公开(公告)号：WO2019130063A1

公开(公告)日：2019-07-04

申请号：PCT/IB2018/001587

申请日：2018-12-18

申请人： MEDINOL LTD.

发明人： SENIN, Vladlen ,  STEIN, Oded

IPC分类号： A61F2/915

CPC分类号： A61F2/915 ,  A61F2210/0014 ,  A61F2220/0058 ,  A61F2230/0069 ,  A61F2240/00 ,  A61F2240/001 ,  A61F2240/002 ,  A61F2250/0067 ,  B23K26/22 ,  B23K26/282 ,  B23K31/027 ,  B23K2101/06

摘要： The present disclosure is directed to a stent manufacturing assembly including an inner shield, a patterned metal sheet, and an outer shield. The patterned metal sheet may include a polymer coating with an embedded therapeutic agent. The inner shield, patterned metal sheet, and outer shield are arranged in a layered configuration and placed in a stent rolling mechanism with a mandrel. In particular, the patterned metal sheet is disposed on the outer shield and the inner shield is disposed on the patterned metal sheet in the layered configuration. In the layered configuration, the stent manufacturing assembly is rolled by the rolling mechanism into a tubular shape and welded to form a tubular stent.

公开(公告)号：WO2019040372A1

公开(公告)日：2019-02-28

申请号：PCT/US2018/047097

申请日：2018-08-20

申请人： YALE UNIVERSITY

发明人： KURAL, Mehmet Hamdi ,  GUI, Liqiong ,  NIKLASON, Laura Elizabeth ,  SALTZMAN, William Mark

IPC分类号： A61F2/00 ,  A61F2/06 ,  A61F2/90 ,  A61L31/14 ,  A61L31/16

CPC分类号： A61F2/91 ,  A61F2250/0067 ,  A61K9/0024 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/114 ,  A61L2300/416 ,  A61M2025/105

摘要： The present invention provides compositions and devices that release (a) a nitric oxide (NO) donor and/or NO, and (b) an agent that aggregates and/or trimerizes the Fas receptor, such as but not limited to a Fas-ligand (FasL). In certain embodiments, the invention includes a stent that elutes (a) a NO donor and/or NO, and (b) FasL. In other embodiments, the invention includes methods of treating a condition, such as intimal hyperplasia, in a subject by administering a stent that releases (a) a NO donor and/or NO, and (b) FasL.

公开(公告)号：WO2017139635A1

公开(公告)日：2017-08-17

申请号：PCT/US2017/017457

申请日：2017-02-10

申请人： SANFORD HEALTH

发明人： PEERY, Curtis

IPC分类号： A61B17/068

CPC分类号： A61F2/0063 ,  A61B17/00234 ,  A61B17/064 ,  A61B17/068 ,  A61B17/29 ,  A61B17/2909 ,  A61B34/30 ,  A61B2017/00473 ,  A61B2017/00477 ,  A61B2017/00858 ,  A61B2017/00876 ,  A61B2017/0647 ,  A61B2017/0648 ,  A61B2017/2926 ,  A61B2017/2946 ,  A61F2002/0068 ,  A61F2002/0072 ,  A61F2210/0076 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2250/0067 ,  A61L31/146

摘要： The present disclosure provides a deployment device that includes (a) an elongate shaft having a first end and a second end, (b) a grasping assembly coupled to the first end of the elongate shaft, where the grasping assembly includes a first jaw and a second jaw rotatable with respect to the elongate shaft, where the grasping assembly is configured to accept a wound closure device between the first jaw and the second jaw, where the wound closure device comprises at least two fixation components connected to and extending therethrough, where each of the first jaw and the second jaw include at least one coupling element configured to be removably coupled to a respective fixation component when the wound closure device is coupled to the grasping assembly, and (c) an actuator coupled to the second end of the elongate shaft, where the actuator is configured to move the grasping assembly between an open position and a closed position.

摘要翻译： 本公开提供了一种展开装置，其包括（a）具有第一端和第二端的细长轴，（b）联接到细长轴的第一端的抓握组件，其中 抓握组件包括相对于细长轴可旋转的第一钳口和第二钳口，其中抓握组件构造成接纳第一钳口和第二钳口之间的伤口闭合设备，其中伤口闭合设备包括至少两个固定部件 连接并延伸穿过其中，其中第一钳口和第二钳口中的每一个包括至少一个联接元件，该至少一个联接元件构造成当伤口闭合装置联接至抓握组件时可拆卸地联接至相应的固定部件，以及（c）致动器 联接到细长轴的第二端，其中致动器构造成使抓握组件在打开位置和闭合位置之间移动。

公开(公告)号：WO2017112856A1

公开(公告)日：2017-06-29

申请号：PCT/US2016/068272

申请日：2016-12-22

申请人： PRODEON, INC. ,  HSU, Thomas ,  HSU, Senzan ,  HSU, Ellen

发明人： HSU, Thomas ,  HSU, Senzan ,  HSU, Ellen

IPC分类号： A61B17/064 ,  A61B17/02 ,  A61F2/00

CPC分类号： A61B17/02 ,  A61B17/064 ,  A61F2/00 ,  A61F2/04 ,  A61F2002/047 ,  A61F2220/0016 ,  A61F2220/0091 ,  A61F2250/0031 ,  A61F2250/0065 ,  A61F2250/0067 ,  A61F2250/0068

摘要： Devices and methods are disclosed for managing and/or treating body tissues obstructing a hollow body lumen, such as the prostatic lobe tissues obstructing the urethra. A scaffolding may be provided with opposing tissue-engaging portions and at least one expansion member configured to transition between a compressed configuration having a reduced distance between the tissue-engaging portions and a deployed configuration having an increased distance between the tissue-engaging portions.

摘要翻译： 公开了用于管理和/或治疗阻塞中空体腔的身体组织的装置和方法，例如阻塞尿道的前列腺叶组织。 脚手架可以设置有相对的组织接合部分和至少一个扩张构件，所述至少一个扩张构件构造成在组织接合部分之间具有减小的距离的压缩构型和具有增加的组织接合部分之间的距离的展开构型之间过渡。 / p>

公开(公告)号：WO2017079659A1

公开(公告)日：2017-05-11

申请号：PCT/US2016/060682

申请日：2016-11-04

申请人： POLY-MED, INC. ,  HILAS, Georgios, T.

发明人： HILAS, Georgios, T. ,  TAYLOR, Mchael, Scott ,  MCMULLEN, Seth, Dylan ,  CLINKSCALES, Kenneth, W.

IPC分类号： A61F2/00

CPC分类号： A61F2/0063 ,  A61F2002/0068 ,  A61F2240/001 ,  A61F2250/0031 ,  A61F2250/0067 ,  D04B21/12 ,  D10B2509/08

摘要： A fabric or mesh construct, and process for making same, which allows for early wound stability and then transitions to a more compliant state exhibiting a substantially constant macro-porous pore structure through the life of the implant to promote good tissue incorporation without bridging.

摘要翻译： 一种织物或网状结构及其制造方法，其允许早期伤口稳定性并且然后转变成在植入物的整个寿命期间呈现基本上恒定的大孔隙结构的更适应状态，以至 促进良好的组织结合而不会桥接。

公开(公告)号：WO2017066355A1

公开(公告)日：2017-04-20

申请号：PCT/US2016/056688

申请日：2016-10-12

申请人： REFLOW MEDICAL, INC.

发明人： FULKERSON, John ,  RIZK, Isa ,  MUSTAPHA, Jihad, A. ,  JIMENEZ, Teodoro, S., Jr.

IPC分类号： A61F2/86 ,  A61F2/95 ,  A61L31/16 ,  A61F2/82

CPC分类号： A61F2/90 ,  A61F2/82 ,  A61F2/848 ,  A61F2/86 ,  A61F2002/8483 ,  A61F2220/0016 ,  A61F2250/0023 ,  A61F2250/0067 ,  A61F2250/0068 ,  A61F2250/0098 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/44

摘要： Expandable elements having drug-delivery features and associated systems and methods are disclosed herein. In one embodiment, a drug-eluting stent includes a radially expandable cylindrical frame having a plurality of struts. The frame is transformable between a low-profile delivery state and an expanded deployed state. A plurality of drug- delivery features are carried by one of the struts and configured to deliver a drug to a treatment site within the patient or piercing through the tissue wall to break the constricting of the vessel wall inwardly. When the frame is in the expanded state within a body lumen of the patient, the drug-delivery features extend radially outwardly away from the strut and are configured to engage and, in some arrangements, pass through a wall of the body lumen.

摘要翻译： 本文公开了具有药物递送特征和相关系统和方法的可扩展元件。 在一个实施例中，药物洗脱支架包括具有多个支柱的可径向扩张的圆柱形框架。 该框架可在低姿态交付状态和展开展开状态之间转换。 多个药物递送特征由支柱中的一个支撑并且被配置成将药物递送至患者体内的治疗部位或者刺穿组织壁以破坏向内收缩血管壁。 当框架在患者的体腔内处于扩张状态时，药物递送特征从支柱径向向外延伸，并且被配置为接合并且在一些布置中穿过体腔的壁。 p>

公开(公告)号：WO2017066009A1

公开(公告)日：2017-04-20

申请号：PCT/US2016/055077

申请日：2016-10-01

申请人： HORIZON SCIENTIFIC CORP.

发明人： ZENG, Min, Frank ,  LO, Pham

IPC分类号： A61F2/06 ,  A61F2/24 ,  A61F2/82 ,  A61F2/90 ,  A61M29/00

CPC分类号： A61F2/2418 ,  A61F2/24 ,  A61F2/2412 ,  A61F2/2433 ,  A61F2/2436 ,  A61F2/246 ,  A61F2/915 ,  A61F2210/0014 ,  A61F2210/0071 ,  A61F2220/0075 ,  A61F2230/0006 ,  A61F2230/0021 ,  A61F2230/0052 ,  A61F2230/0071 ,  A61F2250/0039 ,  A61F2250/0067

摘要： A heart valve assembly has a frame having an anchoring section defined by a plurality of rows of cells, with each cell defined by a plurality of struts that encircle each cell, and a pair of legs extending from the anchoring section. The assembly also includes a leaflet assembly that has a plurality of leaflets that are stitched to the legs. The heart valve assembly is delivered to the location of a native mitral annulus, and the anchoring section is deployed inside the left atrium such that the anchoring section is completely retained in the left atrium, and the legs and leaflets extend through the native mitral annulus.

摘要翻译： 心脏瓣膜组件具有框架，该框架具有由多排细胞限定的锚定部分，每个细胞由围绕每个细胞的多个支柱限定，以及一对腿，该一对腿从 锚定部分。 该组件还包括具有多个小叶的小叶组件，小叶被缝合到腿上。 心脏瓣膜组件被递送到天然二尖瓣环的位置，并且锚定部分被部署在左心房内部，使得锚定部分完全保留在左心房中，并且腿和小叶延伸穿过天然二尖瓣环。

公开(公告)号：WO2017053935A1

公开(公告)日：2017-03-30

申请号：PCT/US2016/053693

申请日：2016-09-26

申请人： SOFFIO MEDICAL INC.

发明人： BELL, Benjamin, David ,  BOURNE, George ,  GELFAND, Mark ,  LI, Jianmin

IPC分类号： A61F2/04 ,  A61M39/02 ,  A61B17/34 ,  A61B17/12

CPC分类号： A61F2/04 ,  A61B17/02 ,  A61B17/12104 ,  A61B17/3423 ,  A61B2017/3492 ,  A61F2002/043 ,  A61F2210/0004 ,  A61F2230/0065 ,  A61F2230/0069 ,  A61F2230/0071 ,  A61F2230/0076 ,  A61F2250/0059 ,  A61F2250/0067 ,  A61M39/0247 ,  A61M2039/0252 ,  A61M2039/0276 ,  A61M2210/1039

摘要： Implantable airway bypass device 150 that relieves trapped air in the lung of a patient having restricted ventilation. The device comprises a conduit that approximately spans the distance of the chest wall, an air intake component (i.e. an open end of a conduit), and a surrounding expandable structure, which further comprises a basket (160) and a neck to surround the air intake component within a voided space in lung tissue, created, and defined by the expandable structure. The expandable structure may bey formed of at least one wire which forms the neck and the basket. The device may further comprise a membrane over at least a portion of an outer surface of the basket and an outer surface of the neck portion.

摘要翻译： 可植入气道旁通装置150，其释放受限通气的患者的肺中被困的空气。 该装置包括大致跨过胸壁的距离的导管，进气部件（即，导管的开口端）和周围的可扩展结构，该可扩展结构还包括篮（160）和围绕空气的颈部 吸入组分在肺组织中的空隙空间内，由可膨胀结构产生并限定。 可膨胀结构可以由形成颈部和篮子的至少一根丝线形成。 该装置还可以包括位于篮的外表面的至少一部分上的膜和颈部的外表面。

公开(公告)号：WO2017044990A1

公开(公告)日：2017-03-16

申请号：PCT/US2016/051512

申请日：2016-09-13

申请人： MAYSE, Martin

发明人： MAYSE, Martin

IPC分类号： A61F2/958 ,  A61B17/24 ,  A61B17/00

CPC分类号： A61F2/04 ,  A61B18/02 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61F2/88 ,  A61F2/958 ,  A61F2002/043 ,  A61F2250/0048 ,  A61F2250/0067 ,  A61M29/02

摘要： Devices, systems, and methods for improving airflow within an airway. One example embodiment includes a method for treating a subject. The method includes (1) placing an expandable object into one or more airways of the bronchial tree of the subject, (2) expanding the expandable object within at least one of the one or more airways such that at least a portion of a wall of the one or more airways is expanded, and (3) placing a stent in the airway such that a portion of the stent is adjacent to the portion of the wall of the one or more expanded airways.

摘要翻译： 用于改善气道气流的装置，系统和方法。 一个示例性实施例包括用于治疗受试者的方法。 该方法包括（1）将可膨胀物体放置在受试者的支气管树的一个或多个气道中，（2）在一个或多个气道中的至少一个气道内扩张可膨胀物体，使得至少一部分壁 一个或多个气道膨胀，并且（3）将支架放置在气道中，使得支架的一部分与一个或多个扩张的气道的壁的部分相邻。

公开(公告)号：WO2017035372A1

公开(公告)日：2017-03-02

申请号：PCT/US2016/048729

申请日：2016-08-25

申请人： INNOVEIN, INC.

发明人： CHIN, Albert K. ,  WALKER, Austin ,  KRAMER, Thomas A.

IPC分类号： A61F2/00 ,  A61F2/01 ,  A61F2/02 ,  A61F2/04 ,  A61F2/06 ,  A61F2/07 ,  A61F2/24

CPC分类号： A61F2/2475 ,  A61F2/91 ,  A61F2/966 ,  A61F2230/001 ,  A61F2250/0039 ,  A61F2250/0067

摘要： A venous valve prosthetic implant for treatment of venous disease may include an expandable anchoring frame, a valve seat attached to the anchoring frame, a ball retention member attached to the anchoring frame, and a ball disposed within the lumen of the anchoring frame, between the valve seat and the ball retention member. The anchoring frame may include a first end, a second end, and a middle valve portion, where the middle valve portion expands to a smaller diameter than a diameter of either the first end or the second end. The ball may move back and forth within the middle valve portion, between a fully open position and a fully closed position.

摘要翻译： 用于治疗静脉疾病的静脉瓣膜假体植入物可以包括可膨胀锚固框架，附接到锚固框架的阀座，附接到锚固框架的球保持构件和设置在锚定框架的内腔内的球之间 阀座和球保持构件。 锚固框架可以包括第一端，第二端和中间阀部分，其中中间阀部分扩展到比第一端或第二端的直径小的直径。 球可以在中间阀部分内，在完全打开位置和完全关闭位置之间来回移动。