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公开(公告)号：WO2009151708A3
公开(公告)日：2010-11-18
申请号：PCT/US2009037809
申请日：2009-03-20
Applicant: GENZYME CORP , PERRICONE MICHAEL A , DZURIS JOHN LYLE , WEEDEN TIMOTHY E , STEFANO JAMES E , PAN CLARK Q , EDLING ANDREA E
Inventor： PERRICONE MICHAEL A , DZURIS JOHN LYLE , WEEDEN TIMOTHY E , STEFANO JAMES E , PAN CLARK Q , EDLING ANDREA E
CPC classification number: C07K14/685 , A61K38/00 , A61K38/34 , A61K47/48246 , A61K47/64 , A61K49/0008 , C07K5/1021 , C07K5/1024 , C07K7/08
Abstract: Provided herein are stable peptide analogs of the native alpha-melanocyte stimulating hormone (a-MSH) having selectivity for the melanocortin 1 receptor (MClR). Also provided herein are pharmaceutical preparations of the a-MSH peptide analogs, as well as methods of using these analogs in the treatment of medical and veterinary conditions involving MClR.
Abstract translation: 本文提供了对黑皮质素1受体（MClR）具有选择性的天然α-黑素细胞刺激激素（a-MSH）的稳定肽类似物。 本文还提供了a-MSH肽类似物的药物制剂，以及使用这些类似物来治疗涉及MClR的医学和兽医病症的方法。
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公开(公告)号：WO2009151708A2
公开(公告)日：2009-12-17
申请号：PCT/US2009/037809
申请日：2009-03-20
Applicant: GENZYME CORPORATION , PERRICONE, Michael, A. , DZURIS, John, Lyle , WEEDEN, Timothy, E. , STEFANO, James, E. , PAN, Clark, Q. , EDLING, Andrea, E.
Inventor： PERRICONE, Michael, A. , DZURIS, John, Lyle , WEEDEN, Timothy, E. , STEFANO, James, E. , PAN, Clark, Q. , EDLING, Andrea, E.
CPC classification number: C07K14/685 , A61K38/00 , A61K38/34 , A61K47/48246 , A61K47/64 , A61K49/0008 , C07K5/1021 , C07K5/1024 , C07K7/08
Abstract: Provided herein are stable peptide analogs of the native alpha-melanocyte stimulating hormone (α-MSH) having selectivity for the melanocortin 1 receptor (MClR). Also provided herein are pharmaceutical preparations of the α-MSH peptide analogs, as well as methods of using these analogs in the treatment of medical and veterinary conditions involving MClR.
Abstract translation: 本文提供了对黑皮质素1受体（MClR）具有选择性的天然α-黑素细胞刺激激素（a-MSH）的稳定肽类似物。 本文还提供了a-MSH肽类似物的药物制剂，以及使用这些类似物来治疗涉及MClR的医学和兽医病症的方法。
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