公开(公告)号：WO2010028090A3

公开(公告)日：2010-03-11

申请号：PCT/US2009/055787

申请日：2009-09-02

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  WEBLER, William, E.

Inventor： WEBLER, William, E.

IPC: A61M25/00

Abstract: An agent delivery catheter that includes an anti-whipping feature, improved assembly of distal parts and/or accuracy / repeatability of needle delivery to a target tissue. Additional features include fitting a catheter with a pneumatic delivery device for delivery of a therapeutic agent without using a needle.

公开(公告)号：WO2009076224A1

公开(公告)日：2009-06-18

申请号：PCT/US2008/085713

申请日：2008-12-05

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  MAGANA, Jesus ,  MIN, Sung Woo ,  VON OEPEN, Randolf ,  NGUYEN, Binh T. ,  EHRENREICH, Kevin J. ,  WEBLER, William E., Jr. ,  LUMAUIG, Rommel ,  CHAN, Gregory W. ,  COFFEY, Lorcan J. ,  YRIBARREN, Travis R.

Inventor： MIN, Sung Woo ,  VON OEPEN, Randolf ,  NGUYEN, Binh T. ,  EHRENREICH, Kevin J. ,  WEBLER, William E., Jr. ,  LUMAUIG, Rommel ,  CHAN, Gregory W. ,  COFFEY, Lorcan J. ,  YRIBARREN, Travis R.

IPC: A61M25/04 ,  A61M25/10

CPC classification number: A61M25/0155 ,  A61M25/0013 ,  A61M25/0068 ,  A61M25/008 ,  A61M25/0082 ,  A61M25/0084 ,  A61M25/04 ,  A61M25/0606 ,  A61M25/1002 ,  A61M25/1011 ,  A61M2025/0081 ,  A61M2025/0092 ,  A61M2025/0096 ,  A61M2025/0681 ,  A61M2025/1047

Abstract: A catheter (10) for delivering an agent to an injection site in a wall of a patient's body lumen, with an elongated shaft (11) having a needle-through lumen (12) slidably containing a needle (13) therein, and an expandable member (15) on the distal shaft section which has a collapsed configuration and a radially expanded configuration. In the radially expanded configuration, the expandable member supports the shaft in a position spaced away from the body lumen wall, and the needle slidably exits the needle-through lumen in the extended configuration through the port (14) spaced away from the body lumen wall as a portion of the expandable member maintains the position of the port section of the shaft in the body lumen. The expandable member typically has an open-walled, helical, or lobed configuration providing a perfusion path along the expandable member.

Abstract translation: 一种用于将药剂递送到患者体腔壁的注射部位的导管（10），细长轴（11）具有可滑动地包含针（13）的针刺腔（12），以及可扩张 所述远侧轴部具有收缩构造和径向扩张构造的构件（15）。 在径向膨胀的构造中，可膨胀构件将轴保持在远离体腔壁的位置，并且针以延伸构型穿过通过与体腔内壁间隔开的端口（14）可滑动地离开针穿腔， 随着可扩张构件的一部分将轴的端口部分的位置维持在体腔中。 可膨胀构件通常具有提供沿着可膨胀构件的灌注路径的开放壁，螺旋形或叶状结构。

公开(公告)号：WO2006068927A3

公开(公告)日：2007-09-20

申请号：PCT/US2005045509

申请日：2005-12-15

Applicant: ADVANCED CARDIOVASCULAR SYSTEM ,  WEBLER WILLIAM E

Inventor： WEBLER WILLIAM E

IPC: A61B5/00 ,  A61F2/958 ,  A61M25/00

CPC classification number: A61B5/6857 ,  A61B1/00096 ,  A61B1/00183 ,  A61B1/0051 ,  A61B1/3137 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/01 ,  A61B5/02007 ,  A61B5/02055 ,  A61B5/4836 ,  A61B5/6851 ,  A61B5/6852 ,  A61B5/6853 ,  A61B5/6885 ,  A61B8/12 ,  A61B2017/22081 ,  A61B2090/3735 ,  A61N5/0601 ,  A61N5/062 ,  A61N2005/0602

Abstract: Methods and apparatuses for positioning medical devices onto (or close to) a desired portion of the interior wall of an internal channel, such as for scan imaging, for photodynamic therapy and/or for optical temperature measurement. In one embodiment, a catheter assembly has a distal portion that can be changed from a configuration suitable for traversing the internal channel to another configuration suitable for scan at least a spiral section of the interior wall of an internal channel, such as an artery. In one example, the distal portion spirals into gentle contact with (or close to) a spiral section of the artery wall for Optical Coherence Tomography (OCT) scanning. The spiral radius may be changed through the use of a guidewire, a tendon, a spiral balloon, a tube, or other ways.

Abstract translation: 将医疗装置定位在（或接近）内部通道的内壁的期望部分（例如用于扫描成像）用于光动力学治疗和/或用于光学温度测量的方法和装置。 在一个实施例中，导管组件具有远端部分，该远端部分可以从适合于穿过内部通道的构造改变为适于扫描内部通道（例如动脉）的内壁的至少螺旋部分的另一构造。 在一个示例中，远端部分与光学相干断层扫描（OCT）扫描的螺旋形部分螺旋地与动脉壁的螺旋部分（或靠近）螺旋。 可以通过使用导丝，腱，螺旋气囊，管或其它方式来改变螺旋半径。

公开(公告)号：WO2009055276A1

公开(公告)日：2009-04-30

申请号：PCT/US2008/079818

申请日：2008-10-14

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  LEONARD, Michael, J. ,  WEBLER, William, E.

Inventor： LEONARD, Michael, J. ,  WEBLER, William, E.

IPC: A61M29/00

CPC classification number: A61M25/1011 ,  A61M2025/0024 ,  A61M2025/1052 ,  A61M2025/1095

Abstract: An agent delivery catheter (10) and method, configured to deliver an agent to an inner surface of a patient's body lumen (30) by forming an agent containment pocket (32) along the inner surface of the patient's body lumen wall between a proximal expandable frame (13) and a distal expandable frame (14), while minimizing ischemic conditions during the procedure.

Abstract translation: 一种药剂递送导管（10）和方法，其被配置为通过沿着患者体腔管壁的内表面形成药剂容纳口袋（32），将药剂递送到患者体腔（30）的内​​表面， 框架（13）和远侧可扩展框架（14），同时使手术期间的缺血状况最小化。

公开(公告)号：WO2007111908A3

公开(公告)日：2007-10-04

申请号：PCT/US2007/007040

申请日：2007-03-20

Applicant: ADVANCED CARDIOVASCULAR SYSTEMS, INC. ,  MANDRUSOV, Evgenia ,  MICHAL, Eugene, T. ,  CHOW, Mina ,  HOSSAINY, Syed Faiyez, Ahmed ,  KILPATRICK, Deborah ,  SIMHAMBHATLA, Murthy ,  CHIU, Jessica, G. ,  CLAUDE, Charles, D. ,  WEBLER, William, E.

Inventor： MANDRUSOV, Evgenia ,  MICHAL, Eugene, T. ,  CHOW, Mina ,  HOSSAINY, Syed Faiyez, Ahmed ,  KILPATRICK, Deborah ,  SIMHAMBHATLA, Murthy ,  CHIU, Jessica, G. ,  CLAUDE, Charles, D. ,  WEBLER, William, E.

IPC: A61F2/84 ,  A61F2/06 ,  A61B17/22 ,  A61M29/02

Abstract: Various apparatuses are described to treat vulnerable plaque with the use of combination drug therapy. In one /embodiment, the apparatus (1001) has an elongated catheter body (1010) adapted for insertion in a body lumen, with a drug delivery device (1013) attached near a distal portion of the elongated body. The drug delivery device is configured to deliver a therapeutic or biologically active agent to stabilize a vulnerable plague. In another embodiment, a drug eluting stent is delivered and deployed in conjunction with a second apparatus that delivers drug in pressurized retrograde perfusion. Still another embodiment uses a uniquely shaped balloon to deploy a stent while utilizing a drug infusion needle to inject drug into the vessel wall through a hollow guide wire.

公开(公告)号：WO2007111908A2

公开(公告)日：2007-10-04

申请号：PCT/US2007007040

申请日：2007-03-20

Applicant: ADVANCED CARDIOVASCULAR SYSTEM ,  MANDRUSOV EVGENIA ,  MICHAL EUGENE T ,  CHOW MINA ,  HOSSAINY SYED FAIYEZ AHMED ,  KILPATRICK DEBORAH ,  SIMHAMBHATLA MURTHY ,  CHIU JESSICA G ,  CLAUDE CHARLES D ,  WEBLER WILLIAM E

Inventor： MANDRUSOV EVGENIA ,  MICHAL EUGENE T ,  CHOW MINA ,  HOSSAINY SYED FAIYEZ AHMED ,  KILPATRICK DEBORAH ,  SIMHAMBHATLA MURTHY ,  CHIU JESSICA G ,  CLAUDE CHARLES D ,  WEBLER WILLIAM E

IPC: A61B17/22 ,  A61F2/82 ,  A61F2/86 ,  A61M29/02

CPC classification number: A61F2/07 ,  A61B5/02007 ,  A61B2017/22077 ,  A61F2/82 ,  A61F2/86 ,  A61F2/90 ,  A61F2/958 ,  A61F2002/077 ,  A61F2220/0058 ,  A61F2250/0067 ,  A61M1/3613 ,  A61M25/104 ,  A61M2025/105 ,  A61M2025/1056 ,  A61M2025/107 ,  A61M2025/1086 ,  A61M2025/1095

Abstract: Various apparatuses and methods are described to treat vulnerable plaque with the use of combination drug therapy. In one embodiment, the apparatus has an elongated catheter body adapted for insertion in a body lumen, with a drug delivery device attached near a distal portion of the elongated body. The drug delivery device is configured to deliver a therapeutic or biologically active agent to stabilize a vulnerable plaque. In another embodiment, a drug eluting stent is delivered and deployed in conjunction with a second apparatus that delivers drug in pressurized retrograde perfusion. Still another embodiment uses a uniquely shaped balloon to deploy a stent while utilizing a drug infusion needle to inject drug into the vessel wall through a hollow guide wire.

Abstract translation: 描述了使用组合药物治疗来治疗易损斑块的各种装置和方法。 在一个实施例中，该装置具有适于插入体腔中的细长导管体，其中药物递送装置附接在细长体的远侧部分附近。 药物递送装置被配置为递送治疗或生物活性剂以稳定易损斑块。 在另一个实施方案中，药物洗脱支架与在加压逆行灌注中递送药物的第二装置一起递送和展开。 另一个实施例使用独特形状的气囊来展开支架，同时利用药物输注针将药物通过空心导丝将药物注入血管壁。

公开(公告)号：WO2007078455A1

公开(公告)日：2007-07-12

申请号：PCT/US2006/045205

申请日：2006-11-21

Applicant: ADVANCED CARDIOVASCULAR SYSTEMS, INC. ,  WEBLER, William, E. ,  YAMBAO, August, R.

Inventor： WEBLER, William, E. ,  YAMBAO, August, R.

IPC: A61M25/00 ,  A61M25/10 ,  A61M29/02 ,  A61M39/08

CPC classification number: A61B17/12022 ,  A61B17/1204 ,  A61M25/0021 ,  A61M25/1002 ,  A61M25/10182 ,  A61M25/10188 ,  A61M25/1027 ,  A61M2025/1052

Abstract: A controlled volume inflation-deflation device (100) to inflate a balloon to occlude a blood vessel by dialing a knob (130) that locks at rotational positions to locate a plunger (110) at equally spaced locations within a syringe (112) of the inflation-deflation device. The inflation-deflation device includes a releasable latch (150) to lock the proximal (140) and distal (120) housings together to hold the plunger forward for occlusion, and to separate and hold the proximal and distal housings to retract the plunger for perfusion. When the inflation-deflation device is returned to the latched position, the balloon is re-inflated to its previous occlusive diameter. Also, an extension tube made of a lower modulus outer material co-extruded over and miscible with a higher modulus inner material may be used to produce a suitably low compliance extension tube for the inflation-deflation device. The balloon may have tapered ends and a cylindrical center portion so that it increases by more equal increments in outer diameter in response to incremental equal increases in inflation volume.

Abstract translation: 一种受控体积的充气 - 放气装置（100），用于通过拨动在旋转位置锁定的旋钮（130）使气囊膨胀以封闭血管，以将柱塞（110）定位在位于 通货膨胀设备。 充气 - 放气装置包括可释放的闩锁（150），用于将近端（140）和远端（120）壳体锁定在一起以将柱塞保持在前面用于闭塞，并且分离并保持近端和远端壳体以缩回用于灌注的柱塞 。 当充气 - 放气装置返回到锁定位置时，将气囊重新膨胀至其先前的闭塞直径。 此外，可以使用由较高模量的内部材料共挤出并可与较高模量的内部材料混合的由较低模量的外部材料制成的延伸管，以产生用于充气 - 收缩装置的合适的柔顺性延伸管。 球囊可以具有锥形端部和圆柱形中心部分，使得响应于增加的充气体积的相等增加，其在外径中增加更多相等的增量。

公开(公告)号：WO2007067323A2

公开(公告)日：2007-06-14

申请号：PCT/US2006/044508

申请日：2006-11-15

Applicant: ADVANCED CARDIOVASCULAR SYSTEMS, INC. ,  WEBLER, William, E. ,  CHOW, Mina

Inventor： WEBLER, William, E. ,  CHOW, Mina

IPC: G06T7/00 ,  G06T17/40

CPC classification number: G06T19/00 ,  A61B8/4245 ,  A61B8/445 ,  A61B8/483 ,  A61B17/3478 ,  A61B2017/00247 ,  A61B2017/00455 ,  A61B2018/00392 ,  G06F19/00 ,  G06T7/32 ,  G06T7/38 ,  G06T2207/30004 ,  G06T2210/41 ,  G16H50/50

Abstract: Methods and apparatuses for the image guidance and documentation of medical procedures. One embodiment includes combining small field of view images into a recorded image of with a large field of view and aligning the small field of view real time image with the recorded image through correlation of imaging data. A location and orientation determination system may be used to track the imaging system and provide a starting set of image alignment parameters and/or provide change updates to a set of image alignment parameters, which is then further improved through correlating imaging data. The recorded image may be selected according to real time measurement of a cardiac parameter during an image guided cardiac procedure. Image manipulations planned based on the recorded image can be stored and applied to the real time information. The position of the medical device may be determined and recorded through manipulating a cursor in a 3-D image space shown in two non-parallel views.

Abstract translation: 图像指导和医疗程序记录的方法和设备。 一个实施例包括将小视野图像组合成具有大视野的记录图像，并通过成像数据的相关将小视野实时图像与记录图像对准。 位置和方向确定系统可以用于跟踪成像系统并提供图像对准参数的起始集合和/或向一组图像对准参数提供改变更新，然后通过相关成像数据进一步改进。 记录图像可以根据图像引导心脏手术期间的心脏参数的实时测量来选择。 基于记录图像计划的图像处理可以被存储并应用于实时信息。 可以通过在两个非平行视图中示出的3-D图像空间中操纵光标来确定和记录医疗装置的位置。

公开(公告)号：WO2006073741A2

公开(公告)日：2006-07-13

申请号：PCT/US2005/045629

申请日：2005-12-16

Applicant: ADVANCED CARDIOVASCULAR SYSTEMS, INC. ,  WANTINK, Ken ,  WEBLER, William, E. ,  LEE, Jeong

Inventor： WANTINK, Ken ,  WEBLER, William, E. ,  LEE, Jeong

IPC: A61M25/00

CPC classification number: A61M25/10 ,  A61M25/0029 ,  A61M2025/004 ,  A61M2025/105

Abstract: An infusion catheter having a distal shaft with an infusion tube extending from a proximal end to a distal end of the distal shaft, and a proximal cannula with an inner dimension and a distal end attached to a proximal end of the distal shaft to define an opening between the inner diameter of the infusion tube and the inner dimension of the proximal cannula. Also, a guidewire tube disposed within the inner dimension and the distal shaft and extending from the proximal end of the proximal cannula to the distal end of the distal shaft. The inner diameter of the infusion tube, the opening, the exterior dimension of the guidewire tube and the inner dimension cooperate and define sufficient cross sectional sizes to allow a treatment agent to be infused between the proximal end of the proximal cannula and the region of interest.

Abstract translation: 输液导管，其具有远侧轴，所述远端轴具有从所述远端轴的近端延伸到远端的输注管，以及近端插管，其具有附接到所述远侧轴的近端的内部尺寸和远端，以限定开口 在输注管的内径和近侧插管的内部尺寸之间。 而且，导丝管设置在内部尺寸和远端轴内并且从近侧插管的近端延伸到远侧轴的远端。 输注管的内径，开口，导丝管的外部尺寸和内部尺寸协调并限定足够的横截面尺寸，以允许治疗剂注入近端插管的近端和感兴趣区域之间 。

公开(公告)号：WO2010028090A2

公开(公告)日：2010-03-11

申请号：PCT/US2009055787

申请日：2009-09-02

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS ,  WEBLER WILLIAM E

Inventor： WEBLER WILLIAM E

IPC: A61M25/00

CPC classification number: A61M25/0054 ,  A61M25/0052 ,  A61M2025/0089

Abstract: An agent delivery catheter that includes an anti-whipping feature, improved assembly of distal parts and/or accuracy / repeatability of needle delivery to a target tissue. Additional features include fitting a catheter with a pneumatic delivery device for delivery of a therapeutic agent without using a needle.

Abstract translation: 包括防鞭打特征，远端部分的改进组装和/或针递送到目标组织的准确性/可重复性的药剂递送导管。 另外的特征包括用气动输送装置来装配导管以输送治疗剂而不使用针。