongqiang , XU, Hengyi , HUI, George , PUSIC, Kae
Abstract: A nanoparticle-based delivery system and methods for its use are disclosed. In one aspect, a nanoparticle-based delivery system comprising at least one molecule such as proteins, DNA/RNA or fragments thereof, carbohydrates, enzymes, chemicals, virus cells, bacteria, parts of a virus, parts of a bacteria, parts of a cell, part of a tissue, or a combination of one or more of these, which shall be referred to as immunogens, are chemically or physically combined with water soluble nanoparticles which, when administered to a living system, is capable of eliciting a desired immunological response More particularly, the invention relates to nanoparticle-based delivery systems that are specifically engineered to enhance humoral or cellular immune response without the use of adjuvants.
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Patent Agency Ranking6.发明申请
公开(公告)号：WO2004066361A3
公开(公告)日：2004-08-05
申请号：PCT/US2004/001895
申请日：2004-01-22
Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS , PENG, Xiaogang , LI, Jianquing , BATTAGLIA, David , WANG, Yongqiang, Andrew , WANG, Yunjun
Inventor： PENG, Xiaogang , LI, Jianquing , BATTAGLIA, David , WANG, Yongqiang, Andrew , WANG, Yunjun
IPC: B32B5/16
Abstract: The present invention provides new compositions containing naear ly monodisperse colloidal core/shell semiconductor nanocrystals with high photoluminescence quantum yields (PL QY), as well as other complex structured semiconductor nanocrystals. This invention also provides new synthetic methods for preparing these nanocrystals, and new devices comprising these compositions. In addition to core/shell semiconductor nanocrystals, this patent application also provides complex semiconductor nanostructures, quantum shells, quantum wells, doped nanocrystals, and other multiple-shelled semiconductor nanocrystals.
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7.发明申请PHOSPHOGLYCERATE KINASE 1 (PGK) PROMOTERS AND METHODS OF USE FOR EXPRESSING CHIMERIC ANTIGEN RECEPTOR 审中-公开磷酸激酶激酶1（PGK）促进剂及其用于表达CHIMERIC抗原受体的方法
公开(公告)号：WO2016115482A1
公开(公告)日：2016-07-21
申请号：PCT/US2016/013637
申请日：2016-01-15
Applicant: NOVARTIS PHARMA AG , NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. , CHINA NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , BROGDON, Jennifer , EBERSBACH, Hilmar, Erhard , GLASS, David , HUBER, Thomas , JASCUR, Julia , JUNE, Carl, H. , LEE, Jihyun , MANNICK, Joan , MILONE, Michael, C. , MURPHY, Leon , POSEY, Avery, D. , SONG, Huijuan , WANG, Yongqiang , WEI, Lai , WU, Qilong , YANG, Qiumei , ZHANG, Jiquan
Inventor： BROGDON, Jennifer , EBERSBACH, Hilmar, Erhard , GLASS, David , HUBER, Thomas , JASCUR, Julia , JUNE, Carl, H. , LEE, Jihyun , MANNICK, Joan , MILONE, Michael, C. , MURPHY, Leon , POSEY, Avery, D. , SONG, Huijuan , WANG, Yongqiang , WEI, Lai , WU, Qilong , YANG, Qiumei , ZHANG, Jiquan
IPC: C07K14/705 , A61K35/17 , C07K16/28
CPC classification number: C07K16/2863 , A61K35/17 , A61K48/0058 , A61K2035/124 , A61P35/00 , A61P35/02 , C07K14/705 , C07K14/7051 , C07K14/70521 , C07K16/28 , C07K16/30 , C07K2319/00 , C07K2319/02 , C07K2319/03 , C12N15/86 , C12N2740/10043 , C12N2740/15043 , C12N2800/60
Abstract: The invention provides compositions and methods for treating diseases associated with expression of a tumor antigen as described herein. The invention also relates to nucleic acids comprising a truncated PGK promoter operably linked to a chimeric antigen receptor (CAR) specific to a tumor antigen as described herein, vectors encoding the same, and recombinant T cells comprising the CARs of the present invention. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises an antigen binding domain that binds to a tumor antigen as described herein.
Abstract translation: 本发明提供用于治疗与本文所述的肿瘤抗原表达相关的疾病的组合物和方法。 本发明还涉及包含与本文所述的肿瘤抗原特异性的嵌合抗原受体（CAR）可操作地连接的截短的PGK启动子的核酸，以及编码本发明的载体的重组T细胞和包含本发明的CAR的重组T细胞。 本发明还包括施用表达CAR的遗传修饰的T细胞的方法，其包含如本文所述结合肿瘤抗原的抗原结合结构域。
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8.发明申请
公开(公告)号：WO2016014565A2
公开(公告)日：2016-01-28
申请号：PCT/US2015041378
申请日：2015-07-21
Applicant: NOVARTIS AG , UNIV PENNSYLVANIA , BROGDON JENNIFER , CHOI EUGENE , EBERSBACH HILMAR , GLASS DAVID , HUET HEATHER , JUNE CARL H , MANNICK JOAN , MILONE MICHAEL C , MURPHY LEON , PLESA GABRIELA , RICHARDSON CELESTE , RUELLA MARCO , SINGH RESHMA , WANG YONGQIANG , WU QILONG
Inventor： BROGDON JENNIFER , CHOI EUGENE , EBERSBACH HILMAR , GLASS DAVID , HUET HEATHER , JUNE CARL H , MANNICK JOAN , MILONE MICHAEL C , MURPHY LEON , PLESA GABRIELA , RICHARDSON CELESTE , RUELLA MARCO , SINGH RESHMA , WANG YONGQIANG , WU QILONG
IPC: C07K16/28
CPC classification number: C07K14/705 , A61K35/12 , A61K38/177 , C07K16/2878 , C07K2317/24 , C07K2317/565 , C07K2317/622 , C07K2317/92 , C07K2319/00 , C07K2319/30
Abstract: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.
Abstract translation: 本发明提供了用于治疗与BCMA表达相关的疾病的组合物和方法。 本发明还涉及对编码BCMA载体的BCMA载体特异性的嵌合抗原受体（CAR）和包含BCMA CAR的重组T细胞。 本发明还包括施用表达包含BCMA结合结构域的CAR的遗传修饰的T细胞的方法。
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公开(公告)号：WO2016014565A3
公开(公告)日：2016-01-28
申请号：PCT/US2015/041378
申请日：2015-07-21
Applicant: NOVARTIS AG , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , BROGDON, Jennifer , CHOI, Eugene , EBERSBACH, Hilmar , GLASS, David , HUET, Heather , JUNE, Carl, H. , MANNICK, Joan , MILONE, Michael, C. , MURPHY, Leon , PLESA, Gabriela , RICHARDSON, Celeste , RUELLA, Marco , SINGH, Reshma , WANG, Yongqiang , WU, Qilong
Inventor： BROGDON, Jennifer , CHOI, Eugene , EBERSBACH, Hilmar , GLASS, David , HUET, Heather , JUNE, Carl, H. , MANNICK, Joan , MILONE, Michael, C. , MURPHY, Leon , PLESA, Gabriela , RICHARDSON, Celeste , RUELLA, Marco , SINGH, Reshma , WANG, Yongqiang , WU, Qilong
Abstract: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.
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公开(公告)号：WO2014044014A3
公开(公告)日：2014-10-02
申请号：PCT/CN2013000697
申请日：2013-06-14
Applicant: WANG YONGQIANG
Inventor： WANG YONGQIANG
CPC classification number: B65D88/005 , B60P3/2205 , B60P3/426 , B65D90/0093 , B65D90/08 , B65D90/14
Abstract: A telescopic tank group comprising multiple tank bodies (1, 2, 3) that can be sleeved within a largest tank body when no load is being carried. When extended or retracted, neighboring tank bodies can be fixed using a stabilizing bolt (9) and a corresponding bolt hole (10). Additionally, a movable sealing flange (11) can further stabilize and seal the tank bodies. By using the structure, a load can be carried in both to- and return-journeys of a transport thereby solving the problem that half of the transport has no load, and more than two types of products can be carried at once.
Abstract translation: 一种伸缩罐组，包括多个罐体（1,2,3），当不承载负载时，该罐体可以套在最大罐体内。 当延伸或缩回时，可以使用稳定螺栓（9）和相应的螺栓孔（10）来固定相邻的罐体。 另外，可移动的密封凸缘（11）可进一步稳定和密封罐体。 通过使用该结构，可以在运输的到达和返回行程中承载负载，从而解决了运输的一半没有负载的问题，并且可以一次运送多于两种类型的产品。
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